George Ferman Profile picture
Jan 9 • 18 tweets • 14 min read • Read on X
Just because someone lacks a fair amount of money, it doesn't mean that he can't get healthier.

So here's the broke man's guide towards improving his health.

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*Standard disclaimer that nothing in this thread should be used as a substitute for medical advice*

Alright, it's George. There are many free or cheap tools you can use in order to improve your health.

Here they are👇

Number 1: Realize that when it comes to food, you can cover A LOT of your nutritional needs with just:
-300 grams of quality shrimp/octopus or squid
-10 whole eggs
-200 grams of beef or lamb heart
-200 grams of raw cheese
-2 pounds of strawberries, oranges, kiwis, berries or something seasonal
-Brewer's yeast/marmite
-100 grams of beef liver
-Adding EVOO, potatoes, mushrooms and easy to digest vegetables in just one of your daily meals
-4 pounds of bone in red meat
per week
Are these the cheapest foods? No.

Are they cheaper than you might expect if they are sourced properly? Yes.

P.S: If you have the space realize that growing a garden turns out to be easier than we think.Image
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Number 2: Work on the lymphatic system through certain massages/exercises.

There are many tools you can use in order to work on the lymphatic system.

Some are free, some have a low cost and some are a bit expensive.

But free ones such as big 6, putting legs up on a wall and similar ones (just Google "lymphatic drainage exercises") can be quite powerful.

Now if you have no idea what the lymphatic system is, it's a subsystem of the circulatory system and the immune system.

It is responsible for filtering out waste products, absorbing fats from the intestines, releasing lymphocytes, gathering the excess fluid from the tissues and bringing it back into the bloodstream in order for us to maintain normal fluid levels.

So it's pretty important.

Just like when it comes to the other tools, i've done a full thread on the lymphatic system as well that you can find here:

x.com/Helios_Movemen…

But please do not underestimate the impact that the simple exercises mentioned above can have on your health.Image
Number 3: Stretching.

Now if you've neglected stretching don't worry, you're not alone.
pubmed.ncbi.nlm.nih.gov/33338988/

As a typical bro i neglected this for a long time as well since mobility drills took care of my warm ups just fine.

But unfortunately since most of us sit for multiple hours a day, do bodybuilding exercises, experience stress and so on, we need to make stretching a priority even if it is for 5 minutes a day.

It's also a great way to unwire and calm the mind.

Not to even mention that poor posture can negatively affect our gut health and gut issues are pretty common these days.

If you're still skeptical, stretching can be superior to walking when it comes to lowering blood pressure.
Number 4: Spending time in the sun/outdoors.

Now since it's the winter and it's cloudy in a lot of places, even if the sun isn't out, you still need to spend time outside for multiple reasons and lux is one of them (you can have even a 100X difference between being indoors and outdoors).

We're evolved to spend our days under BRIGHT light and when we don't do so, our sleep, energy levels, mood and a lot more will suffer.

Now when it comes to sunlight this thread covers the basics, a lot of the common misconceptions and has some interesting studies.
x.com/Helios_Movemen…

If you want to take it a step further, you can expose yourself to natural light first thing in the morning and throughout the day without sunglasses, contacts or glasses if possible.

A basic principle that we can not ignore when it comes to health, is that a holistic spectrum of light hitting our eyes every day is necessary in order for us to keep being healthy and anything that messes with this (artificial blue light, wearing sunglasses, glasses, contacts etc) will result in sickness.

That's because each wavelength of light activates or deactivates different functions in our body through photoreceptors in the eyes and skin, along with the suprachiasmatic nucleus, SCN, the master clock. When you wear sunglasses for example, you are messing with the signal that tells your body that it should produce melanin in order to protect you from the UV rays of the sun.

So you are literally signaling to your body that it’s not sunny outside when it is and you prevent it from starting a series of protective reactions through the pituitary and pineal gland.

Also, if you have sunglasses on constantly, your eyes will miss some of the 1,400+ wavelengths that you NEED by default in order for your eyes to be healthy.

In general, by messing up with the light that goes through the retina, we can not properly stimulate the hypothalamus which is responsible for regulating every single one of our hormones.Image
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Number 5: Exercise

Movement is medicine and having an active lifestyle (walking daily, lifting, playing sports etc) is of course a cornerstone for our health and crucial for our hormonal health, brain health, mood and a lot more.

