When a country sets its pharmaceutical prices based on the prices in other countries, it disincentivizes offering drugs in other countries if they're poorer.
We can see how this plays out in Europe, where the poorest countries get new drugs on a massive delay.
This leads to a lot of situations where, if people complain about high prices, it's appropriate to respond like so:
'The price of $drug is so high in America!'
'Ah, but there is a price.'
The lower the prices, the longer the delays, the more lives lost.
People might be able to limit the side-effects of GLP-1 drugs by avoiding Ozempic/Wegovy and instead using Mounjaro/Zepbound.
The reason has to do with Zepbound's other ingredient besides GLP-1: GIP🧵
GIP is short for either gastric inhibitory peptide or glucose-dependent insulinotropic polypeptide.
It was originally called gastric inhibitory peptide, but people now prefer the 'insulinotropic' name because the gastric stuff rarely happens in normal circumstances.
Basically, it's an inhibiting secretin hormone that holds back gastric acid secretion somewhat and stimulates insulin secretion a lot.
The timeline of key discoveries undergirding GIP's therapeutic potential is quite long and leads all the way back to the 1970s.
Pharmaceutical R&D is on death's doorstep and its current rebound is fragile and temporary.
Returns are already below the cost of capital, and any additional harms to profitability will drain the life-blood of the future, instantly snuffing out biomedical progress.
I am talking about the engine of survival, the thing that explains so much of why so many of us are alive today, and the thing that will keep you alive in the future.
This is also the thing that might eventually bring you immortality.
Destroy it, and we all lose.
Attacking pharmaceutical returns right now is also a form of redistribution of future returns to a state enemy, China.
Real data says "No", because the U.S. gets favorable prices for generic drugs and it primarily consumes generic drugs. In fact, they're 91% of prescriptions!
But then, we have a mystery:
If the prices America tends to pay are, in fact, reasonable, then why does it account for such a large share of all global spending on drugs?
When we think of the U.S. overpaying, we're thinking about 9% of purchases and forgetting the 91% for which it has better prices
The reason the U.S. does so much health spend is not high prices, it's high consumption
America is rich, so it buys a lot of healthcare! For example:
They're the famous Terracotta Warriors from the mausoleum of the first Chinese Emperor Qin Shihuang, and researchers have recently begun scanning their faces to learn more about them, possibly including their ethnic backgrounds🧵
It's unknown if these lifelike statues were based on real people.
But, under the assumption that they were, we can get a lot of information about who they were, because people's faces vary from group to group.
If you've played the game "Ethnoguessr", you're familiar with this.
The researchers looking into these warriors were allowed to take some of them out, from across the various pits they're buried in.
Conservatives love to attack the Great Society as if it's responsible for modern high divorce and low marriage rates as well as high Black crime rates.
But this is a narrative-based belief, not a statistically-justified one. High Black crime rates precede the Great Society.
The Great Society gets a lot of senseless blame.
Some people say it caused people to work a lot less. Not clearly supported: