A new study indicates strawberries reduce blood vessel inflammation by decreasing harmful Coprobacillus gut bacteria and boosting beneficial Lachnospiraceae
Did you know Lachnospiraceae ferment dietary fiber to produce short-chain fatty acids (SCFAs) like butyrate, propionate, and acetate...
SCFAs are beneficial because they support: 1. Gut lining & reduce inflammation 2. Metabolism & insulin sensitivity 3. Healthy cholesterol levels & blood pressure 4. Decrease appetite via BHB-Phe (see previous post) 5. Benefit brain health via the gut-brain axis
To increase Lachnospiraceae eat more:
1. Dietary fiber from fruits, vegetables, whole grains & legumes
2. Polyphenol-rich foods, e.g. strawberries, blueberries, matcha green tea & dark chocolate...
3. Prebiotics e.g. inulin, garlic, onions & asparagus
NEW STUDY: 50-80% of us will experience back pain in our lives. OSK is shown to alleviate cellular senescence 🧟 & back pain 🐀 suggesting epigenetic reprogramming might address this major economic burden & #1 cause of human disability… 🧵
OSK stands for Oct4, Sox2 and Klf4, three genes that are part of a set that Shinya Yamanaka showed can make adult cells into pluripotent stem cells. The gene products are transcription factors that control how genes are turned on and off (during embryogenesis)
Back pain accounts for $250 billion/yr in the U.S. due to medical costs & lost workdays. Most developed countries are similarly affected economically
GLP1 receptor agonists are looking like longevity drugs. A new study reports that drug-induced improvements in bone mass are mediated by the NAD-dependent SIRT1 enzyme.
If so, could NAD boosters work with GLP-1 drugs? Some thoughts...🧵
This new study is consistent with studies showing NMN, an NAD booster & SIRT1 activator, improves bone mass in mice
This paper summarizes the evidence that GLP1RA drugs benefits bone
I am proud to have worked with the dream team that developed this next-gen epigenetic clock using buccal cheek swab data, one of the largest clock studies...
Measuring the pattern of chemicals on DNA called methyls (-CH3) is a representation of the cell's environment, and can predict aging and lifespan
The mTOR inhibitor Sapanisertib is a putative longevity molecule that makes human skin cells & prematurely old fish healthier
Combined with metformin (a putative longevity drug), 79% of human patients with advanced or metastatic solid tumors achieved disease control. Promising results.
Metformin’s metabolic benefits might counterbalance Sapanisertib’s potential side effects, like insulin resistance, seen in some patients taking the mTOR inhibitor rapamycin frontiersin.org/journals/neuro…
Sapanisertib could outperform rapamycin (below) due to its broader mTOR inhibition. Rapamycin primarily inhibits mTORC1, one of the two complexes of mTOR, leading to partial suppression of mTOR signaling...
NEW STUDY: Intermittent fasting (IF) significantly alters the microbiome of mice, with reductions in the gut production of obeticholic acid, a bile acid that induces expression of gut-derived hormones, and an increase in N-acetylglycine production
The known beneficial effects of obeticholic acid on glucose and lipid metabolism and particularly hepatic inflammation in rodents make it a potential candidate for the treatment of nonalcoholic steatohepatitis (NASH)