Even plain walking it is also a great way to balance your blood sugar after meals.

Flat out sitting all day is unnatural and ruins our mood, cardiovascular health and digestion.
pubmed.ncbi.nlm.nih.gov/30409414/Image
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Number 6: Spending less time on social media/using them more conciously.

sciencedirect.com/science/articl…

First and foremost, you are probably aware by now that billions of dollars are spent on social media algorithms each year in order to make them as addictive as possible but in order to do that obviously, our own emotions need to be used against us and obviously, our emotional health has a great impact on our physical health.

They are designed to keep us on a sympathetic state for as long as possible but this has a greater negative impact which thankfully is realized as soon as someone decides to take a break.

In order to understand how but it has gotten, scientists actually study the effects of "doomscrolling".

This is not a joke. It has gotten THAT bad.

You can read this paper for starters if you are interested in the topic:
Number 7: Grounding.

You can have the perfect nutrition, the perfect workout plan, get the most cutting-edge supplements and substances that are supposed to do miracles, but if you do not ground, you will never reach true peak levels of health.

We carry a constant flow of electrical charge which we need to discharge and if we never do this and thus never restore and maintain the body’s natural electrical state, disease will inevitably happen.

Our bodies need lots of stuff in order to be healthy and one of them is grounding. In modern societies, we are bombarded with sources of oxidative stress but the good news are that the surface of the earth, possesses a limitless and continuously renewed supply of free or mobile electrons as a consequence of a global atmospheric electric circuit.

When you’re grounding, you’re transferring these electrons (negatively charged subatomic particles) from the earth to your body which can produce a reduction reaction and thus reduce oxidative stress (free radicals have unpaired electrons)).

A direct earth connection enables both diurnal electrical rhythms-free electrons to flow from the earth to the body and neutralize the positively charged free radicals.

Every cell in our bodies is affected by electromagnetic fields and just as your cells can’t be healthy under and unhealthy environment, they can’t be healthy under unhealthy electromagnetic fields.

pubmed.ncbi.nlm.nih.gov/25848315/
pubmed.ncbi.nlm.nih.gov/31831261/
pubmed.ncbi.nlm.nih.gov/28987038/
pubmed.ncbi.nlm.nih.gov/36481428/
pubmed.ncbi.nlm.nih.gov/22291721/

Grounding is free and consistently practicing it will skyrocket all aspects of your health and well-being.

If you don't ground daily, you haven't covered the absolute foundation of what you need to do to be healthy by default in our nnEMF filled world and you can change that by even 30 minutes a day.Image
Number 8: Some type of gratitude practice.

Believe it or not, this was built in in everyone's life for a long time.

Every culture had various traditions and practices based on this because let's face it, negative stuff happens all the time.

The same thing is true today and if we are only exposed to problems, sooner or later it will have a negative impact on the way we think so we need to balance this out.

Any type of gratitude practice will put you in a very healing emotional state.

pmc.ncbi.nlm.nih.gov/articles/PMC10…Image
Number 9: Fasting.

Now, this might annoy some people, which is fine, but i don’t think that fasting is a tool for beginners.

I think that most people should start by consuming more micronutrients and providing the right building blocks before considering fasting.

That being said, fasting can obviously be a good tool for both physical and spiritual reasons that has been praised for thousands of years.

It can also have many other benefits such as recognizing the hyper-consumer culture that’s around food.

Note: If you are going to fast, slam down electrolytes (the salts, not the ones filled with things such as artificial sweeteners) and have a snack with you just in case your blood sugar drops too much (if you feel dizzy even after consuming electrolytes, just stop and break the fast))).
Number 10: Breathing techniques.

Our breath affects our entire body breath is such as powerful tool.

Some of my favorite breathing techniques are:
1. Breathe very slowly and aim to get one breath every 10 seconds (try a 4 second inhale and a 6 second exhale (since the exhale triggers the relaxation response).

You can also try breathing for 4 seconds, holding your breath for 1 and exhaling for 5 seconds.

If you do 5-6 rounds of these, you will find yourself more relaxed.

