I suspect "The Sort" can greatly increase your exposure to time-wasting incompetenceđź§µ
The obvious example of how The Sort exposes you to incompetence is that nowadays, competent people don't go into the public sector all that often.
This is a mixed bag: while the government is a poor use of human capital, it needs some to avoid holding back the rest of society.
There are also a lot of fairly menial service sector jobs that you'll run into all the time, and these are less obviously, but no less problematized by The Sort.
Why? Because in the past, socioeconomic status was less cognitively stratified.
You can still see this today in many developing economies, where intelligence is slowly becoming more related to socioeconomic status as markets develop and opportunity expands.
The improvements to The Sort mean that fewer and fewer smart people are born into and remain in bad conditions.
But that also means that fewer and fewer smart people spend a long time in menial service sector jobs.
Accordingly, the quality of the work in those jobs is worse than if the job had more intelligent people working it.
Why? The first reason is that smarter people just do jobs better: They make fewer mistakes, operate more efficiently, often even have higher moral standards, etc.
The second reason is that, because smart people do jobs better, they teach less smart people how to do the job better, either directly or by example.
When you have more and less intelligent people play games, combining them brings up the less able.
In effect, many jobs are becoming more and more of left tail-exclusive jobs, with the effect being that they're done worse and worse, making your life harder and wasting more of your time when you run into them.
But it doesn't have to be this way!
Ever been to a Buc-ee's?
They're Texas' amazing gas station/car wash combo stores, and they're known
(A) Being pleasant, and
(B) Very publicly paying their employees well.
If you've been to a Buc-ee's you might have noticed that they offer discounted gas if you wash your car.
Their car washes are very long and the wait times are minimal compared to other offerings.
They have minimal human involvement.
Because Buc-ee's embraces productivity-improving tools and builds, and pushes their employees to be efficient, they can afford to pay them well and to pass on lots of savings to customers, and they also pass on saved time over other car washes.
Productivity enhancements that eliminate the involvement of human labor have the opportunity to cut out increasingly-inefficient human components of jobs.
If the carwash is nearly fully automated, the wages can be respectable and slow' human involvement can be minimized.
And where will the people currently working those jobs go?
Take manufacturing employment. When industrial robots are installed, employment goes down in that area, but up more in non-manufacturing jobs.
The disemployed move jobs.
Wages tend to go up. They tend to move to better jobs, or at least jobs that are less dangerous, less monotonous, and which are better compensated.
And crucially, that left tail? It might move closer to the rest of the cognitive pack, meaning its members can skill up.
Automation might be even more of an engine of progress and life improvement than people generally assume, and it might make all of our lives better off by fixing some of the downsides of The Sort.
Thanks, robots!
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The revolution in organ transplants is here thanks to gene editing.
A 62-year-old man on dialysis needed a new kidney. Doctors implanted him with a pig's kidney that had been given 69 edits to be human-compatible.
He immediately stopped needing dialysis.
This man was insanely unhealthy before and after the operation, but at least the organ transplant worked.
On day eight he had his only hiccup, a rejection episode that was easily overcome with a hit from some monoclonal antibodies and some corticosteroids.
For background on how insanely unhealthy this man was, just look at his prior history.
He did die 52 days after the operation, but it was still a success. He died from an unrelated heart attack, with no evidence of xenotransplant rejection, and he had stable kidney function.
High schoolers think it's funny to self-report being transgender.
This makes estimates of trans percentages and other stats unreliable.
Students who self-report as trans also frequently report being blind 7-foot-tall crackheads who belong to a gang and never visit the dentist.
The study is from 2014, and of course, we might "know" (who can say, given the nutty response patterns?) that transgender numbers have greatly increased since then.
In a 2017 follow-up it was found that the issue remained.
Cutting out just the most obvious "mischievous responders" halved the rates of "LGBQ-Heterosexual disparity" in 20 a composite of 20 different health measures.
This one didn't deal with trans identity so much, but it's probably even more affected than general gay results.
Is red meat good for your heart? The answer depends on who you ask.
If you ask someone paid by the meat industry, they say it's good for you, or at least neutral.
If you ask a financially independent researcher, they say it's neutral, or more likely harmful.
This happens all over the place.
For example, when studying mindfulness, as a group, only authors who, say, offer mindfulness courses, speaking arrangements, and have book deals publish positive effects.
The beta blocker propranolol reliably impairs memory consolidation.
The above result is for healthy volunteer samples. This is the result for clinical samples.
It's effectively the same picture.
This result holds up to corrections for publication bias. In fact, there's barely any evidence for publication bias, and trim-and-fill does nothing here.
So I'm reasonably confident in the memory formation impairment effects of propranolol based on this evidence.
Today the New England Journal of Medicine published the second big win for lifesaving N-of-1 gene therapies.
They might have just saved a baby's life from being snuffed out by a fatal, ultrarare metabolic condition.
This is good for the baby, but maybe for many others too đź§µ
The deficiency the baby was born with is carbamoyl-phosphate synthetase 1 or CPS1 deficiency.
CPS1 is a mitochondrial enzyme that is involved in detoxification during the urea cycle. If you lack it like this baby, you tend to see hyperammonemia (ammonia buildup) right away.
This buildup is typically but not always deadly.
Roughly half of those who develop the condition in early infancy end up dying from it.
And for those who don't, the result is usually not a good life: dialysis, mental retardation, liver transplantation, restrictive dieting, etc.