My intuition is that these go together:

MCTs / Fructose / Gelatin / Ethanol

and these go together:

Stearic acid / BCAAs / Glucose (Starch) / Lactose

and combining the categories, or eating other macros (palmitic, PUFAs, MUFAs, sucrose) puts you into a new type of 'swamp' Category 1 is basically the liver yelling at the body "hey metabolize this shit there's too much stuff here."

(Would require choline + thiamine supplementation to not harm the liver.)

Category 2 is like your cells saying hey we have enough calories lets just stop eating and keep the extra stuff in the blood til we're ready

Had no idea this was going on in the background while honey diet was blowing up

- High carb, low protein meals induce FGF21 in man
- Metabolic rate increased from low protein meals
- Lean mass is spared during 5 weeks of protein restriction

Now just do it with sugar!

They maintained body weight but needed to eat more to stay the same weight nature.com/articles/s4225…

Quick IQmaxxing update:

I just bought a Brainbit (via alphabeats bundle -- $200 off right now, linked below). It's an EEG device with an SDK so I can develop custom apps if needed.

There's compelling data that increasing alpha waves can improve IQ-related things like shape rotation, but I feel like there must be higher fidelity EEG signals that are closer to IQ than just 'alpha waves.'

So at minimum, I could use alphabeats to improve IQ slightly by improving my access to alpha wave brain states. At best, I will be able to identify better EEG signals and have a better metric to optimize for.

(Hence my choice for Brainbit over Muse -- Brainbit gives me raw data with no 'dev application,' while Muse doesn't.)

@johnsonmxe has this compelling theory of vasocomputation where blood flow / smooth muscle contraction is intimately related to thinking. Recently, people on X talked about how niacin reverses LSD hallucinations. The idea was that the flushing effect of niacin opens up blood vessels in the default mode network, restoring normal thought that was inhibited by vasoconstriction from LSD.

Neuronal activity is intimately related to this, but if I wanted to measure any EEG/blood flow correlations, fNIRS would need to be added to EEG. Unfortunately I haven't been able to find any consumer fNIRS headbands with raw data available out of the box, and there are issues with overlapping the consumer fNIRS headbands with the Brainbit.

May end up making a DIY-fNIRS headband to fix this!

I think that if I want to increase IQ, I need to get measurement time down to minutes rather than hours, and not suffer IQ test training effects. Hopefully EEG / fNIRS can provide useful proxies.

/end update Startup idea for anyone wanting a mission: Make simple combo wearables (fNIRS + EEG, for example) and give users raw data access out of the box. Charge a little bit of money for assembling it and bootstrap the company. There are 100s of papers on making low cost devices, because academics are poor. Idk why this doesn't exist for consumers yet.

"Visualizing the Swamp" - exfatloss

How to avoid being fat: @exfatloss
exfatloss.com/p/visualizing-…

The 'Alt-Right Cancer Cure'

Fenbendazole, Mebendazole, and Ivermectin.

But how do they actually work? 🤔

Thread🧵 These drugs are all known as "dewormers."

But are they killing parasites in cancer patients? Do parasites cause cancer?

Let's dig into the mechanism to find out:

Everyone's talking about seed oils—but why are they actually bad? 🤔

Thread 🧵 For most of human history, omega-6 fats from animal and fruit sources made up only around two percent of our diet. Today, with the rise of seed oils, we’re looking at levels closer to ten percent.

Here’s why this shift is so disruptive:

If I limit my food to very few things, I never have a day where I feel bad: cheese, OJ, honey, milk, coffee, coconut oil.

I can feel good eating many other foods but health becomes more shaky. With bread or pasta my energy level feels lower but I don’t feel ‘bad.’ Too much beef can make me tired. Never makes me feel ‘bad,’ but it doesn’t put me in a super high energy state.

Vegetables can make me feel acutely bad if not well cooked enough. Tomatoes and potatoes can give me headaches.

After the honey diet, I was the biggest and leanest I had ever been.

The months following it (starting 2024), I had significant work stress and went off diet/stopped going to gym as much. I got into a rut and started thyroid to get out of it.

I just got fatter and lost muscle.

I made the mistake below: eating a high fat diet while adapting to thyroid.

I was ravenously craving calorically dense food due to the increased metabolic rate that the NDT (natural desiccated thyroid) gave me, and ice cream was the most satiating. This marks the second time ice cream made me fat.

NDT and ice cream were effective at mitigating the stress and getting me out of the rut, but now it's time to fix the physique.

Just started the honey diet again today with slight modifications. I forgot how good this made me feel.

(as a recap: infinite sugar from 7am-3pm, fast 3-7, then eat dinner to meet protein and fat requirements after 7pm)

Honey diet v2; the modifications:

1. Instead of raw-dogging honey, I'm making honey-sweetened lemonade. Much tastier.

2. Adding in more fruit for more nutrient density and to slightly increase protein intake in the day. (Remember, 2000 calories of OJ = 30g protein, similar to other fruit sources.) My favorites are mandarin oranges and cherries, though they're expensive. To make it cheaper, and to snack while working, I'm leaning on raisins.

3. Since I'm on NDT my protein requirements are probably higher. I'll be adding ~two toasts with tomato sauce for a savory mid-day snack, which gives 8g protein, <1g fat, and 50g carbs.

4. I had insatiable McDouble™ cravings which @faustianpeatler found to maybe be dietary cholesterol cravings. To mitigate this, I'm adding shrimp (and some eggs) as a main protein source at dinner to increase dietary cholesterol.

5. Before, I did gym at 5pm to burn off the blood sugar. After seeing my CGM data, I found that gym wasn't required to burn all the sugar before dinner -- it went down to baseline even while sedentary. I'm moving the gym session to the morning, just out of personal preference. This is another reason why I'm adding a few extra grams of protein in the day.