2. Wim Hof breathing

3. Buteyko (yes, there is a typo in the pic)Image
Number 11: Sweating.

You might think that sweating is just a bonus great tool for us to deal with the toxic loads that we're exposed to daily but think again.

Sweating for example can even improve our gut health and this isn't a joke. Image
Number 12: Mitigating the artificial blue light in devices such as your PC or laptop with free programs like f.lux.

Artificial blue light that's emitted from these devices, can even exacerbate your acne in case you're struggling with it and contribute to skin ageing.

In summary:

Artificial blue light is a range of the visible light spectrum with a wavelength between 400 and 495 nm.

A few things that exposure to artificial blue light can cause include:
-Raise corticotropin-like intermediate peptide (ACTH(18-39)) which functions as an insulin secretagogue in the pancreas
-Raise cortisol
-GnRH deficiency (GnRH signals to the pituitary gland to make and secrete things such as LH and FSH which are crucial for testosterone and progesterone)
-Melanin degradation
-Neuropathy (damaged nerves)
-Insomnia
-Fatigue
-Suppress BDNF (brain-derived neurotropic factors is obviously a neurotropic factor found in the brain (but also expressed in the retina and even the kidneys) which supports the health of neurons and synapses).
-Increase leptin (leptin is a hormone made mainly by adipose cells which acts on receptors in the hypothalamus in order to control our hunger signals among other things)
-Depression
-Headaches
-Gut issues (mainly by messing vasoactive intestinal polypeptide (VIP) which stimulates pancreatic bicarbonate secretion, bile salts and similar things)
-Migraines
-Anxiety
-Dark circles
-Adrenal fatigue (a very underrated cause behind the adrenal fatigue epidemic that’s been noticed)
-Dehydration (it messes vasopressin (essential for fluid and electrolyte balance)
-Dysregulated circadian rhythm (you are literally signaling to your body non stop that you’re in the middle of the desert)
-Skin aging
-Suppress melatonin
and a lot more.Image
Number 13: Visualization. Image
Number 14: Sleeping in a dark room.


For millions of years, we lived under the influence of sources of light with a lux of 0.0001-3.4 at night.

But now?
You can live even under 500! This is 50.000 times MORE in some cases.

And poor sleep is not something to take lightly.mdpi.com/1422-0067/22/2…
Other things to consider include:
-Water filters
-NOT using toxic hygiene products (saves you money0
-Hot springs
-Some cold exposure
-Binaural beats
-Using supplements such as taurine, glycine, magnesium glycinate, trace mineral and creatine before going fancy with >$80 supplements
That was it.
I hope that you enjoyed these simple and straight to the point suggestions or at least got some food for thought.

If you did, make sure to leave a like/RT.
For more (not that cheap):
fitandball.gumroad.com/l/thesystem23

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More from @Helios_Movement

Jul 16
Here’s a guide on the most powerful antioxidant that exists and how to optimize its production for better:

•Energy levels
•Skin health
•Libido
•Gut health
•Cardiovascular health
•Immune system function
and more.

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*Standard disclaimer that nothing in this thread should be used as a substitute for medical advice*

It's George.

The most powerful antioxidant is not vitamin C, E or even glutathione.

Even though all of these are extremely important since each one has unique roles within the human body (for example, glutathione is critical for detoxification) the most powerful antioxidant is free and it's called melatonin.Image
Melatonin, chemically known as N-acetyl-5-methoxytryptamine, is classified as an indoleamine that is derived from the amino acid tryptophan.

It is evolutionarily ancient and present in organisms from bacteria to humans.

Now technically speaking, since it is synthesized in many non-endocrine organs and doesn't target a specific organ it’s not a hormone (melatonin fits this in the pineal context only).

So melatonin also acts as a paracrine and autocrine signaling molecule, influencing cellular processes across multiple tissues without requiring endocrine-specific pathways.Image
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Read 20 tweets
Jul 13
THE ULTIMATE MICRONUTRIENT GUIDE.

A detailed discussion on the importance of over 25 vitamins, minerals and their bioavailable sources.

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*Standard disclaimer that nothing in this thread should be used as a substitute for medical advice*

First of all, vitamins are organic substances that are generally classified as either fat soluble or water soluble.

Fat soluble vitamins such as: vitamin A, vitamin D, vitamin E and vitamin K dissolve in fat and tend to accumulate in the body.

