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PolyBio Profile picture
PolyBio
@polybioRF
501(c)3 transforming how #LongCovid, #ME/CFS & Lyme+ are studied, diagnosed, and treated. Leading the #LongCovid Research Consortium.
Apr 27 • 14 tweets • 3 min read
Breaking: Park-Pagliuca Fund Donates $10 Million to PolyBio Long COVID Cure Initiative

PolyBio Research Foundation today announced a $10M donation to support the Long COVID Cure Initiative (LCCI), a program designed to deliver treatments to millions of Long COVID patients by translating key academic findings into real-world diagnostic tests, faster and more targeted clinical trials, and accessible, patient-ready therapies. 
prnewswire.com/news-releases/…A man with reddish brown hair wears a blue surgical mask and lab goggles and looks under a lab hood to pipette liquid. 2/ Funding was provided by the Park-Pagliuca Fund, a philanthropic collaboration between the families of Todd Park and Steve Pagliuca, each of whom have family members impacted by Long COVID.
Apr 24 • 11 tweets • 4 min read
Breaking: New PolyBio-supported Study Identifies Microclots, Endothelial Injury Markers and Neutrophil Activation in Children and Young Adults with Long COVID

A new study supported by PolyBio Research Foundation studied children and young adults with Long COVID, providing evidence linking endovascular inflammation, increased quantity and size of fibrin-amyloid “microclots,” and neutrophil activation, and finding detectable Spike protein in a subset.  
polybio.org/new-study-poly…Image 2/ Published in Pediatric Research, the study helps clarify the biological basis of cardiovascular symptoms in an important but understudied Long COVID population, and advances scientific insights that will support future diagnostic development.

nature.com/articles/s4139…
Dec 10, 2025 • 9 tweets • 2 min read
How PolyBio is driving forward ME/CFS research 🧵

In 2025, PolyBio’s cofounders helped identify biomarkers that divide ME/CFS patients into two subgroups. One group showed elevated MMPs & cytokines consistent with CNS inflammation; the other showed unique immune correlations linked to joint hypermobility.Image 2/ Researchers also found altered cytokine interactions, including disrupted fractalkine and eotaxin pathways, which may drive neuroinflammation and cognitive symptoms.
Nov 18, 2025 • 12 tweets • 3 min read
BREAKING: New machine learning study identifies distinct Long Covid symptom endotypes across four major cohorts

👉🏻PolyBio-supported research uses questionnaire-based machine learning to successfully identify global Long Covid endotypes 🧵 Image 2/ Key Findings
•1,661 participants across four international cohorts
•9–12 endotypes per cohort, revealing distinct biological subgroups
•Three validated severity levels derived purely from symptoms
•Three disease trajectories including a progressive subgroup
•Ten global endotypes identified through cross-cohort meta-analysis
•Symptom surveys validated by health status and antibody responses

polybio.org/new-machine-le…
Oct 11, 2025 • 6 tweets • 2 min read
Breaking: PolyBio-supported researchers at MGH/Harvard have developed a microfluidic device that quantitatively measures fibrinaloid clots (microclots): tiny, abnormal clumps in the blood that may play a key role in the biology of Long COVID: polybio.org/new-microfluid…Image 2/ The new device technology enables rapid standardized quantification (counting) of microclot burden from small blood samples.
Oct 7, 2025 • 4 tweets • 2 min read
Dr. Morgane Bomsel is studying SARS-CoV-2 persistence in Long Covid patients’ platelets and megakaryocytes. Thus far, their early data shows that spike protein and viral RNA “can be found in at least 2/3 of the Long Covid patients’ [megakaryocytes]… this research suggests MKs may form SARS-CoV-2 reservoirs in Long Covid patients, which may produce platelets sheltering infectious SCV2.” 2/ PolyBio is supporting the continuation of Dr. Bomsel’s work to analyze platelet, megakaryocyte, and blood samples from Long COVID patients. The team is determining if persistent SCV2 infection of such cells is associated with deregulation (e.g., microclotting), changes in serotonin storage, or altered metabolism. Biological data will be correlated with patient clinical data in a multimodal analysis to define molecular targets associated with Long COVID.

polybio.org/projects/sars-…Image
Aug 13, 2025 • 12 tweets • 3 min read
1/ BREAKING: Infections can be major drivers of Aging Processes, new PolyBio review paper delineates

A new scientific review written by PolyBio’s core team challenges the long-held assumption that human aging unfolds in a sterile environment. The authors argue that lifelong exposure to viruses, bacteria, fungi, and parasites—many of which persist in tissues and nerves—can directly accelerate aging processes.

