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thetranscendedman Profile picture
@atranscendedman
Mar 22, 2025 • 1 tweets • 1 min read • Read on X
Kyoto researchers studied 216 adults aged 23 to 81 and found that lower levels of naïve CD8+ T cells before vaccination predicted weaker antibody responses to COVID-19 mRNA vaccines.

academic.oup.com/intimm/advance…

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More from @atranscendedman

thetranscendedman Profile picture
Jan 11
This is my Long COVID story/routine. It's personal, a little controversial, and not a prescription.

Much of it is evidence-based, if you're curious use x.com/search-advanced on my account and you'll find the studies I've shared.

thread below 👇 x.com/atranscendedma…
1/ I’ve been managing Long COVID for 5 years now. You learn a lot about chronic illness in months, but years make it familiar in a way you never asked for.

I got COVID in January 2021. It was moderate-severe (probably hospital-worthy), and I was never quite the same afterward.
2/ I live with extreme stress. A high-conflict marriage (now divorcing), a demanding tech job, two kids I care for, graduate school, NIH involvement, and all of it while sick.

It's hard to heal when you never get a day off.
Read 47 tweets
thetranscendedman Profile picture
Dec 20, 2025
This might be the clearest explanation of Long COVID biology the NIH has released yet.

Essential viewing on the pathophysiology. 🧵

Long COVID is often described as a mystery, but the NIH’s Dr. Avindra Nath argues it’s actually a triad of known biological failures.

Viral ghosts hiding in our tissues, blood vessels leaking in the brainstem, and an immune system that has forgotten how to turn off.
The immune profile is strikingly specific and exhausted. B-cells are failing to mature. T-cells are too tired to fight.

Meanwhile, the brain’s innate immune system is on fire.

It is a biological stalemate that looks remarkably, undeniably like ME/CFS.
Read 6 tweets
thetranscendedman Profile picture
Nov 28, 2025
PolyBio Fall 2025 Symposium (@polybioRF)

🧵below
SARS-CoV-2 spike protein persists in the plasma of people with Long COVID, independent of vaccination.

Higher spike levels correlate with platelet infection and mitochondrial dysfunction, suggesting active viral remnants may drive symptoms. Image
In Long COVID, megakaryocytes and platelets carry infectious SARS-CoV-2, form aggregates, and shift to glycolytic metabolism.

These viral reservoirs may drive clotting, inflammation, and fatigue by spreading infection and altering energy use. Image
Read 98 tweets
thetranscendedman Profile picture
Nov 19, 2025
3rd Long COVID International Conference 2025

🧵below
In a study of over 3,500 adults with past COVID, NIH researchers found 10.3% had long COVID symptoms.

Of those, 46% had lasting symptoms, 35% had ups and downs, and 19% recovered.

Economic hardship may raise the risk of symptoms persisting. Image
Researchers found that people with long COVID show disrupted metabolism of essential fatty acids for at least 6 months, including arachidonic acid and DHA.

These pathways help control inflammation and recovery. Image
Read 72 tweets
thetranscendedman Profile picture
Jul 24, 2025
If you listen to one thing about Long COVID this month, it's this.

So sad I missed this months ago.

viavid.webcasts.com/viewer/event.j…
UCSF scientists and collaborators suggest SARS-CoV-2 may mimic cancer by persisting in the body, evading immune detection, and disabling tumor suppressor genes like p53 and RB.
In long COVID patients, researchers observed chronic immune dysregulation, exhausted T cells, and reduced cytotoxic NK cells hallmarks also seen in viral-related cancers.
Read 9 tweets
thetranscendedman Profile picture
Dec 22, 2024
What if the NIH focused on basic science and testing existing COVID treatments instead of studies on melatonin and light therapy?

Articles like this are frustrating because they highlight the waste in treating symptoms without addressing the root cause.

kevinmd.com/2024/12/long-c…
It’s astonishing that massive trials can continue despite patient protests and clear evidence showing resources should be redirected.

It seems no one wants to confront the hard truth, even when we could reinvest in more worthwhile projects.
Imagine spending millions to prove that melatonin or light therapy helps with sleep, or that exercising with pacing and PEM awareness is beneficial.

It’s an absurd waste of time and money. I’ve yet to see a convincing argument to justify it.
Read 17 tweets

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