David Sinclair Profile picture
Jan 9, 2025 6 tweets 3 min read Read on X
A new study indicates strawberries reduce blood vessel inflammation by decreasing harmful Coprobacillus gut bacteria and boosting beneficial Lachnospiraceae

What other foods increase Lachnospiraceae gut bacteria? 🧵 tinyurl.com/4max8s8jImage
Did you know Lachnospiraceae ferment dietary fiber to produce short-chain fatty acids (SCFAs) like butyrate, propionate, and acetate... Image
SCFAs are beneficial because they support:
1. Gut lining & reduce inflammation
2. Metabolism & insulin sensitivity
3. Healthy cholesterol levels & blood pressure
4. Decrease appetite via BHB-Phe (see previous post)
5. Benefit brain health via the gut-brain axis Image
To increase Lachnospiraceae eat more:

1. Dietary fiber from fruits, vegetables, whole grains & legumes

2. Polyphenol-rich foods, e.g. strawberries, blueberries, matcha green tea & dark chocolate... Image
3. Prebiotics e.g. inulin, garlic, onions & asparagus

4. A capful of unfiltered apple cider vinegar

And avoid antibiotic overuse! Image
Here's the paper:
tinyurl.com/4max8s8jImage

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More from @davidasinclair

Mar 21
For 25 years, my team has been told we were wrong, by scientists, big pharma, the media, ethicists, and trolls. It hasn’t been easy

Looking back, it was 100% worth it

Here’s why you should believe in yourself… 🧵
In my 20s and 30s, I didn’t realize that criticism is actually a positive sign. It’s easy to see in retrospect, but those days were incredibly tough for all of us in the Sinclair lab and a lesson for everyone who’s looking to change the world Image
Image
First big discovery:

DNA instability & epigenetic changes are a universal cause of aging (1996-1999). Critics immediately said we were wrong but we pushed on Image
Read 15 tweets
Mar 16
So great to see the OG work that helped spark the longevity revolution taken to the next level:

New paper confirms two main causes of aging:
1. DNA instability -> epigenetic noise
2. Mitochondrial decline
...independently causing failure of the cell

Is this relevant to us? 🧵 Image
Firstly, Dan Gottschling is a legend, having discovered yeast epigenetic gene silencing at the gender genes (a/alpha), telomeres, and painfully scooped me as a postdoc in 1996 by publishing epigenetic silencing at the ribosomal DNA (rDNA) 😆 ... Image
In my postdoc with Leonard Guarente in the 1990s, we predicted (below in my notebook) then confirmed something strange in aging yeast: tiny circles of "extrachomosomal" DNA accumulating inside old cells Image
Read 25 tweets
Mar 8
Osteoarthritis & back pain affects millions of people. Instead of managing symptoms, imagine rebuilding joints by making them young

New study shows the reprogramming gene combo OSK regrows joints in mice & effect depends on TET2 so it's epigenetic...🧵 Image
While limited to mouse models, these findings add to a growing body of evidence that rejuvenation by epigenetic reprogramming may safely reverse aging-related decline in multiple tissues, or whole body one day Image
These experiments used local AAV-OSK delivery directly into the knee joint. Treated animals showed improved cartilage structure and reduced subchondral bone thickening compared with controls Image
Read 16 tweets
Mar 1
According to ITOA, NAD declines with age, causing epigenetic changes & disease susceptibility

In 2010, we showed NAD-dependent enzyme, SIRT3, protects the heart 🐁

New study says NAD precursor NMN protects the heart via SIRT3 in mice fed a Western diet

Why's that important? 🧵 Image
In the United States alone, about 1 in 5 deaths is due to cardiovascular disease. That’s roughly 700K-900K deaths per year. Globally, cardiovascular disease causes nearly 20 million deaths annually
Metabolic dysfunction is a major driver. In the US, ~40 percent of adults are obese and nearly 1 in 3 adults has metabolic syndrome

Globally, more than 500 million people are living with diabetes
Read 15 tweets
Feb 22
Good news: Another study showing that fasting can help cancer patients. A 16 hour fast enhanced the cancer-killing activity of T cells and synergized with immunotherapy to reduce tumor size, ostensibly by causing cancer cells to release the amino isoleucine... 🧵 Image
In the tumor microenvironment (TME), there was increased isoleucine processing and intracellular acetyl-coA, along with increase expression of genes involved in the starvation response, autophagy
There were also alterations in glutamine metabolism, a known source of energy for cancer cells
Read 9 tweets
Feb 1
New "Cardiometabolic Clock" identifies biomarkers that associate with disease & early death:

1. HbA1c
2. Creatinine
3. Lymphocyte %
4. Urea nitrogen (BUN)
5. Red Cell Dist. width (RDW)
6. Pulse
7. Systolic blood pressure

Now you can calculate your CardioMetAge! Image
Heres the formula: 𝐶𝑎𝑟𝑑𝑖𝑜𝑀𝑒𝑡𝐴𝑔𝑒𝑃𝑟𝑒𝑑𝑖𝑐𝑡 = 0.831320 × 𝑎𝑔𝑒 + 19.5734 × log( 𝐻𝑏𝐴1𝑐 + 1) + 1.77394 × 𝑅𝐷𝑊 + 0.0760217 × 𝑆𝐵𝑃 + 6.18803 × 𝑐𝑟𝑒𝑎𝑡𝑖𝑛𝑖𝑛𝑒 − 0.148076 × 𝑙𝑦𝑚𝑝ℎ𝑜𝑐𝑦𝑡𝑒 𝑝𝑒𝑟𝑐𝑒𝑛𝑡 + 0.218946 × 𝑀𝐶𝑉 + 0.105980 × 𝑝𝑢𝑙𝑠𝑒 𝑟𝑎𝑡𝑒 + 0.0603608 × 𝑃𝑃 + 0.636711 × 𝑈𝐴 + 2.40001 × log( 𝐶𝑅𝑃 + 1) + 0.0283277 × 𝑊𝐶 + 0.0754119 × 𝐵𝑈𝑁 − 101.454
Candidate measures tested in the model: Body composition, waist circumference, waist-to-height ratio, glucose, HbA1c, albumin, ALP, CRP, creatinine, blood urea nitrogen (BUN), UA, lymphocyte percent, mean corpuscular volume (MCV), white blood cell count (WBC), red cell distribution width (RDW), AST, ALT, HDL, triglycerides, total cholesterol, BP, pulse pressure (PP) and pulse rate.
Read 4 tweets

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