💉i have a guess!!! Part of my time on my educational path, I was spending in the clinic in Neuro opthalmology. We had a lot of patients that had age-related macular degeneration or diabetes related. They would go for the eye injections of things like alflibercept. I'm not a neurophthalmologist however I worked with them and I learned things.
Im just typing on my phone so you're going to have to bear with me.
"significantly increases the risk of developing a condition called non-arteritic anterior ischemic optic neuropathy, or NAION, more than doubling the likelihood.
NAION is a rare condition that causes a lack of blood flow to part of the optic nerve, which connects the eye to the brain. Without blood flow, the affected areas swell up, stop working correctly and start to die, resulting in severe vision loss or blindness, according to the Cleveland Clinic. "
All right. Ozempic mimics naturally occurring hormone called glucagon-like peptide-1 . That's GLP-1. It signals to the brain that you are full, suppressing appetite and reducing food intake.
But this is acting like a ligand. And a ligand attaches itself to a receptor. It's like a lock and key.
GLP-1 (glucagon-like peptide-1) is a ligand, specifically acting as the natural ligand for the glucagon-like peptide-1 receptor (GLP-1R). The ligand matches the lock and then it signals the body to do things and in this case it signals not to be hungry.
And the ligand can have different shapes but also have charge. And some of these receptors also respond to a charge. We're talking about positive and negative charges.
And below chief nerd is being awesome and posting that there's an eye condition occurring as a result of ozempic.
Well, one might have the thought that the ligand that is made synthetically for ozempic has a chance of connecting with other receptors in the human body.
And the eye, has receptors, and one receptor is called Endothelin-1 (ET-1)
ET-1 is a ligand that binds to endothelin receptors (EDNRA and EDNRB) to cause vasoconstriction, which can cause decreased blood flow to the retina and optic nerve head.
And this condition might be treated by endothelin receptor antagonist. That means it increases blood flow by interacting with that receptor and it gives it a different signal.
But here's the thing: this has already been studied.
"Glucagon-like peptide-1 receptor agonist liraglutide inhibits endothelin-1 in endothelial cell by repressing nuclear factor-kappa B activation".
So they already knew. Because this research happened over 10 years ago.
They already knew it there was a link.
I don't have the full mechanism figured out and it's a Saturday night at 9:00 p.m. and this lady should be doing something else but here we are.
Im just typing on my phone so you're going to have to bear with me.
"significantly increases the risk of developing a condition called non-arteritic anterior ischemic optic neuropathy, or NAION, more than doubling the likelihood.
NAION is a rare condition that causes a lack of blood flow to part of the optic nerve, which connects the eye to the brain. Without blood flow, the affected areas swell up, stop working correctly and start to die, resulting in severe vision loss or blindness, according to the Cleveland Clinic. "
All right. Ozempic mimics naturally occurring hormone called glucagon-like peptide-1 . That's GLP-1. It signals to the brain that you are full, suppressing appetite and reducing food intake.
But this is acting like a ligand. And a ligand attaches itself to a receptor. It's like a lock and key.
GLP-1 (glucagon-like peptide-1) is a ligand, specifically acting as the natural ligand for the glucagon-like peptide-1 receptor (GLP-1R). The ligand matches the lock and then it signals the body to do things and in this case it signals not to be hungry.
And the ligand can have different shapes but also have charge. And some of these receptors also respond to a charge. We're talking about positive and negative charges.
And below chief nerd is being awesome and posting that there's an eye condition occurring as a result of ozempic.
Well, one might have the thought that the ligand that is made synthetically for ozempic has a chance of connecting with other receptors in the human body.
And the eye, has receptors, and one receptor is called Endothelin-1 (ET-1)
ET-1 is a ligand that binds to endothelin receptors (EDNRA and EDNRB) to cause vasoconstriction, which can cause decreased blood flow to the retina and optic nerve head.
And this condition might be treated by endothelin receptor antagonist. That means it increases blood flow by interacting with that receptor and it gives it a different signal.
But here's the thing: this has already been studied.
"Glucagon-like peptide-1 receptor agonist liraglutide inhibits endothelin-1 in endothelial cell by repressing nuclear factor-kappa B activation".
So they already knew. Because this research happened over 10 years ago.
They already knew it there was a link.
I don't have the full mechanism figured out and it's a Saturday night at 9:00 p.m. and this lady should be doing something else but here we are.
@houmanhemmati
@drdrew
@DrJBhattacharya
I know one of you is an ophthalmologist :)
@drdrew
@DrJBhattacharya
I know one of you is an ophthalmologist :)
4/ Even though this is endotheliun 1 and not ET 1
Then we look at the possibility of
.link.springer.com/article/10.100…
Then we look at the possibility of
.link.springer.com/article/10.100…
5/ 💉🚨👀👀👀
So then we look at the function of endotheliun 1 not just et1
Science!!!!