Water soluble vitamins such as: vitamin C and the B-complex vitamins must dissolve in water before they can be absorbed by the body, and therefore cannot be stored.

Any water-soluble vitamins unused by the body are primarily lost through urine.

Minerals are inorganic elements present in soil and water, which are absorbed by plants or consumed by animals and include things such as: calcium, magnesium, potassium, zinc, copper and iodine.Image
Before we get into the functions of each one, why they are so important, where you can get them from and so on, here are some important notes👇

Note 1: Your micronutrient needs partly depend on your macronutrient split.

And it's quite easy to understand since different macronutrients are metabolized through pathways that rely on specific vitamins, minerals and other micronutrients as cofactors or regulators.

High protein diets require a bit extra: B6, B9, B7, B12, magnesium and molybdenum.

High carb diets require a bit extra: B1, B3, magnesium, zinc and potassium.

High fat diets require a bit extra: choline, electrolytes and L carnitine.

Note 2: All nutrients work synergistically.
Examples include:
-Selenium, sulfur, iodine, CoQ10, manganese, vitamin E, B2, iron
-Thiamine, manganese and magnesium.
-B6 and B2.
-Zinc and copper.
-Retinol, DHA, E and B2.
-Vitamin K and retinol.
-Potassium and sodium.
-Choline and B9.
-B5 and K.
-Iron, B2, B12, B9 copper, D, retinol and C.
-Vitamin D, magnesium and retinol.
Etc

Note 3: Be aware of certain things that deplete us of various micronutrients, interfere with their absorption or increase the need for certain micronutrients:

1. Excessive sweating
Nutrients it mainly depletes:
-Electrolytes but especially potassium

2.Alcohol Nutrients it mainly depletes:
-B vitamins
-Electrolytes
-Vitamin K

3. Sodium fluoride, bromine etc
Nutrients they mainly interfere with:
-Minerals and especially trace minerals

4. Smoking
Nutrients it mainly depletes:
-Retinol
-Vitamin C
-Taurine

5. Phytic acid
Nutrients it mainly depletes:
-Minerals

6. Stimulants
Nutrients they mainly deplete:
-Vitamin C
-Electrolytes
-B1
-B2
-B5

7. Statins Nutrients they mainly deplete:
-CoQ10
-Vitamin D
-Vitamin A, K and E depending on the dosage

8. Birth control pills
Nutrients they mainly deplete:
-Everything, just stop using them

9. Antidepressants Nutrients they mainly deplete:
-B vitamins
-Vitamin K
-Vitamin D

10. Blood pressure medication
Nutrients they mainly deplete:
-B vitamins
-Electrolytes

11. Stress Nutrients it mainly depletes:
-Minerals

12. Heavy metals
-MineralsImage
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Read 21 tweets
Jul 10
Do you want to know the real "secret" for getting healthier?
It's called optimizing your circadian rhythm.

Your CR controls the health of:
-Your hormones
-Your hair (not a joke)
-Your tendons (also not a joke)
-Your skin
-Your gut
-Your liver
-Your brain
-Your heart
and in general, everything.

So a dysregulated circadian rhythm leads to every biological process becoming dysregulated.

If you still don't believe that this is crucial to understand, shift work ALONE is a class 2A carcinogen (tap in the pics).

Let me repeat that because it's wild.

You can eat the perfect diet and workout all you want but if you work a night shift, you are exposed to a class 2A carcinogen.

Now let's proceed into discussing what the circadian rhythm is and how to optimize it.Image
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So, circadian rhythms are 24-hour cycles that are part of the body’s internal clock, one example is the sleep-wake cycle, which are influenced and controlled by:

1. The suprachiasmatic nucleus (SCN) / the central master clock (a bilateral structure located in the hypothalamus directly above the optic chiasm)

and

2. Peripheral clocks in organs such as the pancreas, liver, heart and even muscle tissues

Now, a misunderstanding might happen due to the examples that we just used, which is that circadian rhythms are only affected by environmental cues.

This is false.

They play indeed a GREAT part but the body makes and keeps its own circadian rhythms for lack of a better term.

Also: Not all biological clocks are circadian.
Now the main time cue for our central clock is light and for our peripheral clocks, food intake will also be a time cue.

