Crémieux Profile picture
May 12 3 tweets 1 min read Read on X
When a country sets its pharmaceutical prices based on the prices in other countries, it disincentivizes offering drugs in other countries if they're poorer.

We can see how this plays out in Europe, where the poorest countries get new drugs on a massive delay. Image
This leads to a lot of situations where, if people complain about high prices, it's appropriate to respond like so:

'The price of $drug is so high in America!'

'Ah, but there is a price.'

The lower the prices, the longer the delays, the more lives lost. Image
This all comes from this paper: aeaweb.org/articles?id=10…

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More from @cremieuxrecueil

May 14
People might be able to limit the side-effects of GLP-1 drugs by avoiding Ozempic/Wegovy and instead using Mounjaro/Zepbound.

The reason has to do with Zepbound's other ingredient besides GLP-1: GIP🧵Image
GIP is short for either gastric inhibitory peptide or glucose-dependent insulinotropic polypeptide.

It was originally called gastric inhibitory peptide, but people now prefer the 'insulinotropic' name because the gastric stuff rarely happens in normal circumstances. Image
Basically, it's an inhibiting secretin hormone that holds back gastric acid secretion somewhat and stimulates insulin secretion a lot.

The timeline of key discoveries undergirding GIP's therapeutic potential is quite long and leads all the way back to the 1970s. Image
Read 25 tweets
May 12
Pharmaceutical R&D is on death's doorstep and its current rebound is fragile and temporary.

Returns are already below the cost of capital, and any additional harms to profitability will drain the life-blood of the future, instantly snuffing out biomedical progress. Image
I am talking about the engine of survival, the thing that explains so much of why so many of us are alive today, and the thing that will keep you alive in the future.

This is also the thing that might eventually bring you immortality.

Destroy it, and we all lose.
Attacking pharmaceutical returns right now is also a form of redistribution of future returns to a state enemy, China.

The West should not forfeit the future to China.

Read 4 tweets
May 12
Does the U.S. overpay for drugs?

Common knowledge says "Yes".

Real data says "No", because the U.S. gets favorable prices for generic drugs and it primarily consumes generic drugs. In fact, they're 91% of prescriptions! Image
But then, we have a mystery:

If the prices America tends to pay are, in fact, reasonable, then why does it account for such a large share of all global spending on drugs? Image
When we think of the U.S. overpaying, we're thinking about 9% of purchases and forgetting the 91% for which it has better prices

The reason the U.S. does so much health spend is not high prices, it's high consumption

America is rich, so it buys a lot of healthcare! For example: Image
Read 13 tweets
May 11
Where are these guys from?

They're the famous Terracotta Warriors from the mausoleum of the first Chinese Emperor Qin Shihuang, and researchers have recently begun scanning their faces to learn more about them, possibly including their ethnic backgrounds🧵 Image
It's unknown if these lifelike statues were based on real people.

But, under the assumption that they were, we can get a lot of information about who they were, because people's faces vary from group to group.

If you've played the game "Ethnoguessr", you're familiar with this.Image
The researchers looking into these warriors were allowed to take some of them out, from across the various pits they're buried in.

This is what the distribution looks like: Image
Read 10 tweets
May 10
PLACE YOUR BETS.

Will this result remain significant after I trim-and-fill it?

Current effect size: 0.8374 (0.5508-1.1240).

r(g, SE) = 0.5908. Image
WILL THE RESULT REMAIN SIGNIFICANT?
WILL THE EFFECT SIZE HALVE OR BE REDUCED MORE GREATLY?
Read 8 tweets
May 9
Conservatives love to attack the Great Society as if it's responsible for modern high divorce and low marriage rates as well as high Black crime rates.

But this is a narrative-based belief, not a statistically-justified one. High Black crime rates precede the Great Society.Image
The Great Society gets a lot of senseless blame.

Some people say it caused people to work a lot less. Not clearly supported:

Some people claim it failed to affect poverty rates.

Negatively supported:
Read 11 tweets

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