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Vipin M. Vashishtha Profile picture
@vipintukur
May 14 • 3 tweets • 1 min read • Read on X
A systematic review & meta-analysis of nearly 140,000 participants found that excess weight and obesity are linked to increased risk of neurological symptoms in #LongCOVID patients 1/ Image
These neurological symptoms include headaches, numbness/tingling, memory issues, vertigo and depression. Researchers suggest that fat tissue may serve as a reservoir for the virus, contributing to prolonged symptoms.  2/ Image
Thus, excess weight, including overweight and obesity, is associated with experiencing neuro-symptoms related to PCC. Individuals with these conditions urgently need enhanced personalized care management in current post-pandemic context. 3/3

journals.plos.org/plosone/articl…

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More from @vipintukur

Vipin M. Vashishtha Profile picture
May 16
A new study, the first to compare inflammation & brain stress in #LongCOVID patients w/ those who have fully recovered shows that those w/continued brain fog & other cognitive issues have a lower ability to adapt to stress & higher levels of inflammation in their brains. 1/ Image
While previous longCOVID studies have shown changes in these markers in mice, this study evaluated the infection's impact on the brain in documented COVID-positive patients. 2/
The pilot study included 17 confirmed COVID patients (10 with longCOVID and seven who were fully recovered with no lingering symptoms). 3/
Read 10 tweets
Vipin M. Vashishtha Profile picture
May 15
A new study suggested that COVID-19 may cause lasting damage to the esophageal epithelial barrier, increasing its permeability & provoking an exacerbated inflammatory response. These changes may explain the prevalence of post-infection gastroesophageal symptoms 1/ Image
This prospective study found that 55 hospitalized patients recovering from COVID reported significantly increased symptoms of heartburn and acid reflux 3 to 6 months after hospital discharge. 2/ Image
Biopsies revealed higher esophageal permeability under acidic conditions, increased IL-8 levels, and elevated expression of Claudin-2, a tight junction protein that weakens epithelial barrier function. 3/ Image
Read 4 tweets
Vipin M. Vashishtha Profile picture
May 13
A new study suggests that
#LongCOVID patients had significantly more dilated capillaries, microhemorrhages, abnormal capillary shapes (neoangiogenesis) and lower capillary density than both recovered COVID patients without LongCOVID and healthy controls. 1/ Image
In this multicenter Italian study, researchers used nailfold videocapillaroscopy (NVC) to identify microvascular damage in Long COVID patients up to 18 months after infection. 2/ Image
Comparing NVC images in patients who had NVC before COVID infection and after COVID infection confirmed new vascular damage following infection. 3/ Image
Read 4 tweets
Vipin M. Vashishtha Profile picture
May 5
A new study shows that coronavirus spike proteins can trigger mast cell degranulation by binding to cellular receptors and activating the Src/PI3K/AKT signaling pathway, leading to increased calcium levels and mast cell granule release. 1/ Image
The activation and degranulation of mast cells (MCs), triggered by a variety of viruses, are intricately linked to viral pathogenesis. However, the precise mechanism underlying virus-induced MC degranulation remains largely unknown. 2/ Image
In this study, researchers demonstrate the ubiquity of coronavirus-induced MC degranulation and investigate the intracellular signaling pathways that mediate this process. 3/ Image
Read 7 tweets
Vipin M. Vashishtha Profile picture
May 5
Tiny RNA molecule may hold the key to treating knee osteoarthritis!

A NEW discovery could pave the way for new breakthroughs in detecting & treating the disease. Researchers identified a circulating microRNA, miR-126-3p, a mechanistic biomarker of osteoarthritis of knee 1/ Image
MiR-126-3p plays a role in reducing blood vessel formation and reducing the severity of knee osteoarthritis, making it not just a signal of disease—but potentially a contributor to it. 2/ Image
Now that scientists are aware of miR-126-3p, they can develop blood tests to detect osteoarthritis of the knee and therapeutics for slowing or even stopping progression. 3/ Image
Read 6 tweets
Vipin M. Vashishtha Profile picture
Apr 30
A new preprint validated earlier findings that genetic factors strongly influence who develops Long COVID, using data from both U.S. (All of Us) and U.K. (Sano GOLD) cohorts with diverse ancestries. 1/ Image
Over 90% of genes identified in the original study were also associated with #LongCOVID in the U.S. population including in Black and Hispanic groups. 2/
These results confirm that combinatorial genetic analysis can uncover more risk genes than traditional Genome-wide association studies (GWAS) and support the continued exploration of drug repurposing candidates for LongCOVID treatment. 3/ Image
Read 6 tweets

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