David Sinclair Profile picture
Jan 9 6 tweets 3 min read Read on X
A new study indicates strawberries reduce blood vessel inflammation by decreasing harmful Coprobacillus gut bacteria and boosting beneficial Lachnospiraceae

What other foods increase Lachnospiraceae gut bacteria? 🧵 tinyurl.com/4max8s8jImage
Did you know Lachnospiraceae ferment dietary fiber to produce short-chain fatty acids (SCFAs) like butyrate, propionate, and acetate... Image
SCFAs are beneficial because they support:
1. Gut lining & reduce inflammation
2. Metabolism & insulin sensitivity
3. Healthy cholesterol levels & blood pressure
4. Decrease appetite via BHB-Phe (see previous post)
5. Benefit brain health via the gut-brain axis Image
To increase Lachnospiraceae eat more:

1. Dietary fiber from fruits, vegetables, whole grains & legumes

2. Polyphenol-rich foods, e.g. strawberries, blueberries, matcha green tea & dark chocolate... Image
3. Prebiotics e.g. inulin, garlic, onions & asparagus

4. A capful of unfiltered apple cider vinegar

And avoid antibiotic overuse! Image
Here's the paper:
tinyurl.com/4max8s8jImage

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More from @davidasinclair

Sep 16
Should aging be called a “disease”? A new philosophy paper says NO

Here are 4 arguments it may do more harm than good... 🧵

What do you think? Image
1. Labeling aging a disease could fuel ageism. Employers already assume older adults are less capable. The “disease” label may reinforce stereotypes and discrimination
2. It could also harm health through belief. If people internalize aging is a disease, they may expect decline, give up on prevention, and suffer worse outcomes
Read 7 tweets
Aug 29
NEW PAPER: Great summary of drugs and supplements that extend lifespan in mice & the likelihood humans will see similar gains in the near future... 🧵 Image
Link to paper by Dr. Adiv Johnson link.springer.com/article/10.100…
According to Adiv, "while there is no doubt that human lifespan is predominantly non-genetic, that aging itself is a highly modifiable process, and that further gains in life expectancy are feasible...
Read 7 tweets
Aug 26
NEWS: @lifebiosciences reports new drug candidate ER-300 improves liver health, while ER-100 restores healthy DNA methylation patterns in the monkey eye, with clear functional improvements. Human trials are on track for January. It’s happening...
🧵 tinyurl.com/4dysm7bvImage
This news is strong evidence that the original vision to develop therapies that reversal of aging to prevent and cure diseases of aging and injuries isn’t just a fanciful idea
nature.com/articles/s4358…
Life Biosciences presented this new data @ARDD_Meeting in Copenhagen this week Image
Read 13 tweets
Aug 19
A new study of 3720 people finds that low quality diets (e.g. refined grains, sodium, solid fats, added sugar & alcohol) associate with a faster pace of aging than healthy diets (e.g. whole fruits, greens, beans, dairy & whole grains) 🧵... Image
The DunedinPACE aging measure was designed to assess the pace of aging by using 20 years of longitudinal measurements of 19 different biomarkers
DNA methylation in peripheral white blood cell samples was profiled using the Illumina Human MethylationEPIC BeadChip
Read 12 tweets
Aug 17
NEW STUDY: NMN protects against alcohol-induced damage to the liver 🍻 Image
A decline in hepatic NAD+ levels due to ethanol exposure is recognized as a key contributor to alcoholic liver injury
Alcoholic liver disease (ALD) encompasses a spectrum of liver damage and impaired liver function resulting from prolonged heavy drinking, including conditions such as fatty liver, steatohepatitis, liver fibrosis, cirrhosis, and hepatocellular carcinoma
Read 7 tweets
Aug 14
Still struck by the dramatic effects of psilocybin on mouse health & lifespan 🍄‍🟫

Here’s some info about this molecule & where people obtain it: 🧵… Image
Over 180 mushroom species contain psilocybin, including Psilocybe cubensis, Psilocybe semilanceata (Liberty caps), and others Image
These mushrooms grow in various regions worldwide, often in damp grasslands or forested areas Image
Read 14 tweets

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