[the pre-dinner protein intake ends up at ~40g just from 2000 calories of fruits and 2 slices of bread, so dinner can be 80-100g protein to meet requirements]

In spirit the diet is the same. It's been quite a while since I felt this good. Excited to keep going. protocol here:


will update with new findings after current experiment concludeslongestlevers.com/fat-loss/honey…

One of the most important things I can tell you:

A TSH > 2 is too high!

If you’ve been thinking “maybe I’m secretly deficient in a nutrient, and once I fix that, everything else will sort itself out,” the nutrient may be thyroid. An ancestral lifestyle: no pollution, no processed foods, tons of UV light/red light, low PUFA naturally, etc. will lead you to a low TSH

but not everyone can achieve that in modern society

Your cells resist insulin when they don’t want glucose.

Your cells are sensitive to insulin when they do want glucose.

Very simple but few actually think about it this way. Your body chose to use glucose as the primary fuel source to keep in the blood because it’s the least glycating/reactive. Fructose and fats (PUFAs) are often more glycating so the body must deal with them first. It can deal with glucose later.

Ate a pound of honey and half pound of dates (as usual), spread from 9am-1pm.

Prelim CGM data:

My blood glucose never even touched 150 today - below the “normal” range for a typical meal.

In fact, last light, I had LOW blood sugar.

My dinner was 1 pound of beef, 1 pound of asparagus, and some coconut aminos.

Maybe not enough carbs in my dinner for the insulin sensitizing effects of my sugar heavy diet?

I’ll compile this (along with whoop data) and do some fancy analysis in a week or so. Will have bloods back in probably 3 weeks.

Hopefully I don’t die of low blood sugar by then.

Very incomplete data but just excited to share

Seed/Fish Oils -> Cancer.

A study in 1995 found that when cancer patients were given seed and fish oils, it stopped the body's 'Natural Killer' cells from killing cancer.

Stopping the oil intake for 3 months restored the body's natural anti-cancer mechanism. Patients were dosed with linoleic acid (seed oils) and EPA/DHA (fish oils).

The linoleic acid was a low dose compared to what would already be in the diet.

It was probably the fish oils.

Using "tanning beds and sun lamps may be the most important and effective way to prevent skin cancer".

Yep. Using tanning beds will prevent skin cancer.

UV-light associated skin cancer comes from severe sunburn (SS). Getting tan prevents this.
scholar.archive.org/work/tx3tekqts…

This is crazy.

UV light does not cause cancer - seed oils do.

Mice who were fed corn oil got skin cancer from UV light exposure. Those fed saturated fat in its place were COMPLETELY protected from cancer.

Saturated fats + sunlight = health.


and this has been replicated:

sci-hub.se/10.1111/j.1751…
pubmed.ncbi.nlm.nih.gov/6520731/

Welcome. Start your journey here. Thread of the things I write about: How hormones impact personal attributes:

https://twitter.com/anabology/status/1694886671571894339?s=20

Corn chips and french fries can be made into solid health foods if homemade.

Made with coconut oil or tallow, both can be eaten to satisfaction with no consequences.

Here’s how I make them in the air fryer:

Corn chips:

Take a stack of nixtamalized (!!) organic corn tortillas, and cut into 4 triangles. You can tell they’re nix’d if they contain “traces of lime”.

Pour over coconut oil after melting on pan. Add salt.

Put a layer the air fryer for 10 mins @ 400F.

Pyruvate may be able to kick you out of reductive stress & restart mito

"In comparison, the changes in the mitochondrial NADH are slower and more complicated. Upon adding pyruvate into the media, mitochondrial NADH levels decreased, recovered and then further increased." The idea here is that pyruvate bypasses glycolysis, increasing NAD+ in cytosol. Quickly, mitochondria becomes oxidized as well, and NADH lowers. Once pyruvate is transported into mito and in TCA though, electrons begin flowing in mitochondria again.

Generally you want to minimize phytoestrogens and maximize phytoprogestins.

When flavones are robustly beneficial, they seem to be 'phytoprogestins' and not interact with estrogen receptor.

Phytoprogestins include:
Apigenin (Parsley)
Epicatechin (Dark Chocolate, Ginger) Couple papers describing phytoprogestins:



mdpi.com/2072-6643/13/1…
sciencedirect.com/science/articl…

I’ve mentioned this before, but LDN is a wonder drug and I recommend it heavily.

It gave me the symptom relief I needed during my PUFA depletion. Without it, I would get into too much pain and eat fast food as a cope.

I’m off of it now, but I 100% needed it. Low dose naltrexone (LDN) can antagonize the endotoxin receptor (TLR4), directly countering inflammatory signaling of gut dysbiosis and protecting against PUFA inflammation.

It got rid of my background pain for the first time. Now I don’t need it after depleting PUFA.

Here’s a recipe for one of my favorite pro-metabolic ‘comfort foods’:

Ganache pudding https://t.co/IDY0d4CLtu

https://twitter.com/anabology/status/1683123763116646401

Unlike traditional ganache, I don’t heat it up, and I eat it alone. Couldn’t think of a better name though.

3 ingredients:
-Cane Sugar
-30% Guar-Free Coconut Cream
-Cocao

(Get organic to avoid toxins)

Sun exposure is associated with lower all cause mortality - the opposite of what BJ seems to think here.

Some think the longevity may be explained by Vit D, but this is too simplistic a view.

Sun exposure is a potent activator of melanocortin signaling - life-giving hormones. https://t.co/Es9yZM6iut

https://twitter.com/bryan_johnson/status/1679147493693722626

Before we dig into melanocortin signaling - know that this effect is from pure UV exposure too:

Tanning booths make you live longer.

https://twitter.com/anabology/status/1660008427580424200