David Sinclair Profile picture
Jan 9 6 tweets 3 min read Read on X
A new study indicates strawberries reduce blood vessel inflammation by decreasing harmful Coprobacillus gut bacteria and boosting beneficial Lachnospiraceae

What other foods increase Lachnospiraceae gut bacteria? 🧵 tinyurl.com/4max8s8jImage
Did you know Lachnospiraceae ferment dietary fiber to produce short-chain fatty acids (SCFAs) like butyrate, propionate, and acetate... Image
SCFAs are beneficial because they support:
1. Gut lining & reduce inflammation
2. Metabolism & insulin sensitivity
3. Healthy cholesterol levels & blood pressure
4. Decrease appetite via BHB-Phe (see previous post)
5. Benefit brain health via the gut-brain axis Image
To increase Lachnospiraceae eat more:

1. Dietary fiber from fruits, vegetables, whole grains & legumes

2. Polyphenol-rich foods, e.g. strawberries, blueberries, matcha green tea & dark chocolate... Image
3. Prebiotics e.g. inulin, garlic, onions & asparagus

4. A capful of unfiltered apple cider vinegar

And avoid antibiotic overuse! Image
Here's the paper:
tinyurl.com/4max8s8jImage

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More from @davidasinclair

Jan 9
New paper: Activation of SIRT1 by SRT1720 improves survival, lowers blood glucose & protects the liver of diabetic rats🐀

So where did sirtuin activators come from and what do they do? A thread...🧵 Image
Sirtuins (named after the "SIR2" gene) were first discovered in yeast in 1979 by Amar Klar & Jasper Rine, & linked to yeast longevity in 1994 by Brian Kennedy & Lenny Guarente... Image
The field has grown a lot since then... Image
Read 14 tweets
Jan 4
Found interesting data on NMN’s effects on skin, hidden in a paper about a molecule found in broccoli 🥦 Some surprising results… 🧵 Image
The paper makes no mention of NMN in the title or abstract, so I was surprised to see NMN studied so extensively… Image
You probably know that NMN stands for nicotinamide mono-nucleotide. It is a precursor that cells use to make NAD+, the fuel for Sirtuin enzymes (SIRT1-7) and many other reactions… Image
Read 25 tweets
Jan 3
New study find that the elimination of defective immune stem cells (HSCs) alleviates aging in mice & transplantation of healthy HSCs into old animals extends their lifespan. Breakdown & implications below...🧵😯 Image
The authors report that a glycoprotein on the surface of hematopoetic stem cells (HSCs) called CD150 can be used to distinguish young from old/defective HSCs... Image
Removing the CD150high HSCs seems to rejuvenate the mouse... Image
Read 16 tweets
Dec 26, 2024
Evidence that jumping genes called retrotransposons deplete stem cells and cause hair loss, which is preventable… 🧵 Image
The researchers deleted a gene in mice called SETDB1, which is required to silence retrotransposons that are integrated into the genome. (Here’s a link to the paper)... tinyurl.com/2deyn7ek
The hair loss was slowed by treating the mice with anti-retroviral medicines called nucleoside reverse transcriptase inhibitors (NRTIs) for HIV patients Image
Read 14 tweets
Dec 18, 2024
Big news: Rare back-to-back studies @Nature provide evidence a bile acid called LCA mediates the health & age slowing benefits of low-calorie diets, and may be the elusive endogenous SIRT1 activator that resveratrol mimics. Details below 🧵
tinyurl.com/55dxb859Image
The 1st paper by Qu et al. shows lithocholic acid (LCA) alone can recapitulate the effects of calorie restriction (CR) in mice, including AMPK activation, muscle regeneration & increased grip strength and running capacity. LCA also increases health and lifespan in nematode worms and flies...Image
The 2nd paper demonstrates that LCA reproduces the benefits of CR via a TULP3–sirtuin–AMPK pathway that requires direct SIRT1 activation... Image
Read 13 tweets
Nov 30, 2024
A new review is out on the pre-clinical & clinical trials of nicotinamide mononucleotide (NMN) and nicotinamide riboside (NR)

First, some background on these molecules...🧵

iadns.onlinelibrary.wiley.com/doi/pdfdirect/…Image
btw, there is no scientific reason for the "vs" in the figure above 😖
This figure from the new paper shows how NR and NMN are used by the NAD salvage pathway to make NAD and activate PARPs and Sirtuins to boost cell defenses Image
Read 15 tweets

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