Bryan Johnson Profile picture
Oct 22, 2024 12 tweets 6 min read Read on X
Genetically, I should be bald.

I started to lose my hair and go gray in my late 20s.

Now, at 47, I’ve got a full head of hair and ~70% of my gray is gone.

Here how I did it.. 🧵 Image
Contrary to popular belief, you can maintain your hair well into your 40s and beyond.

In 12 months, I went from a Norwood 3 to a Norwood 2. Norwood is a hair loss scale, as indicated in the image.

Here’s how I achieved these results:
Image
1. Start early:

Don’t wait for visible loss.

Many lose up to 50% of their hair before they even realize it.

The best time to work on your hair is before you start losing it. Sources (1) (2)
2. Nutrition:

Make sure you're getting adequate:

+ Protein: including collagen peptides and sufficient methionine, cyteine, and lysine in addition to taurine, to support collagen, keratin, and elastin synthesis. Ref (3)

+ Omega-3 fatty acids: for antioxidant effects and improving scalp circulation. Ref (4)

+ Key vitamins & minerals: including iron, selenium, and biotin. Ref (3)

The Blueprint stack has all of these. ↓Image
3. Customized topicals:

I use a personalized Rx formula based on my genetics to prevent and reverse hair loss. Roots byGA (5)

Here are the ingredients in my formulation: Minoxidil (7%), Cetirizine HCl (1%), Latanoprost (0.004%), Dutasteride (0.25%), Melatonin (0.1%), Caffeine (0.2%), Tretinoin (0.0125%), Vitamin D3 (1,000IU/ML), Vitamin E (10 IU/ML).

5% minoxidil is a solid budget alternative. Apply 1 mL to scalp at night or in the morning (or both), massage thoroughly.

Note that some people experience side effects with a topical such as itchy skin, headaches etc. so monitor for those.
4. Red light therapy:

Six minutes a day and you can be doing your morning routine as you wear it. A study on 44 males (age 18-49) showed that treatment with 655nm laser cap for 25 min every other day for a duration of 16 weeks resulted in a 39% increase in hair growth compared to placebo. Ref (6)

An affordable Blueprint red light cap coming soon.
5. Oral minoxidil:

I take 3.75 mg a day. I started with 2.5 mg and evaluated for side effects.

In a double-blind, placebo-controlled randomized clinical trial involving 90 men with androgenetic alopecia AGA, oral minoxidil (5 mg daily) was found to have similar efficacy to topical minoxidil (5% solution applied twice daily) after 24 weeks.Ref (7)

Oral minoxidil is generally considered safe at low doses, but it can have side effects such as hypertrichosis (excessive hair growth) and headaches.Image
When starting any new hair regimen:

+ Start slow
+ Introduce 1 product at a time
+ Monitor closely for side effects
+ Give each addition 3 months to show results
+ 5% minoxidil alone is sufficient for many
+ Consider personalization based on your genetic profile, health, diet type and nutritional condition to reverse any deficiencies (e.g. omega3, protein...) revealed by blood testing.
In December, I'll have a hair growth serum for you. I've been experimenting and refining the formulation for two years.
A final note that I’m in touch with several companies that are building novel hair regrowth therapies. They are promising and exciting.

They’re still years out but it’s cool to think that hair loss may no longer be a thing we have to think about. Just one reason why the future is going to be amazing. #dontdie
For my full protocols and guides visit Project Blueprint here:

blueprint.bryanjohnson.com/pages/blueprin…

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More from @bryan_johnson

Sep 3
My 4+ hour daily routine resets my blood vessels to perform like they did in my teenage years. 🧵 Image
0/ Here is the level of vascular function reset and rejuvenation enabled by my morning routine, every single day

+ Central blood pressure: 86 mmHg (lower than 99% of males < 20)
+ Peripheral blood pressure: Systolic 94/ Diastolic 56 (lower than 99% of males < 20)

+ Vascular elasticity and compliance (softness):
a) Augmentation pressure: -1 mmHg (lower than 50% of males < 20)
b) Augmentation index: -4% (lower than 60% of males < 20)
1/ I previously shared that my sauna protocol has restored my vascular function and blood flow to levels typical of a healthy 20–25 year old. This effect has been observed consistently, whether the readings are taken upon waking or later in the day.

However, my morning routine, which combines exercise sauna, red/NIR light therapy, and HBOT or IHHT, takes this to the next level.

Daily, it guides my arteries and vascular system into a state of relaxation, akin to a soothing massage for your blood vessels.

Here’s what we’ve noticed and how it unfolds:
Read 6 tweets
Aug 31
This is big. OpenAI and Retro used a custom model to make cellular reprogramming into stem cells ~50× better, faster, and safer. Similar Wright brothers’ glider to a jet engine overnight.

We may be the first generation who won't die.

Let's take a look at what they did. 🧵 Image
0/ AI Redesigns the Engines of Cellular Reprogramming

OpenAI and Retro Biosciences reported a landmark achievement: using a domain-specialized protein design model, GPT-4b micro, they created engineered reprogramming factors that deliver over 50× higher efficiency in generating induced pluripotent stem cells (iPSCs), with broad validation across donors and cell types. These AI-designed proteins not only accelerate reprogramming but also enhance DNA repair, overcoming DNA damage as one cellular hallmark of aging hinting at relevance for aging biology.
1/ 0/ From Yamanaka’s Discovery to Today

In 2006, Shinya Yamanaka identified four transcription factors; Oct4, Sox2, Klf4, and c-Myc (OSKM), capable of resetting differentiated adult cells into a pluripotent, embryonic-like state. This breakthrough opened two revolutionary doors in biology:

1) Full reprogramming: completely erasing cell memory, identity, to generate pluripotent stem cells (iPSCs) for regenerative medicine, tissue engineering, and disease modeling.

