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PolyBio Profile picture
@polybioRF
Dec 14 • 5 tweets • 2 min read • Read on X
1/ PolyBio's Dr. Michael Peluso presented evidence from the PolyBio-supported Long-Term Impact of Infection with Novel Coronavirus (LIINC) study out of UCSF at 2024's Demystifying Long COVID International Conference.

Here are the highlights. Image
2/ Antigen Persistence in LIINC Study
• Spike antigen persistence in post-acute COVID patients detected in 13% from 3-6m, 11% from 6-10 m & 7.4% from 10-14 m after infection
• 2x higher risk of Spike persistence in hospitalized patients Image
3/ Evidence of Antigen Persistence from CTLs
• CD8+ T-lymphocytes specific for Spike were detected in 45% of Long COVID patients vs. 5% of the general population (via plasma samples)
• Provides evidence that the S antigen persists in LC patients Image
4/ What We Know About Viral Persistence
• SARS-CoV-2 can persist via active replication or as an inert virus, or simply involve production of viral proteins
• Immune microenvironments may be a site of replication Image
5/ This evidence was gathered as a part of the PolyBio-supported LIINC study. LIINC is continuing to collect patient biopsy samples from a variety of tissues to assess viral persistence in Long COVID:

polybio.org/projects/liinc…

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More from @polybioRF

PolyBio Profile picture
Oct 30
We are excited to announce an $800,000 donation to Mount Sinai to support a clinical trial of the drug rapamycin in patients with long COVID. The trial will be conducted at CoRE: a clinic directed by Dr. David Putrino and PolyBio's Dr. Amy Proal:
polybio.org/polybio-suppor…
2/ "We extremely motivated to run a clinical trial for an affordable, generic drug with the potential to help long COVID patients" says Dr. Proal, who serves as PolyBio's President and Scientific Director of CoRE.
3/ Blood samples from trial participants will be sent to Dr. Akiko Iwasaki's laboratory at Yale University where analysis will determine how use of rapamycin impacts parts of the immune response.
Read 12 tweets
PolyBio Profile picture
Oct 22
PolyBio’s Fall Symposium is fast approaching on Friday November 8!

From 11 AM to 5 PM, our partner scientists will discuss updates to their #longcovid research projects. The lightning talk schedule is as follows:

polybio.org/fall-2024-symp…
Amy Proal, PhD
PolyBio Research Foundation
11:00 – 11:10 am ET (3:00- 3:10 pm UTC)
An overview of PolyBio’s complex chronic illness research & clinical trials program Image
Morgane Bomsel, PhD
Centre National de la Recherche Scientifique
11:10 – 11:20 am ET (3:10 – 3:20 pm UTC)
SARS-CoV-2 persistence & impact on long COVID megakaryocytes and platelets Image
Read 25 tweets
PolyBio Profile picture
Aug 6
PolyBio Research Foundation is excited to announce a $1M donation to UCSF.  The donation will allow the UCSF LIINC team to study #ME/CFS patients with advanced technologies, several of which have never yet been used in the field: polybio.org/1m-polybio-don…
Image
2/ Funds for the collaboration were gifted to PolyBio from several #ME/CFS families and Kanro – a philanthropic fund to support open source #scientific research established by Vitalik Buterin, creator of Ethereum.
3/ Started in April 2020, the PolyBio-supported LIINC study was among the first collaborative studies of #LongCovid in the U.S. The team has since enrolled more than 1000 individuals and published more than 25 papers on LongCovid biology.
Read 18 tweets
PolyBio Profile picture
Aug 5
Yes enough already! These leads on #LongCovid disease mechanisms are HUGE, which is why we’re doing everything in our power to support the team moving forward
2/ First we’re supporting the LIINC study, in part to serve as as a clinical sample & data core for the #LongCovid Research Consortium (LCRC), with samples shared with other international teams: polybio.org/projects/suppo…
3/ Then we’re supporting the PASC #Tissue Program to collect multiple tissues including gut, lymph node, CSF + bone marrow to test if tissue-based based #viral persistence drives Long COVID, and can be altered via clinical trials targeting reservoirs: polybio.org/projects/liinc…
Read 6 tweets
PolyBio Profile picture
Jul 27
We are excited to have supported this new study via our #LongCovid Research Consortium.  The project team are our incredible @CUBoulderBN colleagues at the University of Colorado Boulder: polybio.org/multiple-hit-m…
Image
2/ The findings suggest that multiple infectious “hits” (#viral and #bacterial) may amplify long-term neuroinflammatory or neuroimmune symptoms in patients with #LongCovid.
3/ More specifically, the team showed that brain exposure to a #SARS-CoV-2 spike protein subunit drove a long-term vulnerability not only to #neuroinflammation, but also to forms of autonomic dysregulation such as increased heart rate and core body temperature.
Read 9 tweets
PolyBio Profile picture
Jul 3
Breaking!: Research published today in Science Translational Medicine and supported by PolyBio Research Foundation shows that the #SARS-CoV-2 virus can chronically persist in the gut of patients with long COVID for over 2 years: polybio.org/chronic-virus-…
2/ The findings, published by a UCSF team known for innovation in HIV research, also documented T cell immune activation across the bodies and brains of people after COVID. This T cell activation was particularly elevated in the spinal cord and gut wall of long COVID participants Image
3/ Long COVID is not a mystery” says UCSF's Michael Peluso MD, who co-led the study. “Our findings provide clear evidence of #virus persistence and sustained immune activation after #COVID-19. We must use this information to test treatments that might get people better.”
Read 13 tweets

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