1/4 “Many of the symptoms displayed during the course of Mustafa’s illness—symptoms that eventually led to a diagnosis of ALS, motor neurone disease—are well documented side effects of statins and are listed in the leaflet that accompanies the tablets. /2 2/4 With such similarities in mind, it seems wise to monitor statin-intolerant patients closely and to weigh up carefully whether the disadvantages of taking these drugs outweigh the benefits for these patients. /3

1/4 Animals will keep eating until they satisfy their protein requirements, so a diet low in protein naturally stimulates overeating. This is why the most effective strategy for reversing Metabolic Syndrome is increasing protein while reducing carbohydrates. /2 2/4 This way of eating tends to stabilize hunger and satiety hormones incredibly well. It also decouples your mitochondria so they become active and eager to burn off energy as heat, increases your lean muscle mass, your metabolism, and your bone density. /3

1/6 Back in 2008 nobody prepared me for what I was about to find out about statins. I was naive, trusting, I believed everything people told me, I am longer that person. Researching statins changed all that. It started when my father was prescribed Atorvastatin post a 2/6 minor stroke. The stroke did little harm, but the medication post stroke destroyed his health. I recall my father telling me he couldn't think any more since he was on these drugs, and he also suffered from muscle damage and acute pancreatitis while on them. /3

1/10 I’m appalled at the response @RLauvray
received from his doctor for refusing statins. Telling him to “get another doctor” is lazy and incurious, ignoring potential harms of statins and using threats to push a drug. This can also happen when doctors are incentivized to /2

https://twitter.com/RLauvray/status/1949984209042276841

2/10 promote cholesterol-lowering meds. Rob, you deserve better. Here’s a thread to help you improve insulin sensitivity naturally.
First, diet is key. Adopt a Low-Carb, High-Fat (LCHF) or Ketogenic diet to stabilize blood sugar. Ditch sugars, fruit juices, sodas, /3

1/8 Statins lower cholesterol by inhibiting HMG-CoA reductase, an enzyme in the liver that drives cholesterol synthesis. Statins can raise blood glucose and contribute to insulin resistance. Here's how: The inhibition of HMG-CoA reductase reduces the production of mevalonate, /2 2/8 a key molecule in the cholesterol synthesis pathway. This also lowers levels of downstream molecules called isoprenoids, like geranylgeranyl pyrophosphate which are important for cell signaling. GGPP is critical for prenylation, a process that activates small proteins. /3

1/11 Lp(a) is an acute-phase reactant, meaning its production in the liver is upregulated during inflammation, and infections. Statins can increase Lp)a levels, as can mRNA vaccines which induce a controlled immune response, triggering inflammation /2

https://twitter.com/ken_trails/status/1947742911946494197

2/11 to stimulate antibody production.
This is driven by pro-inflammatory cytokines like interleukin-6 which stimulate hepatocytes to increase Lp(a) synthesis. Infections, especially acute ones (e.g., bacterial or viral), trigger systemic inflammation, elevating acute-phase /3

1/6 Balance is critical. Insulin regulation optimizes cholesterol’s vital functions. Cell structure, hormone production, and brain health,while preventing disease.
Insulin has a profound effect on Cholesterol. It turns up the cholesterol making machinery by turbocharging the /2 2/6 activity of the enzyme that actually controls cholesterol manufacturing in your body. This enzyme is called HMG-CoA Reductase. You can improve your lipid profile by simply lowering your insulin levels. By doing so you avoid all of the serious "side effects" of statin /3

1/8 WHAT THE LDL is going on ? "Because the presence of coronary artery disease can be associated with the proportion of small dense LDL, we analyzed the effect of statins on small dense LDL subfractions in persons without CAD. /2 2/8 Unexpectedly, in that analysis, the proportion of small, dense LDL was significantly HIGHER in patients who were treated with Statins. Moreover, there were no differences in CRP, plasma fibrinogen, HOMA–IR, body mass index, or metabolic syndrome between the Statin and /3

1/5 Coenzyme Q10 is an antioxidant, a membrane stabilizer, and a vital component in the mitochondrial electron transport chain. CoQ10 also regulates gene expression and apoptosis (cell death). It is an essential co-factor of uncoupling proteins and permeability /2 2/5 transition pores, and has anti-inflammatory, redox modulatory, and neuroprotective effects. It is essential to life. It can prevent the oxidation of LDL which, when oxidized, can lead to plaque build up and hardening of the arteries. /3

1/6 Modern medicine is akin to an auto mechanic tuning up the radio to drown out the sound of a failing engine. The practice of medicine has completely lost its way. Remedies that treat symptoms and only offer some relief have replaced the search for cures. No one noticed. /2 2/6 However, the problem is much more pervasive and sinister than that. The first & most basic tenet of medicine is "do no harm". That principle has been so utterly corrupted by the drug industry that it no longer plays into the practice of medicine. Bribes are not . /3

1/10 Chronic inflammatory diseases, such as rheumatoid arthritis, lupus, psoriasis, & infections such as periodontal disease (p.gingivalis), & HIV, are associated with an increased risk of heart disease. Patients with these disorders also have an increase in coronary artery /2 2/10 calcium measured by CT & carotid intima media thickness measured by ultrasound. WHY ?? Because inflammation & infections induce a variety of alterations in lipid metabolism that may initially DAMPEN inflammation or fight infection, but if chronic, can contribute to the /3

