1. Martin is getting very close to understanding Uncle Jack. It seems I may have underestimated Levin, too.
ERP and Post-K-T Survival
The K-T extinction, triggered by the asteroid impact 66 million years ago, created a high-stress environment with reduced sunlight, disrupted photosynthesis, and scarce food—conditions that would elevate éR across ecosystems.
Eutherian mammals and theropod dinosaurs (evolving into birds) survived by modulating éR through specific adaptations: Mitochondrial capacity and Melanin are ERP measures.
Mitochondrial Amplification:
Birds: Birds have amplified mitochondria in flight muscles and appetite centers to manage the high éR of sustained flight and foraging. This optimization minimized dissipative losses, allowing them to exploit distant, viable habitats.
Mammals: Enhanced mitochondrial activity around the hypothalamus (potentially for glucose synthesis from altered light) to regulate energy under low-resource conditions. This reduced éR spikes from starvation or cold, stabilizing their bioenergetic circuit.
Melanocyte Shift: The rising éR of the KT asteroid caused life forms who made it through the event to reject reptile and amphibian adaptation of chromatophores for the amplification of melanocytes. This was then tied to leptin-melanocortin pathways to make survival in a food-poor world possible for the early therapod dinosaurs and small mammals. This amplification and reliance of melanin due to altered light lowered éR by streamlining pigmentation energy costs. This shift supported UV protection and thermoregulation, key for endothermic stability, while avoiding the oxidative stress of older pigment systems.
Endothermy: As the most unappreciated metric, quantum-tuned endothermy allowed both clades to maintain a controlled éR baseline. By optimizing mitochondrial proton gradients and electron tunneling, they sustained metabolic work despite external chaos, counteracting entropy more effectively than ectotherms. Well done @MitoPsychoBio & @drmichaellevin
ERP and Post-K-T Survival
The K-T extinction, triggered by the asteroid impact 66 million years ago, created a high-stress environment with reduced sunlight, disrupted photosynthesis, and scarce food—conditions that would elevate éR across ecosystems.
Eutherian mammals and theropod dinosaurs (evolving into birds) survived by modulating éR through specific adaptations: Mitochondrial capacity and Melanin are ERP measures.
Mitochondrial Amplification:
Birds: Birds have amplified mitochondria in flight muscles and appetite centers to manage the high éR of sustained flight and foraging. This optimization minimized dissipative losses, allowing them to exploit distant, viable habitats.
Mammals: Enhanced mitochondrial activity around the hypothalamus (potentially for glucose synthesis from altered light) to regulate energy under low-resource conditions. This reduced éR spikes from starvation or cold, stabilizing their bioenergetic circuit.
Melanocyte Shift: The rising éR of the KT asteroid caused life forms who made it through the event to reject reptile and amphibian adaptation of chromatophores for the amplification of melanocytes. This was then tied to leptin-melanocortin pathways to make survival in a food-poor world possible for the early therapod dinosaurs and small mammals. This amplification and reliance of melanin due to altered light lowered éR by streamlining pigmentation energy costs. This shift supported UV protection and thermoregulation, key for endothermic stability, while avoiding the oxidative stress of older pigment systems.
Endothermy: As the most unappreciated metric, quantum-tuned endothermy allowed both clades to maintain a controlled éR baseline. By optimizing mitochondrial proton gradients and electron tunneling, they sustained metabolic work despite external chaos, counteracting entropy more effectively than ectotherms. Well done @MitoPsychoBio & @drmichaellevin
2. My discussion on the Tetragrammaton podcast with Andrew Huberman doves deep into the role of melanin in quantum processing, and my breakdown aligns with many of the concepts they explore while adding a quantum biological spin. Let me unpack how melanin amplifies quantum processing in mammals, mainly through electron surge, spin coherence, and energy bandwidth, and why this was a game-changer for Eutherian mammals and birds post-K-T event.
