Isn't it crazy that the WHO literally admits that working the night shift causes cancer?
This is why - and how to make sure you're fully protected (🧵1/7):
The conclusion was built off of multiple lines of evidence.
Studies like the two below showed 2-3X risk of cancers in people who work the night shift.
While not all studies showed the association, there is more than enough reason biologically to believe that this is one of the worst things you can do for your health.
To understand why - we must understand the circadian rhythm.
Your body regulates EVERYTHING on based on the time of day.
Things are mainly orchestrated by a series of clock proteins - these regulate the expression of various genes throughout the body.
These genes end up regulating everything: hormones, metabolism, digestion, everything.
Estimates from 10-50% of all genes are under circadian regulation.
It cannot be understated how important that is.
If this process of gene regulation via circadian clock proteins is thrown off, nearly every process in every tissue will also be thrown off.
And that can leave you susceptible to disease - including cancer.
MitoQ works mainly as a mitochondrial targeted antioxidant.
A deficiency of antioxidants relative to reactive oxygen species within the mitochondria can both damage the structure of the mitochondria and reduce its energy generation capacity.
Most antioxidants work throughout the cell - mitoQ has the unique ability to target the mitochondria specifically.
Typically dosed at 10-20 mg.
#2 PQQ
PQQ acts as a redox factor.
While it's antioxidant properties are massively potent (~100X vitamin C), its real power comes in its ability to recycle NADH back into NAD+.
NAD+ plays a central role in allowing our cells to burn energy, and it also activates factors like sirtuins which upregulate various metabolic processes.
People take NAD+ precursors like NMN and NR to replenish levels, but the real issue is that our cells often get backed up with NADH, and they can't convert it back into NAD+.
This study was posted in the American Journal of Clinical Nutrition in 2002.
They thought that since gelatin, rich in glycine, is able to stimulate insulin secretion more than other proteins, that it might have an effect on blood sugar with a meal.
To test their theory, they recruited healthy volunteers and gave them a small amount of glucose (25g).
Then, at a different time, they did the same amount of glucose with glycine.
The amounts of glycine were between 3.6-5.4 grams.
Participants were middle aged and were generally healthy.
They took 200 mg of L-Theanine per day for 4 weeks.
Prior to this, theanine's anti-stress properties were mainly noticed after a single dose, so they set out to see its effects over a more extended dosing period.
All 3 of the primary outcomes were improved with L-Theanine.
After 4 weeks, the self-rated depression scores were markedly lower with L-Theanine administration.