Share this page!

Enter URL or ID to Unroll

You can paste full URL like: https://x.com/threadreaderapp/status/1644127596119195649
or just the ID like: 1644127596119195649

How to get URL link on X (Twitter) App

  1. On the Twitter thread, click on or icon on the bottom
  2. Click again on or Share Via icon
  3. Click on Copy Link to Tweet
  4. Paste it above and click "Unroll Thread"!
  5. More info at Twitter Help
David Sinclair Profile picture
@davidasinclair
Oct 29, 2024 • 7 tweets • 2 min read • Read on X
Scrolly
Effect of longevity interventions on epigenetic clocks:

Strongest:
1. Arthritis therapy/anti-TNFa
2. Metformin
3. HBOT
4. AC-11
5. Bypass
6. Ketamine
7. Vegan/Mediterranean

No effect:
1. Rapamycin
2. Omegas
3. Exercise
4. Vitamin B
5. CR/IF
6. Ozempic
7. Follistatin
More ⬇️ Image
DNA methylation (DNAme) age reductions. Red asterisks represent statistical significance
* P<0.05; ** 0.01; *** 0.001 Image
No effect on DNAme age: Image
Negative effect on DNAme age: Image
Blood biomarkers that serve as proxies for DNAme age and diets:

CystatinC - kidney function
HBA1c - glucose / diabetes
CRP - inflammation/ heart disease
ALK - liver / bone health
Triglycerides - serum fat / heart disease Image
From the Longevity Interventional Studies Community & lab of Albert Higgins Chen @YaleMed. The manuscript can be accessed @biorxivpreprint and has not yet been peer reviewed and might change during this process - like defining what “ART” is 🙏
biorxiv.org/content/10.110…
@YaleMed @biorxivpreprint Why might ketamine change DNAme? Ketamine can reduce methylation at specific sites within the BDNF gene, potentially improving brain health, which might positively affect other cells and blood biomarkers. Or maybe it acts via peripheral nerves 💪

• • •

Missing some Tweet in this thread? You can try to force a refresh
　

Keep Current with David Sinclair

David Sinclair Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @davidasinclair

David Sinclair Profile picture
Jan 18
Amazing! Placing mice in low air pressure every other day slows hair loss, weight gain, osteoporosis & extends median lifespan by 12%. Ascribed to the killing of senescent, zombie cells

Could exercise, high altitude, or a drug have similar benefits? Let’s dig in🧵 Image
Firstly, hypobaric (low) pressure should not to be confused with hyper-baric oxygen therapy (HBOT), which is also studied by longevity researchers, though there may be overlapping hormetic mechanisms between the two @NaturePortfolio
I’ve always wondered if living at a high altitude is healthier, but the evidence is weak. Maybe it needs to be pulsed: high pressure -> low pressure -> high pressure -> low pressure to induce hormesis Image
Read 19 tweets
David Sinclair Profile picture
Jan 14
New study indicates that a decrease in nerve cell cholesterol caused by cortisol, inflammation & low SIRT1 activity may be a cause of major depression.

So, do statins exacerbate depression?

And since SIRT1 is NAD⁺-dependent, could NAD⁺ boosters treat or prevent depression? …🧵Image
Around 5–5.7% of adults worldwide experience depressive disorders at any given time. >280 million people! Image
Lifetime depression diagnoses in the U.S. have risen. ~29% report ever being diagnosed, up from ~20% a decade ago Image
Read 16 tweets
David Sinclair Profile picture
Jan 4
Cannabidiol (CBD) does amazing things. According to a new study it:

* Increases SIRT1 & autophagy ✅
* Decreases mTOR ✅
* Upregulates SOX2 & OCT4 ✅
* Preserves telomeres ✅
* Reduces inflammatory NF-kB ✅
* Slows stem cell aging ✅

🧵 Image
CBD, or cannabidiol, is the second most prevalent active ingredient in marijuana, with no effects indicative of any abuse or dependence potential
Mesenchymal stem cells (MSCs) are used to treat various degenerative diseases. Their therapeutic potential is limited by their aging in the dish as they are expanded in number. The researchers tested if CBD could help
Read 10 tweets
David Sinclair Profile picture
Oct 7, 2025
Statistically, you should not exist:

– Life-friendly universe: 1/10⁶⁰
– Earth + moon: 1/10⁹
– Multicellular life: 1/10⁴
– Intelligence & civilization: 1/10⁹
– Your genome: 1/70 trillion

You’ve already won the lottery 10 times in a row. Ignore small people & enjoy!
Equivalent odds: winning the Powerball jackpot 10 times in a row
Flipping 272 heads in a row
Read 7 tweets
David Sinclair Profile picture
Oct 4, 2025
DNA breaks from cosmic rays disrupt the epigenome and release virus-like retrotransposons. Not wild theory. Fact

X-rays and CT scans probably do too but no one talks about it
This study in 2008 was the first evidence for the information theory of aging in mammals - the idea that DNA breaks and other major stresses cause chromatin modifiers like SIRT1 to relocate, which disrupts the epigenome & changes the expression of genes in ways that cause aging Image
Just re-read this paper and I’ve realized it was 15 years ahead of its time. Still is
Read 4 tweets
David Sinclair Profile picture
Oct 2, 2025
Some plant polyphenols (resveratrol, quercetin & berberine) turn out to be dual modulators of both SIRT1 & GSK3b - important pathways for neuroprotection & epigenetic age resets... 🧵Image
In 2008, we showed movement of the NAD-dependent enzyme SIRT1 away from regulated genes to DNA breaks (which happen every day in every cell) is a key process in the loss of epigenetic information that we have proposed leads to aging and diseases
cell.com/fulltext/S0092…Image
And in 2023, we showed GSK3b inhibitors are a key component of epigenetic age reversal cocktails, in vitro
aging-us.com/article/204896Image
Read 5 tweets

Did Thread Reader help you today?

Support us! We are indie developers!

This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Don't want to be a Premium member but still want to support us?

Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal

Or Donate anonymously using crypto!

Ethereum

0xfe58350B80634f60Fa6Dc149a72b4DFbc17D341E copy

Bitcoin

3ATGMxNzCUFzxpMCHL5sWSt4DVtS8UqXpi copy

Thank you for your support!

Follow Us!

Send Email!

:(