Michael Peluso on viral persistence at Demystifying Long COVID International 2024

Small thread 🧵 1/ "At the beginning of the pandemic I was not a believer in SARS-CoV-2 persistence, but have now become more convinced with data emerging"

Demystifying Long COVID International Conference 2024.

Mini-thread as most content is repeated from earlier this year. 🧵 1/ Introduction covered the importance of Long COVID. Mostly building on-top of Peluso/Deeks recent mechanisms paper.

Various sessions on how Long COVID impacts various cohorts and systems.

Will post interesting posters real quick:

I’m open-sourcing a multi-agent Long COVID project from my Master’s Program at UT Austin to explore the disease’s mechanisms, suggest interventions, and test combination treatments.

github.com/JonDouglas/lon… You can view the output of previous runs in these two folders.

gpt-4o-mini - github.com/JonDouglas/lon…

gpt-4o - github.com/JonDouglas/lon…

Example of interventions identified for each model:

PolyBio Fall Symposium 2024 thread 🧵

1/ Amy Proal introduces the Fall Symposium. PolyBio is a non-profit org building a collective to solve diseases like Long COVID, ME/CFS, and more

They recently published a new project page to see how these projects map to the human body



2/polybio.org/consortium-pro…

🧬 MENSA tech uses new antibodies to detect ongoing COVID-19 & viral reactivations in #LongCOVID. With 60% accuracy for SCV2, EBV, CMV, HSV2, it offers diagnostics from a single blood sample.

Differentiates between infection and vaccination responses.

medrxiv.org/content/10.110… This is important. Here's why:

- Accurate detection of viral persistence
- Identification of latent reactivation
- Single blood sample
- High sensitivity & specificity
- Distinguishes infection & vaccination
- Extend to other chronic illnesses
- Non-invasive
- Clinical biomarker

Demystifying Long COVID North American Conference 2024

🧵of my personal opinions on discussion points 1/ The sincerity of this problem is being addressed by many partners around the world. The NIH, CDC, public & private research, etc

RECOVER out here with the radical transparency!

#LongCovid
New Areas of Focus!