"Abstract
Endothelin is a potent vasoactive peptide occurring in three isotypes, ET-1, ET-2, and ET-3. Through its two main receptors, endothelin A and endothelin B, it is responsible for a variety of physiological functions, primarily blood flow control. Recent evidence from both human and animal models shows involvement of endothelin in diabetes, retinal circulation, and optic neuropathies. Increased circulating levels of endothelin-1 (ET-1) have been found in patients with diabetes, and a positive correlation between plasma ET-1 levels and microangiopathy in patients with type-2 diabetes has been demonstrated. In addition to its direct vasoconstrictor effects, enhanced levels of ET-1 may contribute to endothelial dysfunction through inhibitory effects on nitric oxide (NO) production. Experimental studies have shown that chronic ET-1 administration to the optic nerve immediately behind the globe causes neuronal damage, activation of astrocytes, the major glial cell in the anterior optic nerve, and upregulation of endothelin B receptors."
pmc.ncbi.nlm.nih.gov/articles/PMC30…
So then we look at the function of endotheliun 1 not just et1
Science!!!!
"Abstract
Endothelin is a potent vasoactive peptide occurring in three isotypes, ET-1, ET-2, and ET-3. Through its two main receptors, endothelin A and endothelin B, it is responsible for a variety of physiological functions, primarily blood flow control. Recent evidence from both human and animal models shows involvement of endothelin in diabetes, retinal circulation, and optic neuropathies. Increased circulating levels of endothelin-1 (ET-1) have been found in patients with diabetes, and a positive correlation between plasma ET-1 levels and microangiopathy in patients with type-2 diabetes has been demonstrated. In addition to its direct vasoconstrictor effects, enhanced levels of ET-1 may contribute to endothelial dysfunction through inhibitory effects on nitric oxide (NO) production. Experimental studies have shown that chronic ET-1 administration to the optic nerve immediately behind the globe causes neuronal damage, activation of astrocytes, the major glial cell in the anterior optic nerve, and upregulation of endothelin B receptors."
pmc.ncbi.nlm.nih.gov/articles/PMC30…
7/ So excuse the pun if we look above at post number six we look at what those receptors are engaged in and they are engaged in things that control blood flow to the eye!
And in this study it's saying that GLP1 acts as an agonist. And what does an agonist do?
agonist is a substance that binds to a receptor and activates it, producing a biological response.
And that study, right there is stating that GLP1 is acting endothelin!
And in the article above it says that is in charge of blood flow to the eye and health of the eye. Vasoactive .
And the other study said that talks about the endothelin ANTAgonist increases blood flow to the eye.
The one on the lower left is the study from 2013 that the researchers above in this study that chief nerd talked about stated they didn't have any clue about prior which is incorrect because I just sat here on my phone doing nothing on a Saturday night kicked back and I found it and what am I a tall Ginger?
😆
And then if we look at the study on the right it's pretty simple one would think?
That would be a starting point if I were a researcher.
This could be incorrect. But it sure looks like a starting point.
frontiersin.org/journals/ophth…
And in this study it's saying that GLP1 acts as an agonist. And what does an agonist do?
agonist is a substance that binds to a receptor and activates it, producing a biological response.
And that study, right there is stating that GLP1 is acting endothelin!
And in the article above it says that is in charge of blood flow to the eye and health of the eye. Vasoactive .
And the other study said that talks about the endothelin ANTAgonist increases blood flow to the eye.
The one on the lower left is the study from 2013 that the researchers above in this study that chief nerd talked about stated they didn't have any clue about prior which is incorrect because I just sat here on my phone doing nothing on a Saturday night kicked back and I found it and what am I a tall Ginger?
😆
And then if we look at the study on the right it's pretty simple one would think?
That would be a starting point if I were a researcher.
This could be incorrect. But it sure looks like a starting point.
frontiersin.org/journals/ophth…
@drdrew
@houmanhemmati
@DrJBhattacharya
@DrJohnB2
@RobertKennedyJr
@MartyMakary
@MartinKulldorff
Hello gentlemen. I added posts four and five which give much more information on the connection between the GLP 1 and then the et1 that's part of the ed1.
Then it gives the parts of the mechanism that link up to the nuclear kappa B activation and the reduction of blood flow vasoconstriction.
Can someone hire me already and bring me back to science, or should I just stay in my role in my new career change? 🤦🏻♀️
@houmanhemmati
@DrJBhattacharya
@DrJohnB2
@RobertKennedyJr
@MartyMakary
@MartinKulldorff
Hello gentlemen. I added posts four and five which give much more information on the connection between the GLP 1 and then the et1 that's part of the ed1.
Then it gives the parts of the mechanism that link up to the nuclear kappa B activation and the reduction of blood flow vasoconstriction.
Can someone hire me already and bring me back to science, or should I just stay in my role in my new career change? 🤦🏻♀️
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