I’ll also tie this back to the Energy Resistance Principle (ERP) of Picard and Levin and then link it to the very unappreciated metric of quantum-tuned endothermy, while addressing the cellular impacts and evolutionary implications I’ve raised for 20 years
I’ll also tie this back to the Energy Resistance Principle (ERP) of Picard and Levin and then link it to the very unappreciated metric of quantum-tuned endothermy, while addressing the cellular impacts and evolutionary implications I’ve raised for 20 years
3. Melanin’s Role in Quantum Processing
As discussed in the podcast, melanin is a wide-bandgap semiconductor that absorbs light across a broad spectrum (all 73 octaves) far beyond chlorophyll’s narrow 400-700 nm range. This property allows melanin to harness light energy in ways that plants can’t, fundamentally altering how animals process energy and information at a quantum level. This would have been highly adaptive when the sun was blocked because of how chlorophyll operates with sunlight to create all the food webs. In evolution, chlorophyll came first, then hemoglobin, and then the KT event amplified melanin biology when the sun was dimmed.
As discussed in the podcast, melanin is a wide-bandgap semiconductor that absorbs light across a broad spectrum (all 73 octaves) far beyond chlorophyll’s narrow 400-700 nm range. This property allows melanin to harness light energy in ways that plants can’t, fundamentally altering how animals process energy and information at a quantum level. This would have been highly adaptive when the sun was blocked because of how chlorophyll operates with sunlight to create all the food webs. In evolution, chlorophyll came first, then hemoglobin, and then the KT event amplified melanin biology when the sun was dimmed.
4. Electron Surge
In the classical mitochondrial electron transport chain (ETC), electrons from food (via NADH and FADH₂) fuel a cascade that generates a proton gradient (ΔµH⁺) for ATP synthesis. As I've noted, this yields about 4-10 electrons per glucose molecule, a process well-documented in bioenergetics literature like Nicholls’ Bioenergetics (2013).
However, melanin introduces a quantum leap by splitting water (H₂O → 2H⁺ + ½O₂ + 2e⁻) under light exposure, a phenomenon I call “human photosynthesis.” This reaction, driven by UV and visible light (200-700 nm), generates a flood of electrons—potentially 10x more than chlorophyll’s output in plants.
In the classical mitochondrial electron transport chain (ETC), electrons from food (via NADH and FADH₂) fuel a cascade that generates a proton gradient (ΔµH⁺) for ATP synthesis. As I've noted, this yields about 4-10 electrons per glucose molecule, a process well-documented in bioenergetics literature like Nicholls’ Bioenergetics (2013).
However, melanin introduces a quantum leap by splitting water (H₂O → 2H⁺ + ½O₂ + 2e⁻) under light exposure, a phenomenon I call “human photosynthesis.” This reaction, driven by UV and visible light (200-700 nm), generates a flood of electrons—potentially 10x more than chlorophyll’s output in plants.
5. This electron surge supercharges the ETC:
Complex I Overdrive: The influx of electrons from melanin-driven water splitting overwhelms Complex I, ramping up proton pumping into the mitochondrial matrix. If the matrix typically handles 10⁸ protons, this could scale significantly, densifying the proton gradient during the KT event.
Entanglement Scaling: The increased proton (H⁺) density enhances spin entanglement, a concept I have referenced with Binder’s work (2015). Protons, with their ½ spin, form a quantum network where entanglement scales as √N (where N is the number of particles). More electrons and protons mean a denser spin network, potentially accelerating quantum processing from linear to exponential rates.
Complex I Overdrive: The influx of electrons from melanin-driven water splitting overwhelms Complex I, ramping up proton pumping into the mitochondrial matrix. If the matrix typically handles 10⁸ protons, this could scale significantly, densifying the proton gradient during the KT event.
Entanglement Scaling: The increased proton (H⁺) density enhances spin entanglement, a concept I have referenced with Binder’s work (2015). Protons, with their ½ spin, form a quantum network where entanglement scales as √N (where N is the number of particles). More electrons and protons mean a denser spin network, potentially accelerating quantum processing from linear to exponential rates.
