A new study indicates strawberries reduce blood vessel inflammation by decreasing harmful Coprobacillus gut bacteria and boosting beneficial Lachnospiraceae
Did you know Lachnospiraceae ferment dietary fiber to produce short-chain fatty acids (SCFAs) like butyrate, propionate, and acetate...
SCFAs are beneficial because they support: 1. Gut lining & reduce inflammation 2. Metabolism & insulin sensitivity 3. Healthy cholesterol levels & blood pressure 4. Decrease appetite via BHB-Phe (see previous post) 5. Benefit brain health via the gut-brain axis
To increase Lachnospiraceae eat more:
1. Dietary fiber from fruits, vegetables, whole grains & legumes
2. Polyphenol-rich foods, e.g. strawberries, blueberries, matcha green tea & dark chocolate...
3. Prebiotics e.g. inulin, garlic, onions & asparagus
In my 20s and 30s, I didn’t realize that criticism is actually a positive sign. It’s easy to see in retrospect, but those days were incredibly tough for all of us in the Sinclair lab and a lesson for everyone who’s looking to change the world
First big discovery:
DNA instability & epigenetic changes are a universal cause of aging (1996-1999). Critics immediately said we were wrong but we pushed on
So great to see the OG work that helped spark the longevity revolution taken to the next level:
New paper confirms two main causes of aging: 1. DNA instability -> epigenetic noise 2. Mitochondrial decline
...independently causing failure of the cell
Is this relevant to us? 🧵
Firstly, Dan Gottschling is a legend, having discovered yeast epigenetic gene silencing at the gender genes (a/alpha), telomeres, and painfully scooped me as a postdoc in 1996 by publishing epigenetic silencing at the ribosomal DNA (rDNA) 😆 ...
In my postdoc with Leonard Guarente in the 1990s, we predicted (below in my notebook) then confirmed something strange in aging yeast: tiny circles of "extrachomosomal" DNA accumulating inside old cells
Osteoarthritis & back pain affects millions of people. Instead of managing symptoms, imagine rebuilding joints by making them young
New study shows the reprogramming gene combo OSK regrows joints in mice & effect depends on TET2 so it's epigenetic...🧵
While limited to mouse models, these findings add to a growing body of evidence that rejuvenation by epigenetic reprogramming may safely reverse aging-related decline in multiple tissues, or whole body one day
These experiments used local AAV-OSK delivery directly into the knee joint. Treated animals showed improved cartilage structure and reduced subchondral bone thickening compared with controls
According to ITOA, NAD declines with age, causing epigenetic changes & disease susceptibility
In 2010, we showed NAD-dependent enzyme, SIRT3, protects the heart 🐁
New study says NAD precursor NMN protects the heart via SIRT3 in mice fed a Western diet
Why's that important? 🧵
In the United States alone, about 1 in 5 deaths is due to cardiovascular disease. That’s roughly 700K-900K deaths per year. Globally, cardiovascular disease causes nearly 20 million deaths annually
Metabolic dysfunction is a major driver. In the US, ~40 percent of adults are obese and nearly 1 in 3 adults has metabolic syndrome
Globally, more than 500 million people are living with diabetes
Good news: Another study showing that fasting can help cancer patients. A 16 hour fast enhanced the cancer-killing activity of T cells and synergized with immunotherapy to reduce tumor size, ostensibly by causing cancer cells to release the amino isoleucine... 🧵
In the tumor microenvironment (TME), there was increased isoleucine processing and intracellular acetyl-coA, along with increase expression of genes involved in the starvation response, autophagy
There were also alterations in glutamine metabolism, a known source of energy for cancer cells