This is why exposure to artificial blue light creates a mess sleep-wise since you are signaling to your master clock that you’re in the middle of the desert which results in it sending signals that generate alertness which will thus keep you awake at night.

This is also why the simple act of eating breakfast, helps people improve their transit time and insulin resistance.Image
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Read 12 tweets
Jul 10
Most people, use the wrong probiotics and end up making their digestive issues worse.

But if you give me 3 minutes i can save you time, money and actually show you how to use them 👇

As always, nothing in here should be used as a substitute for medical medical.

Now probiotic supplements have been very popular for quite some time and can be extremely helpful tools in recovering from digestive issues.

Yet there are a lot of misconceptions about them, so here are some things that will help you understand better and use them more effectively.

First and foremost, before we talk about anything else, keep in mind the following:

Supplements are not FDA-regulated as drugs, so always go for third-party tested products.

Then, in order for probiotics to work, they need to obviously survive the stomach acid in order to reach the gut so always see if the specific brand you want to use mentions something such as "enteric-coated capsules" in the label.

Now, probiotics are classified based on the following 3 things.

1. The genus
2. The species
3. The strain

So when you see the term "Lactobacillus reuteri ATCC 55730", lactobacillus is the genus, reuteri is the species and ATCC 55730 is the strain.

The potency of probiotics is measured in CFUs, aka Colony-Forming Units.

You might also see the term AFUs being used that stands for Active Fluorescent Unit.Image
The main 3 genus of probiotics you will encounter in supplements are the following:

1. Lactobacillus genus

These species produce lactic acid and primarily colonize the small intestine.

The main species include:

-Lactobacillus acidophilus with strains such as NCFM, LA-14, CL1285, DDS-1 and UALa-01

These strains should be avoided with people who struggle with pathogen overgrowths and especially for people who have SIBO (why plenty of people who have SIBO can start having fruit without many issues after they start addressing it, but as soon as they eat yogurt for example, all hell breaks loose (especially if they go for some brands such as activia)) BUT they can have certain benefits in case you are not struggling with an overgrowth with the main one being helping antibiotic-associated diarrhea and supporting the immune system.

-Lactobacillus rhamnosus with strains such as GG (LGG), HRVD113-US, SD-GG-BE, LRH020
Now this one, is a great species that has all the benefits that probiotics are supposed to have but can also help with IBS way more than other probiotic genus, help us excrete mycotoxins better and has even shown to reduce atopic dermatitis.

*If you want to try one, the first one is the GG (LGG) strain.

- Lactobacillus plantarum with strains such as PS128, SD-LP1-IT, UALp-05, PPLP-217, SD-LPLDL-UK, TWK10.
This one is weird. It works great for histamine intolerance and supporting the brain but only if you have addressed the main things first.

By this i mean that if your histamine intolerance springs from gut dysbiosis and certain nutrient deficiencies for example, then adding plantarum won't do much by itself and you will feel that you've wasted your money.

But if you have addressed these, experienced improvements and are looking for an extra 20% improvement in symptoms, it can be a great addition.

(This is true for all supplement of course but not to this extent).

It's also an underrated tool for improving nutrient absorption.

-Lactobacillus casei with strains such as DN-114 001, HRVD300-US, UALc-03, Lbc80r, SD-CECT9104-SP
Now this has actually been shown to improve IBD, BUT, only if it's not paired with an overgrowth since strains such as DN-114 001 ferment sugars very efficiently.

It's also shown to reduce respiratory infections but not as effective as Lactobacillus paracasei (it's mainly advertised for allergic rhinitis symptoms after all).

-Lactobacillus reuteri with strains such as ATCC 55730, PBS072, RD830-FR, SD-LRE2-IT
This one is quite popular and for good reasons.

But MOST products have a ridiculous amount (we are talking about more than 50 billion CFUs) and even though it can reduce methane production in methane-dominant SIBO, improving constipation by producing antimicrobial compounds such as reuterin, these high doses can overwhelm the small intestine, increasing bacterial load.

This simple and underrated reasons is why so many people with SIBO praise this genus while others hate it.

Now of course it has plenty of benefits such as promoting mucus production, balancing lipids, reducing ulcer and even supporting androgens.

