1. Panama Canal in the News

Historical Perspective

On the many workers' lives lost trying to build it:

Who were they and where did they come from?
2. First Attempt (French)

In the 1880s, the French tried but failed to build a Panama Canal.

They finally gave up in 1889, after years of fighting a recalcitrant landscape, ferocious disease and spiralling costs

AND the deaths of 22,000 workers! .

archive.ph/8FqKiImage
3. From Suez to Panama

Ferdinand de Lesseps's success in building the Suez Canal in 1869 was utterly derailed by the abysmal failure of his subsequent effort to build the Panama Canal due to disease.

Bankruptcy!

800 thousand people had invested their savings in the project! Image
4. The Dead Workers and Engineers

The Engineers were from France

The Workers were mainly from the West Indies, chiefly Jamaica, but with also many Chinese "Coolies"

pancanal.com/en/the-french-…
5. This project had a large turnover of labor!

Laborers were mostly Jamaicans & Men from the Antilles, South American Indians & Chinese, all controlled by Frenchmen.

The maximum force employed at any one time was reached in 1884 with more than 19,000.

web.mst.edu/lib-circ/files…Image
6. Malaria took more lives than Yellow Fever

Both were constant & attentive!

The sick avoided the hospitals whenever possible because of its reputation for propagating disease

St. Charles Ward, Ancon Hospital where 1200 Frenchmen Died of Yellow Fever

journalpanorama.org/article/mosqui…Image
Image
7. The Death Toll

Much of the death toll was never recorded.

Along with yellow fever and malaria cases, there were an estimated 27,000 labourers and engineers killed between 1881 and 1889.

web.mst.edu/lib-circ/files…Image
Image
8. Is De Lesseps a Canal Digger or a Grave Digger?

Asked Harpers Weekly at the time.

"Torrrential Rain, Devastating Floods, Millions of Tarantulas, Bugs, Rats and Snakes, not to mention Mosquitoes, Yellow Fever and Malaria"

web.mst.edu/lib-circ/files…Image
Image
9. Beyond the Chagres River

Are paths that lead to death
To the fever’s deadly breezes,
To malaria’s poisonous breath!
Beyond the tropic foliage,
Where the alligator waits,
Are the mansions of the Devil
His original estates!

James Stanley Gilbert

journalpanorama.org/wp-content/upl…Image
Image
10. "This country is literally poisoned"

The climate was deadly and ceaseless rains triggered mudslides that buried Caribbean workers alive.

3/4 of French engineers died within 3 months of arriving.

30 - 40 workers a day died in 1882 & 1883

history.com/news/panama-ca…Image
11. Who Died (1)

“it is recorded that under French control of the Canal project, 12,875 workers were on the payroll, of which 10,844 were British Afro-Antilleans: 9,005 Jamaicans, 1,344 Barbadians and 495 Saint Lucians”.

elfarodelcanal.com/en/ethnic-grou…Image
12. Who Died (2)

After the Afro-Antillean, Spanish participation was the most important. According to official records of the time:

"8,298 Spaniards were hired for the construction of the Panama Canal, most of them Galicians, but also from the Basque Country and Asturias” Image
13, Who Died (3)

Panamá’s Chinese immigrants arrived after a hellish journey from their homeland. Sailing from Shantou on ships called “floating hells” because of the inhumane conditions of the journey, many of these workers later died of tropical diseases & committed suicide
14. No Opium!

Recruiting agents "promised them heaven & earth & opium & many arrived duped or with contracts that they had no intention of fulfilling“

After construction of the railroad, many went into the construction of the French Canal.

revista.drclas.harvard.edu/the-chinese-of…
15. Then the Americans Came & Built it

Between 1904 & the end of construction in 1913, the US recorded the deaths of 5,855 canal workers.

When combined with the deaths from the French venture, it amounted to 500 lives lost for each mile of the canal.

history.com/news/panama-ca…Image
16. "Culebra Gorge" nicknamed “Hell’s Gorge"

"the Culebra Cut was a cauldron of noise where risks of death ranged from drowning to electrocution. Workers blasted away with upwards of 60 million pounds of dynamite which could ignite prematurely in the tropical Panamanian climate" Image
17. Quinine

Workers were often deafened as a side effect of using quinine to ward off malaria, which led to deadly railroad accidents

One fell trying to hop on a train & the wheel of another train cut his body right in two "as if chopped with a machete"

history.com/news/panama-ca…
18. Forgotten Casualties

The workers lived like second-class citizens, subject to a Jim Crow-like regime, with bad food, long hour, low pay & constant danger.

In the 1980s, filmmaker Roman Foster went looking for these workers; most were in their 90s.

theconversation.com/the-panama-can…
19. Fosters’s film Diggers (1984)

This documentary highlights the men from the Caribbean who laboured on one of the most dangerous areas, the Culebra Cut, but received no recognition.

20. Artificial Limb Boom

by 1912, A.A. Marks supplied more than 200 artificial limbs, paying for an ad in The New York Sun:

"celebrating how their limbs helped the many men who met with accidents, premature blasts, railroad cars"

theconversation.com/the-panama-can…Image
21. Public Health Lessons From The Panama Canal

In this essay from the September 1913 issue of Popular Science, Dr. John Silas Lankford from the University of Texas describes "The Lesson Of Canal Zone Sanitation"

popsci.com/article/techno…Image
22. Learning from Failures

1. A large part of the eventual success on the part of the USin building a canal at Panama came from avoiding the mistakes of the French

2. A lack of knowledge of sanitation & tropical diseases contributed greatly to the demise of the French endeavor Image
23. US success at Panama benefitted from:

1. Twenty years of advances in health, medicine, hygiene, engineering & construction.

2. The project left behind by the French. In 1903, 30% of the work was complete & the French left behind high quality materials, buildings, & work.
24. Some Historical Video Clips

Panama Canal Operations, 1913-1914

youtube.com/watch?v=WOXKNv…

Construction of the Panama Canal [1913-1914]

(Reel 1-5 of 5)

youtube.com/watch?v=Dnfz8e…

Construction of the Panama Canal [1913-1914]

(Reel 2-5 of 5)

youtube.com/watch?v=rA9kPf… Image
25. Today is the 25thm🎄Christmas Day🎅

Why not say a prayer for the souls of those 27,000 men who died building the Panama Canal under infernal conditions, and be grateful that this was not our fate in this lifetime.

