A new study indicates strawberries reduce blood vessel inflammation by decreasing harmful Coprobacillus gut bacteria and boosting beneficial Lachnospiraceae
Did you know Lachnospiraceae ferment dietary fiber to produce short-chain fatty acids (SCFAs) like butyrate, propionate, and acetate...
SCFAs are beneficial because they support: 1. Gut lining & reduce inflammation 2. Metabolism & insulin sensitivity 3. Healthy cholesterol levels & blood pressure 4. Decrease appetite via BHB-Phe (see previous post) 5. Benefit brain health via the gut-brain axis
To increase Lachnospiraceae eat more:
1. Dietary fiber from fruits, vegetables, whole grains & legumes
2. Polyphenol-rich foods, e.g. strawberries, blueberries, matcha green tea & dark chocolate...
3. Prebiotics e.g. inulin, garlic, onions & asparagus
New paper: Activation of SIRT1 by SRT1720 improves survival, lowers blood glucose & protects the liver of diabetic rats🐀
So where did sirtuin activators come from and what do they do? A thread...🧵
Sirtuins (named after the "SIR2" gene) were first discovered in yeast in 1979 by Amar Klar & Jasper Rine, & linked to yeast longevity in 1994 by Brian Kennedy & Lenny Guarente...
Found interesting data on NMN’s effects on skin, hidden in a paper about a molecule found in broccoli 🥦 Some surprising results… 🧵
The paper makes no mention of NMN in the title or abstract, so I was surprised to see NMN studied so extensively…
You probably know that NMN stands for nicotinamide mono-nucleotide. It is a precursor that cells use to make NAD+, the fuel for Sirtuin enzymes (SIRT1-7) and many other reactions…
New study find that the elimination of defective immune stem cells (HSCs) alleviates aging in mice & transplantation of healthy HSCs into old animals extends their lifespan. Breakdown & implications below...🧵😯
The authors report that a glycoprotein on the surface of hematopoetic stem cells (HSCs) called CD150 can be used to distinguish young from old/defective HSCs...
Removing the CD150high HSCs seems to rejuvenate the mouse...
Evidence that jumping genes called retrotransposons deplete stem cells and cause hair loss, which is preventable… 🧵
The researchers deleted a gene in mice called SETDB1, which is required to silence retrotransposons that are integrated into the genome. (Here’s a link to the paper)... tinyurl.com/2deyn7ek
The hair loss was slowed by treating the mice with anti-retroviral medicines called nucleoside reverse transcriptase inhibitors (NRTIs) for HIV patients
Big news: Rare back-to-back studies @Nature provide evidence a bile acid called LCA mediates the health & age slowing benefits of low-calorie diets, and may be the elusive endogenous SIRT1 activator that resveratrol mimics. Details below 🧵 tinyurl.com/55dxb859
The 1st paper by Qu et al. shows lithocholic acid (LCA) alone can recapitulate the effects of calorie restriction (CR) in mice, including AMPK activation, muscle regeneration & increased grip strength and running capacity. LCA also increases health and lifespan in nematode worms and flies...
The 2nd paper demonstrates that LCA reproduces the benefits of CR via a TULP3–sirtuin–AMPK pathway that requires direct SIRT1 activation...
btw, there is no scientific reason for the "vs" in the figure above 😖
This figure from the new paper shows how NR and NMN are used by the NAD salvage pathway to make NAD and activate PARPs and Sirtuins to boost cell defenses