Josh Wolfe Profile picture
Nov 23, 2024 17 tweets 7 min read Read on X
1/ New Lux quarterly letter to LPs...

Our theme? Tech, venture, global markets told in...

...Four parables of Four brothers
1 Prometheus
2 Menoetius
3 Epimetheus
4 AtlasImage
2/ The The Prometheus Promise––is Extending Human Limits what we call extensionalism

technology is not just augmenting our natural senses, but fundamentally extending and transforming them inImage
Image
3/ From sight, sound, touch, hearing and now…smell.

Technology extends our senses (“extensionalism”) with many Lux family co’ leading the way from

@physical_int + CTRL-Labs + Auris Surgical Robotics (touch)
@EikonTX + @Matterport (sight)
Chromatic (hearing)
@Osmo_Labs (smell)Image
4/The lever + pulley of antiquity gave way to the steam shovel + excavator

Even the modern state's quest for legibility––what James Scott (Seeing Like a State) saw as drive to make complex systems measurable + manageable––Lux cos extend sensed in sea + space @saildrone @planetImage
@physical_int @EikonTX @Matterport @Osmo_Labs @saildrone @planet 5/ From genetically modified pigs with life-saving organs successfully transplanted into humans in dire need with no alternatives…

…to AI infrastructure with important 2nd order effects underway…. Image
@physical_int @EikonTX @Matterport @Osmo_Labs @saildrone @planet 6/
Today's largest Al clusters use around 100,000 Nvidia H100 chips and consume roughly 100 megawatts of power. Next year's clusters will scale to 300,000-500,000 chips requiring nearly a gigawatt of power — about the consumption of a small city. Image
7/ we see 2 futures emerging

1 Distributed compute can eliminate need for massive monolithic clusters––as per our investment in @togethercompute

2 As industry fixates on bigger data centers + more powerful chips––Apple quietly has showing how to run models directly on devices w/ limited memoryImage
8/ America only has a handful of locations that can provide the gigawatt-scale power these massive clusters will require.

While we're bullish on the seeming resurgence of elemental energy - our rebrand of nuclear––abundant natural gas from the Texas Permian seems a wiser bet.Image
@physical_int @EikonTX @Matterport @Osmo_Labs @saildrone @planet @togethercompute 9/ NYC's emergence as a major Al hub with 20 new unicorns in 2023 and 10 more already in 2024.

BUT…beneath the surface excitement though, we identified critical insights that are grounding our investment approach from the irrationality of the markets Image
10/ Epimetheus represents the danger of divorcing motivation from consequence. The benefits of the future start with tradeoffs of the present constrained by decisions of the past.

Higher for longer is our posture on the natural cost of capital, regardless of what the Fed does.Image
@physical_int @EikonTX @Matterport @Osmo_Labs @saildrone @planet @togethercompute 11/

We have 4 main strategies for current market:

1 Lux Labs
2 Corporate Spin-offs (globally)
3 Tactical Global Opportunities
4 “Fixware” (aka maintenance) (globally) Image
12/ While techno-optimists focus on frothy greenshoots, they're missing the industry's further desertification: over 30% of 50,000 private cos are trapped in late-stage limbo while >730 unicorns are trapped in exit-less purgatory, with nearly 50% over 10yrs old + dragging down returns like sea-sinking anchors…Image
13/ We are particularly excited about Lux Labs

14/ Lux Labs formalizes our nearly twenty-year track record of transitioning breakthrough science from the laboratory to the marketplace.

We have successfully spun out or have been first investors behind de-risked technologies and teams from big tech. Examples include Osmo and Physical Intelligence from Google, Aeva (and another not yet disclosed) from Apple, and Evolutionary Scale from Meta. These unlock value by giving breakthrough teams and technologies the funds, freedom and focused entrepreneurial attention to thrive.Image
@physical_int @EikonTX @Matterport @Osmo_Labs @saildrone @planet @togethercompute 15/
Globally we are particularly excited about Israel + Japan +UK
🇮🇱🇯🇵🇬🇧 Image
@physical_int @EikonTX @Matterport @Osmo_Labs @saildrone @planet @togethercompute 16/ Image
17/ As we look to the remainder of 2024 and beyond, several trends bear watching:

the acceleration of Al capabilities beyond language models into biology, chemistry and physical systems; the growing imperative for domestic manufacturing and supply-chain resilience; the continued convergence of commercial and defense technology; the evolution of experimental science through automation; and finally, the transformation of healthcare through sci-fi breakthroughs like xenotransplantation.

In the end, we return to where we started: compassionately competitive, motivated and mission-driven, helping to write the future, one breakthrough at a time.

We're betting on the impatient optimists who refuse to wait for permission to build the future.Image

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More from @wolfejosh

Mar 18
1/ New paper from @ylecun et al on alternative approach for AI to learn more biologically...

paper basically says AI is super smart but still can't learn like a toddler can...

the main critique Image
the main critique...

is that top models today dont learn once deployed.

and curating data + training pipelines + filtering out noise is all done by humans in loop instead of being an intrinsic skill of the AIs...

here's Claude explaining the paper simply Image
3/ not quite Kahneman style but they call it System A +B

System A = learning from observation

this is self-supervised learning like predicting next word or video frame. good at making representations but passive and struggles to understand cause + effect... Image
Read 7 tweets
Feb 21
1/ The shift from GPU capex (NVDA) to memory intelligence is already underway (SK, Samsung, Micron).

