Crémieux Profile picture
Apr 7, 2025 21 tweets 7 min read Read on X
Researchers put together an incredible workplace wellness program that provided thousands of workers with paid time off to receive biometric health screening, health risk assessments, smoking cessation help, stress management, exercise, etc.

What did this do for their health?🧵 Image
So, for starters, this program had a large sample and ran over multiple years.

Because of it, we have evidence on what people do with clinical health info, with exercise encouragement and advice, with nutritional knowledge, through peer effects, and so on. Image
Participants in the treatment group were prompted to participate with cash rewards ranging from $50 to $350.

Go to screening? Earn some money, help yourself by bolstering your knowledge about yourself and potentially improving your health.

What could be simpler? Image
The participants certainly seemed to think so.

The cash rewards did get more people into screenings and advising, and they even got some people moving more.

If estimates from earlier studies were to be believed, this effort should even do enough to save employers money!
But that didn't work.

Average monthly medical spending didn't change when comparing the treatment to the control group. Image
In fact, this study stands out in the literature, as getting nulls across basically every outcome relevant to the employer.

Health and wellness incentives and opportunities did not make people less absent or medically costly, or much else (which we'll get to).Image
Before getting to other outcomes, we have to ask: Why trust this over other results? A few reasons:

For one, it was bigger than other studies in the experimental literature.

For two, it was preregistered, publicly archived, and independently analyzed by outside researchers.
All of that on its own is really good. But what really takes the cake is that the prior literature was impacted by p-hacking and publication bias, whereas these researchers committed to publishing their results regardless. Image
Who do you trust more?

"We aren't financially conflicted and we'll publish regardless of what happens and of course we provide data and code."

or "p = 0.04, this program is life-changing (ignore my financial conflicts of interest :))"

I know my answer, you know my answer.
Now let's talk other outcomes.

Medical spending: not affected in total, admin-wise, drug-wise, office-wise, hospital-wise, or in terms of any utilization metric.

Employment and productivity: Didn't affect employee retention, salaries, promotions, sick leave, overtime, etc.
More employment and productivity: Didn't affect job satisfaction or feelings of productivity. BUT, did affect views about management priorities on health (increased) and the likelihood of engaging in a job search (increased).

That's backfiring, potentially.
Participants failed to increase their number of gym visits, didn't participate in the IL marathon, 10k, or 5k more often, despite smoking cessation advice and help they didn't smoke less, they didn't report better health, hell, they became (marginally-significantly) fatter!
Across basically every metric, the results were null, null, and--my favorite--null.

And this is what we expect with credible intervention evaluations of high-quality samples. This is so common, in fact, that it's been dubbed the "Stainless Steel Law":Image
But the most amazing detail, in my opinion, is that this study went further:

It explained why prior observational work showed such large benefits for workplace wellness programs.

The reason is selection: health-conscious employees selected into the program and stuck with it!Image
These programs' effectiveness is a classic example of selection leading to results that simply cannot be trusted.

But... how?! Why?! After all, this program had all the ingredients that so many prominent people think will solve America's public health issues.
The answer is that they misunderstand people.

Most people are lazy, commitment is hard

My recommendation to ppl who haven't learned that is to do a clinical rotation or read abt the thousands of programs across America that have done food delivery coaching, etc., with no effect
This leads me to something important:

Do you know why Ozempic works so well and has enjoyed such incredible popularity of late?

If you can understand these headlines, you'll get it. Image
Image
Image
Ozempic makes it automatic to lose weight.

It takes out the effort, and people have an easier time doing more (in this case, work) than they do being asked to eat less or doing things that simultaneously bore and fatigue them (exercise) without a commitment mechanism like a boss Image
For this reason, GLP-1RAs are going to decisively beat all efforts to advise people, to provide them with healthy food and instructions on how to prepare it, and all of that tried-and-true advice that's been around and in vogue for decades, but clearly hasn't worked.
To top this all off, here's the result of a contemporaneous large, cluster-randomized controlled trial of workplace wellness programs at BJ's Wholesale Club.

