Crémieux Profile picture
Feb 12, 2025 • 10 tweets • 4 min read • Read on X
The biggest news of the day should once again be about DOGE.

A new Executive Order was passed a few minutes ago.

It empowers DOGE to spearhead the complete reorganization of the federal governmentđź§µ Image
The first part of this Order is simple:

The OMB will put out a plan to make the federal workforce smaller and more efficient, including a stipulation that agencies must remove four existing employees for each new hire, with some exceptions. Image
The second part is meatier.

New hires have to be approved by newly-installed DOGE Team Leads in each agency. These Team Leads will report what goes on in the agency they're assigned to on a monthly basis.

But that's not even the big part yet. Image
Third, agency heads will prepare for a massive reduction in the federal workforce.

This workforce reduction will apply to employees not performing necessary and statutorily mandated functions, so if Congress isn't protecting your job, you're likely leaving. Image
Fourth, suitability judgments about the excepted service will be expanded.

People who do not meet certain legal obligations, people who do not certify NDA compliance, and people who steal or misuse government resources are deemed no longer suitable for employment in it. Image
Here's the really big part of this order. It's kind of buried down deep, but it's very important:

Agencies are ordered to develop a comprehensive reorganization plan that identifies offices that can be purged because they lack statutory protections, and offices to consolidate. Image
Putting this all together, what the Order entails is a massive reorganization of the federal workforce and the streamlining of the civil service to make its operation line up with the goals of DOGE.

Not only that, but it empowers DOGE by embedding Team Leads for oversight.
Couple this with the February 4 OPM memo on CIOs, and what we have is staggering:

The federal government will be centralized, stripped down, and more intimately controlled by the President and his delegates, with control enhanced via DOGE.

This is the biggest news of the day, and it's hard to overstate just how big it is.

Because the federal government has grown so unwieldy that no one can provide you with a semblance of an outline of it, measures like this may just be needed to tame the beast.

Get ready!
You can read the EO here: whitehouse.gov/presidential-a…

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More from @cremieuxrecueil

Jun 9
Because America has made the wise decision to compensate blood donors, it has ended up supplying some 70% of the world's blood plasma.

This is one of America's top exports, and each year, America saves hundreds of thousands of lives because it does this. Image
Some people argue against plasma donation on the basis of it being disproportionately used by poorer people

They say it's exploitative: they feel that selling something your body makes is wrong if disparate in ways they care about

But it's a lifesaver!

There's also research indicating that plasma donation can be healthy!

(And there's more indicating that, with compensation, it might reduce crime in the local area.)

Read 4 tweets
Jun 7
It's Pride Month, so let's talk about why San Francisco is so incredibly gay.

Military policy.

đź§µ Image
In 1982, Randy Shilts published his biography of Harvey Milk, entitled "The Mayor of Castro Street".

For those who don't know, Harvey Milk was the first open homosexual to be voted into public office in the state of California.

He was on the San Francisco Board of Supervisors. Image
The biography contains a fair bit of background, not just about Harvey Milk, but about San Francisco's gay community more generally.

In its early years, San Francisco attracted large waves of mainly male migrants motivated by the promise of gold in California. Image
Read 18 tweets
Jun 1
My Uber driver says

- His license is suspended
- He was once a soldier for a Mafia family
- He's telling me about his time in Rikers
- He's showing me YouTube videos
- He's telling me his theories about Jews
He's telling me about gang wars he was in ad a kid.

He's wondering why all the Chinese girls are lined up - for an audition?

He says to go to Mother's Ruin for latin prostitutes.

All of this entirely unprompted.
"Yeah, these African guys, yeesh"

"I couldn't fuck that whore because I got the erectile dysfunction."

He just keeps going.
Read 6 tweets
May 29
This is just not true and it's sad that people believe it.

It's also indicting, when it's so obviously false if you just look out into the world. What you see should match what the statistics clearly show:

Estimated marriage effects for men and women are almost always similarđź§µ Image
In that chart, I used the GSS and found something many people replicate:

1. Cross-sectionally, there's a relationship between being married and life satisfaction. It's similar for men and women.

2. Within persons—causally!—marriage boosts life satisfaction, but more for women.
Leveraging the same within-person design, we can use the Add Health dataset to look at stress and depression.

For both sexes, the effects are indistinguishable.

But they're also mostly not real: it's just that people who get married tend to be less stressed and depressed! Image
Read 10 tweets
May 26
As a recap on my appearance, Eli Lilly is pursuing:

- A one-dose drug for preventing most heart disease
- A vaccine for chlamydia
- A vaccine for gonorrhea
- A vaccine for Epstein-Barr
- A drug that lets you stay awake longer and feel more rested

It's a golden age of pharma! Image
And remember, Eli Lilly's big break historically was the University of Toronto licensing them to produce insulin.

They started off by giving it out for free, saving the world's diabetics at a time when there was no treatment available.

They've always been a force for good. Image
I think

- The heart disease drug will succeed
-- Will it commercialize? It can, easily. But I'm 50/50 due to the competition
- Chlamydia and gonorrhea vax will succeed, but I don't see much commercial potential with Lilly
- EBV vaccine will fail with Lilly, succeed eventually
Read 5 tweets
May 25
Eli Lilly has done it.

They've gone and made what seems to be a powerful, permanent gene therapy for LDL cholesterol.

That means they'll be able to effectively prevent most heart disease with a single infusion! Image
Almost all of the side effects were just things you see with any infusion. Some people react poorly to needles and having to sit for a while🤷‍♀️

And that's what we expect, because the people with good PCSK9 genes naturally are totally fine. This therapy catches the rest of us up!
This is amazing stuff, beating drug administration because it's permanent, and it only gets better from here.

We are going to get so healthy, so fast. Our grandkids are going to hear about heart attacks and have never actually seen one.

Source: nejm.org/doi/full/10.10…
Read 5 tweets

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