That Canal is Theirs! Image
unroll the Panama Canal @threadreaderapp Image
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More from @BillyBostickson

May 8
22. Biased Sampling distorts Geography!

They use a dataset skewed toward Yunnan & Laos (p. 16), leading to phylogeographic models that place SARS-CoV ancestors far from Wuhan & Guangdong (p. 12).

This sampling bias undermines the reliability of their geographic inferences.
23. Neglecting Alternative Hypotheses

No SARS-CoV-like viruses near emergence sites?

They completely overlook non-bat reservoirs, like civets or pangolins, which could explain local circulation (p. 15).

This omission weakens their claim of distant ancestor origins (p. 12).
24. Inconsistent Molecular Clock Rates

The paper misuses variable NRR-specific clock rates, which give inconsistent SARS-CoV ancestor dates (e.g., 1944–2014 for SARS-CoV-2, p. 9).

Without any validation of bat-specific rates, this approach has no rational grounding (p. 14).
Read 8 tweets
May 8
5. Why did they resort to using the POW model?

To show that :

"our inferences of the time of the ancestors of human SARS-CoVs and their closest bat sarbecoviruses are UNBIASED"
6. Captain Obvious Strikes Again (1)

"we show that the ancestors of SARS-CoV-1 & SARS-CoV-2 likely circulated in horseshoe bat populations 100s to 1000s km away from the sites of the emergence of these viruses in humans & as recently as one to six years prior to this emergence"
7. Captain Obvious Strikes Again (2)

"Our findings indicate that there would not have been sufficient time for the direct bat virus ancestor to reach the locations of emergence of the human SARS-CoVs via normal dispersal through bat populations alone"
Read 12 tweets
May 8
1. Last sick joke of the Zoonati?

Fragments of human SARS-CoVs share recent common ancestors with bat viruses

SARS-CoV-like viruses have circulated in Asia for millennia

Ancestors of human SARS-CoVs likely circulated in China & Laos

Ancestors traveled unexpectedly fast
2. No Pangolins allowed!

There is insufficient temporal signal when calibrating a molecular clock using tip dating with sarbecoviruses sampled from bats & pangolins, likely as a consequence of limited sampling across space & time.

Therefore, we used SARS-CoV-1 genomes!
3. Definitely no pangolins!

As sampling locations of SARS-CoV-1, 2 & pangolin sarbecoviruses likely do not represent where their direct bat virus ancestors circulated, we EXCLUDED their locations from phylogeographic analyses to avoid the IMPACT of dispersal of non-bat hosts!
Read 24 tweets
May 4
1⃣ Virological 🦠 Whistleblower 😮‍💨?

"I worked with researchers in this space - virology + combatting future pandemics - in the decade before the pandemic".
2⃣ One Fact

"The one fact that the last 5 years never readily disclosed is that the core ideology of this community of researchers was fundamentally divided"
3⃣ Lab based creation of super-viruses

"About half of the researchers, including many leading virologists whose names appeared in the news, believed and argued passionately for the lab-based creation of super-viruses and super-bacteria"
Read 12 tweets
Apr 23
1. The Second Lab Leak

Turning and turning in the petri dish,
The scientists cannot hear the warnings;
Genes recombine; the barriers cannot hold,
Evil virology is loosed upon the world,
The blood-dimmed tide is loosed, and everywhere
The ceremony of innocence is drowned;
2. The Second Lab Leak

The best lack critical thinking, while the professors
Are full of furious bias.
Surely some revelation is at hand;
Surely the cover up is now banned?
Lab Leak! Hardly are those words out
When a vast image out of Human Folly
Troubles my sight:
3. Somewhere in Wuhan

somewhere in the cell lines of a Chinese laboratory
A shape with pangolin body and the head of a bat,
A gaze blank and pitiless as the sun,
Is moving its long tongue, while all about it
Reel shadows of the indignant molested bats.
Read 6 tweets
Apr 22
🧵As promised, here is my counter critique & rebuttal of some points made by @gadboit about the Pangolin Papers Hypothesis.

His theory seems to be that SARS-COV-2 emerged like Aphrodite, from BANAL BAT viruses, possibly with some FCS tweaking & no Pangolins coronaviruses needed.
🧵1. Introduction

@gadboit claims BANAL-52’s 96.8% similarity and natural recombination outweigh my lab + PangolinCoV hypothesis for SARS-CoV-2’s origin.

However, my evidence shows PangolinCoV signatures, WIV lab work & recombination are stronger.

researchgate.net/publication/39…
@gadboit 🧵2. @gadboit claims BANAL-52’s 96.8% similarity & ACE2 binding make it closer to SARS-CoV-2 than PCoVs (~91%) & that PCoV features could come from bat CoVs.

But GD PCoV’s RBD (97% identity) needs no mutations for hACE2, unlike BANALs.

See Wrobel et al:

nature.com/articles/s4159…
Read 28 tweets

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