Similar intervention, somewhat optimistic effects, and, once again, no results to show for it. Image

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More from @cremieuxrecueil

Jun 1
My Uber driver says

- His license is suspended
- He was once a soldier for a Mafia family
- He's telling me about his time in Rikers
- He's showing me YouTube videos
- He's telling me his theories about Jews
He's telling me about gang wars he was in ad a kid.

He's wondering why all the Chinese girls are lined up - for an audition?

He says to go to Mother's Ruin for latin prostitutes.

All of this entirely unprompted.
"Yeah, these African guys, yeesh"

"I couldn't fuck that whore because I got the erectile dysfunction."

He just keeps going.
Read 6 tweets
May 29
This is just not true and it's sad that people believe it.

It's also indicting, when it's so obviously false if you just look out into the world. What you see should match what the statistics clearly show:

Estimated marriage effects for men and women are almost always similar🧵 Image
In that chart, I used the GSS and found something many people replicate:

1. Cross-sectionally, there's a relationship between being married and life satisfaction. It's similar for men and women.

2. Within persons—causally!—marriage boosts life satisfaction, but more for women.
Leveraging the same within-person design, we can use the Add Health dataset to look at stress and depression.

For both sexes, the effects are indistinguishable.

But they're also mostly not real: it's just that people who get married tend to be less stressed and depressed! Image
Read 10 tweets
May 26
As a recap on my appearance, Eli Lilly is pursuing:

- A one-dose drug for preventing most heart disease
- A vaccine for chlamydia
- A vaccine for gonorrhea
- A vaccine for Epstein-Barr
- A drug that lets you stay awake longer and feel more rested

It's a golden age of pharma! Image
And remember, Eli Lilly's big break historically was the University of Toronto licensing them to produce insulin.

They started off by giving it out for free, saving the world's diabetics at a time when there was no treatment available.

They've always been a force for good. Image
I think

- The heart disease drug will succeed
-- Will it commercialize? It can, easily. But I'm 50/50 due to the competition
- Chlamydia and gonorrhea vax will succeed, but I don't see much commercial potential with Lilly
- EBV vaccine will fail with Lilly, succeed eventually
Read 5 tweets
May 25
Eli Lilly has done it.

They've gone and made what seems to be a powerful, permanent gene therapy for LDL cholesterol.

That means they'll be able to effectively prevent most heart disease with a single infusion! Image
Almost all of the side effects were just things you see with any infusion. Some people react poorly to needles and having to sit for a while🤷‍♀️

And that's what we expect, because the people with good PCSK9 genes naturally are totally fine. This therapy catches the rest of us up!
This is amazing stuff, beating drug administration because it's permanent, and it only gets better from here.

We are going to get so healthy, so fast. Our grandkids are going to hear about heart attacks and have never actually seen one.

Source: nejm.org/doi/full/10.10…
Read 5 tweets
May 24
Are White women the primary beneficiaries of affirmative action?

That's a real claim that's commonly advanced by journalists, and the claim has gone so far that it's even made its way into academic publications and policy.

But the claim is completely false🧵 Image
This claim doesn't make a lot of sense. After all, shouldn't the primary beneficiaries of affirmative action be the people who the policies primarily target?

In America, that's African Americans and, among them, women get an added benefit. How could it be Whites? Image
To figure out where the claim comes from, I started reading supposed sources.

Often enough, journalists will just take the claim for granted without providing *any* source.

It's just tacit knowledge now, and that's not good!

Then, when you hit a source, it's not supportive: Image
Read 13 tweets
May 7
World War I devastated Britain and likely slowed down its technological progress🧵

The reason being, the youth are the engine of innovation.

Areas that saw more deaths saw larger declines in patenting in the years following the war. Image
To figure out the innovation effects of losing a large portion of a generation's young men who were just coming into the primes of their lives, the authors needed four pieces of data.

The first were the numbers and pre-war locations of soldiers who died. Image
The next components were the numbers and locations of patent filings.

If you look at both graphs, you see obvious total population effects. So, areas must be normalized. Image
Read 12 tweets

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