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Crémieux

@cremieuxrecueil

Mar 11

President Trump just sent a hugely important memo to all agency heads.

It instructs them to inform courts filing injunctions against them that, per the law, plaintiffs have to post a security equal to the potential costs of the injunction to the Federal Government.

So, if you, a plaintiff demand the government make good on a payment of $2 billion that they were going to cancel, you must post $2 billion, just in case it's later found that the injunction was wrongful.

This means the injunctions will stop.

Activists groups are trying to get injunctions against the government to force massive payments to continue.

They will lose many of these battles, but now the battles probably won't even take place in most cases, because these securities are enormous and they won't make them.

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Crémieux

@cremieuxrecueil

Mar 11

Proposed DOGE target:

In 1992, Congress told the FDA to approve generic drugs within 180 days of submitting Abbreviated New Drug Applications (ANDAs).

Since 2006, they've failed, and generic drug approvals lag badly. Getting back to 180 days would save hundreds of billions.

There really is no good excuse here for doing this slowly, because

1. Generic drugs are drugs that are already in use. We know they're OK to approve!

2. Generic drugs make it possible for the healthcare system to save so much money that fast approval can pay for itself.

Chart via: sciencedirect.com/science/articl…

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Crémieux

@cremieuxrecueil

Mar 10

On the left, you can see child autism diagnoses.

On the right, you can see states with policies that give schools more money when their students are diagnosed with autism.

When these policies pass, autism diagnoses increase by almost 25%!

Incentives really do matter for autism diagnoses.

For example, people on SSI receive larger payouts if they're diagnosed with autism.

After the economic downturn in 2008, the most heavily impacted age group started getting diagnosed with autism at an incredible rate:

Similarly, because laws in many places mandate providing more resources to autistic children, parents have sought to get their mentally retarded children diagnosed as autistic.

Using California as an example, more than a quarter of the rise 1992-2005 was due to this:

Read 12 tweets

Crémieux

@cremieuxrecueil

Mar 10

The U.S. reports a higher maternal mortality rate than many peer nations like Canada, the United Kingdom, and France.

But the key word there is "reports".

How America classifies maternal mortality varies from peer nations, and this matters🧵

If you go based on the official reports, America's maternal mortality has actually increased since about 1999.

Rising maternal mortality is a disgrace and a tragedy.

But that's if it's really rising. America's rise has more to do with this checkbox on death certificates.

The U.S. used to code maternal deaths as any deaths during childbirth or the immediate postpartum period, under the old ICD-9 classification.

When they switched to ICD-10, the classification expanded to any deaths during pregnancy, childbirth, or 42 days of the end of pregnancy.

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Crémieux

@cremieuxrecueil

Mar 5

During Bernie's second set of questions in today's Senate confirmation hearing, @DrJBhattacharya came very close to describing the U.K.'s RECOVERY trial and arguing that the U.S. should emulate that sort of pragmatic clinical trial.

Bernie cut him off, but he shouldn't have🧵

The RECOVERY Trial was the in-patient equivalent to the community-level PRINCIPLE Trial.

Both were trials run in the U.K. to figure out what works for keeping people off of serious treatments like ventilators and out of the morgue after they've been infected with COVID-19.

RECOVERY was an amazing success, but it can't be done in the U.S., because America's healthcare resources are not aligned like they are in the U.K.

In Britain, the NHS and the country's death index (how deaths are tracked) enable people to be easily signed up and tracked.

Read 11 tweets

Crémieux

@cremieuxrecueil

Mar 5

There's a new GLP product that's even more effective than Semaglutide or even Tirzepatide: Retatrutide!

It leads to fast, and massive weight loss by not just suppressing appetite, but also by upregulating metabolism.

Side effects aren't the norm, and until you get to the high doses, they're uncommon and largely comparable to placebo.

This new GLP product also helps the liver a lot thanks to the addition of another ingredient beyond the GLP-1 and GIP in Tirzepatide: Glucagon, GCG.

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