sciencedirect.com/science/articl…Image 2/ “Pathogens, especially herpesviruses and certain microbes, produce proteins and metabolites that disrupt immune signaling, damage mitochondria, alter gene expression, and reshape the epigenetic landscape,” says paper first author and PolyBio President Dr. Amy Proal.
Jul 25, 2025 • 6 tweets • 2 min read
1/ Breaking: PolyBio announces the appointment of Sarah Kalloch as its new Chief Operating and Innovation Officer

Sarah is a mission-driven leader with 20+ years of driving innovation at the intersection of strategy and systems change. She has started to work directly with PolyBio CEO Dr. Amy Proal & the Board of Directors to drive the Foundation’s strategic growth and operational excellence. 

polybio.org/polybio-resear…Image 2/ Sarah brings over two decades of leadership experience across mission-driven organizations to PolyBio. Most recently she served as Founding Executive Director of the Good Jobs Institute, where she championed scalable job-quality and operations strategies. During her tenure, the Institute partnered with more than 30 companies and investors, helping improve millions of frontline jobs.Image
Jul 2, 2025 • 9 tweets • 2 min read
BREAKING: Invivyd and lead researchers Dr. Amy Proal, Dr. David Putrino & Dr. Michael Peluso form SPEAR (Spike Protein Elimination and Recovery) study group to assess the effects of Monoclonal Antibody Therapy for Long COVID & COVID-19 Post-Vaccination Syndrome

investors.adagiotx.com/news-releases/… 2/ Invivyd announced today that it has formed a best-in-class clinical and translational study group, the SPEAR Study Group, with leading investigators focused on the biology and clinical disease or injury associated with chronic exposure to SARS-CoV-2 virus or mRNA vaccine-mediated spike protein.
Jun 21, 2025 • 11 tweets • 3 min read
Breaking: PolyBio’s Dr. Amy Proal clarifies infectious drivers of aging at Boston Summit

PolyBio President and Research Director Dr. Amy Proal joined the Boston Aging Code Summit this past week. The Summit brought together leading academics, entrepreneurs, and investors to share the latest breakthroughs and big ideas shaping the future of aging and longevity science.

polybio.org/polybios-dr-am…Image Dr. Proal participated in the “Master Switches of Aging” panel at the Summit. The other panelists included NeuroAge CEO Christin Glorioso, and quadraScope Venture’s Scientific Director José Navarro Betancourt. Image
May 20, 2025 • 9 tweets • 3 min read
BREAKING: PolyBio and WE&ME-supported study identifies two distinct ME/CFS subtypes

🧪Collaborative research uncovers immune and biomarker patterns that could help subclassify ME/CFS and guide future treatments.

polybio.org/polybio-and-we…Image 2/ A PolyBio-supported study published last week in the Journal of Immunology sheds new light on the myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) disease process.

academic.oup.com/jimmunol/advan…
May 15, 2025 • 10 tweets • 5 min read
PolyBio’s Spring Symposium is tomorrow, May 16th 11-5 ET. The event will bring together scientists from several disciplines to cover the following topics:

Viral Persistence
Clinical Trials
Tissue Pipelines
Vascular & Clotting
Immune system function
Brain & Nervous system
Long Covid gut
Cardiovascular
Microbiome
Neurodegenerative disease
Tick-borne vector-borne illness

us02web.zoom.us/webinar/regist… VIRAL PERSISTENCE

John Wherry—11:20 AM ET
T cells as biosensors of viral persistence in Long COVID

Francis Eun Lee—1:20 PM ET
Use of MENSA to identify an immune snapshot for SARS-CoV-2 persistence and herpesvirus reactivation in Long COVID

Sara Cherry—2:30 PM ET
Long COVID: Defining viral RNA reservoirs in the gastrointestinal tract

Saurabh Mehandru-2:40 PM ET
Investigating the role of SARS-CoV-2 gastrointestinal tract persistence in Long COVID
pathogenesis

Esen Sefik—3:00 PM ET
A humanized mouse model of SARS-COV-2 RNA
persistence

Steven Deeks—3:20 PM ET
The Reservoir Assay Validation and Evaluation Network (RAVEN) as a model to inform SARS-CoV-2 reservoir diagnosticsImage
May 3, 2025 • 35 tweets • 16 min read
At PolyBio, our Long COVID Research Consortium & related complex chronic illness projects are moving full speed ahead. On Friday May 16 we have planned an online Symposium where PolyBio-supported researchers will present updates on their projects. The symposium schedule is below!

