Great to see this new piece in @ScienceMagazine highlighting LongCovid clinical trials working to target #SARS-CoV-2 persistence. We are proud to be supporting nearly all the teams/trials mentioned in the piece via our LongCovid Research Consortium: science.org/content/articl… 2/ They include the trial at Sinai where @PutrinoLab , @polybio’s Dr. Amy Proal and Akiko Iwasaki’s group at Yale “will study two broad-spectrum antivirals that don’t require viral replication to work: Truvada and Selzentry, both approved for HIV”: polybio.org/projects/a-cli…

We are excited to announce a 2nd series of collaborative projects & clinical trials supported via our LongCovid Research Consortium: polybio.org/new-longcovid-… 2/ The projects/trials further address #SARS-CoV-2 persistence in #LongCOVID, plus the impact of viral activity on #Alzheimer’s & cardiovascular disease. They include:

PolyBio is glad to have supported this Nature Immunology paper showing #LongCovid immune dysregulation connected to potential #SARS-CoV-2 tissue reservoirs. Learn more about the findings here: polybio.org/polybio-suppor… 2/ Overall, Long COVID patients showed differences in the distributions of their T cells, implying ongoing #immune responses. The team also documented a mis-coordination between the SARS-CoV-2-specific T and B cell responses of Long COVID patients.

We are excited to announce a $15M gift from Kanro: a philanthropic fund to support scientific research established by Vitalik Buterin, co-founder of Ethereum: finance.yahoo.com/news/polybio-r… 2/ The funding will support a second phase of research and clinical trials via the #LongCovid Research Consortium (LCRC): a global scientific collaboration to rapidly and openly study core biological drivers of Long COVID: polybio.org/longcovid

We are excited to share that @MBVanElzakker & team at @MGHMartinos have published a preprint with the results of a high-resolution #LongCovid imaging study. They identified neuroinflammation across a wide range of brain regions in LongCovid patients: polybio.org/polybio-suppor… 2/ They additionally found that #neuroinflammation positively correlated with blood measures related to vascular dysfunction. The study is supported via our LongCovid Research Consortium

PolyBio is proud to have supported this new study by @MichaelPelusoMD & team. They identified tissue-based T cell activation in body sites such as brainstem/bone marrow + #SARS-CoV-2 RNA persistence in colorectal tissue up to 2 years post-COVID-19: medrxiv.org/content/10.110… 2/ More specifically they performed whole-body positron emission tomography (#PET) imaging in a group of 24 participants at time points ranging from 27-910 days following acute SARS-CoV-2 infection using a novel radiotracer that quantifies activated T lymphocytes

PolyBio is excited to be leading the LongCovid Research Consortium (LCRC): a global scientific collaboration to rapidly & comprehensively study #LongCovid disease mechanisms, with a focus on SARS-CoV-2 reservoir (). LCRC projects we are supporting include:polybio.org/longcovid 1. Perelman School of Medicine University of Pennsylvania: “Long COVID: Using #SARS-CoV-2 specific T cells as biosensors of viral persistence” 👉 Learn more here: polybio.org/projects/long-…

This is an important talk @resiapretorius gave at the @polybioRF Seminar Series. Her early pilot data (~10 subjects) shows that #LongCovid patients have abnormal microclots in their blood samples that are indicative of endothelial + platelet dysfunction: 2/ The microclots in the LongCovid samples contain serum amyloid A, fibrinogen, complement factors, and cytoskeletal kerratin. Dr. Pretorius has already filed a patent for diagnosing #LongCovid using detection of these deposits. She is also writing a paper on her findings.