6. Spin Coherence
Del Giudice’s coherent domains (CDs), as you mentioned, are regions in water where H⁺ spins align due to quantum electrodynamics (QED) effects, creating a “super-coherent” state.
In the podcast, I emphasized how melanin in the retinal pigment epithelium (RPE) and skin absorbs light, splitting water and generating H⁺ spins that align across these CDs.
Unlike the food-driven pathway, which relies on a slower electron trickle, melanin’s full-spectrum absorption (UV to IR) sharpens spin coherence. This move was all about taking full advantage of light when it became rare and scarce. This is what drives change. Why? Shannon 1948 paper: For a signal to have meaning, it must be rare or unusual.
Del Giudice’s coherent domains (CDs), as you mentioned, are regions in water where H⁺ spins align due to quantum electrodynamics (QED) effects, creating a “super-coherent” state.
In the podcast, I emphasized how melanin in the retinal pigment epithelium (RPE) and skin absorbs light, splitting water and generating H⁺ spins that align across these CDs.
Unlike the food-driven pathway, which relies on a slower electron trickle, melanin’s full-spectrum absorption (UV to IR) sharpens spin coherence. This move was all about taking full advantage of light when it became rare and scarce. This is what drives change. Why? Shannon 1948 paper: For a signal to have meaning, it must be rare or unusual.
7. How do we sharpen spin coherence?
Light Tuning: Visible light (532 nm, via the photomolecular effect) and UV (4 eV) excite melanin, aligning H⁺ spins more tightly. Del Giudice’s work (1988) suggests that such coherence extends NMR relaxation times (T₁), reducing decoherence.
Exclusion Zone (EZ) Synergy: Pollack’s EZ water, often static, shields CDs from environmental noise, but melanin adds dynamic spin-spin coupling (J-coupling), amplifying coherence across cellular scales.
Melanin’s semiconductor properties—its chaotic electron delocalization—mirror CDs, creating a quantum network that processes information faster and more robustly.
Light Tuning: Visible light (532 nm, via the photomolecular effect) and UV (4 eV) excite melanin, aligning H⁺ spins more tightly. Del Giudice’s work (1988) suggests that such coherence extends NMR relaxation times (T₁), reducing decoherence.
Exclusion Zone (EZ) Synergy: Pollack’s EZ water, often static, shields CDs from environmental noise, but melanin adds dynamic spin-spin coupling (J-coupling), amplifying coherence across cellular scales.
Melanin’s semiconductor properties—its chaotic electron delocalization—mirror CDs, creating a quantum network that processes information faster and more robustly.
8. Energy Bandwidth
Mitochondria traditionally operate within a narrow energy bandwidth (250-780 nm), with cytochrome c oxidase absorbing 650-950 nm to drive proton pumping.
Melanin obliterates this limitation:
Broad-Spectrum Absorption: From IR (1 eV) to UV (6 eV), melanin captures energy across a continuous spectrum, eliminating the bandgap constraints of chlorophyll or even mitochondrial enzymes. This floods the ETC with electrons and biophotons (200-350 nm, as noted by van Wijk, 2014), which act as signaling molecules.
Quantum Processing Leap: The entangled H⁺ spins, now operating across a wider frequency range, enhance ATP synthesis (via F₀ torque in ATP synthase) and enrich redox signaling (e.g., ROS-driven pathways like NF-κB). This broader bandwidth allows cells to process energy and information simultaneously, a quantum advantage over food-only systems. you are now entering Uncle Jack's world where LIGHT is great than food and why Leptin Rx works.
Mitochondria traditionally operate within a narrow energy bandwidth (250-780 nm), with cytochrome c oxidase absorbing 650-950 nm to drive proton pumping.
