Crémieux Profile picture
Dec 20, 2024 17 tweets 6 min read Read on X
Psychotic people follow scripts.

Let's talk about the glass delusion, the Middle Ages' bout with a mass psychogenic illness marked by people believing they were made of glass. Image
Glass was a valuable commodity in Europe. It was primarily owned by the noble and well-to-do, and it had a notable purpose in alchemy.

Its perception as the technology of the time was as one that's both fragile and valuable, like the nobility. Image
Glass was the relatively novel technology people knew, and they knew things could be transmuted into glass. Delusional people also thought transmutation could affect them.

Take King Charles VI.

He truly believed his body was made of glass. Image
This delusion was such that Charles felt he had to build his life around it.

He had iron rods fastened into his clothing to hold him up, and he didn't allow his advisors to approach him, lest they accidentally shatter him.

This illness set in during his twenties. Image
The age when his psychotic bouts started is remarkably consistent with when the illness starts today.

Were he alive today, he probably would have been prescribed antipsychotics for his condition. Image
But Charles was alive long before his condition was understood.

He also wasn't its only sufferer. As alchemy's popularity grew, more people started to suffer the glass delusion.

They understood glass as fragile, and themselves as fragile, and they acted out that script. Image
For the well-off, the delusion was treated as legitimate. Many nobles came to wear padded buttocks.

But in one case, in Saint Germain, a doctor took a man who thought his butt was made of glass and beat him until he stopped believing in the delusion.

Apparently that worked. Image
Amusingly, in Rene Descartes' Meditations on First Philosophy, he remarked on the glass delusion and used it as an example of how people can see the world in totally different ways.

Of course, he did say that the perception was insane.Image
Fast forward to the 19th century and factories are beginning to dot the landscape of Europe.

With the change in popular technology, people's delusions followed suit.

With industry, the delusions became industrial. People imagined they were being influenced by vast machines. Image
Patients who presented with this belief in intricate, far off machines that controlled their actions and influenced their lives could never explain how they worked.

Just as people didn't know how they became glass, they didn't get how machines were affecting them. Image
Factories influenced the world, machines could obviously influence us, thus...

Schizophrenics' delusions are tailored to what they vaguely know, and they learn about those half-baked delusions from others, the times, etc.

Consider exorcism. Its modern script came from a movie! Image
People today know about parasites, chronic pain, post-viral conditions, toxic poisoning, and more, and they have an amazing tool for finding and promoting related scripts:

The internet! Image
Thousands of people today believe they have a skin condition called Morgellons.

It's not real.

They just believe they're developing sores and lesions, and hairs are sprouting from them, but they're really picking themselves raw and getting freaked out by cotton fibers. Image
The sufferers from this condition are deeply unwell, and they spread their unwellness to other people through posting about their condition online.

People know about all the requisite concepts, and they see something on themselves and imagine it's a real symptom.

But it's not.
There are no demons, there's no Morgellons, people cannot be made of glass, and there's no big machine out there influencing people and miraculously disappearing the moment those concepts go out of fashion and get replaced by other ones with nary a cure invented.
And this keeps happening!

People are always inventing new conditions or imagining they're afflicted by something real when they're not, by reading into symptoms and gaslighting themselves.

And they sometimes act incredibly mad in these bouts of belief. Image
A subset of people today seem vulnerable to scripts, and some seem to have always been vulnerable to it.

It makes you wonder: must psychotic people always be like this? And what can we do to cure them of their delusions?

I suggest we don't give in with padded buttocks.

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More from @cremieuxrecueil

Jun 1
My Uber driver says

- His license is suspended
- He was once a soldier for a Mafia family
- He's telling me about his time in Rikers
- He's showing me YouTube videos
- He's telling me his theories about Jews
He's telling me about gang wars he was in ad a kid.

He's wondering why all the Chinese girls are lined up - for an audition?

He says to go to Mother's Ruin for latin prostitutes.

All of this entirely unprompted.
"Yeah, these African guys, yeesh"

"I couldn't fuck that whore because I got the erectile dysfunction."

He just keeps going.
Read 6 tweets
May 29
This is just not true and it's sad that people believe it.

It's also indicting, when it's so obviously false if you just look out into the world. What you see should match what the statistics clearly show:

Estimated marriage effects for men and women are almost always similar🧵 Image
In that chart, I used the GSS and found something many people replicate:

1. Cross-sectionally, there's a relationship between being married and life satisfaction. It's similar for men and women.

2. Within persons—causally!—marriage boosts life satisfaction, but more for women.
Leveraging the same within-person design, we can use the Add Health dataset to look at stress and depression.

For both sexes, the effects are indistinguishable.

But they're also mostly not real: it's just that people who get married tend to be less stressed and depressed! Image
Read 10 tweets
May 26
As a recap on my appearance, Eli Lilly is pursuing:

- A one-dose drug for preventing most heart disease
- A vaccine for chlamydia
- A vaccine for gonorrhea
- A vaccine for Epstein-Barr
- A drug that lets you stay awake longer and feel more rested

It's a golden age of pharma! Image
And remember, Eli Lilly's big break historically was the University of Toronto licensing them to produce insulin.

They started off by giving it out for free, saving the world's diabetics at a time when there was no treatment available.

They've always been a force for good. Image
I think

- The heart disease drug will succeed
-- Will it commercialize? It can, easily. But I'm 50/50 due to the competition
- Chlamydia and gonorrhea vax will succeed, but I don't see much commercial potential with Lilly
- EBV vaccine will fail with Lilly, succeed eventually
Read 5 tweets
May 25
Eli Lilly has done it.

They've gone and made what seems to be a powerful, permanent gene therapy for LDL cholesterol.

That means they'll be able to effectively prevent most heart disease with a single infusion! Image
Almost all of the side effects were just things you see with any infusion. Some people react poorly to needles and having to sit for a while🤷‍♀️

And that's what we expect, because the people with good PCSK9 genes naturally are totally fine. This therapy catches the rest of us up!
This is amazing stuff, beating drug administration because it's permanent, and it only gets better from here.

We are going to get so healthy, so fast. Our grandkids are going to hear about heart attacks and have never actually seen one.

Source: nejm.org/doi/full/10.10…
Read 5 tweets
May 24
Are White women the primary beneficiaries of affirmative action?

That's a real claim that's commonly advanced by journalists, and the claim has gone so far that it's even made its way into academic publications and policy.

But the claim is completely false🧵 Image
This claim doesn't make a lot of sense. After all, shouldn't the primary beneficiaries of affirmative action be the people who the policies primarily target?

In America, that's African Americans and, among them, women get an added benefit. How could it be Whites? Image
To figure out where the claim comes from, I started reading supposed sources.

Often enough, journalists will just take the claim for granted without providing *any* source.

It's just tacit knowledge now, and that's not good!

Then, when you hit a source, it's not supportive: Image
Read 13 tweets
May 7
World War I devastated Britain and likely slowed down its technological progress🧵

The reason being, the youth are the engine of innovation.

Areas that saw more deaths saw larger declines in patenting in the years following the war. Image
To figure out the innovation effects of losing a large portion of a generation's young men who were just coming into the primes of their lives, the authors needed four pieces of data.

The first were the numbers and pre-war locations of soldiers who died. Image
The next components were the numbers and locations of patent filings.

If you look at both graphs, you see obvious total population effects. So, areas must be normalized. Image
Read 12 tweets

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