Crémieux Profile picture
Feb 20 • 17 tweets • 6 min read • Read on X
The biggest news today should probably be about one of the Executive Orders from yesterday evening.

Trust me, it's big.

The President just authorized DOGE to start cutting regulationsđź§µ Image
This order starts off huge.

Remember those recently-created DOGE Team Leads going into every agency? They're going to work with agency heads and the OMB to review all of the regulations across a number of huge categories.

Which categories? Let's see.

Image
The first category is those rules and regulations which violate the law of the land: unlawful and unconstitutional regulations, things that agencies enacted but which they shouldn't have been able to. Image
Now you might ask: Who decides what's lawful or unlawful, constitutional or unconstitutional, a good or a bad interpretation of statutes, prohibitions, and the law writ large?

Try to keep up, because the administration outlined this a few days ago:
The next category of regulations that DOGE will be purging is sizable.

DOGE was tasked with purging the federal government of socially significant regulations that Congress didn't roll out, and regulations that are costly for private entities without benefitting the public more. Image
This next category of regulations is where things get huge.

DOGE will be purging all regulations that impede innovation and infrastructure, make it harder to response to natural and manmade disasters, and just generally anything unnecessarily standing in the way of business. Image
Now obviously this is a major task, but don't worry: the next section says which regulations to focus on first.

It says to focus on regulations that are particularly important. This is totally logical: get rid of the big barriers to growth first, and then move down the list. Image
The next section might be my favorite part of this whole Order.

This section calls for an end to bureaucratic overreach.

It says that if a bureaucrat is doing more than they're required to, they need to stop it. This means fewer bureaucrats abusing their 'authority'. Image
Additionally, if agencies are currently engaged in overreach in the enforcement of rules and regulations, they're going to stop.

This can also apply to rules and regulations that the President does not want enforced in a given way based on his valid interpretation of said rule. Image
And finally, the Order says what to do with new regulations:

Run them by DOGE, and if they're a barrier to business or a burden on the public, they won't go into effect.Image
Every new regulation will be reviewed and every existing regulation will be reviewed too, and all barriers to growth that can be extirpated from the Federal Register will be extirpated from it.

This authority is expansive and unprecedented, and the admin was building to this.
And just to be sure, there's still more to come.

DOGE is enabling the digitization of records, the installation of modern systems and tools that will enable the U.S. to be governed in a modern, rapid, and flexible way.

That's its purpose, is making a 21st-century government.
And why?

Well obviously because regulations are burdensome, the spending has been too high, and so on, but this Order contains another clue. Image
One of Trump's goals is ending the secret fourth branch of government that persists between Presidencies and ensures Democrats are always in power.

It is an explicit goal of this Administration to end the "Administrative State."
In their Fact Sheet on this Executive Order, the Presidency stated that it is their goal to end the extreme burdens on the American people from this unconstitutional fourth branch of government, and to stop them from prying into American lives forevermore. Image
It is hard to overstate how huge this Order is.

There are hundreds of thousands of federal regulations, and a very large portion of them can be stripped back with executive authority alone.

And now, DOGE has been enabled to start that process, with all that entails.
That entails a lot, but I'll cut myself off here. And keep in mind, this is just the first month of this administration.

Here's the Executive Order: whitehouse.gov/presidential-a…

Here's the Fact Sheet: whitehouse.gov/fact-sheets/20…

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More from @cremieuxrecueil

Aug 26
Retatrutide is more effective at generating weight loss and other benefits for the people who take it, but there does seem to be a cardiac safety signal.

This could potentially be important *for people who have preexisting atrial fibrillation and CVD.* Image
Keep in mind, only one of these events became serious and the rest just passed: "Reported cardiac arrhythmias were mild to moderate in severity with the exception of one severe adverse event."

The reason for this signal seems to be a dose-dependent increase in heart rate.
Increasing heart rate could help to explain the added benefits of the drug for weight loss.

But I have doubts. Why? Because the heart rate increase was linearly dose-dependent, but weight loss tapped out at 8mg. Image
Read 7 tweets
Aug 26
Gerrymandering is the death of centrism in America.

The more districts are uncompetitive, the less hope there is for moderate candidates, and the less value there is in moving to the center.

Gerrymandering means a more divisive and polarized America, with poorer governanceđź§µ Image
A recent paper in the American Economic Review made the value of competitive elections clear using data from America and France.

Looking at American elections, when candidates are in their primaries, they're more radical. When they compete with the other party, they moderate. Image
The same thing is observed in France, where the multi-round elections come with extensive moderation for some, slight moderation for others, and essentially no moderation for those who are already at the nation's center. Image
Read 24 tweets
Aug 25
The World Health Organization frequently adopts irresponsible positions.

For example, they recommended against using non-sugar sweeteners (NSS)—zero-calorie stuff like aspartame.

Why?

Because of non-causal evidence. But all the causally-informative evidence said it was good! Image
On the one hand, you have causal evidence screaming about one direction of effects that are theoretically expected. Among this evidence, there's one bad sign, but it's marginally significant (p = 0.012) among a bajillion effects examined.

AND THEY GOT THE EFFECT SIZE WRONG.Image
See that highlighted 95% CI? It looks really precise, no?

If you go to the actual study, you'll see it's about switching from sugary to sugar-free hot cocoa, and the effect they report is actually 0.

Where did they get that estimate?! They don't say, but it went in their meta! Image
Read 10 tweets
Aug 25
I'm going to speculate about why von Neumann was omitted from Oppenheimer. Threadđź§µ

"With the Russians it is not a question of whether but of when."

"If you say why not bomb them tomorrow, I say why not today? If you say today at 5 o'clock, I say why not one o'clock?" Image
Before the Senate, when asked about his ideology:

"I am violently anti-Communist and much more militaristic than the norm." Image
When he was told that Oppenheimer said Manhattan Project scientists had "known sin" for their work on the atomic bomb, he replied:

"Sometimes someone confesses a sin in order to take credit for it." Image
Read 20 tweets
Aug 25
The White House just issued an executive order to end cashless bail.

Over the last decade or so, many jurisdictions have adopted a policy where criminal offenders can walk free without having to pay bail.

They then routinely go on to commit more crime. This targets thatđź§µ Image
Briefly, the way bail works in the U.S. is that the court allows a pretrial defendant—someone accused of a crime—to leave jail before their trial date if they can put up cash which they'll earn back if they appear for court. Image
This system works reasonably well for keeping jails reasonably uncrowded and ensuring that people show up for trial.

Critics allege that this system is unfair, however, because many defendants cannot make bail. They don't have the financial means, so they're kept in detention. Image
Read 18 tweets
Aug 25
It's true.

Semaglutide works worse than Tirzepatide and Retatrutide, and it has much worse side effects. Image
When you compare Tirzepatide and Semaglutide head-to-head on side effects, it's just no contest, and we know exactly why this is.

It should be noted that Retatrutide has a side effect profile like Tirzepatide's. It too manages to beat Semaglutide.

Image
There is a drug that's now being tested as an addition to Semaglutide, and that'd be Cagrilintide.

Cagrilintide is a synthetic version of amylin, and it does seem to have glucose-regulating as a well as weight loss-inducing effects.

So, how does CagriSema compare?Image
Read 8 tweets

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