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thetranscendedman Profile picture
@atranscendedman
Nov 13, 2024 • 1 tweets • 1 min read • Read on X
US study of 936 essential workers: 3 doses of mRNA COVID vaccine linked to 24% lower risk of long COVID symptoms after mild cases, especially for neurological and gastrointestinal issues.

academic.oup.com/jid/advance-ar…

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More from @atranscendedman

thetranscendedman Profile picture
Dec 20
This might be the clearest explanation of Long COVID biology the NIH has released yet.

Essential viewing on the pathophysiology. 🧵

Long COVID is often described as a mystery, but the NIH’s Dr. Avindra Nath argues it’s actually a triad of known biological failures.

Viral ghosts hiding in our tissues, blood vessels leaking in the brainstem, and an immune system that has forgotten how to turn off.
The immune profile is strikingly specific and exhausted. B-cells are failing to mature. T-cells are too tired to fight.

Meanwhile, the brain’s innate immune system is on fire.

It is a biological stalemate that looks remarkably, undeniably like ME/CFS.
Read 6 tweets
thetranscendedman Profile picture
Nov 28
PolyBio Fall 2025 Symposium (@polybioRF)

🧵below
SARS-CoV-2 spike protein persists in the plasma of people with Long COVID, independent of vaccination.

Higher spike levels correlate with platelet infection and mitochondrial dysfunction, suggesting active viral remnants may drive symptoms. Image
In Long COVID, megakaryocytes and platelets carry infectious SARS-CoV-2, form aggregates, and shift to glycolytic metabolism.

These viral reservoirs may drive clotting, inflammation, and fatigue by spreading infection and altering energy use. Image
Read 98 tweets
thetranscendedman Profile picture
Nov 19
3rd Long COVID International Conference 2025

🧵below
In a study of over 3,500 adults with past COVID, NIH researchers found 10.3% had long COVID symptoms.

Of those, 46% had lasting symptoms, 35% had ups and downs, and 19% recovered.

Economic hardship may raise the risk of symptoms persisting. Image
Researchers found that people with long COVID show disrupted metabolism of essential fatty acids for at least 6 months, including arachidonic acid and DHA.

These pathways help control inflammation and recovery. Image
Read 72 tweets
thetranscendedman Profile picture
Jul 24
If you listen to one thing about Long COVID this month, it's this.

So sad I missed this months ago.

viavid.webcasts.com/viewer/event.j…
UCSF scientists and collaborators suggest SARS-CoV-2 may mimic cancer by persisting in the body, evading immune detection, and disabling tumor suppressor genes like p53 and RB.
In long COVID patients, researchers observed chronic immune dysregulation, exhausted T cells, and reduced cytotoxic NK cells hallmarks also seen in viral-related cancers.
Read 9 tweets
thetranscendedman Profile picture
Dec 22, 2024
What if the NIH focused on basic science and testing existing COVID treatments instead of studies on melatonin and light therapy?

Articles like this are frustrating because they highlight the waste in treating symptoms without addressing the root cause.

kevinmd.com/2024/12/long-c…
It’s astonishing that massive trials can continue despite patient protests and clear evidence showing resources should be redirected.

It seems no one wants to confront the hard truth, even when we could reinvest in more worthwhile projects.
Imagine spending millions to prove that melatonin or light therapy helps with sleep, or that exercising with pacing and PEM awareness is beneficial.

It’s an absurd waste of time and money. I’ve yet to see a convincing argument to justify it.
Read 17 tweets
thetranscendedman Profile picture
Nov 22, 2024
Michael Peluso on viral persistence at Demystifying Long COVID International 2024

Small thread 🧵
1/ "At the beginning of the pandemic I was not a believer in SARS-CoV-2 persistence, but have now become more convinced with data emerging" Image
2/ Cats can get a chronic illness called FIP in GI tract and is treated with coronavirus therapeutics.

Should work more closely with veterinary sciences. Image
Read 20 tweets

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