David Sinclair Profile picture
Jan 9 6 tweets 3 min read Read on X
A new study indicates strawberries reduce blood vessel inflammation by decreasing harmful Coprobacillus gut bacteria and boosting beneficial Lachnospiraceae

What other foods increase Lachnospiraceae gut bacteria? 🧵 tinyurl.com/4max8s8jImage
Did you know Lachnospiraceae ferment dietary fiber to produce short-chain fatty acids (SCFAs) like butyrate, propionate, and acetate... Image
SCFAs are beneficial because they support:
1. Gut lining & reduce inflammation
2. Metabolism & insulin sensitivity
3. Healthy cholesterol levels & blood pressure
4. Decrease appetite via BHB-Phe (see previous post)
5. Benefit brain health via the gut-brain axis Image
To increase Lachnospiraceae eat more:

1. Dietary fiber from fruits, vegetables, whole grains & legumes

2. Polyphenol-rich foods, e.g. strawberries, blueberries, matcha green tea & dark chocolate... Image
3. Prebiotics e.g. inulin, garlic, onions & asparagus

4. A capful of unfiltered apple cider vinegar

And avoid antibiotic overuse! Image
Here's the paper:
tinyurl.com/4max8s8jImage

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More from @davidasinclair

Mar 13
NEW STUDY: 50-80% of us will experience back pain in our lives. OSK is shown to alleviate cellular senescence 🧟 & back pain 🐀 suggesting epigenetic reprogramming might address this major economic burden & #1 cause of human disability… 🧵 Image
OSK stands for Oct4, Sox2 and Klf4, three genes that are part of a set that Shinya Yamanaka showed can make adult cells into pluripotent stem cells. The gene products are transcription factors that control how genes are turned on and off (during embryogenesis)
Back pain accounts for $250 billion/yr in the U.S. due to medical costs & lost workdays. Most developed countries are similarly affected economically Image
Read 8 tweets
Mar 12
GLP1 receptor agonists are looking like longevity drugs. A new study reports that drug-induced improvements in bone mass are mediated by the NAD-dependent SIRT1 enzyme.
If so, could NAD boosters work with GLP-1 drugs? Some thoughts...🧵 Image
This new study is consistent with studies showing NMN, an NAD booster & SIRT1 activator, improves bone mass in mice Image
This paper summarizes the evidence that GLP1RA drugs benefits bone Image
Read 10 tweets
Mar 8
Imagine being able to predict or detect diseases with a cheek swab? NEW STUDY finds a cheek clock associates with 33 conditions:

1. Various cancers
2. Aging
3. Prediabetes
4. Depression
5. Lung fibrosis
6. Chemicals
7. Fatty liver

How is it possible? 🧵
tinyurl.com/4db5r2tc
I am proud to have worked with the dream team that developed this next-gen epigenetic clock using buccal cheek swab data, one of the largest clock studies... Image
Measuring the pattern of chemicals on DNA called methyls (-CH3) is a representation of the cell's environment, and can predict aging and lifespan Image
Read 13 tweets
Mar 3
10 quotes from Thomas Kuhn that changed my life and have never been more relevant:

1. The competition between paradigms is not the sort of battle that can be resolved by proofs

(Scientists, read that again) Image
2. When paradigms change, the world itself changes with them Image
3. The proponents of competing paradigms practice their trades in different worlds Image
Read 11 tweets
Mar 1
The mTOR inhibitor Sapanisertib is a putative longevity molecule that makes human skin cells & prematurely old fish healthier

Combined with metformin (a putative longevity drug), 79% of human patients with advanced or metastatic solid tumors achieved disease control. Promising results.

Could S+M be a longevity combo and who owns it? 🧵
tinyurl.com/bdbkx2re
Metformin’s metabolic benefits might counterbalance Sapanisertib’s potential side effects, like insulin resistance, seen in some patients taking the mTOR inhibitor rapamycin
frontiersin.org/journals/neuro…Image
Sapanisertib could outperform rapamycin (below) due to its broader mTOR inhibition. Rapamycin primarily inhibits mTORC1, one of the two complexes of mTOR, leading to partial suppression of mTOR signaling... Image
Read 13 tweets
Feb 26
NEW STUDY: Intermittent fasting (IF) significantly alters the microbiome of mice, with reductions in the gut production of obeticholic acid, a bile acid that induces expression of gut-derived hormones, and an increase in N-acetylglycine production

Why is this interesting? 🧵 Image
A couple of studies have identified serum N-acetylglycine (NAG) as a correlate of weight status and see an inverse relationship between N-acetylglycine and BMI
Link to microbe paper: …ritionandmetabolism.biomedcentral.com/articles/10.11…
Link to NAG paper: journals.plos.org/plosone/articl…
The known beneficial effects of obeticholic acid on glucose and lipid metabolism and particularly hepatic inflammation in rodents make it a potential candidate for the treatment of nonalcoholic steatohepatitis (NASH) Image
Read 5 tweets

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