Register here: us02web.zoom.us/webinar/regist… Amy Proal, PhD
11:00 am ET (3:00 pm UTC)

An overview of PolyBio’s complex chronic illness research & clinical trials program

Dr. Proal will detail PolyBio’s collaborative infrastructure to study and treat infection’s chronic consequences across a wide range of conditions. These include long COVID, ME/CFS and tick-borne/vector-borne illness, but also Alzheimer’s disease, cardiovascular disease, and even human aging.Image
Apr 24, 2025 • 6 tweets • 2 min read
1/ “[SARS-CoV-2] S1 protein leads to lower glucocorticoids,” said Dr. Matt Frank, who worked on a project to create a “multi-hit” model of Long Covid. “This may then disinhibit brain immune cells such as microglia, thereby priming these cells to subsequent inflammatory insults,” like a later bacterial or viral infection. 2/ PolyBio supported the research by Dr. Frank and team on neuroimmune priming in Long COVID. The team recently published their findings in the journal Brain, Behaviour and Immunity.

polybio.org/multiple-hit-m…
Apr 19, 2025 • 24 tweets • 5 min read
BREAKING: PolyBio-supported study reveals long-term immune and metabolic damage after COVID-19 infection

New preprint study reveals profound & long-lasting biological disruptions that can follow a SARS-CoV-2 infection, i.e. changes connected to altered metabolism & cancer-associated epigenetic changes

polybio.org/polybio-suppor… 2/ New research published by scientists from the University of California San Francisco reveals that COVID-19 can lead to significant and enduring alterations in the immune and metabolic systems of impacted individuals. Preprint data showing measures of inflammasome activity and oxidative stress in monocytes from participants with and without prior COVID-19.
Apr 15, 2025 • 14 tweets • 3 min read
BREAKING: Chan Soon-Shiong Family Foundation donation expands PolyBio Long COVID program

Funds will support exploration of SARS-CoV-2’s potential to drive cancer, as well as continued work delineating persistence of the virus in long COVID tissue & therapies to clear persistent virusTwo scientists look at imaging on a computer in a dark clinic room at UCSF. They are both wearing black respirators. Photo credits Noah Berger. 2/ PolyBio Research Foundation is excited to announce a donation from the Chan Soon-Shiong Family Foundation. Funds will facilitate the expansion of PolyBio’s Long COVID Research Consortium (LCRC) – a global collaboration of scientists working to rapidly study and treat long COVID.A scientist at UCSF points to data from their team showing SARS-CoV-2 spike RNA in gut tissue collected from a long COVID patient. (Photo by Noah Berger)
Mar 28, 2025 • 5 tweets • 2 min read
BREAKING: Development of a spike protein-specific radiolabeled antibody used with PET imaging shows presence of spike in brain & lungs of macaque monkeys 3 months post-COVID; provides new viral reservoir detection opportunity for long COVID: nature.com/articles/s4146… 2/ This PolyBio-supported project at UCSF is working to develop similar imaging methods. The goal is to detect spike protein associated with SARS-CoV-2 reservoirs throughout the body & brains of long COVID patients: polybio.org/projects/use-o…A pink bone with blue + red bone marrow to the right of a zoomed in microscope image of cells with red dots to depict viral persistence. To the left of the circular image of cells is a pink and purple gastrointestinal tract. Directly above the cells is a pink neuron with several branches.
Feb 11, 2025 • 20 tweets • 3 min read
BREAKING: Cutting-edge Recommendations Provide Treatment Path for Millions of Long COVID patients 💊

In a new report global experts outline key considerations to address persistent SARS-CoV-2; provide a roadmap to test critical new long COVID therapies: polybio.org/cutting-edge-r…Image 2/ Long COVID, a debilitating condition following #SARS-CoV-2 infection, continues to disable tens of millions of people globally, yet no approved treatments exist. However, long #COVID is not a mystery.
Dec 20, 2024 • 7 tweets • 2 min read
News 👉A new study published in Nature Communications has unveiled a crucial connection between chronic #infection with Cytomegalovirus (HCMV), and the development of #Alzheimer’s disease in certain individuals:

polybio.org/new-research-i… 2/ The research, led by a team of scientists at Arizona State University who are part of PolyBio's research network, suggests that in some individuals, HCMV may remain active in the #gut.
Dec 14, 2024 • 5 tweets • 2 min read
1/ PolyBio's Dr. Michael Peluso presented evidence from the PolyBio-supported Long-Term Impact of Infection with Novel Coronavirus (LIINC) study out of UCSF at 2024's Demystifying Long COVID International Conference.

Here are the highlights. Image 2/ Antigen Persistence in LIINC Study
• Spike antigen persistence in post-acute COVID patients detected in 13% from 3-6m, 11% from 6-10 m & 7.4% from 10-14 m after infection
• 2x higher risk of Spike persistence in hospitalized patients Image
Oct 30, 2024 • 12 tweets • 3 min read
We are excited to announce an $800,000 donation to Mount Sinai to support a clinical trial of the drug rapamycin in patients with long COVID. The trial will be conducted at CoRE: a clinic directed by Dr. David Putrino and PolyBio's Dr. Amy Proal:
polybio.org/polybio-suppor… 2/ "We extremely motivated to run a clinical trial for an affordable, generic drug with the potential to help long COVID patients" says Dr. Proal, who serves as PolyBio's President and Scientific Director of CoRE.