-Lactobacillus crispatus with strains such as SD-LCR01-IT

The main benefit for this is helping prevent bacterial vaginosis and yeast infections by maintaining vaginal pH.

-Lactobacillus fermentum with strains such as SD-LF8-IT

This will have some benefits for a niche issue but overall it's not worth it especially if you have any bacterial overgrwoth.

-Lactobacillus salivarius with strains such as SD-LS1-IT

This is quite interesting for reducing plaque and bacteria related to gum disease.

-Lactobacillus bulgaricus
Don't like it. It can help lactose intolerance but it's even that effective for it and it make pathogen overgrowths way worse.Image
2. Bifidobacterium genus

These produce short-chain fatty acids (SCFAs) like butyrate and primarily colonize the large intestine.

The main species include:

-Bifidobacterium lactis with strains such as HN019, Bi-07, Bi-04, BB-12, SD-BS5-IT, HRVD524-US, SD150-BE, SD-CECT8145-SP, SD-MB2409-IT

This can have benefits such as supporting the immune system, improving lactose intolerance and reducing constipation while being relatively safe for people who have moderate pathogen overgrowths (why it's some times promoted for patients with SIBO), but colostrum does all these and better.

So it's worth it in the case someone can't really afford colostrum in my opinion.

-Bifidobacterium longum with strains such as 1714, SD-BB536-JP, HRVD90b-US, SD-CECT7347-SP, ssp. longum, ssp. infantis
Now i like this one way more.

It's also safe for people with SIBO (not so much for candida though) and has been shown to modulate the gut brain axis, support both IBD and IBS, improve eczema, lactose intolerance (especially in infants) and even support the immune system.

-Bifidobacterium breve with strains such as SD-BR3-IT, HRVD521-US

The benefits and studies on these are too general (at least for my taste) but it's interesting for elderly people where it's shown to have the most benefits (avoid it if you have any severe overgrowth though).

-Bifidobacterium bifidum
This is the go to for people who have candida albicans overgrowths and don't react well to S. boulardii.

It's also shown to help people with IBS and support the immune system.

-Bifidobacterium infantis with strains such as SD-M63-JP, ISTILOS B. infantis
This is very interesting for infants who struggle with colic/ulcers and eczema (why it's often added in infant probiotic formulas).

-Bifidobacterium animalis with strains such as ssp. lactis BL050, BB-12

This is also primarily used for improving the digestion of children especially when it comes to constipation.Image
Read 5 tweets
Jul 6
Toxins are indeed one of the primary drivers behind a lot of people's health issues but most of the detox advice is false.

Here's what you need know presented as a 10-step plan.
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*Standard disclaimer that nothing in this thread should be used as a substitute for medical advice*

One of the worst (but very common) mistakes someone can do when entering his health journey is to underestimate the impact that toxins have on our health.

While topics such as nutrition are becoming more and more mainstream, topics such as detoxing are still considered almost conspiratorial and for valid reasons a lot of the time to be honest.

But certain toxins such as heavy metals for example have a bigger (and faster) negative impact on our health than dietary toxins and if you’ve struggled with them you know that this is true.

So it is an undeniable reality that we’re exposed to more toxins than we’ve ever been through our food, personal care products, household items, clothing and even the air we breathe, something which is hiding behind a lot of health issues such as:

-Premature gray hair
-Histamine intolerance
-Gut issues
-Fatigue
-Brain fog
-MCAS
-Increased susceptibility to pathogens/gut issues
-Alzheimer’s
-Parkinson’s
-Liver issues
-Respiratory Issues
-Cardiovascular issues
-Reproductive issues
-Kidney issues
-Skin issues
-Hormonal issues
-High blood pressure
-ED
and more.Image
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And of course it is not hard to understand why this is the case.

For example:
1. Certain yeasts and fungi for example are known to "feed" on mercury as a protective measure (they absorb the mercury until it can be released in an organic form) and besides this, mercury antagonizes selenium which is crucial for hypochlorite.

2. Certain heavy metals such as cadmium can displace zinc which is crucial for our immune system, reproductive health, hormonal health and can also reduce PPARs and CYP4A11 and negatively affect our PNS and CNS.

3. Lead can negatively affect the bones since it's very similar to calcium and this is also how it partly negatively affects acetylcholine and the hypothalamus.

