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Nov 23 28 tweets 6 min read Read on X
Another New Study Shows That Youngest People Are By Far Hardest Hit By Serious #LongCovid Brain Diseases Such as Memory Loss, Seizures, Movement Disorders, Etc, From 'Mild' Virus

'Younger and middle-age individuals are disproportionally affected' by Long Covid brain diseases 'regardless of acute COVID-19 severity' study shows.WILEY "Online Library  Annals of Neurology / Early View  aOpen Access  Neurologic Manifestations of Long COVID Disproportionately Affect Young and Middle-Age Adults  Natasha A. Choudhury MD, Shreya Mukherjee BA, Tracey Singer BS, Aditi Venkatesh BS, Gina S. Perez Giraldo MD, Millenia Jimenez BS, Janet Miller BS, Melissa Lopez MPH ... See all authors v  First published: 22 November 2024 https://doi.org/10.1002/ana.27128  About Sections  Research Article  cc  Abstract  Objective To investigate neurologic manifestations of post-acute sequelae of SARS-CoV-2 infection (Neuro-PASC) in post-h...
The latest study which is published in the Annals of Neurology journal is just the latest to show that 'mild' Covid is far more severe in younger people than older ones:

This is a consistent finding across multiple studies at this point:
Covid, of course, loves to infect the brain and cause multiple serious ongoing diseases after acute infection:

In the present study, they found that:

'Younger and middle-age individuals are disproportionally affected by Neuro-PASC )post-acute sequelae)...Objective To investigate neurologic manifestations of post-acute sequelae of SARS-CoV-2 infection (Neuro-PASC) in post-hospitalization Neuro-PASC (PNP) and non-hospitalized Neuro-PASC (NNP) patients across the adult lifespan.  Methods  Cross-sectional study of the first consecutive 200 PNP and 1,100 NNP patients evaluated at a Neuro-coronavirus disease 2019 (COVID-19) clinic between May 2020 and March 2023. Patients were divided into younger (18-44 years), middle-age (45-64 years), and older (65+ years) age groups.  Results  Younger and middle-age individuals accounted for 142 of 200 (71%) ...
...regardless of acute COVID-19 severity.'

Noting that:

'younger and middle-age patients suffer from a higher burden of Neuro-PASC symptoms and cognitive dysfunction contributing to decreased QoL (Quality of Life)...
....Neuro-PASC principally affects adults in their prime, contributing to profound public health and socioeconomic impacts warranting dedicated resources for prevention, diagnosis and interventions'
Thanks for reading - please consider joining my Patreon and supporting to continue the work we're doing: patreon.com/c/EnemyInAStat…
Some of the Long Covid brain disease symptoms noted in the study are shown here:

The study looked at both hospitalized and those not hospitalized (ie: 'mild' acute cases) and found that younger people were far more likely to develop serious brain diseases as a result of... TABLE 3A. Neurologic symptoms and signs attributed to PASC in post-hospitalization Neuro- PASC (PNP) patients across the adult lifespan  Overall PNP  PNP 18- 44 years  PNP 45-64  years  PNP 65+  years  P  manifestations (median [IQR])  Neurologic symptoms n (6)  24  Brain fog  0.06  0.49  Headache  32 (80)  60 (58.5)  21 (36.2)  <0.0001  Numbness/tingling  23 (57.5)  63 (61.8)  27 (46.6)  0.18  Dizziness  25 (62.5)  60 (58.8)  26 (44.8)  0.14  Myalgia  Pain other than chest  Dysgeusia  Anosmia  Tinnitus  138 (69)  173 (86.5)  113  (56.5)  113  (56.5)  111 (55.5)  106 (53)  93 (46.5)  87 (43...
...infection.

The ages of those studied were split into 3 categories: with 18-44 making up the youngest group, followed by 45-64 (representing middle-aged) and lastly, older people: 65+

As well as younger people being far harder hit by Long Covid brain diseases... NNP 18- 44 years  NNP 45- 64 years  NNP 65+  years  TABLE 3B. Neurologic symptoms and signs attributed to PASC in non-hospitalized Neuro-PASC (NNP) patients across the adult lifespan  Overall NNP  P  Blurred vision  Ischemic Stroke  Seizure  Movement disorder  Meningitis  Encephalitis  Focal sensory deficit  Focal motor deficit  Hemorrhagic stroke  Other symptom n (6)  Fatigue  Shortness of breath  Depression/anxiety  Insomnia  Chest nain  Abbreviations: COVID = coronavirus disease; dysf = dysfunction; IQR = interquartile range; Neuro-PASC = neurologic post- acute sequelae of SARS-CoV-2 inf...
...they also found that they are much more likely to have ongoing shortness of breath, depression/anxiety, insomnia, ongoing chest pain, etc..

