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Emmanuel Profile picture
@ejustin46
Oct 12, 2024 • 8 tweets • 3 min read • Read on X
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LARGEST MULTI-ANCESTRY GENOME-WIDE ASSOCIATION STUDY (GWAS) of Long COVID

...using data from over 53,000 cases and 120,000 controls from the 23andMe research cohort
H/t @VirusesImmunity
medrxiv.org/content/10.110…Image
2) This study looked at the genetics behind "Long COVID" - the persistent symptoms some people experience after recovering from COVID-19. Using data from over 53,000 Long COVID patients and 120,000 healthy controls, the researchers conducted the largest genetic analysis ... Image
3) ...of Long COVID to date.
They identified three key genetic regions linked to Long COVID risk:

▶️ Genes involved in the immune system's response to infection. This suggests immune dysfunction plays a role in Long COVID. Image
4)▶️ The ABO gene, which has previously been associated with COVID-19 severity. This indicates that factors affecting the initial COVID-19 infection may influence the development of Long COVID.
▶️ Genes related to viral suppression and inflammation pointing ... Image
5) ... to underlying biological pathways that could contribute to Long COVID.

Interestingly, the study also found strong genetic connections between Long COVID and other chronic conditions with similar symptoms, like chronic fatigue and depression. Image
6) This implies that some people may be genetically predisposed to developing post-viral syndromes after COVID-19.

Overall, these findings provide important insights into the genetic basis of Long COVID. Image
7) This could help identify individuals at high risk and guide the development of targeted treatments for this debilitating condition.

Thanks for reading 🙏 and thanks to @23andMeResearch and @ninaadsc for this study
8) And safeguard yourself from COVID-19, avoid reinfection, as even mild cases can pose significant risks.

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More from @ejustin46

Emmanuel Profile picture
Jan 26
NIPAH VIRUS
Jumping to conclusions during outbreaks only fuels panic and misunderstanding; NOT EVERY VIRUS OUTBREAK is a PANDEMIC.

We raised the alarm about Nipah in 2023, but it’s essential not to confuse an epidemic related to this virus, ... Image
2) ...like the one in India, with a pandemic risk or a situation like COVID-19.
Nipah virus is transmitted primarily from animals, especially bats, to humans. It spreads through direct contact with infected animals, their secretions, or contaminated foods.
3) Human-to-human transmission occurs only through close contact, such as touching or caring for an infected person, as well as sharing fluids like saliva or blood.
We cannot equate a virus transmitted through fluids with a respiratory virus like SARS-CoV-2. Image
Read 7 tweets
Emmanuel Profile picture
Nov 28, 2025
"70% to 90% of our CELLS are completely RENEWED in less than 5 YEARS!
So If we’re mostly "New", why are so many still struggling with SARS-CoV-2?

We will tackle this question, which is more complex than it seems, in several posts. Image
2) First, let's say a few words about cell renewal.
70% to 90% of our cells are renewed over time. This turnover occurs in various cell types, including skin, blood, and immune cells, allowing the body to replace damaged or aged cells.
sciencefocus.com/the-human-body…Image
3) For instance, red blood cells have a lifespan of about 120 days, while skin cells regenerate every few weeks.
Even with significant cell renewal, aging persists due to changes in our DNA.
sciencefocus.com/the-human-body…Image
Read 5 tweets
Emmanuel Profile picture
Nov 26, 2025
UNRAVELING CO-INFECTION:
How SARS-CoV-2 and Other Viruses Interact ?
(In layman's terms)

Two groundbreaking studies exploring the complex dynamics of viral co-infection!
biorxiv.org/content/10.110…
biorxiv.org/content/10.110… Image
Image
2) Co-infection occurs when a person is infected by more than one virus at the same time. This can lead to interesting and sometimes complex interactions between the viruses Image
3) In one study about SARS-CoV-2, researchers found that when different versions of this virus infect the same person, they can mix their genetic material through a process called recombination. This means that the new version of the virus can have traits from both parent viruses Image
Read 6 tweets
Emmanuel Profile picture
Nov 24, 2025
ENVELOPE PROTEIN and LONG COVID

For more than three years, we have been emphasizing that the envelope protein is an essential component and that we cannot limit our focus to just the spike protein. We are now uncovering its role in long COVID. Image
2) Here are some insights on the E protein and its role in long COVID, as discussed in this recent study.
pmc.ncbi.nlm.nih.gov/articles/PMC12…Image
3) The Envelope (E) protein of SARS-CoV-2 plays a crucial role for several reasons:

▶️ Virus Assembly and Release: The E protein is essential for the virus's assembly and budding from infected cells, contributing to its stability and infectivity.
Read 8 tweets
Emmanuel Profile picture
Nov 21, 2025
"N''oubliez jamais" (Never forget - Joe Cocker)🧵

In 2022, COVID-19 was the second leading cause of death globally, with the repercussions of the virus far from over. The lasting impact of the pandemic continues to affect lives around the world.
2)
3)
Read 5 tweets
Emmanuel Profile picture
Nov 20, 2025
LONG COVID : Sticky Microclots in the blood !

Recent research may have identified a key factor contributing to long COVID: microscopic clots intertwined with immune system debris in the blood. These unusual structures were found to be nearly 20 times more prevalent ... Image
2) ...in long COVID patients compared to healthy individuals. The clots, associated with neutrophil extracellular traps (NETs), suggest a potential biological marker for persistent symptoms. Image
3) These microclots could impede blood flow in small vessels, leading to issues like brain fog, fatigue, and shortness of breath. Image
Read 4 tweets

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