Mold and mycotoxins are some of the primary drivers behind a lot of people's health issues.
Here are some basic things to consider.
Thread 🧵
Here are some basic things to consider.
Thread 🧵
*Standard disclaimer that nothing in this thread should be used as a substitute for medical advice*.
It's George.
First and foremost, we are all exposed to various kinds of mold.
Mold overall is not the issues, certain types that release mycotoxins such as:
-Aflatoxins such as aflatoxin B1 that are produced by Aspergillus species.
-Ochratoxins such as ochratoxin A that is produced by Aspergillus and Penicillium sp.
-Trichothecenes that encompass about 100 subtypes of metabolites from Fusarium species.
-Zearalenone that is produced by Fusarium species.
-Fumonisins that are metabolites produced by Fusarium species.
-Ergotamine / Ergot alkaloids that are compounds created by Claviceps species.
It's George.
First and foremost, we are all exposed to various kinds of mold.
Mold overall is not the issues, certain types that release mycotoxins such as:
-Aflatoxins such as aflatoxin B1 that are produced by Aspergillus species.
-Ochratoxins such as ochratoxin A that is produced by Aspergillus and Penicillium sp.
-Trichothecenes that encompass about 100 subtypes of metabolites from Fusarium species.
-Zearalenone that is produced by Fusarium species.
-Fumonisins that are metabolites produced by Fusarium species.
-Ergotamine / Ergot alkaloids that are compounds created by Claviceps species.
are the problem since these can cause anything from cancer, infertility, G.I issues, MCAs, kidney disease all the way to mitochondrial dysfunction (fatigue to put it simply) and eczema once they are:
1. Ingested (most common route of exposure)
2.Inhalated
3. Or contacted with the skin
1. Ingested (most common route of exposure)
2.Inhalated
3. Or contacted with the skin
Now what should you do in order to prevent these from negatively impacting your health?.
Step 1: First and foremost, identify the most common sources of mycotoxins which are:
-Pork (pigs are often fed grains contaminated with ochratoxin A)
-Nuts such as peanuts
-Coffee
-Grains
-Pollen supplements
-Dried fruit
-Water-damaged building materials
Step 1: First and foremost, identify the most common sources of mycotoxins which are:
-Pork (pigs are often fed grains contaminated with ochratoxin A)
-Nuts such as peanuts
-Coffee
-Grains
-Pollen supplements
-Dried fruit
-Water-damaged building materials
Step 2: Shop locally.
When it comes to grains and dried fruit, for example some may have fungal problems in the field but plenty of them grow mold during storage and shipping.
When it comes to grains and dried fruit, for example some may have fungal problems in the field but plenty of them grow mold during storage and shipping.
Step 3: Optimize endogenous glutathione and production and glucuronidation.
Most mold toxins are detoxed via a pathway called glucuronidation.
Glutathione (the substance that’s been made in the glutathione pathway) is made mainly from three amino acids: glycine, cysteine, and glutamine.
In this case, optimizing the endogenous glutathione production can help you mainly battle ochratoxin and aflatoxin B1.
So provide glycine, B6, magnesium, NAC and eat some cruciferous vegetables (particularly organic cabbage for starters).
Most mold toxins are detoxed via a pathway called glucuronidation.
Glutathione (the substance that’s been made in the glutathione pathway) is made mainly from three amino acids: glycine, cysteine, and glutamine.
In this case, optimizing the endogenous glutathione production can help you mainly battle ochratoxin and aflatoxin B1.
So provide glycine, B6, magnesium, NAC and eat some cruciferous vegetables (particularly organic cabbage for starters).
Step 4: a-MSH max.
90% of mold-exposed patients have low levels of a-MSH.
Now POMC is a precursor polypeptide primarily produced in the pituitary gland, the skin and the hypothalamus.
I like to call it a “master precursor” even though it’s incorrect because it gets cleaved into crucial peptides like a-MSH, ACTH, CLIP, Gamma-MSH and beta-endorphin by enzymes like prohormone convertases (PC1/3 and PC2).
Its expression and upregulation is influenced by a variety of physiological, environmental and molecular factors one of them being: UV light exposure (especially UVB (280–320 nm)) that stimulates POMC expression in keratinocytes and melanocytes in the skin (up to 30% increase).
When UVB light penetrates the skin, it causes DNA damage in keratinocytes, activating the tumor suppressor protein p53 and UVA (320–400 nm) activates photoreceptors like neuropsin (OPN5) which further enhances POMC expression.
90% of mold-exposed patients have low levels of a-MSH.
Now POMC is a precursor polypeptide primarily produced in the pituitary gland, the skin and the hypothalamus.
I like to call it a “master precursor” even though it’s incorrect because it gets cleaved into crucial peptides like a-MSH, ACTH, CLIP, Gamma-MSH and beta-endorphin by enzymes like prohormone convertases (PC1/3 and PC2).
Its expression and upregulation is influenced by a variety of physiological, environmental and molecular factors one of them being: UV light exposure (especially UVB (280–320 nm)) that stimulates POMC expression in keratinocytes and melanocytes in the skin (up to 30% increase).
When UVB light penetrates the skin, it causes DNA damage in keratinocytes, activating the tumor suppressor protein p53 and UVA (320–400 nm) activates photoreceptors like neuropsin (OPN5) which further enhances POMC expression.
Now when a key cleavage products of POMC is Alpha-MSH (Melanocyte-Stimulating Hormone)
This one is expressed mainly in the hypothalamic arcuate nucleus and nucleus tractus solitarius of the brainstem and stimulates melanocytes to produce eumelanin, inhibits pro-inflammatory cytokines such as IL-6, TNF-alpha, improves our libido (melanotan I and II Synthetic analogs of α-MSH), regulates our appetite, and supports our immune system and brain.
