Thread by @Marion436842126

1/6 Great thread from @Mangan1 !
I would also add that LDL particle size matters.
Not all LDL is equal. LDL (low-density lipoprotein) carries cholesterol, but its particle size matters for heart disease risk. Small, dense LDL (sdLDL) is more atherogenic (plaque-causing)
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https://twitter.com/Mangan150/status/1922999431239962901

2/6 than large, fluffy LDL. sdLDL is more plaque-promoting because it’s easily oxidized and triggers inflammation. Macrophages engulf oxidized sdLDL, forming foam cells. Foam cells are a key driver in the development and progression of atherosclerosis. /3

3/6 What causes ⬆️ sdLDL ? Insulin resistance, high Triglycerides/low HDL, metabolic syndrome, & chronic infections (like oral bacteria P. gingivalis) can drive inflammation, shifting LDL toward small, dense particles.
Diets matter too. Refined carbs & inflammatory seed oils /4

4/6 (high in linoleic acid) can worsen sdLDL profiles. Poor oral health, with bacteria like P. gingivalis found in arterial plaques, adds to the risk.
Standard lipid tests miss LDL particle size. Get advanced tests like NMR lipid profiles or VAP tests for particle size and /5

5/6 number. Also, check fasting insulin for insulin resistance and CRP for inflammation.
Fight back with diet and hygiene. LCHF diets, Keto or Carnivore with whole foods, avoiding seed oils like soybean, corn oil etc., can boost large, fluffy LDL and reduce sdLDL.
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6/6 Manage gum health to lower infection risk, (root canals can be a reservoir for infections). Takeaway: sdLDL’s plaque-promoting potential, driven by foam cells, inflammation from seed oils, and infections like P. gingivalis, matters more than a number on your lipid profile.