Melanin obliterates this limitation:
Broad-Spectrum Absorption: From IR (1 eV) to UV (6 eV), melanin captures energy across a continuous spectrum, eliminating the bandgap constraints of chlorophyll or even mitochondrial enzymes. This floods the ETC with electrons and biophotons (200-350 nm, as noted by van Wijk, 2014), which act as signaling molecules.
Quantum Processing Leap: The entangled H⁺ spins, now operating across a wider frequency range, enhance ATP synthesis (via F₀ torque in ATP synthase) and enrich redox signaling (e.g., ROS-driven pathways like NF-κB). This broader bandwidth allows cells to process energy and information simultaneously, a quantum advantage over food-only systems. you are now entering Uncle Jack's world where LIGHT is great than food and why Leptin Rx works.
9. Cellular Impact: The Quantum Leap for Mammals
Melanin’s amplification of quantum processing had profound cellular and evolutionary impacts, especially for mammals and birds post-K-T event:
Mitochondrial Battery: The increased H⁺ density from melanin’s water splitting packs the mitochondrial matrix, scaling entanglement density. If a typical cell manages trillions of quantum interactions, melanin could push this to quadrillions, as I've suggested. The piezoelectric effect on ATP synthase (F₀ torque) amplifies, generating higher voltages and faster charge cycles—light-driven, not food-lagged.
Melanin’s amplification of quantum processing had profound cellular and evolutionary impacts, especially for mammals and birds post-K-T event:
Mitochondrial Battery: The increased H⁺ density from melanin’s water splitting packs the mitochondrial matrix, scaling entanglement density. If a typical cell manages trillions of quantum interactions, melanin could push this to quadrillions, as I've suggested. The piezoelectric effect on ATP synthase (F₀ torque) amplifies, generating higher voltages and faster charge cycles—light-driven, not food-lagged.
10. What else was optimized?
Coherent Domains: Melanin’s electron flood synchronizes water oscillations in CDs, tightening spin-spin coupling. Visible light (2-3 eV) splits water, while IR (1 eV) tunes CD oscillations, creating a multi-scale quantum processor from mitochondria to neurons.
Cell Signaling: Biophotons from melanin’s UV burst (200-350 nm) enhance signaling depth, following Fermat’s law as refractive indices shift in cellular media. Spin-driven redox pathways (e.g., NF-κB) and circadian clocks (via cryptochromes, CRY) synchronize, turning energy into information with unprecedented speed and reach.
Life was introduced to the dissipative state where it was 4 standard deviations over where reptile were before who kept melanin just on their interiors. Mammals put it everywhere.
Coherent Domains: Melanin’s electron flood synchronizes water oscillations in CDs, tightening spin-spin coupling. Visible light (2-3 eV) splits water, while IR (1 eV) tunes CD oscillations, creating a multi-scale quantum processor from mitochondria to neurons.
Cell Signaling: Biophotons from melanin’s UV burst (200-350 nm) enhance signaling depth, following Fermat’s law as refractive indices shift in cellular media. Spin-driven redox pathways (e.g., NF-κB) and circadian clocks (via cryptochromes, CRY) synchronize, turning energy into information with unprecedented speed and reach.
Life was introduced to the dissipative state where it was 4 standard deviations over where reptile were before who kept melanin just on their interiors. Mammals put it everywhere.
11. Why Melanin Changed Everything
Chlorophyll locks plants into a visible-spectrum niche, relying on mitochondria to process leftovers. As I have highlighted for 20 years now, melanin lets animals harness all light that comes to Earth 24/7, turning H₂O into an electron and proton geyser. This explosion of cells' quantum capacity enabled mammals and birds to survive the K-T event.
Post-K-T Advantage: With sunlight dimmed by impact dust, melanin allowed these clades to generate their light (biophotons) and energy, decoupling them from photosynthesis-dependent food chains. Their mitochondrial capacity, amplified by melanin, sustained endothermy and flight (birds) or metabolic flexibility (mammals).