So, in order to optimize a-msh focus on:
-Morning sunlight exposure (10–30 minutes).
-Managing stress (it can reduce alpha-MSH production by 25% in animal models)
-Minimizing blue light at night.
-Cold exposure (in mice it can increases POMC expression by even 25%).
-Managing stress to prevent ACTH dominance.
-Supporting nutrition with tyrosine, vitamin C, zinc and copper in order to enhance prohormone convertase activity
This one is expressed mainly in the hypothalamic arcuate nucleus and nucleus tractus solitarius of the brainstem and stimulates melanocytes to produce eumelanin, inhibits pro-inflammatory cytokines such as IL-6, TNF-alpha, improves our libido (melanotan I and II Synthetic analogs of α-MSH), regulates our appetite, and supports our immune system and brain.
So, in order to optimize a-msh focus on:
-Morning sunlight exposure (10–30 minutes).
-Managing stress (it can reduce alpha-MSH production by 25% in animal models)
-Minimizing blue light at night.
-Cold exposure (in mice it can increases POMC expression by even 25%).
-Managing stress to prevent ACTH dominance.
-Supporting nutrition with tyrosine, vitamin C, zinc and copper in order to enhance prohormone convertase activity
Step 6: Test for:
● Satratoxin G and H
● Roridin A, E and H
● Verrucarin A and J
● Zearalenone
● Aflatoxin M1 (AFM1)
● Sterigmatocystin (STG)
● Roridin E
● Ochratoxin A (OTA)
● Enniatin B1
● Verrucarin A
● Gliotoxin
● Mycophenolic Acid
● Chaetoglobosin A
● Citrinin
● Satratoxin G and H
● Roridin A, E and H
● Verrucarin A and J
● Zearalenone
● Aflatoxin M1 (AFM1)
● Sterigmatocystin (STG)
● Roridin E
● Ochratoxin A (OTA)
● Enniatin B1
● Verrucarin A
● Gliotoxin
● Mycophenolic Acid
● Chaetoglobosin A
● Citrinin
Step 7: Use certain binders depending on what came back positive.
When it comes to aflatoxin, what works is: saccharomyces boulardii, bentonite clay and activated charcoal (AC).
When it comes to gliotoxin what works is: saccharomyces boulardii and bentonite clay.
When it comes to zearalenone what works is: zeolites, saccharomyces boulardii, bentonite clay.
When it comes to ochratoxin what works is: activated charcoal and zeolites.
When it comes to enniatin B what works is: bentonite clay and activated charcoal.
When it comes to trichothecese what works is: bentonite clay, activated charcoal and chlorella.
When it comes to aflatoxin, what works is: saccharomyces boulardii, bentonite clay and activated charcoal (AC).
When it comes to gliotoxin what works is: saccharomyces boulardii and bentonite clay.
When it comes to zearalenone what works is: zeolites, saccharomyces boulardii, bentonite clay.
When it comes to ochratoxin what works is: activated charcoal and zeolites.
When it comes to enniatin B what works is: bentonite clay and activated charcoal.
When it comes to trichothecese what works is: bentonite clay, activated charcoal and chlorella.
Also:
-Consider the Lactobacillus rhamnosus strain GG and the L. rhamnosus strain LC705 for zearalenone, curcumin or/and blackseed oil for aflatoxin B1.
-Two swiss knifes that help with exposure to pretty much any of these are quercetin and saffron.
-Keep the humidity levels at your house at a healthy level by using a dehumidifier.
-Use an infrared sauna instead of the classic one due to the humidity levels.
-If you have mold in your house, remove with the help of a professional or if you can not afford it, search for items such as biobalance.
-Consider stronger antifungals and working on biofilms if you have been struggling with it for a long time and do not forget about tissues such as the ones found in the nose.
-Consider the Lactobacillus rhamnosus strain GG and the L. rhamnosus strain LC705 for zearalenone, curcumin or/and blackseed oil for aflatoxin B1.
-Two swiss knifes that help with exposure to pretty much any of these are quercetin and saffron.
-Keep the humidity levels at your house at a healthy level by using a dehumidifier.
-Use an infrared sauna instead of the classic one due to the humidity levels.
-If you have mold in your house, remove with the help of a professional or if you can not afford it, search for items such as biobalance.
-Consider stronger antifungals and working on biofilms if you have been struggling with it for a long time and do not forget about tissues such as the ones found in the nose.
I hope that you found something useful in this thread.
If you did, make sure to leave a like/RT.
If you did, make sure to leave a like/RT.
https://x.com/Helios_Movement/status/1908088357659259023
And if you want to learn more, check lesson 3 in this: fitandball.gumroad.com/l/thesystem23
A few studies:
sciencedirect.com/science/articl…
journals.asm.org/doi/full/10.11…
pmc.ncbi.nlm.nih.gov/articles/PMC42…
sciencedirect.com/science/articl…
pmc.ncbi.nlm.nih.gov/articles/PMC91…
pmc.ncbi.nlm.nih.gov/articles/PMC74…
pmc.ncbi.nlm.nih.gov/articles/PMC58…
pubmed.ncbi.nlm.nih.gov/28844113/
pmc.ncbi.nlm.nih.gov/articles/PMC62…
sciencedirect.com/science/articl…
journals.asm.org/doi/full/10.11…
pmc.ncbi.nlm.nih.gov/articles/PMC42…
sciencedirect.com/science/articl…
pmc.ncbi.nlm.nih.gov/articles/PMC91…
pmc.ncbi.nlm.nih.gov/articles/PMC74…
pmc.ncbi.nlm.nih.gov/articles/PMC58…
pubmed.ncbi.nlm.nih.gov/28844113/
pmc.ncbi.nlm.nih.gov/articles/PMC62…
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