1/14 Picture landing on a planet with intelligent life, and they ask, “How do you treat heart disease on Earth ?” You’d likely mention statins, drugs that lower cholesterol. But when they ask, “What’s the cost to your body ? here’s the answer. /2 2/14 Statins block the mevalonate pathway, cutting cholesterol to reduce heart disease risk. Sounds good ? But cholesterol is a key building block for vital biochemicals. Blocking this pathway depletes critical compounds and causes other issues. Let’s break it down./3

1/7 Let’s cut through the noise and stick to the science. Statins block HMG-CoA reductase, disrupting the mevalonate pathway, which reduces cholesterol but also depletes Coenzyme Q10 and many other vital biochemicals critical for cell survival, particularly in /2 2/7 mitochondria-heavy tissues like the heart. This isn’t a statin “side effect” but a direct consequence of the pathway inhibition, leading to cardiomyocyte dysfunction or apoptosis. The truth about the effects of statins on the cardiovascular system is found in research /3

1/9 Have we been misled again ? Do statins need to cross the blood-brain barrier (BBB) to cause cognitive dysfunction, or does their blockade of the mevalonate pathway alone do the job ? I believe the latter, and it’s a serious concern. /2 2/9 Statins are prescribed to lower cholesterol by inhibiting HMG-CoA reductase, blocking the mevalonate pathway. This doesn’t just reduce cholesterol, it deprives brain cells of mevalonate and its critical products.
/3

1/4 Yes, Astrocytes, specialized brain cells, produce cholesterol locally via the HMG-CoA reductase pathway. The blood brain barrier,(BBB) a tightly regulated network of endothelial cells, effectively prevents lipoprotein-bound cholesterol (LDL or HDL from the liver and diet) /2

https://twitter.com/SWVirgo432/status/1939519162520686878

2/4 from entering the brain. This isolation ensures the brain maintains its own cholesterol pool, protecting it from fluctuations in blood cholesterol levels.
However, Statins are relatively small organic compounds (MW 390.5–558.6) of natural or synthetic origin, having /3

1/10 GLP-1 drugs (Mounjaro, Wegovy, Ozempic) activate GLP-1 and GIP receptors, boosting incretin hormones. This triggers more insulin release when needed, cuts liver glucose production, and slows digestion. Sounds great, but there’s a catch… /2 2/10 Pancreatitis Risk is Serious: These drugs can overstimulate pancreatic cells, causing inflammation (pancreatitis). MHRA confirms 10 UK deaths linked to pancreatitis from these drugs. This is a known class effect, yet the risks feel downplayed. Lives are at stake. /3

1/5 Statins are prescribed worldwide and a high percentage of Statin users suffer from adverse effects especially on skeletal muscle. More recently, new onset Diabetes has been reported in subjects on Statin ‘therapy’. The Pro-oxidant effects of statins are known & evidence /2 2/5 that Statins induce alterations in intracellular calcium homeostasis and mitochondrial dysfunction is clear. It’s not a giant step to conclude that Statin-induced inhibition of mitochondrial respiration leads to oxidative stress that opens a calcium-dependent permeability /3

1/9 Statins cause cellular stress (e.g., oxidative stress from statin-induced mitochondrial dysfunction) which can damage DNA, potentially leading to mutations if repair mechanisms fail. It is inevitable that everyone taking statins long term will develop one or more of the /2 2/9 direct effects of statin use. Despite all the hype of drug company engineered study results on the so called “benefits” of statins, the hard truth proves otherwise. Some people have immediate symptoms after one dose; others report symptoms only after /3

1/5 Magic trick - Take statins, choke off the liver cell life cycle so Reductase kicks into overdrive to trick liver cells into mass-producing cholesterol receptors that soak up supposedly "bad" blood cholesterol, most of which the liver normally makes via the mevalonate /2 2/5 pathway. Cells rely on the mevalonate pathway to produce essential molecules for growth, energy, and survival, making its disruption significant.
Get a blood test and -Eureka ! LDL "bad" cholesterol is lower, just like magic. However, statins block key mevalonate pathway /3

1/6 STATINS: THE GRAND ILLUSION: When statins are ingested, the liver absorbs most of the drug, blocking mevalonate synthesis. This deprives liver cells of cholesterol & isoprenoids. Cells respond by increasing reductase to restart mevalonate production as a survival mechanism./2 2/6 Elevated reductase tricks the nucleus into producing more LDL receptors, which pull cholesterol from the blood into liver cells. However, cells remain starved of isoprenoids due to the blocked mevalonate pathway. As cholesterol rises in liver cells via LDL receptors, they /3

1/6 No one can deny that Statins do exactly what they are designed to do: suppress cholesterol production and reduce measurable blood serum levels. The question is, rather, at what price do they accomplish this feat, and for what ultimate purpose ? /2 2/6 With the National Cholesterol Education Program Guidelines, having been designed by "experts" on the payroll of Statin drug manufacturers, requiring ultra-low levels to obtain a strictly theoretical and numerical definition of "health," Statin drugs are guaranteed /3