Quantum-Tuned Endothermy: Tying this to the ERP, melanin lowered éR by optimizing energy transformation. The electron surge reduced dissipative losses, while spin coherence minimized oxidative stress, allowing these animals to maintain metabolic stability in chaos.
Cultural Context: My reference to “Anubians at 28°N” suggests ancient humans in sun-rich regions (e.g., Egypt) maximized melanin’s potential, their mitochondria “singing” with quantum efficiency. Modern humans, in “LED caves,” just like the elite of Egypt buried in the gold sarcophagus disrupt this with blue light, stalling quantum processing and elevating éR—leading to disease, as the ERP predicts.
Chlorophyll locks plants into a visible-spectrum niche, relying on mitochondria to process leftovers. As I have highlighted for 20 years now, melanin lets animals harness all light that comes to Earth 24/7, turning H₂O into an electron and proton geyser. This explosion of cells' quantum capacity enabled mammals and birds to survive the K-T event.
Post-K-T Advantage: With sunlight dimmed by impact dust, melanin allowed these clades to generate their light (biophotons) and energy, decoupling them from photosynthesis-dependent food chains. Their mitochondrial capacity, amplified by melanin, sustained endothermy and flight (birds) or metabolic flexibility (mammals).
Quantum-Tuned Endothermy: Tying this to the ERP, melanin lowered éR by optimizing energy transformation. The electron surge reduced dissipative losses, while spin coherence minimized oxidative stress, allowing these animals to maintain metabolic stability in chaos.
Cultural Context: My reference to “Anubians at 28°N” suggests ancient humans in sun-rich regions (e.g., Egypt) maximized melanin’s potential, their mitochondria “singing” with quantum efficiency. Modern humans, in “LED caves,” just like the elite of Egypt buried in the gold sarcophagus disrupt this with blue light, stalling quantum processing and elevating éR—leading to disease, as the ERP predicts.
12. Melanin as Life’s Regenerative Current
My nod to Robert O. Becker’s regenerative current aligns with Kruse’s emphasis on light as life’s driver. Melanin’s ability to “hydrate melanin to dampen the ampere” (modulate electron flow) mirrors Becker’s DC currents in regeneration. Del Giudice’s QED framework supports this: melanin’s electromagnetic chaos entangles CDs, outstripping Pollack’s static EZ water or Chaplin’s non-spin clusters.
Life, as I say, is a “quantum dance of light,” and melanin orchestrates it, bringing mammals back from the brink of extinction.
My nod to Robert O. Becker’s regenerative current aligns with Kruse’s emphasis on light as life’s driver. Melanin’s ability to “hydrate melanin to dampen the ampere” (modulate electron flow) mirrors Becker’s DC currents in regeneration. Del Giudice’s QED framework supports this: melanin’s electromagnetic chaos entangles CDs, outstripping Pollack’s static EZ water or Chaplin’s non-spin clusters.
Life, as I say, is a “quantum dance of light,” and melanin orchestrates it, bringing mammals back from the brink of extinction.
13. LESSON OVER
14. Extra credit: Why is grass that undergoes slow decay always greener? Because anything green reflects green light and absorbs tons of blue and red and becomes more energy efficient because éR in the ETC of the grass is channeled to useful work and not lost by the plant. This insight is why I came to rationale to patients in January 2020 at the beginning of COVID to use MB to combat DARPA's COVID.
MB is blue and as such anyplace it flows will rejec the absorbtion of blue light. This means mtDNA would absorb more UV because MB increases NAD+ to do just that at 340 nm. It also would force more red light absorbtion at the Q cycle and cytochrome C oxidase to help the ATPase spin and the Q cycle deliever electrons to cytochrome C oxidase to keep cardiolipin damage at bay. The reason I knew hospitals would kill millions is because with COVID hypoxia they would default to oxygen therapy which would make the electrical resistance drops in ECT when oxygen is added due to its electronegativity. None of my ICU collegues listened to me but as soon as I started pushing MB when they left shift their patients got better. Vitamin C will do the same but MB is way better at the process.
