David Sinclair Profile picture
Jan 9 6 tweets 3 min read Read on X
A new study indicates strawberries reduce blood vessel inflammation by decreasing harmful Coprobacillus gut bacteria and boosting beneficial Lachnospiraceae

What other foods increase Lachnospiraceae gut bacteria? 🧵 tinyurl.com/4max8s8jImage
Did you know Lachnospiraceae ferment dietary fiber to produce short-chain fatty acids (SCFAs) like butyrate, propionate, and acetate... Image
SCFAs are beneficial because they support:
1. Gut lining & reduce inflammation
2. Metabolism & insulin sensitivity
3. Healthy cholesterol levels & blood pressure
4. Decrease appetite via BHB-Phe (see previous post)
5. Benefit brain health via the gut-brain axis Image
To increase Lachnospiraceae eat more:

1. Dietary fiber from fruits, vegetables, whole grains & legumes

2. Polyphenol-rich foods, e.g. strawberries, blueberries, matcha green tea & dark chocolate... Image
3. Prebiotics e.g. inulin, garlic, onions & asparagus

4. A capful of unfiltered apple cider vinegar

And avoid antibiotic overuse! Image
Here's the paper:
tinyurl.com/4max8s8jImage

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More from @davidasinclair

Oct 7
Statistically, you should not exist:

– Life-friendly universe: 1/10⁶⁰
– Earth + moon: 1/10⁹
– Multicellular life: 1/10⁴
– Intelligence & civilization: 1/10⁹
– Your genome: 1/70 trillion

You’ve already won the lottery 10 times in a row. Ignore small people & enjoy!
Equivalent odds: winning the Powerball jackpot 10 times in a row
Flipping 272 heads in a row
Read 7 tweets
Oct 4
DNA breaks from cosmic rays disrupt the epigenome and release virus-like retrotransposons. Not wild theory. Fact

X-rays and CT scans probably do too but no one talks about it
This study in 2008 was the first evidence for the information theory of aging in mammals - the idea that DNA breaks and other major stresses cause chromatin modifiers like SIRT1 to relocate, which disrupts the epigenome & changes the expression of genes in ways that cause aging Image
Just re-read this paper and I’ve realized it was 15 years ahead of its time. Still is
Read 4 tweets
Oct 2
Some plant polyphenols (resveratrol, quercetin & berberine) turn out to be dual modulators of both SIRT1 & GSK3b - important pathways for neuroprotection & epigenetic age resets... 🧵Image
In 2008, we showed movement of the NAD-dependent enzyme SIRT1 away from regulated genes to DNA breaks (which happen every day in every cell) is a key process in the loss of epigenetic information that we have proposed leads to aging and diseases
cell.com/fulltext/S0092…Image
And in 2023, we showed GSK3b inhibitors are a key component of epigenetic age reversal cocktails, in vitro
aging-us.com/article/204896Image
Read 5 tweets
Oct 1
Can cheek swab DNA reveal meaningful signals about your health, diseases and biological age?🏃‍♂️🏃‍♀️🧵... Image
Background: DNA methylation (DNAme) is a chemical modification of DNA on the "Cs" in DNA, which changes over time, the rate of which depends on how healthy you live over the course of your life... ⏰ Image
Smoking and obesity accelerate DNAme changes, and healthy diets slow them. We can read these changes using DNA sequencing or DNA hybridization chips. This is how we arrive at DNAme age clocks... Image
Read 16 tweets
Sep 28
Exciting new paper @nature that could explain why inflammation rises as we age and why healthy diets and exercise suppress inflammation 👏 🧵 Image
Various mitochondrial stressors, such as pathogen infection and metabolic deficiencies, trigger the release of mtDNA into the cytosol and an inflammatory response, but why? Image
Under certain circumstances, including in senescent cells, there are decreased levels of deoxyribonucleotide triphosphates (dNTPs) for making DNA, with a corresponding increase in the levels of ribonucleotide monophosphates (rNMPs)… Image
Read 9 tweets
Sep 22
NEW STUDY: The amino acid L-theanine, first isolated from green tea in the 1940s, is used to improve mood and sleep 🍵 Study in mice finds L-theanine suppresses metastasis of prostate cancer, the second most common cause of death in men worldwide... 🧵 Image
L-theanine is known to reduce inflammation, stress and anxiety, among other effects. It is primarily found in tea leaves, especially green & black. Also in supplements. Common doses are 100 - 400 mg/d Image
A great way to get L--theanine is a green tea matcha = 30-140 mg L-theanine 🍵

I drink 1-3 double-scoop green tea matchas. I use organic ceremonial grade tea, frothed almond milk, allulose, and dont burn it with boiling water. Learned from @chefserenapoon Image
Read 5 tweets

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