Post

More from @davidasinclair

David Sinclair

@davidasinclair

Mar 8

Osteoarthritis & back pain affects millions of people. Instead of managing symptoms, imagine rebuilding joints by making them young

New study shows the reprogramming gene combo OSK regrows joints in mice & effect depends on TET2 so it's epigenetic...🧵

While limited to mouse models, these findings add to a growing body of evidence that rejuvenation by epigenetic reprogramming may safely reverse aging-related decline in multiple tissues, or whole body one day

These experiments used local AAV-OSK delivery directly into the knee joint. Treated animals showed improved cartilage structure and reduced subchondral bone thickening compared with controls

Read 16 tweets

David Sinclair

@davidasinclair

Mar 1

According to ITOA, NAD declines with age, causing epigenetic changes & disease susceptibility

In 2010, we showed NAD-dependent enzyme, SIRT3, protects the heart 🐁

New study says NAD precursor NMN protects the heart via SIRT3 in mice fed a Western diet

Why's that important? 🧵

In the United States alone, about 1 in 5 deaths is due to cardiovascular disease. That’s roughly 700K-900K deaths per year. Globally, cardiovascular disease causes nearly 20 million deaths annually

Metabolic dysfunction is a major driver. In the US, ~40 percent of adults are obese and nearly 1 in 3 adults has metabolic syndrome

Globally, more than 500 million people are living with diabetes

Read 15 tweets

David Sinclair

@davidasinclair

Feb 22

Good news: Another study showing that fasting can help cancer patients. A 16 hour fast enhanced the cancer-killing activity of T cells and synergized with immunotherapy to reduce tumor size, ostensibly by causing cancer cells to release the amino isoleucine... 🧵

In the tumor microenvironment (TME), there was increased isoleucine processing and intracellular acetyl-coA, along with increase expression of genes involved in the starvation response, autophagy

There were also alterations in glutamine metabolism, a known source of energy for cancer cells

Read 9 tweets

David Sinclair

@davidasinclair

Feb 1

New "Cardiometabolic Clock" identifies biomarkers that associate with disease & early death:

1. HbA1c
2. Creatinine
3. Lymphocyte %
4. Urea nitrogen (BUN)
5. Red Cell Dist. width (RDW)
6. Pulse
7. Systolic blood pressure

Now you can calculate your CardioMetAge!

Heres the formula: 𝐶𝑎𝑟𝑑𝑖𝑜𝑀𝑒𝑡𝐴𝑔𝑒𝑃𝑟𝑒𝑑𝑖𝑐𝑡 = 0.831320 × 𝑎𝑔𝑒 + 19.5734 × log( 𝐻𝑏𝐴1𝑐 + 1) + 1.77394 × 𝑅𝐷𝑊 + 0.0760217 × 𝑆𝐵𝑃 + 6.18803 × 𝑐𝑟𝑒𝑎𝑡𝑖𝑛𝑖𝑛𝑒 − 0.148076 × 𝑙𝑦𝑚𝑝ℎ𝑜𝑐𝑦𝑡𝑒 𝑝𝑒𝑟𝑐𝑒𝑛𝑡 + 0.218946 × 𝑀𝐶𝑉 + 0.105980 × 𝑝𝑢𝑙𝑠𝑒 𝑟𝑎𝑡𝑒 + 0.0603608 × 𝑃𝑃 + 0.636711 × 𝑈𝐴 + 2.40001 × log( 𝐶𝑅𝑃 + 1) + 0.0283277 × 𝑊𝐶 + 0.0754119 × 𝐵𝑈𝑁 − 101.454

Candidate measures tested in the model: Body composition, waist circumference, waist-to-height ratio, glucose, HbA1c, albumin, ALP, CRP, creatinine, blood urea nitrogen (BUN), UA, lymphocyte percent, mean corpuscular volume (MCV), white blood cell count (WBC), red cell distribution width (RDW), AST, ALT, HDL, triglycerides, total cholesterol, BP, pulse pressure (PP) and pulse rate.

Read 4 tweets

David Sinclair

@davidasinclair

Jan 18

Amazing! Placing mice in low air pressure every other day slows hair loss, weight gain, osteoporosis & extends median lifespan by 12%. Ascribed to the killing of senescent, zombie cells

Could exercise, high altitude, or a drug have similar benefits? Let’s dig in🧵

Firstly, hypobaric (low) pressure should not to be confused with hyper-baric oxygen therapy (HBOT), which is also studied by longevity researchers, though there may be overlapping hormetic mechanisms between the two @NaturePortfolio

I’ve always wondered if living at a high altitude is healthier, but the evidence is weak. Maybe it needs to be pulsed: high pressure -> low pressure -> high pressure -> low pressure to induce hormesis

Read 19 tweets

David Sinclair

@davidasinclair

Jan 14

New study indicates that a decrease in nerve cell cholesterol caused by cortisol, inflammation & low SIRT1 activity may be a cause of major depression.

So, do statins exacerbate depression?

And since SIRT1 is NAD⁺-dependent, could NAD⁺ boosters treat or prevent depression? …🧵

Around 5–5.7% of adults worldwide experience depressive disorders at any given time. >280 million people!

Lifetime depression diagnoses in the U.S. have risen. ~29% report ever being diagnosed, up from ~20% a decade ago

Read 16 tweets

Share this page!

Enter URL or ID to Unroll

David Sinclair

Try unrolling a thread yourself!

More from @davidasinclair

David Sinclair

David Sinclair

David Sinclair

David Sinclair

David Sinclair

David Sinclair

Did Thread Reader help you today?

Don't want to be a Premium member but still want to support us?

Send Email!