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Emmanuel Profile picture
@ejustin46
Oct 12 • 8 tweets • 3 min read • Read on X
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LARGEST MULTI-ANCESTRY GENOME-WIDE ASSOCIATION STUDY (GWAS) of Long COVID

...using data from over 53,000 cases and 120,000 controls from the 23andMe research cohort
H/t @VirusesImmunity
medrxiv.org/content/10.110…Image
2) This study looked at the genetics behind "Long COVID" - the persistent symptoms some people experience after recovering from COVID-19. Using data from over 53,000 Long COVID patients and 120,000 healthy controls, the researchers conducted the largest genetic analysis ... Image
3) ...of Long COVID to date.
They identified three key genetic regions linked to Long COVID risk:

▶️ Genes involved in the immune system's response to infection. This suggests immune dysfunction plays a role in Long COVID. Image
4)▶️ The ABO gene, which has previously been associated with COVID-19 severity. This indicates that factors affecting the initial COVID-19 infection may influence the development of Long COVID.
▶️ Genes related to viral suppression and inflammation pointing ... Image
5) ... to underlying biological pathways that could contribute to Long COVID.

Interestingly, the study also found strong genetic connections between Long COVID and other chronic conditions with similar symptoms, like chronic fatigue and depression. Image
6) This implies that some people may be genetically predisposed to developing post-viral syndromes after COVID-19.

Overall, these findings provide important insights into the genetic basis of Long COVID. Image
7) This could help identify individuals at high risk and guide the development of targeted treatments for this debilitating condition.

Thanks for reading 🙏 and thanks to @23andMeResearch and @ninaadsc for this study
8) And safeguard yourself from COVID-19, avoid reinfection, as even mild cases can pose significant risks.

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More from @ejustin46

Emmanuel Profile picture
Oct 14
PLASMA CELLS, BONE MARROW and VACCINATION🧵

"Missing immune cells may explain why COVID-19 vaccine protection quickly wanes"
science.org/content/articl…Image
2) Recent research suggests that a lack of certain immune cells may explain why COVID-19 vaccine protection fades quickly. Scientists found that people who received multiple vaccine doses often did not produce long-lived plasma cells, which are crucial for lasting immunity.
3) These cells typically develop when B cells encounter a virus, but the spacing of SARS-CoV-2's spike proteins makes this process difficult. Improving vaccine design to better present these proteins could lead to more durable immunity against COVID-19.
Read 5 tweets
Emmanuel Profile picture
Oct 14
Identification and genetic characterization of five novel bat coronaviruses from Yunnan, China

bmcvetres.biomedcentral.com/articles/10.11…Image
2) This study examined coronaviruses in bats from Yunnan, China. Researchers found 7 new coronaviruses, including 5 alpha-coronaviruses and 2 beta-coronaviruses. Genetic analysis revealed unique features in these viruses, like additional genetic segments. Image
3) One virus had recombined across different bat species, suggesting potential to infect other animals. However, this virus showed low ability to bind human receptors, limiting its risk to humans. Image
Image
Read 4 tweets
Emmanuel Profile picture
Oct 13
MITOCHONDRIA and SARS-COV-2
(A mega-thread🧵 with 16 studies)

When the virus damages the mitochondria, the energy-producing centers of our cells ... Image
2)
3)
Read 11 tweets
Emmanuel Profile picture
Oct 13
IMMUNOGENICITY to SARS-COV-2 ?
(Mega-thread🧵 with 7 studies just published ! 💯)

We need to approach this topic, with a lot of humility, acknowledging that we are just starting to grasp the complexities of our immune system's response to SARS-CoV-2. Image
2) "Real-world assessment of immunogenicity in immunocompromised individuals following SARS-CoV-2 mRNA vaccination: a two-year follow-up of the prospective clinical trial COVAXID"

Immunocompromised patients often don't respond well to COVID-19 vaccines ... thelancet.com/journals/ebiom…Image
3)..leading to the need for extra booster shots. In a 2-year study of 364 patients from a trial, blood samples showed that more vaccine doses and past infections improved immune responses, despite some treatments weakening them. Continuous boosters are crucial for these patients. Image
Read 15 tweets
Emmanuel Profile picture
Oct 12
"Synergistic evolution:
the DYNAMIC ADAPTATION of SARS-CoV-2 and human PROTECTIVE IMMUNITY in the real world"

journalofinfection.com/article/S0163-…Image
2) This study examined how the SARS-CoV-2 virus and the human immune system have been evolving together over the past 3 years of the pandemic.

Key findings:

- The virus has adapted to evade the immunity built up from previous infections and vaccines ... Image
3) ...creating 3 distinct "versions" or "serotypes" of the virus.
- Antibodies from an earlier infection often could not effectively neutralize newer variants, especially the highly evasive XBB lineage. Image
Read 5 tweets
Emmanuel Profile picture
Oct 12
The WORLD'S LARGEST MONTHLY WASTEWATER REPORT,
Monitoring 26 Countries -October 10, 2024

The analysis across the monitored countries reveals a diverse landscape, with trends varying widely between increasing, decreasing, and stable patterns.
…stewater-observatory.jrc.ec.europa.eu/#/bulletinImage
Image
2) This complexity underscores the need for caution in drawing swift conclusions about the current waves.

**Overview by Country:**

- Increasing Trends: Four countries—Austria, Germany, Greece, and the Netherlands—have reported rising levels of SARS-CoV-2 in wastewater. Image
3) - Decreasing Trends: Six countries—Belgium, Denmark, Latvia, the United States, New Zealand, and Japan—are experiencing declining trends.

- Stable Trends: Seven countries—Finland, Luxembourg, Slovakia, Switzerland, Türkiye, Japan, and Canada—exhibit stable patterns, with ... Image
Read 11 tweets

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