What will be next?

Even the best HBM chips are constrained by how they get architected into systems...
2/ Nvidia's GPU racks have a fixed compute-to-memory ratio. It is baked in + hard to change.

It is GREAT for training––and a WALL for memory-intensive inference...
3/ We found a company with 1,000x more memory than a standard enterprise server.

1 of their servers replaces up to 10 conventional racks.

Less floor space. Less power. Less cooling. Same or better output...
Read 7 tweets
Feb 20
New Lux LP letter dropping this weekend...
2/ Q4 2025 Lux LP Letter… Image
3/ the DILUTION DELUSION
vs CONFIDENT CONCENTRATION

physics teaches that systems in disequilibrium eventually corrrect and the questions is never whether, but how––and how violently.

excess energy must dissipate whethery by gradual cooling or explosive release… Image
Read 11 tweets
Dec 5, 2025
1/Today at private investor gathering I pitched

LONG
Adobe (ADBE)

SHORT
basket of scientific publishers
Wiley
Elsevier
Springer Nature

AI overestimation oversold Adobe (down 40%)

AI underestimation along with 2 other catalysts is set to crack the oligopoly of publishers
2/ first $ADBE thesis then the short basket + weighting

reasonably clean dislocation in large-cap SW

Stock ~$325 (down ~40% from highs)

Mult compressed from ~40x to ~20x

EV/EBITDA ~11–12x (10yr low)

mkt sees "value trap" facing existential AI threat

I see category error
3/ I'll argue the consensus bear case:

"AI kills the seat" + commoditizes design

one AI-augmented designer replaces three

Adobe loses its moat, got disrupted, growth is slowing + it’s milking a hostage customer base...
Read 25 tweets
Nov 25, 2025
1/ We are ABSOLUTELY insanely lucky to be able to witness this conversation

MASTERCLASS in military + geopolitical strategy + Arab/Israeli conflict

@havivrettiggur's brilliance+ Dan Schueftan's realpolitik rationality

watch whole thing or pick any segment🤯
2/Key excerpts (summarized).
Hard to disagree with anything.

The Nature of the Enemy + "Barbarism"

The Definition of Barbarism: Barbarism is not just violence; it is a societal decision to value the death of the enemy over the lives of one's own children. When Hamas places weapons in tunnels but forces civilians to stay above ground during war, they are declaring that they do not care for their own survival, only the destruction of Jews.

The "Love of Death" is Literal: We must stop projecting Western rationalism onto enemies who openly declare, "You Jews will lose because you love life; we will win because we love death." This is not a slogan; it is a strategic doctrine that renders traditional deterrence mechanisms (like threat of death) ineffective.

The Danger of "Happy Wife, Happy Life" Geopolitics: The Western belief that economic prosperity ("a better life") leads to moderation is a fatal fallacy. The Second Intifada was launched when Palestinians had their best economic situation in history. You cannot buy off an ideology that considers killing Jews a higher calling than feeding children.

Culture is Deterministic: You cannot "de-radicalize" a society that does not want to change. Just as Libya’s failure is cultural rather than resource-based, Gaza’s failure is rooted in a culture where the only role models are those who kill Jews. The West’s refusal to discuss culture—viewing it as "progressive" to ignore it—blinds them to reality.
3/ (Summary continued) Strategic Realpolitik
Solutions are for Crossword Puzzles: In the Middle East, serious problems do not have solutions. The two-state solution is a fantasy for the "simpleminded." The only realistic strategy is combining "damage control" with the use of opportunity. If you are looking for a solution, you are looking for something that does not exist.

"Violent Maintenance" is the Only Peace: There will never be "peace" in the Western sense. There is only the constant destruction of the enemy's capacity to wage war. Israel must adopt a policy of "violent maintenance"—preemptively destroying capabilities (like factories and tunnels) before they can be used, regardless of the immediate diplomatic cost.

The "New York Times" Test: When fighting "barbarians," proportional response is a mistake. The response must be so overwhelming that it shatters the enemy's will. A good rule of thumb for Israel: "If the New York Times is not outraged, it's the wrong response.".

Western Aid Funds the Conflict: The West is funding its own enemies. Palestinians are the only refugees in history paid billions for generations to remain refugees. This funding teaches them that "behaving like barbarians" is a profitable business model that attracts French, British, and American support.
Read 5 tweets
Nov 6, 2025
1/ 🚨Today history in AI 💻+ biology 🧬was made!

CZI led by Mark Zuckerberg + Priscilla Chan who've admirably committed tens of billions (and the entirety of their wealth to CZI) has acquired Lux family co Evolutionary Scale––just 2yrs after it's founding at a great multiple...Image
2/ We first teamed w/ @alexrives cofounder of EvolutionaryScale ~10yrs ago

cofounding Lux family Kallyope (cutting-edge bioetch focused on gut-brain axis)

Alex had the prescience to see the future of bio was computer science + AI. So he got his PhD at NYU and then... Image
@alexrives 3/...then Alex went to Meta, built an absolute cutting-edge AI bio group and published work that competed with Alphafold/Deepmind.

I tried to convince him to spinout in late winter of 2022––but Meta was funding him too well...

BUT THEN! A twist of fate Image
Read 7 tweets

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