MB and Mitochondrial Resistance: MB, by oxidizing NADH to NAD+,this influences the ETC (step 7). By increasing NAD+ availability, MB reduces the "load" on Complex I, effectively lowering resistance to electron flow and boosting ETC efficiency. This helps maintain the proton gradient (ΔμH⁺, step 8) and ATP production (step 9), counteracting mitochondrial dysfunction.
Melanin and Tissue Resistance: Melanin, a dark semiconductive pigment, contributes to tissue-level resistance by facilitating electron transfer in response to light. If melanin is dehydrated or absent, tissue resistance might drop (oxygen problem = ARDS), disrupting energy flow. MB compensates for these effects by acting as an alternative electron carrier, effectively increasing resistance in a controlled way to restore proper energy transformation.
Deuterium and Resistance: I've also mentioned for 20 yrs that deuterium’s impact on the NADH/NAD+ couple, which slows ETC speeds and disrupts the Q-cycle. Deuterium increases resistance in a detrimental way by slowing electron transfer (step 7). MB, by promoting NAD+ production with H⁺ (not deuterium), reduces this aberrant resistance, restoring efficient energy flow. MB can affect the spin effect of the extra neutron in deuterium. This is why it works in cancer too.
Neurosurgeons who do a ton of trauma cases know MB it modulates éR in the ETC to ensure energy is directed into useful work (ATP synthesis) rather than being lost as heat or ROS. If you remember the podcast with @JonesDanny and I talked about the one neurosurgery case that changed my life, the little girl I operated on all night during @Metallica 24 playlist, I had MB running in most of the night as I worked to remove the bone from her brain.
I was worried about this 16 yr old being able to recover from these injuries so I went peddle to the metal on MB. Way outside the package insert. Why?
MB use has broader implications: Resistance in Distributed Biological Systems
I knew that her neural, vascular, and other anatomical networks distribute and transform energy into information by varying resistance regions (éR) across massively distributed membrane systems working in parallel alignment. My profound insight that night almost got me fired when I told my staff doctor to get the fuck out of the room. Why did I go all in?
Neural Networks: The brain’s parallel processing relies on varying resistance across billions of neurons and synapses. This allows energy (ion gradients, bioelectricity) to be transformed into information (thought, memory, behavior). I wanted to perserve as much of her cognition as I could as I worked. This was the same idea I had on Rick Rubin for his open hear t surgery. Peter Attia told Rick I was nuts but Rick has that little girl to thank for the advice I gave his Stanford surgeon. The surgeon did not take it, but Rick did. He trusted me. Now the Famous Attia knows something he did not before. Not surprising since he never finished a residency so his clinical skills are not what they could be.
Vascular Networks: The circulatory system uses resistance to compute how to distribute energy (oxygen, nutrients). For example, during hypoxia (as in COVID-19), resistance in pulmonary vessels increases to redirect blood to better-oxygenated lung regions (a process called hypoxic pulmonary vasoconstriction).
Cellular Networks: Mitochondria within cells form networks that dynamically adjust resistance based on energy demand. For instance, during high ATP demand, resistance in the ETC decreases to speed up electron flow, while during low demand, resistance increases to prevent ROS production. Preserving Ricks cochlea from ROS damage was key in my recs to him on bypass.
In all these systems, resistance isn’t static—it’s a dynamic variable (éR) that organisms adjust to direct energy flow and process information. This mirrors how microcircuits use resistors to control current and perform computations. Seems like MB effects are well known by mitochodnriacs. I wonder why? ;)
MB is blue and as such anyplace it flows will rejec the absorbtion of blue light. This means mtDNA would absorb more UV because MB increases NAD+ to do just that at 340 nm. It also would force more red light absorbtion at the Q cycle and cytochrome C oxidase to help the ATPase spin and the Q cycle deliever electrons to cytochrome C oxidase to keep cardiolipin damage at bay. The reason I knew hospitals would kill millions is because with COVID hypoxia they would default to oxygen therapy which would make the electrical resistance drops in ECT when oxygen is added due to its electronegativity. None of my ICU collegues listened to me but as soon as I started pushing MB when they left shift their patients got better. Vitamin C will do the same but MB is way better at the process.