4. Other heavy metals have a high affinity for sulfhydryl groups and can inactivate COMT.

5. All heavy metals will increase the formation of ROS and almost all of them induce apoptosis in the neural cells.

6. Mercury can lead to anxiety since it inhibits glutamate re-uptake and lead can also lead to issues such as a anxiety.

7. Aluminum can lead to fatigue since it decreases the concertation of magnesium in various parts of our bodies and even the spinal cord

8. Heavy metals discussed here alter mitochondrial membrane permeability

9. Arsenic is known to harm oxidative phosphorylation, various mitochondrial enzymes, decrease things such as IL-10 while increasing IL-6-8-12 and TNF-a, it inhibits DNA repair by inhibiting PARP-1 and even cause skin issues by decreasing the expression of keratinocytes.

10. Heavy metals (let's take arsenic as an example) also harm our (males') reproductive system by impairing NF-kB and thus negatively affecting spermatogenesis.

11. All of toxins mentioned here will negatively affect the citric acid cycle.

12. Arsenic is well known to initiate the upturn of intracellular calcium and cause changes in synaptic transmission in general.

13. Other toxins such as thallium and the edema they produce in the cerebral hemispheres are known to negatively affect the brain for over 40 years now.

14. Mercury negatively affects the way oxygen is transported due to the effects that it has on hemoglobin.

15. The negative effects that xenobiotics like BPA have on the liver is a common reason for high levels of SHBG .

16. Atrazine is a known endocrine disruptor found in herbicides that turned male frogs into female frogs.

17. Acetamide is known to cause tumors in various animals for over 25 years.Image
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Read 22 tweets
Jul 6
Here's a guide for improving:
-Acne
-Psoriasis
-Eczema
-Rosacea
-Vitiligo
-Seborrheic dermatitis
that will finally make you understand the driving factors each one and the biggest levers you can pull to improve them.

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*Standard disclaimer that nothing in this thread should be used as a substitute for medical advice*

Now it’s quite common to think that the skin is this very simple and almost purely aesthetic part of the body when in reality it is quite fascinating and complex.

So let’s begin this thread with a basic anatomical model of the skin's layers, since i believe it will help you understand the issue you are facing better and more easily.Image
We have:
1. The epidermis (the outermost layer of the skin).
The epidermis is an avascular (lacking blood vessels) epithelium that serves as a protective barrier and varies in thickness depending on the part of the body (it’s thicker in your palms for example, compared to the eyelids).

The main epidermal cell types are:
-Keratinocytes (the majority), whose main roles are to produce keratin and undergo keratinization to replenish the upper layers (keratinization is a process where keratinocytes “mature”, then fill with keratin, lose organelles and die in order to form the stratum corneum).

Keratinocytes in the epidermis also convert 7-dehydrocholesterol to vitamin D3 upon UV exposure

-Melanocytes (5–10%) whose main role is to synthesize melanin in melanosomes to protect against UV damage.

-Langerhans cells (2–4%) that are antigen-presenting cells for immune defense.

-Merkel cells (<1%) that are sensory cells for touch detection.

It is also composed of the following sublayers:

-Stratum corneum.
This is made out of 15–30 layers of flattened, dead, anucleate keratinocytes (corneocytes) filled with keratin, embedded in a lipid matrix (ceramides, cholesterol) that acts as a waterproof barrier against mechanical abrasion, pathogens and so on.

-Stratum lucidum.
This is only found in parts such as your palm and soles, it’s made out of 2–3 layers of tightly packed keratinocytes with no nuclei or organelles, containing keratin precursor such as elidin that enhances barrier function in thick skin.

-Stratum granulosum.
This is made out of 3–5 layers of flattened keratinocytes with keratohyalin granules and lamellar bodies that are lipid-secreting organelles whose function is to initiate keratinization and release lipids to form the waterproof barrier.

-Stratum spinosum.
This is made out of 8–10 layers of polyhedral keratinocytes connected by desmosomes, giving a "spiny" appearance under a microscope that contains pre-keratin filaments and provides structural strength and flexibility.

-Stratum basale.
This one is a single layer of cuboidal/columnar cells anchored to the basement membrane via hemidesmosomes, whose function is a stem cell layer for keratinocyte regeneration.Image
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