anabology Profile picture
Nov 9, 2024 11 tweets 3 min read Read on X
Everyone's talking about seed oils—but why are they actually bad? 🤔

Thread 🧵Image
For most of human history, omega-6 fats from animal and fruit sources made up only around two percent of our diet. Today, with the rise of seed oils, we’re looking at levels closer to ten percent.

Here’s why this shift is so disruptive:
In small amounts, omega-6 fats served a useful evolutionary purpose.

Embedded in cell membranes at low concentrations, and being quite reactive, they were the perfect inflammatory signal. Image
When cells were damaged, enzymes could easily cleave off these omega-6s, releasing them to trigger a targeted inflammatory response—a signal to the body that something needed repair.

This was an efficient, low-level warning system, tuned to indicate real injury or infection. Image
But with the modern surge in omega-6 intake, we’re flooding our cells with these fats.

Now, when omega-6s are constantly present in our diet, they’re also constantly circulating in our blood, primed to be used as inflammatory signals.
To the immune system, it’s as if there’s ten times the cellular injury at any given moment.

The result? Chronic inflammation.
We’re seeing immune responses that were meant for acute, genuine threats now triggering on a near-constant basis, leading to inflammatory conditions like obesity, accelerated aging, unhealing wounds, blindness, and other damage.
And it’s not just in processed food—fryer oils, for instance, are packed with these pre-degraded inflammatory compounds, intensifying the issue.

Since aspirin blocks these inflammatory seed oil metabolic pathways, you could think of modern fryer oil as the "anti-aspirin."
Seed oils aren't just extra calories.

They distort our body’s warning system, overwhelming it with ‘damage’ signals that don’t exist.

This is just the tip of the iceberg. Image
If there's one takeaway I can give you:

DON'T EAT FRIED FOOD FROM RESTAURANTS!

We could return to safe dining if we replace current fryer oils (seed oils) with tallow, but currently, this is the most damaging food out there -- even more than processed foods.
high* oops. It’s high but not used for inflammatory pathways until cleaved by enzymes, to clarify.

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More from @anabology

Apr 20
My intuition is that these go together:

MCTs / Fructose / Gelatin / Ethanol

and these go together:

Stearic acid / BCAAs / Glucose (Starch) / Lactose

and combining the categories, or eating other macros (palmitic, PUFAs, MUFAs, sucrose) puts you into a new type of 'swamp'
Category 1 is basically the liver yelling at the body "hey metabolize this shit there's too much stuff here."

(Would require choline + thiamine supplementation to not harm the liver.)

Category 2 is like your cells saying hey we have enough calories lets just stop eating and keep the extra stuff in the blood til we're ready
Cat 1 best to worst "on mechanism:"
(no comments about health)

1. Pure fructose / Pure C6
2. Agave syrup / MCT oil
3. Sugar / Coconut oil
(I think it stops working below here because too much glucose + palmitic)
Read 5 tweets
Mar 10
Had no idea this was going on in the background while honey diet was blowing up

- High carb, low protein meals induce FGF21 in man
- Metabolic rate increased from low protein meals
- Lean mass is spared during 5 weeks of protein restriction

Now just do it with sugar! Image


They maintained body weight but needed to eat more to stay the same weight nature.com/articles/s4225…Image
Sugar would work differently than simply 'high carb'

The diet in the study:
"contained a high proportion of carbohydrates derived from white bread, rice, pasta, and fruits."

If they do it with sugar, FGF21 will be over-induced and the subjects will lose weight, imo.
Read 6 tweets
Jan 3
Quick IQmaxxing update:

I just bought a Brainbit (via alphabeats bundle -- $200 off right now, linked below). It's an EEG device with an SDK so I can develop custom apps if needed.

There's compelling data that increasing alpha waves can improve IQ-related things like shape rotation, but I feel like there must be higher fidelity EEG signals that are closer to IQ than just 'alpha waves.'

So at minimum, I could use alphabeats to improve IQ slightly by improving my access to alpha wave brain states. At best, I will be able to identify better EEG signals and have a better metric to optimize for.

(Hence my choice for Brainbit over Muse -- Brainbit gives me raw data with no 'dev application,' while Muse doesn't.)

@johnsonmxe has this compelling theory of vasocomputation where blood flow / smooth muscle contraction is intimately related to thinking. Recently, people on X talked about how niacin reverses LSD hallucinations. The idea was that the flushing effect of niacin opens up blood vessels in the default mode network, restoring normal thought that was inhibited by vasoconstriction from LSD.

Neuronal activity is intimately related to this, but if I wanted to measure any EEG/blood flow correlations, fNIRS would need to be added to EEG. Unfortunately I haven't been able to find any consumer fNIRS headbands with raw data available out of the box, and there are issues with overlapping the consumer fNIRS headbands with the Brainbit.

May end up making a DIY-fNIRS headband to fix this!

I think that if I want to increase IQ, I need to get measurement time down to minutes rather than hours, and not suffer IQ test training effects. Hopefully EEG / fNIRS can provide useful proxies.

/end update
Startup idea for anyone wanting a mission: Make simple combo wearables (fNIRS + EEG, for example) and give users raw data access out of the box. Charge a little bit of money for assembling it and bootstrap the company. There are 100s of papers on making low cost devices, because academics are poor. Idk why this doesn't exist for consumers yet.
Here's the bundle (click I don't have a headband) -- I'm not an affiliate.

listenalphabeats.com/product
Read 4 tweets
Nov 28, 2024
"Visualizing the Swamp" - exfatloss

How to avoid being fat: Image
@exfatloss for those who don't want to think, u take the right/upward diagonal for fat, horizontal for protein, and lower right diagonal for carbs
Read 4 tweets
Nov 11, 2024
The 'Alt-Right Cancer Cure'

Fenbendazole, Mebendazole, and Ivermectin.

But how do they actually work? 🤔

Thread🧵Image
These drugs are all known as "dewormers."

But are they killing parasites in cancer patients? Do parasites cause cancer?

Let's dig into the mechanism to find out:
Fenbendazole and mebendazole both disrupt microtubules, a mechanism shared by FDA-approved cancer drugs like taxol (which came from the Pacific yew tree).

By disrupting the skeleton of the cell, these drugs stop cell division.

But they may do more than just halt cancer growth.Image
Read 20 tweets
Jun 17, 2024
If I limit my food to very few things, I never have a day where I feel bad: cheese, OJ, honey, milk, coffee, coconut oil.

I can feel good eating many other foods but health becomes more shaky. With bread or pasta my energy level feels lower but I don’t feel ‘bad.’
Too much beef can make me tired. Never makes me feel ‘bad,’ but it doesn’t put me in a super high energy state.

Vegetables can make me feel acutely bad if not well cooked enough. Tomatoes and potatoes can give me headaches.
Too much olive oil, avocados, or any other >5% PUFA food makes me fatter and brings my childhood migraines back.

Too much milk/cheese can actually make me tired, but I rarely get too much when it’s from lattes and cottage cheese.
Read 5 tweets

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