Further, the study found that younger people reported a much lower quality of life (QoL) as a result of Long Covid diseases: in  r  18-44  .  60  40-  20-  0  PNP PROMIS T-Score  A 10033 70 3  80  60  40-  20  33  70  45-64 64  30  23 63  30  23  65+ 61 30  18-44  Cognitive CoU Function  Fatigue  Sleep Disturbance  Anxiety  Depression  Cognitive Function  Fatigue  Sleep Disturbance  Anxiety  Depression  .  +₺  *  PNP Toolbox T-Score  C 100- 18-44 (n=21)  80  60  40  20  .  45-64 (n=60)  . 65+ (n=38)  T Processing Speed  Attention  T Executive Function  Working Memory  Processing Speed  Attention  Executive Function  Working Memory  NNP Toolbox T-Score  O  D 1007. 18-44 (n=271)  80  60  40-  20.  45-64 (n=257)  65...
'Quality of life and cognitive results in post-hospitalization (PNP) and non-hospitalized (NNP) neurologic post-acute sequelae of SARS-CoV-2 infection (Neuro-PASC) patients, ages 18–44, 45–64, and 65+ years...
...Patient-reported outcomes measurement information system (PROMIS) T-scores for PNP (A), and NNP (B) patients show significant differences in NNP patients in the quality of life (QoL) domains of fatigue and sleep disturbance...
...National Institutes of Health (NIH) Toolbox T-scores for PNP (C), and NNP (D) patients reveal borderline age-related differences in executive function in the PNP group and significant age-related differences in the NNP group for executive function and working memory.'
As is noted in the conclusion to the study: the findings have:

'far-reaching implications for public health. Because younger and middle-age people are the most frequently and severely affected by Neuro-PASC, whether this could potentially translate into a higher or earlier incidence...Our study also has far-reaching implications for public health. Because younger and middle- age people are the most frequently and severely affected by Neuro-PASC, whether this could potentially translate into a higher or earlier incidence of subsequent cognitive impairment and neurodegenerative diseases in this population is a matter of serious concern for our clinic patients. A study of electronic medical records of 35,362 COVID-19 outpatients in Denmark showed an increased relative risk (RR) of 3.5 for Alzheimer's disease and 2.6 for Parkinson's disease compared to outpatients who did no...
...of subsequent cognitive impairment and neurodegenerative diseases in this population is a matter of serious concern for our clinic patients.'

They also note the already well-established link between Covid and developing serious, degenerative brain diseases, such as dementia,,,
...and Parkinson's:

'A study of electronic medical records of 35,362 COVID-19 outpatients in Denmark showed an increased relative risk (RR) of 3.5 for...
....Alzheimer's disease and 2.6 for Parkinson's disease compared to outpatients who did not have COVID-19.36 A meta-analysis of 12 studies including 2.6 million post-COVID-19 cases and...
...30.4 million controls showed a significant association between SARS-CoV-2 infection and increased risk of new-onset Alzheimer's disease (HR = 1.50), dementia (HR = 1.66), and Parkinson's disease (HR = 1.44) among COVID-19 survivors'
They note that contrary to the many lies (they say very generously hypothesis ) of 'mild' in young people, the hardest hit by the virus are the youngest people: Conclusions  Together, these data refute our initial hypothesis that the burden of Neuro-PASC will be greater for older adults. Our study demonstrates the opposite finding that younger and middle-age patients with Neuro-PASC are more severely affected than older patients, regardless of the severity of their acute COVID-19 and hospitalization status. We showed that younger and middle-age patients suffer from a higher burden of neurologic symptoms, fatigue, sleep disturbance, and cognitive dysfunction contributing to decreased QoL, compared to older patients with Neuro-PASC. However, older Ne...
'Together, these data refute our initial hypothesis that the burden of Neuro-PASC will be greater for older adults. Our study demonstrates the opposite finding that younger and middle-age...
...patients with Neuro-PASC are more severely affected than older patients, regardless of the severity of their acute COVID-19 and hospitalization status.'

Study link:
onlinelibrary.wiley.com/doi/10.1002/an…
Why are younger people so much harder hit by the 'mild' virus?

The Authors speculate that this is because younger people have a better immune response and as much of the serious disease caused by Covid is actually due to the immune system going into overdrive...
...which again is the exact opposite of the original hypothesis - where younger people and kids were supposed to be 'mildly' affected due to their superior immune systems: of course, you could believe that if you knew nothing about Covid and what it actually does.

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More from @EnemyInAState

Nov 11
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What gets me are the people sitting around them who start to get nervous—pulling their shirts up so they cover a nostril surreptitiously. Image
... and nervously squirming in the seat, looking like they want to get up and sit somewhere else but don't want to be rude.

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'could make you sick if you breathe it in or if it gets in your eyes, nose, or mouth.'

And recommends that a:
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'Head cover or hair cover
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Nov 7
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The UK'S CDC (UKHSA) has now confirmed a further two cases following on from the one announced last week: bringing the official total in the UK up to 3: this is almost certainly an undercount and likely many cases are going untested...

The virus has been causing devastation for a while now in the Congo:

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Oct 31
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