SARS-CoV-2 variants are not simply competing with each other, but are in fact WORKING TOGETHER in a COOPERATIVE MANNER !!! 🤔 pmc.ncbi.nlm.nih.gov/articles/PMC10…
2) This study looked at how different versions of the COVID-19 virus, called variants, have evolved over time. The researchers found that these variants are not just competing with each other, but are actually working together.
3) As new variants emerge, they take in and use the genetic changes (mutations) from previous variants, rather than completely replacing them. This suggests the variants are building on each other's changes, not just trying to beat each other.
4) The study also showed that the combination of mutations in each variant helps balance out the extreme effects that individual mutations can have. This indicates the variants are working together to maintain a healthy balance, not just one variant dominating.
5) Another key finding was that the variants adapt to different seasons and locations in a coordinated way. The genetic signatures (haplotypes) of the variants became disconnected across regions due to seasonal changes.
6) This implies the variants are adjusting to environmental conditions together, not competing for a single environment.
Overall, the researchers conclude the variants exhibit "cooperative evolution." The accumulation of mutations creates a complex but balanced landscape ...
7) ...suggesting the variants are evolving together as a connected population, not just outcompeting each other.
In summary, the COVID-19 virus variants are not simply competing. They are working together by building on each other's changes, balancing extreme effects, and ...
8) ... adapting to different environments in a coordinated way. This cooperative evolution allows the virus to rapidly diversify and adapt as a united population.
Thanks for reading 🙏 and happy safe year 2025 😷
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ENTROPY UNLEASHED:
How Viral Protein Interactions Drive Coronavirus Adaptation in Bats and Humans
Entropy, in a general sense, refers to the level of disorder or randomness in a system. biorxiv.org/content/10.110…
2) When we talk about protein interactions and viral behavior, entropy can be viewed as a measure of how complex and varied these interactions are.
In the context of the study about coronavirus interactions in bat and human cells, here's a simplified breakdown.
3) **Complex Interactions**: The study identifies how proteins from the coronavirus interact with host cells (both bats and humans). These interactions can be highly ordered (low entropy) or more chaotic (high entropy).
Patients care most about how COVID-19 affects their health and daily life, including for those with long COVID. Scientists focus on understanding the virus to find better treatments. Both views are important for dealing with the pandemic.
2) I'm bringing up this topic because, after talking so much about the disease, its long-term effects, treatments, and vaccines, many people have forgotten that we are dealing with the most dangerous virus humanity has ever faced.
Organelles provide the possibility for the virus to organize its RNA in PROTECTED structures, concentrate REPLICATION machinery ... nature.com/articles/s4146…
2) ...compartmentalize the replication process, and hide from immune detection.
Figure 1g - The large perinuclear clusters of viral RNA demonstrate how the viral RNA is organized into PROTECTED structures.
2) Figure 3d- The nanoscale puncta of the viral RNA-dependent RNA polymerase (nsp12) within and around the viral RNA clusters show the concentration of REPLICATION machinery.
SARS-CoV-2: The VIRUS That MASTERFULLY "ADAPTS" to SPREAD FURTHER !
If you were SARS-CoV-2, you could choose to spread in two ways: you could release a lot of tiny particles into the air to infect many people, or you could release just a few super infectious particles ...
2) ... that are really good at making someone sick.
This study published in Nature shows that some variants of the virus are especially strong, meaning they can infect with fewer particles, making it easier for them to spread quickly! nature.com/articles/s4429…
3) Researchers found that different variants of SARS-CoV-2, like Alpha, Delta, and Omicron, have unique abilities to spread. For instance, the Delta variant was shown to be more infectious, meaning it could spread more easily and required fewer viral particles to cause illness...
CORONAVIRUSES and the BRAIN:
Exploring Hidden Links to Neurological Diseases
Human coronaviruses (HCoVs) include seven types, with MERS-CoV, SARS-CoV-1, and SARS-CoV-2 being the most contagious and causing severe pandemics.
2) These viruses mainly affect the respiratory system, causing symptoms like cough, fever, and breathing difficulties.
Recent evidence suggests a link between HCoVs and brain disorders.
3) This study looks at how these viruses may be associated with neurodegenerative diseases such as Alzheimer’s and Parkinson’s. It also examines the long-term effects of HCoV infections and on similarities between HCoV proteins and those related to brain diseases.