MB and Mitochondrial Resistance: MB, by oxidizing NADH to NAD+,this influences the ETC (step 7). By increasing NAD+ availability, MB reduces the "load" on Complex I, effectively lowering resistance to electron flow and boosting ETC efficiency. This helps maintain the proton gradient (ΔμH⁺, step 8) and ATP production (step 9), counteracting mitochondrial dysfunction.
Melanin and Tissue Resistance: Melanin, a dark semiconductive pigment, contributes to tissue-level resistance by facilitating electron transfer in response to light. If melanin is dehydrated or absent, tissue resistance might drop (oxygen problem = ARDS), disrupting energy flow. MB compensates for these effects by acting as an alternative electron carrier, effectively increasing resistance in a controlled way to restore proper energy transformation.
Deuterium and Resistance: I've also mentioned for 20 yrs that deuterium’s impact on the NADH/NAD+ couple, which slows ETC speeds and disrupts the Q-cycle. Deuterium increases resistance in a detrimental way by slowing electron transfer (step 7). MB, by promoting NAD+ production with H⁺ (not deuterium), reduces this aberrant resistance, restoring efficient energy flow. MB can affect the spin effect of the extra neutron in deuterium. This is why it works in cancer too.
Neurosurgeons who do a ton of trauma cases know MB it modulates éR in the ETC to ensure energy is directed into useful work (ATP synthesis) rather than being lost as heat or ROS. If you remember the podcast with @JonesDanny and I talked about the one neurosurgery case that changed my life, the little girl I operated on all night during @Metallica 24 playlist, I had MB running in most of the night as I worked to remove the bone from her brain.
I was worried about this 16 yr old being able to recover from these injuries so I went peddle to the metal on MB. Way outside the package insert. Why?
MB use has broader implications: Resistance in Distributed Biological Systems
I knew that her neural, vascular, and other anatomical networks distribute and transform energy into information by varying resistance regions (éR) across massively distributed membrane systems working in parallel alignment. My profound insight that night almost got me fired when I told my staff doctor to get the fuck out of the room. Why did I go all in?
Neural Networks: The brain’s parallel processing relies on varying resistance across billions of neurons and synapses. This allows energy (ion gradients, bioelectricity) to be transformed into information (thought, memory, behavior). I wanted to perserve as much of her cognition as I could as I worked. This was the same idea I had on Rick Rubin for his open hear t surgery. Peter Attia told Rick I was nuts but Rick has that little girl to thank for the advice I gave his Stanford surgeon. The surgeon did not take it, but Rick did. He trusted me. Now the Famous Attia knows something he did not before. Not surprising since he never finished a residency so his clinical skills are not what they could be.
Vascular Networks: The circulatory system uses resistance to compute how to distribute energy (oxygen, nutrients). For example, during hypoxia (as in COVID-19), resistance in pulmonary vessels increases to redirect blood to better-oxygenated lung regions (a process called hypoxic pulmonary vasoconstriction).
Cellular Networks: Mitochondria within cells form networks that dynamically adjust resistance based on energy demand. For instance, during high ATP demand, resistance in the ETC decreases to speed up electron flow, while during low demand, resistance increases to prevent ROS production. Preserving Ricks cochlea from ROS damage was key in my recs to him on bypass.
In all these systems, resistance isn’t static—it’s a dynamic variable (éR) that organisms adjust to direct energy flow and process information. This mirrors how microcircuits use resistors to control current and perform computations. Seems like MB effects are well known by mitochodnriacs. I wonder why? ;)
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