"Vitat in vitro sed non evadit in vivo."
Moving most of my activity over to Blue. I will continue to monitor my account on TwiXter & occasionally respond
12-2/ The CDC's ww numbers indicate a long tail for this wave, but it shows the West and NE back to interwave levels. These numbers are all normalized to the previous year's numbers, so I don't know if this long tail may be an artifact of the way they normalize. I trust Biobot. 
8-2/ The CDC's wastewater survey shows SARS2 numbers are trending downward in all regions except the Midwest. Note: The CDC normalizes these against the previous year, so they don't give us absolute concentrations. Biobot does, but they haven't published an update in past 2 wks. 
6-2/ As US COVID waves go, wastewater numbers indicate this has been on the low side, but we don't really know if the viral shedding of JN.1 and its descendants has remained consistent with previous variants. 
4-2/ Other CDC data pages seem to be up and running, though. Their wastewater numbers seem to indicate the current XEC COVID wave has peaked. Biobot hasn't published an update recently, so I don't have a reality check for CDC's data. 
2-2/ CDC's ww graph shows a higher rise in the Midwest and less so in the South. Of course, the CDC normalizes its numbers against the previous year, so these are relative numbers—not avg SARS2/PMMoV concentrations in CpmL units. Biobot methodology seems more straightforward. 
52-2/ Of the big 3 respiratory viruses (per CDC), COVID still trails RSV and influenza in test positivity, but has now passed RSV in the number of ED visits. 
50-2/ The folks at Biobot haven't posted an update for two weeks, so I don't have any good aggregate wastewater numbers for the US (b/c the CDC doesn't publish nat'l data in CpmL units). So, let's zoom in on what's happening in some big city sewersheds. NY State first... 
44-2/ I'll point out again: COVID interwave ww concentrations are order of magnitude higher than flu and RSV ww concentrations (peak Flu A is that little red X under COVID)—perhaps due to differences in their viral shedding? But SARS2 is always circulating relatively high levels. 
42-2/ COVID ED visits are following the downward wastewater trend. Although there may be delays in tabulation, weekly deaths (per 100k) may clock in at the lowest any time since the start of the pandemic. Hospitalizations dropping, too. 
36-2/ ED visits seem to have peaked as well—although the 5-17 age cohort is lagging other age groups—probably due to the opening of schools across the US. But crude death rate rose to .3/100K the 3rd week of August. They may be dropping now (or not yet). 
34-2/ O/c, Sentinelle tracks aggregated ARI numbers—COVID isn't broken out of the stats—but if COVID cases had increased due to the Olympics, they weren't high enough to impact the overall ARI numbers. Worth noting that the summer KP.x wave seems to have minimally affected FR. 
32-2/ For instance, NYC's (Manhattan's) wave started late, showed a sharp upward trend, and now it's dropping off quickly. Boston's wave started earlier, and was less pronounced, but it's dropping off... 
30-2/ The current wave is manifesting itself unevenly across different sewersheds. For instance, San Jose shows the current wave as big as the last one, but 40 miles up the road, Oakland doesn't show much of wave at all... 
51-2/ This wave is shaping up to surpass, the BQ.1 wave at the end of last year. But despite JN.1's immune evasiveness (at least in vitro) and ACE2 binding scores (at least in vitro) which are lightyears beyond Omicron, it's not another Omicron. Zooming out... 
49-2/ CDC's NWSS says the same w/ Midwest having highest ww activity. Biobot and NWSS numbers are 10-14 days old. We probably haven't reached BQ.1 territory, yet, but soon will. 
39-2/ Emergency Department visits are falling. Hospitalizations may trail the ED curve by a week or two, but they seem to have peaked as well... 
37-2/ Midwest still climbing, but the South—where case rates were 2x higher than the rest of the US 3-4 weeks ago—has the sharpest drop in wastewater numbers. The CDC's ww percent change category chart shows things leveling off, too. I never found that metric useful because… 
