Emmanuel Profile picture
Nov 17 4 tweets 2 min read Read on X
H5N1 is currently a ZOONOTIC OUTBREAK, NOT A PANDEMIC !!!

For over two years, we have been raising concerns about the transmission of this virus from birds to mammals, and subsequently to humans.

At this time, H5N1 remains a zoonotic outbreak, which is characterized by ... Image
2) ...a sudden rise in disease cases from animals to humans within a specific area or population.
Even if we are at stage 3 in the virus's progression, (as I indicated in my last thread 👇), for H5N1 to be classified as a pandemic ...
3) ... there would need to be sustained human-to-human transmission, which requires specific mutations in the virus that have not yet occurred.

Those eager to declare a pandemic should revisit the studies we've consistently shared over the past two years. Image
4) It's essential to stay accurate in our fight against diseases; the only pandemic we are currently facing is COVID-19.

H5N1 still needs many mutations before human-to-human transmission can occur.

Thanks for reading 🙏

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More from @ejustin46

Nov 19
SARS-COV-2 POPULATION IMMUNITY: EPITOPES, EPITOPES and EPITOPES !

An epitope is a small part of a molecule (like a protein) that the immune system recognizes and binds to, triggering a response.
journals.plos.org/plospathogens/…Image
2) This study examined how the antibody response targets different parts of the SARS-CoV-2 spike protein, depending on a person's prior infection and vaccination history. The researchers created a panel of mutant spike proteins to map the key epitopes ... Image
3) ...recognized by neutralizing antibodies. They found that primary infections with different variants elicited distinct antibody targeting patterns, highlighting the antigenic diversity between variants. Image
Read 5 tweets
Nov 19
Time is of the essence: effectiveness of dairy farm control of H5N1 is limited by fast spread

Weekly bulk milk testing for H5N1 is often too late; better surveillance and focus on biosecurity are needed for effective intervention.
buff.ly/3YWGRCyImage
2) Very interesting data/figures

Fig. 1 Epidemic curve of H5N1 at the farm levels Image
3) Fig. 2 : Surveillance and control strategies require knowledge of both the basic repro- duction number and the intrinsic growth rate. Image
Read 4 tweets
Nov 18
UPDATE of AVIAN INFLUENZA (H5N1) INFECTION in ADULT PATIENTS

A great narrative review 💯👍
Thanks to @DavidJoffe64
accpjournals.onlinelibrary.wiley.com/doi/abs/10.100…Image
2) Avian influenza, or "bird flu," is a major public health concern worldwide. The H5N1 strain is particularly dangerous, with high rates of transmission and death. While it mainly infects birds, this virus can also spread to humans, leading to severe illness.
3) Diagnosing avian flu requires specialized testing of respiratory samples. Early treatment with antiviral medications like oseltamivir is essential to manage the infection. Preventing exposure by avoiding contact with infected birds and animals is a key prevention strategy. Image
Read 5 tweets
Nov 18
The "DOUBLE INSULT" of SARS-CoV-2 INFECTION:
Acute Illness and Reactivation of Latent Viruses Contribute to Long COVID

biorxiv.org/content/10.110…Image
2) The study examined over 1,000 hospitalized COVID-19 patients and found that many had reactivation of viruses they were already carrying, like Epstein-Barr virus and cytomegalovirus. Image
3) These reactivated viruses were linked to more severe COVID-19 symptoms and worse outcomes, including higher risk of death.

The researchers also saw that the reactivated viruses triggered specific immune responses, like increased inflammation and changes in gene activity. Image
Read 5 tweets
Nov 18
AVIAN INFLUENZA A (H5N1, H5N6, H9N2 and H7N9) viruses in China

Diverse group of viruses, each influenced by its unique ecological and social factors, for example density of pig or human population emerged as common significant predictors for H5N1
frontiersin.org/journals/publi…Image
2) This study examined the patterns and risk factors for human infections with different strains of avian influenza viruses (H5N1, H5N6, H9N2, H7N9) in China from 2011-2024.

The researchers found that the geographic distribution of cases varied by virus type. Image
3) H5N1 and H5N6 infections were mostly concentrated in eastern and southwestern China, while H9N2 and H7N9 were more widely spread across the country. The timing of cases also differed - H5N1 showed seasonal patterns, while H5N6 and H9N2 had sporadic cases throughout the year. Image
Read 7 tweets
Nov 18
H5N1 INFECTION through the MOTHER'S MILK

The results showed that intramammary H5N1 infection led to 100% mortality in the ferret dams and their suckling kits 😨
biorxiv.org/content/10.110…Image
2) This study looked at how the H5N1 bird flu virus can spread from infected dairy cows to their newborn calves through the mother's milk.

The researchers infected the mammary glands (breast tissue) of mother ferrets with the H5N1 virus found in dairy cows. Image
3) They found that this led to 100% of the mother ferrets and their nursing baby ferrets dying from the infection.

The virus was able to reach very high levels in the infected mothers' milk and spread to the babies' respiratory systems when they drank the milk. Image
Read 6 tweets

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