42-1/ COVID update for epidemiological weeks 41-42 of 2024.
COVID is down down down—at least in the US. And my bad, Biobot hasn't switched to a monthly report. They still seem to be reporting weekly. My neuro-atypical mind missed the dropdown report menu button.
42-2/ COVID ED visits are following the downward wastewater trend. Although there may be delays in tabulation, weekly deaths (per 100k) may clock in at the lowest any time since the start of the pandemic. Hospitalizations dropping, too.
42-3/ Lots of scary stories in the MSM that XEC will bring on the next COVID wave RSN (Real Soon Now). Its frequency is growing, but so far it hasn't stopped the downward trend in cases (at least in the US). Its frequency *is* growing fast, though.
42-4/ While US numbers are dropping, some countries are on the rise—Germany, for instance. And the Netherlands. Driven partially by XEC...
42-5/ XEC is close to 50% in Germany a few weeks ago. And ~35% in the Netherlands. Notice that they're not coming off a wave like we are. I'm guessing that the current 3 XEC.x variants will not kick off the next wave in the US. Maybe their descendants will, though.
42-6/ OTOH, down under in Australia, their COVID hospitalizations are lower than ever. Not much wastewater testing happening in AUS, but in the greater Sydney area, WW numbers remain relatively low. NSW respiratory notifications show same pattern for COVID.
42-7/ As for other respiratory viruses in the US, I'll start with hCoVs because a reader asked: "Will SARS-CoV-2 become as common as OC43?" If we look at Biofire's (proprietary) Syndromic Trends, SARS2 has always been the big kahuna of coronaviruses. OC43 on the rise though…
42-8/ The big question is whether SARS2 will become as harmless as hCOV cold viruses. @arijitchakrav thinks it won't. I was going to link to his thread where he argues it won't, but he blocked me for calm mongering. But I'd say if current trends continue, it will eventually.
42-9/ Flu season seems to be delayed in the US. But the flat line in the WHO positivity numbers is weird. However, Biofire shows that the incidence of flu viruses is still very low—but is that the start of a slight uptick in A H3 influenzas?
42-10/ And since I'm on Biofire, Rhinoviruses seem to have peaked. Hmmm. But if the (loose) inverse correlation between RVs and SARS2 holds, we might see an uptick in SARS2 sooner than later.
And RSV rates are starting to rise...
42-11/ That's all for this update. I've got a few interesting papers that I need to read in the hopper (including a big masking metastudy). I'll report back on them in my Epi Week 44 update. Oh, and get your COVID booster! And your flu shot, too (if you haven't already done so).
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16-1/ My pathogen update for epi weeks 15-16 of 2025.
Per Biobot, national SARS2 wastewater concentrations as of 12 April were almost down to the levels of post-Omicron interwave gaps. I suspect they're there now.
16-2/ If patterns hold, SARS2 should maintain this low level of circulation for a few weeks before climbing again in an upward curve. Though previous summer peaks have been late Aug/early Sept, I wouldn't be surprised to see the next wave peak in July or early Aug. We'll see.
16-3/If the trends hold, COVID-19 weekly mortality rates and ED visits will drop below levels of previous interwave gaps in the next few weeks. COVID-19 is still holding on to 14th place as most common cause of death, but I wonder if it won't drop off the top 15 by the end of 25.
14-1/ My pathogen update for epi weeks 13-14 of 2025.
As of 28 March, we're not down to previous interwave SARS2 circulation levels yet—except for the Western region of the US. But the rest of the US should be there by the 3rd week of April.
14-2/ COVID hospitalizations, ED visits, and deaths all tracking downward as of two weeks ago.
14-3/ Flu season is receding as well. As with most previous seasons, we've got a long tail of influenza B cases, but they're nowhere near the numbers of influenza A cases.
12-1/ My pathogen update for epi weeks 11-12 of 2025. The XEC COVID wave hasn't fully receded yet. Biobot shows that as of March 15, SARS2 wastewater levels haven't fallen to previous interwave gaps except for the Western region of the US.
12-2/ The CDC's ww numbers indicate a long tail for this wave, but it shows the West and NE back to interwave levels. These numbers are all normalized to the previous year's numbers, so I don't know if this long tail may be an artifact of the way they normalize. I trust Biobot.
12-3/ If there is a long tail, it's due to the LP.8.1x brood that continues to gain traction against XEC.x. I expected the LP.8.1x's to top out at about 30%, but CoV-Spectrum shows they've reached 50%. O/c, there were only 3 LP.8.1x descendants a month ago. Now there are 19.
10-1/ My pathogen update for epi weeks 9-10 of 2025. I'm renaming this a "pathogen update" because SARS-CoV-2 is fading into endemicity. That doesn't mean that COVID-19 won't remain a public health problem, but we've got a bunch of other pathogens that we need to keep our eye on.
10-2/ But speaking of COVID-19, the current wave is receding. Both the CDC's wastewater activity levels and Biobot's wastewater concentration chart show a downward trend in all regions of the US,
10-3/ This XEC wave had the lowest rates of hospitalizations, ED visits, and deaths of any variant wave so far (at least for the US). And rates of test positivity for RSV and Influenza outpaced COVID this respiratory season.
8-1/ My COVID update for epidemiological weeks 7-8 of 2025.
The current COVID wave continues to be the mildest in terms of hospitalizations and mortality since the pandemic began. And it doesn't look like LP.8.1 will break out to boost the current XEC wave.
8-2/ The CDC's wastewater survey shows SARS2 numbers are trending downward in all regions except the Midwest. Note: The CDC normalizes these against the previous year, so they don't give us absolute concentrations. Biobot does, but they haven't published an update in past 2 wks.
8-3/ While ED visits and deaths due to COVID remain low compared to previous waves, influenza is the respiratory virus causing the most ED visits — although we're probably past the peak for flu cases now.
6-1/ My COVID update for epidemiological weeks 5-6 of 2025.
Biobot's latest wastewater numbers indicate the current XEC wave has receded a bit—but we might see a secondary bump as the numbers level off in West and Midwest, and climb a bit in the South.
6-2/ As US COVID waves go, wastewater numbers indicate this has been on the low side, but we don't really know if the viral shedding of JN.1 and its descendants has remained consistent with previous variants.
6-3/ When it comes to ED visits, hospitalization, and mortality, this has been the mildest wave ever in the US. But...