We're seeing an uptick in U.S. Covid transmission with 1 in 115 actively infectious.
The percentage of the population actively infectious has increased from 0.7% last week (based on updated data) to 0.9% this week.
The uptick is barring retroactive downward corrections.
We place the "lull point" as likely around Oct 20, but it could be +/- 2 weeks around that. Looking back at the late-summer wave, you'll see the date of the high point was quite arbitrary, and the same is true for the "lull."
There is presently considerable variation by region and even when examining the same region across different data sources. Some areas are still cooling off, while others are increasing markedly, as one would expect in the peri-lull area. There's also a lot of volatility across other data sources not included in our model (e.g., WastewaterSCAN up 43% nationally from Oct 18-25, but back down on the most recent data point on the 26th).
You'll note two updates in the current PMC forecasting model starting this week. These are described in detail in the technical appendix.
1) Biobot's sun rises again. 🌅 Our composite indicator of Covid transmission had been weighted 40% Biobot and 60% CDC. When Biobot abruptly stopped reporting for several weeks in a row during the summer wave, we were forced to downgrade them to 0% with no data coming in. After weeks of consistent reporting and a near-perfect correlation with recent CDC data (r=.95), we have re-included them in our current case-estimation model at 20% Biobot and 80% weight for CDC. Note, some of our pandemic "running total" estimates are marginally adjusted downward, as Biobot reported a slightly narrower (leptokurtic) late-summer wave. Having two high-quality data sources for estimating current transmission increases precision in real-time estimates and prepares for the eventuality that one source by experience a gap in reporting near the winter peak.
2) Best-Case and Worst-Case Scenarios. In figure 3 (upper right of dashboard), we have added 50% and 95% confidence bands. See the Technical Appendix for estimation details. Essentially, consider the 50% band (shaded area) the normal variation, and the boundaries of the 95% band (light dashed lines) the worst- and best-case scenarios, barring something nearly unforeseen (approximately 2.5% chance of a worse or better scenario). We encourage non-scientists to provide feedback on that figure, as it is challenging to present more detailed data in ways that are easily digestible. In Version 1 of the forecast (Aug 2023-Aug 2024), we reported several forecasting models and a compositive. It's unclear how helpful this was to readers, as we got surprisingly little feedback on it. With 15 months of forecasting, we now have the data to provide meaningful confidence bands. If helpful, we will keep it. If not, we will change the graphical depiction or replace them.
Info for new readers:
For those unfamiliar with the PMC model, find full weekly reports for the past 14+ months at pmc19.com/data
The models combine data from IHME, Biobot, and CDC to use wastewater to estimate case levels (r = .93 to .96) and forecast levels the next month based on typical (median) levels for that date and recent patterns of changes in transmission the past 4 weeks.
Our work has been cited in top scientific journals and media outlets, which are fully sourced in a detailed technical appendix at pmc19.com/data/PMC_COVID…
Examples include JAMA Onc, JAMA-NO, BMC Public Health, Time, People, TODAY, the Washington Post, the Institute for New Economic Thinking, Salon, Forbes, the New Republic, Fox, CBS, and NBC. See pgs 10-11 at the above link.
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🌍Want to track COVID transmission accurately worldwide?
This PMC thread walks you through leading dashboards with information more up to date than WHO & EU directories.
🧵 1/
The Pandemic Mitigation Collaborative (PMC) Dashboard provides weekly COVID updates for the U.S., using wastewater surveillance derived case estimation models and analytic forecasting.
Our international directory includes official government dashboards & those developed by citizen scientists.
We exclude countries that have stopped reporting in the past 2-12 months even if on EU or WHO lists. We also exclude low-quality data from opt-in testing programs.
🧵 3/
🔥Biggest uptick since Jan
🔥1 in 167 actively infectious
🔥>2 million weekly infections
🔥700-1,200 resulting excess deaths from weekly infections
Track transmission closer to home w/our new state & international resources 👇
🧵1/6
PMC COVlD Dashboard, Jun 23, 2025 (U.S.)
🔹With >90% probability, we have entered the 11th COVlD wave.
🔹In a room of 50 people, there is already a 1 in 4 chance of an exposure.
🔹We expect nearly 15 million infections in the next month, and rising.
🧵2/6
PMC COVlD Dashboard, Jun 23, 2025 (U.S.)
We continue to expect transmission to break 500,000 daily infections in the U.S. around July 9th.
This is the same prediction as last week, as the forecast was dead on. Yet, there is considerably uncertainty around this timing.
Current transmission (red line) closely tracks that of summer 2023 (yellow line).
We expect to break 500k daily infections between July 9 and the end of July. Our current forecast...
2) PMC COVlD Dashboard, June 16, 2025 (U.S.)
Our current forecast is a bit more aggressive, predicting breaking 500k daily infections by July 9. The 2023 trend suggests end of July.
The 95% confidence interval shows large variation. Note that...
3) PMC COVlD Dashboard, June 16, 2025 (U.S.)
Note that CDC and Biobot both had retroactive corrections to last week's data, meaning the relative "lull" will last a little longer than the uncorrected data suggested. No big news on NB.1.8.1.
1) Here's a quick example of how the federal government is censoring the best scientific research. It's not just cuts to ongoing research.
It's new grant submissions too...
2) In January, I re-submitted a promising Covid/cancer grant to a non-federal funder. Hundreds of pages. Hundreds of hours of work. The best proposal I've submitted as a scientist.
Out of curiosity, I used Sean Mullen's Scan Assist tool to see how many banned words it had...
3) The proposal had 1,750 banned words. No big deal -- they're non-federal.
BUT I had planned to submit a smaller version to NIH this month as a "back up." Impossible!
It's not a matter of using a thesaurus or the find/replace command. The grant is on *Covid*...
CDC wastewater surveillance data show transmission rising. This is our forecast if transmission growth follows typical patterns.
The high & low estimates could be thought of as optimistic & pessimistic scenarios for NB.1.8.1.
2) PMC COVlD Dashboard, June 9, 2025
Notice that current transmission (red line, lower left) tracks closely with two years ago (yellow), slightly below the median (gray), and not far below last year (orange).
Consider each of these trajectories realistic scenarios.
3) PMC COVlD Dashboard, June 9, 2025
All indications are that we are headed into the start of an 11th national wave in the U.S.
We could percolate near the lull point another couple weeks (fingers crossed), but that scenario is becoming less likely.
National COVlD transmission recently fell to its lowest levels since the pre-Delta era.
It's go-time for many who have delayed medical appointments. The situation will likely get much worse in Jul/Aug.
2/ PMC COVlD Dashboard, June 2, 2025 (U.S.)
An estimated 1 in 211 are actively infectious. Most states are "low" or "very low" per CDC.
The situation remains serious even in a relative "lull." >1.5 million weekly estimated infections to result in 600-900 excess deaths.
3/ PMC COVlD Dashboard, June 2, 2025 (U.S.)
By the end of the month, we forecast an increase to 450k daily infections. If NB.1.8.1 takes off, closer to 600k. If overhyped, percolating only slightly higher.