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𝕵𝖔𝖍𝖓 𝕵𝖆𝖈𝖔𝖇𝖘 🇬🇧 Profile picture
@johnjljacobs
Nov 4 • 3 tweets • 2 min read • Read on X
COVID-19 vaccination reduces the risk of cardiovascular events after COVID-19 infection. People who had COVID-19 before or without being vaccinated are at higher risk of cardiovascular events for at least two years. pmc.ncbi.nlm.nih.gov/articles/PMC10…Image
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And some other data. Drastic effects, especially in acute phase, but also in chronic phase (accounting for time). Image
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More from @johnjljacobs

𝕵𝖔𝖍𝖓 𝕵𝖆𝖈𝖔𝖇𝖘 🇬🇧 Profile picture
Sep 10
Remarkable research conclusions.
SARS-2 infection is directly associated with changes in the brain (due to brain infection).
The authors conclude that lockdown is the cause, without looking at infection as a putative cause.
The main argument of ... 1/3
nature.com/articles/s4158…

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...the authors is that they do not know about sex disparity of the virus.
Literature, however, does: more males died due to Covid, more females has long covid.
So data might be correct, unusually accelerated brain maturation in adolescents and that this accelerated ...
2/3
brain maturation was much more pronounced in females than in males.
This can be explained by differences related to infection without the need to postulate a contribution or differential effect of lockdown.

In short, SARS-2 infections affect adolescents brains!
3/3
Read 8 tweets
𝕵𝖔𝖍𝖓 𝕵𝖆𝖈𝖔𝖇𝖘 🇬🇧 Profile picture
May 13
New lethal late-onset disease after COVID-19.
Anti-MDA5+ dermatomyositis is characterised by rapidly progressive interstitial lung disease (ILD) &high mortality.
MDA5 is an RNA sensor & and a key pattern recognition receptor for the SARS-CoV-2 virus.

1/9 thelancet.com/action/showPdf…
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Autoimmune disease triggered by SARS-CoV-2 infection noticed in 60 patients. Rapid & often lethal progression of autoimmune diseases, mechanistically and related to SARS-CoV-2 and found in COVID-19 aftermath.
2/9 Image
Dermatomyositis (DM) is a systemic autoimmune dis-
ease characterized by muscle and skin inflammation
and potentially fatal-internal organ involvement, typically interstitial lung disease (ILD) leading to progressive pulmonary fibrosis.
3/9
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Read 11 tweets
𝕵𝖔𝖍𝖓 𝕵𝖆𝖈𝖔𝖇𝖘 🇬🇧 Profile picture
Apr 12
original antigenic sin #OAS deals with antibodies and might be important for protection from infection and herd immunity.

T-cell immunity might be key to protect from (serious) disease by eliminating infected cells and yielding cross-protective immunity.
1. Vaccine for T-cells protects from moderate-severe disease.
2. CD4, CD8 epitopes crucial for cross-protection against sever disease.
3. CD8 in protective immunity. pubmed.ncbi.nlm.nih.gov/38318376/
pubmed.ncbi.nlm.nih.gov/38318166/
pubmed.ncbi.nlm.nih.gov/38379003/
4. Antibodies not needed for protection.
5. idem
6. T-cell immunity last longer than antibodies.
7. T-cell eliminate hypermutated variants.
8. idem
pubmed.ncbi.nlm.nih.gov/38456504/
pubmed.ncbi.nlm.nih.gov/38486021/
pubmed.ncbi.nlm.nih.gov/38543904/
pubmed.ncbi.nlm.nih.gov/38211584/
pubmed.ncbi.nlm.nih.gov/38211583/
Read 9 tweets
𝕵𝖔𝖍𝖓 𝕵𝖆𝖈𝖔𝖇𝖘 🇬🇧 Profile picture
Apr 11
Does vaccination prevent immune responses against mutated SARS-CoV-2. #COVID #AntigenicSin
Paper seems to conclude this, but how sound are its conclusions on original antigenic sin?

1/7
 🧵on virus immunology.nature.com/articles/s4146…
Note that immunity is compared between
Unvaccinated and omicron (O) infection (inf).
3x Wildtype (WT) vaccine + O inf year later.
3x Wildtype (WT) vaccine, tested immediately.
SARS-CoV-2 immunity wanes in time
2/7 Image
⬇️Less antibodies specific against receptor-binding domain (RBD) of Omicron
⬇️Less neutralization of free virus
⬆️B-cells against RBD of WT virus, less against O virus
3/7

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Read 10 tweets
𝕵𝖔𝖍𝖓 𝕵𝖆𝖈𝖔𝖇𝖘 🇬🇧 Profile picture
Mar 9
COVID-19 is an important contributor to cardiovascular disease.
Therefore the @escardio has made a collection of information on this subject.


1/8escardio.org/Education/ESC-…
COVID-19 affects many organ systems, including cardiovascular (CV) system.
COVID-19 remains a pervasive risk, not only for individuals with pre-existing CV diseases but also for those previously healthy, who may develop CV conditions as a consequence of SARS-2.

2/8
Epidemiology, pathophysiology & diagnosis

3/8 academic.oup.com/eurheartj/arti…
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Read 9 tweets
𝕵𝖔𝖍𝖓 𝕵𝖆𝖈𝖔𝖇𝖘 🇬🇧 Profile picture
Jan 31
Links between @UNRWA and #Hamas.

Sincee 07/10/2023
3000 UNRWA teachers celebrating 7/10.


Booby-trapped tunnel into a clinic run by UNRWA


Hamas Terror Tunnel Next to UNRWA School


1/7unwatch.org/report-unrwas-…
thetower.org/0808-dark-side…
fdd.org/analysis/2023/…
@WSJ “Our intelligence indicates that out of approximately 12,000 UNRWA employees in the Gaza Strip, about 10% are Hamas or Islamic Jihad operatives, and another 50% are first-degree relatives of a Hamas operative,”

2/7jns.org/israel-calls-t…
Throughout UNRWA's 60 years, the agency has done nothing to promote creative resolutions to the Palestinian refugee problem. Instead, it has done everything possible to support the Palestinians in their "right of return" aspirations.

3/7 huffpost.com/entry/terror-a…
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Read 10 tweets

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