2) Partial reprogramming: transient expression to roll back cellular age without erasing cell identity.

This remarkable discovery won Yamaka the Nobel Prize for Physiology or Medicine in 2012.

Yet, in practice, OSKM are astonishingly inefficient (<0.1% conversion, requiring +3 wees of culture) and carry oncogenic risks, particularly from c-Myc. These limitations have long restricted their therapeutic potential. These limitations have limited the progress in regenerative medicine due to the difficulty of scaling the safe and reliable production induced pluripotent stem cells.Image
Read 6 tweets
Aug 29
I sacrificed my fertility for this message:
ice your balls in the sauna

After icing improved my fertility markers,
I removed the ice to validate

The boys suffered. More than we initially thought.
Here’s my latest results explained. 🧵 Image
0/ Results from sauna experiment

27 daily sauna sessions with ice on balls:
+ total motile count ↑ 57%
+ motility ↑ 16%,
+ total count ↑ 43%

2 weeks without icing (15 sauna sessions with full heat on balls)

my boys’ motility decreased, counts unaffected
total motile count ↓ 54%
motility ↓ 57%
total count ↑ 6%

direct hit to motility and total motile count due to mature sperms in storage (sperm is stored for a couple weeks between full maturation and ejaculation in the Epidimysis).Image
1/ One week post re-icing: misleading partial recovery (values compared to pre-sauna baseline)
total motile count ↓2%
motility ↓ 34%
total count ↑ 56%

4 weeks post re-icing: 2nd wave of heat effects: large drop in count, motility.
total motile count ↓ 56%
motility ↓ 50%
total count ↓ 9%

Latent hit to counts and motility:
heat damages early spermatogenesis (meiosis) and later sperm maturation (morphological changes, tail formation, and cytoplasmic loss) leading to a reduction in sperm count and motility.

The effect is latent because the "faulty batches" from heat exposure with fewer total and motile sperm are only apparent in test after being stored for a couple weeks in the epididymis.Image
Read 5 tweets
Aug 28
5 things you can do to combat phone addiction 🧵

1. Set ALL NOTIFICATIONS OFF as your default

It takes 23 mins on avg to regain focus after being distracted by your phone. Only allow text notifications from people who contact you in an emergency.Image
If you do need notifications, be strategic about which ones you allow: Image
2. Resist the urge to check Instagram and TikTok

Apps like One Sec or Opal let you add loading screens before accessing addictive apps.

They can force you to look at yourself in the camera for a few seconds, or make you spin your phone around 4 times before granting access.

If that doesn’t work:
The app Brick comes with a physical “brick” to lock or unlock groups of apps on your phone.
+ Put the brick on your fridge
+ Tap your phone against it to block all non-work apps
+ Go to the kitchen to unlock if you need to check something or spend 15 mins on social media

You can also give someone else the Brick to keep you accountable.Image
Read 6 tweets
Aug 27
A brain measurement shows why I’m weird.
And why I love my haters.

This brain MRI reveals personality traits.
Here's what my report shows and my worst brain marker. 🧵 Image
0/ My brain age is 5 years younger than my chronological age. It’s 42. Image
1/ How some of my brain regions explain my personality Image
Read 8 tweets
Aug 20
Genetically, I should be bald.

But I’m not.

I've worked very hard to maintain my hair....I've tried a lot of things over the years to stop hair loss and grow strong healthy hair. I’ve injected PRP and dutasteride into my scalp way too many times. That hurts like hell and I don’t think the PRP helped at all.

I tried a lot of other things too and few if any actually work. So my team and I built our own solution.

It’s the most advanced formulation I’ve seen.

It’s now available if you want to give it a try. Like all things with hair, you need to be consistent for at least 4 months.

Here’s what’s in it and why I’m excited about it.Image
0/ What the product has:

+ 8 biomimetic peptides, more than any other product. And in the highest concentrations.

+  We put every peptide in its own patented delivery system so it reaches the exact receptor it’s designed to target for maximum impact.

+ We integrated patented nanofluorosome technology that is activated by the Blueprint Laser Cap (avail in Sept).

The serum is water-based, lightweight and dries completely residue free.

Layers of interventions and actives stacked upon each other.
1/ The ingredients

Blueprint Peptide Serum:
1. sh-oligpeptide-1 - EGF
2. sh-oligiopeptide- 4 - Thymosin-β4
3. sh-polypeptide-4 SCF
4. sh-polypeptide -7 hGH
5. sh-polypeptide -9 VEGF
6. sh-Polypeptide-59 PDGF
7. sh-Polypeptide-86 Follistatin
8. Copper Tripeptide-1 GHK Tripeptide-1

Blueprint Shampoo (scalp treatment)
sh-oligopeptide-1 - EGF
sh-oligopeptide- 4 Thymosin-β4
sh-polypeptide -1 bFGF
sh-polypeptide -7 hGH
sh-polypeptide -9 VEGF
sh-polypeptide -11 aFGF
sh-polypeptide -71 -VIP
Copper Tripeptide-1 GHK
Read 4 tweets

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