Salvatore Mattera Profile picture
Nov 17, 2024 15 tweets 4 min read Read on X
When people talk about the devastation from COVID, they usually cite the number of people who died (7 million, 20 million, 30 million) or the economic cost ($14 trillion, $35 trillion, etc) but this pales in comparison to the true cost, something most people do not understand or talk about:
About 1 in 4 American adults have developed some type of long term health issues from their COVID infections. Data is limited, but it seems reasonable to assume this ratio is similar in other countries. Image
It was once widely believed that children weren't nearly as affected, but recent research has shown that's sadly not the case, with a similar share of kids and teenagers having long lasting health problems from their COVID infections Image
What's worse, there doesn't seem to be any reliable way to protect yourself from this besides avoiding infection. Vaccination has only a limited impact, and lifestyle is almost irrelevant: Even 18 year old US marines in peak physical condition developed long lasting health problems at a similar rateImage
In its mildest form, this might mean fatigue that lasts a few months. In the most extreme form, you might find yourself completely bed-bound, unable to work or care for yourself for months or years.
And no one - literally no one - understands what this is or how to fix it. There is no doctor, no scientist, no medical authority on the entire planet that can explain what's causing this or how to fix it, except to say that catching COVID is very bad.
No one knows if this is one disease state, or hundreds. If certain people are susceptible because of genetics, or environment, or if it's truly random. There are some hypotheses and some interesting findings, but nothing that even approaches a consensus.
And for that reason, no one knows what will happen to these people. We do know that these people are very likely to get reinfected with COVID, probably dozens more times over the rest of their lives. This may make their health issues worse, perhaps significantly so
What I find most disturbing about this is that the interest in figuring out the answers to these questions is almost non-existent. Funding for it is a mere pittance. Earlier this year, the NIH committed a mere ~$500M to research it: Image
That might sound like a lot, but for comparison, the NIH commits over 5X as much annually to HIV research. I'm not arguing to reduce the HIV research budget, but the percentage of Americans with HIV is well less than 1%. HIV is much better understood - we know how to avoid it and how to treat itImage
There's a bill floating around Congress that would bump the amount dedicated to research up to a modest $1 billion a year. So far, it's gotten commitment only from Democrats, most of whom would be described as far left. With the recent election, who knows if it even stands a chance of passing.
And this is for a disease that, again, affects about a quarter of the public, that no one understands, and that is not going away. It's hard to describe the disconnect between leadership and reality as anything other than bizarre.
Given that we know that at least a quarter of people are susceptible, and that everyone is on track for infinite COVID reinfections, and that every reinfection may make these people worse, it's entirely plausible that we may soon be living in a world where a large chunk of the population is significantly disabled
This might not be likely, but again, no one can really say with any real authority what the odds are one way or the other. And if it does happen, it would be one of the worst health disasters in human history. And yet...there's just nothing from any of our leaders anywhere
#MAHA

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More from @SalvMattera

May 15
I'm a finance guy, not a doctor. I don't understand much about medicine, but I do understand risk. I think a lot of problems with medicine come from the fact that it doesn't price risk correctly.
In most systems, individual participants bear some risk. "Let the buyer beware," and so on. But this isn't really the case in medicine.
Most of the risk in the medical system is transferred up the chain to a sort of amorphous bureaucracy. Drugs are given a stamp of approval at the highest level by people who will never actually treat the patients consuming them.
Read 19 tweets
May 3
One of my doctors is a PhD that studies Long COVID. He uses data from RECOVER. They have cohorts of people who, when they started collecting the data, were never infected with COVID. At some point, they became infected. About 10% consistently develop Long COVID
I was asking him about the concept of phenotyping patients based on their symptoms. And he said it was more or less impossible given how widely heterogenous everyone's presentation was. No two people were ever exactly the same
Some people's symptoms develop during the acute infection, and just never go away. Other people get them months later. People commonly have new symptoms that emerge months later, while other symptoms that they had seem to go away
Read 5 tweets
Apr 30
I posted about how there are treatments for Long COVID and a few people responded that the treatments that are out there are completely inaccessible to the average person. Well, here's a short guide on how you can seek treatment:
if your only option is to work with a run of the mill GP, don't emphasize your Long COVID. Emphasize specific symptoms that you have that can respond to various treatments. For example, if you have a racing heart rate, you can emphasize that and many GPs will give you beta blockers
You can build a relationship with your GP and
. convince them to prescribe increasingly exotic things. If what they're giving you isn't working, and they've been seeing you for a long time, and you start to bring them research, they may write a script for something you want
Read 16 tweets
Apr 25
Here's a list of health trends that I think are driven by Long COVID:
Creatine gummies. Many people with Long COVID supplement with creatine and report an improvement.
Electrolyte powders. Especially ones that are high in salt. Many people with Long COVID develop dysautonomia, often POTS, and drinking salt water is widely regarded as the most effective treatment
Read 6 tweets
Apr 24
Adding a new feature for Help for Long COVID - overview summaries of all the reviews posted online for a given treatment. Check out the first one for LDN:
If you don't have the time or energy to write your own LDN review, you can simply vote on the accuracy of this summary. Or you can leave a thumbs up or thumbs down on LDN. Just create an account and log in.
Read 6 tweets
Apr 20
When it comes to getting treatment as a Long COVID patient, the biggest gap is around masking and prevention. I've been to 2 Long COVID clinics at major universities, and dozens of different doctors and specialists. Almost none of them emphasized masking or prevention
The Stanford Long COVID clinic told me that reinfection wasn't a big deal in their experience - that most patients who were reinfected experienced a temporary set back, but ultimately, it didn't matter.
This is completely contrary to the evidence, which shows that reinfection is very dangerous for people with Long COVID, often leading to a permanent decline in their health Image
Read 10 tweets

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