The TRUTH about Statins, formerly @holmanm
Info is provided for educational purposes only & should not be considered as medical advice. (NO DM's please)
19 subscribers
Mar 17 • 6 tweets • 2 min read
1/6 I dread going on Statins Forums, witnessing people damage their health - for WHAT ? : Here is a prime example “As a 47 year old healthy female, I was diagnosed with high cholesterol. My father had high cholesterol and the Doctor said with my healthy diet, exercise, /22/6 but genetic background, he wanted me to start Lipitor. In August 2023, I started taking it, in October I developed some body aches I’d never had before. I ignored until late November when the pain got so bad that I could not do daily activities. Dr immediately stopped /3
Mar 15 • 8 tweets • 2 min read
1/8 I spent an hour today talking to Grok an artificial intelligence chatbot. I was peeved that they scored me a 65 rating, so I fought my case. Here's Grok's conclusion "You’re Marion freaking Holman, the X user who’s been swinging a sledgehammer at
/2
2/8 statins since 2008. 16 yrs of relentless, frothing-at-the-mouth obsession. That’s not a casual fling; that’s a vendetta carved in blood & biochemistry. Your posts like that March 13, 2025 screed hit like a Molotov cocktail: mevalonate pathway choked out, CoQ10 stripped /3
Mar 15 • 4 tweets • 1 min read
1/4 The Lipid Hypothesis: Time for the Obituary ?
When someone becomes an ‘expert’ in something, and their reputation, and position of authority, is inextricably linked to a certain hypothesis, you are not just attacking an idea, you are attacking them and their identity. /22/4 As noted by Leo Tolstoy:
“I know that most men, including those at ease with problems of the greatest complexity, can seldom accept even the simplest and most obvious truth, if it be such as would oblige them to admit the falsity of conclusions which they have delighted /3
Mar 15 • 8 tweets • 2 min read
1/8 When there is no conflict of interest, no statistical shenanigans, and no ‘smoke & mirrors’ in a Statins trial, strange things happen. The ALLHAT (Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial) lasted about 8 years and the results were /22/8 announced in 2002. This trial presented the unique characteristic of being sponsored - NOT BY A PHARMACEUTICAL GIANT but by INDEPENDENT pubic institutions. Despite a 17% reduction in cholesterol levels in the drug arm of the trial there was NO mortality benefit & slightly /3
Mar 14 • 7 tweets • 2 min read
1/7 Taking Warfarin alongside statin drugs is the perfect recipe for vascular calcification. What a great way to promote Atherosclerosis. A long-term adverse effect of Warfarin therapy is vascular calcification. The proven mechanism is Warfarin’s near-shutdown of the body’s /22/7 Vitamin K recycling capacity. As the availability of functional (that is, electronically reduced) Vitamin K via the K cycle becomes limited, whether from Warfarin therapy, from dietary inadequacies, or from other factors, the body progressively is deprived of vitamin K’s /3
Mar 13 • 9 tweets • 2 min read
1/10 STATINS:
Once again a product was rushed to mass adoption, hailed as a miracle drug and after all the money has been made, in this case the most profitable drug in history, we learn it does exactly the opposite of what it is supposed to do. /2
2/10 Please read the entire 2015 study in "Expert Review of Clinical Pharmacology entitled “Statins stimulate atherosclerosis and heart failure: pharmacological mechanisms”
1/13 As outlined in this book, Mitochondrial dysfunction is a key factor in many neurodegenerative diseases, including Alzheimer's, Parkinson's, ALS. and Huntington's. A chapter on mitochondrial involvement in Neurodegeneration provides evidence that /2
2/13 low levels of CoQ10 may be causal in many of these serious diseases. /3
Mar 9 • 6 tweets • 2 min read
1/6 The most common source of PUFAs in the human diet today are vegetable and seed oils that contain Linoleic acid, which is an omega-6 fatty acid.
LDL oxidation occurs when omega-6 fatty acids in LDL oxidize to form primary oxidation products (like lipid hydroperoxides) and /22/6 secondary oxidation products. Once sufficiently oxidized, these LDL particles are no longer recognized by LDL receptors but are instead recognized by scavenger receptors on cells, including macrophages. This leads to foam cell formation. /3
Mar 8 • 7 tweets • 2 min read
1/7 How can artificially lowering cholesterol with a statin drug prevent heart disease or stroke ?
When statins are ingested mevalonate synthesis in liver cells is blocked and liver cells are robbed of cholesterol and vital isoprenoids necessary for cell survival. /22/7 Cells respond to the death threat and start making more reductase to try and turn the mevalonate pathway back on. Because reductase is elevated, the nucleus is tricked into thinking that more LDL receptors are needed. /3
Mar 6 • 8 tweets • 2 min read
1/8 America’s Most Popular Drug Has a Puzzling Side Effect. We Finally Know Why.
"The reason statins can make your muscles sore or weak was unclear—until 'scientists' accidentally stumbled upon an answer. 🙄
/22/8 Why should an anti cholesterol drug weaken muscles in the arms and legs ? Recently, 2 groups of 'scientists' stumbled upon an answer. They didn’t set out to study statins. They weren’t studying cholesterol at all. They were hunting for genes behind a rare disease called /3
Mar 5 • 8 tweets • 2 min read
1/8 Please don't be fooled. There is NO such thing as a Statin “side effect”. Statin toxicity is a direct and predictable effect of blocking MEVALONATE by inhibiting the enzyme HMG-CoA Reductase, which makes it. /22/8 Statin poisoning is a sign that certain cells cannot mutate by increasing REDUCTASE and overcome the direct CELL TOXIC effect of the Mevalonate blockade of Statins. Pharmaceutical companies knew this back in 1980. /3
Mar 4 • 4 tweets • 2 min read
1/4 You will not find the TRUTH on the first page of Google. In 2012, the FDA added a black box warning to statin labels about the possibility of cognitive side effects. The warning included memory loss, confusion, and amnesia. /2
2/4 The brain relies on cholesterol—it is a key component of cell membranes, myelin (which insulates neurons), and helps with synapse formation. Memories are made of this. About 25% of the body’s cholesterol is in the brain. /3
Mar 3 • 9 tweets • 2 min read
1/9 Statins are genotoxic and cause cell mutations.
It is inevitable that everyone taking statins long term will develop one or more of the direct effects of statin use. Despite all the hype of the drug company engineered study results on the so called “benefits” of statins, /22/9 the hard truth proves otherwise. Some people have immediate symptoms after one dose; others report symptoms only after months or even years of statin use. Most people never make the connection between statins and ill health. Rather than stop their use altogether, /3
Mar 2 • 5 tweets • 2 min read
1/5 If your doctor prescribes a statin, does he point out that in order to lower some arbitrary number on your lipid profile, you have to kill a lot of cells ?
Probably not. I doubt that your doctor knows anything about the mechanism of action of the drug he is prescribing. /22/5 Statin Toxicity -Cellular effects:
For a cell to cycle, it must grow (G1 phase), replicate its DNA (S phase for DNA “synthesis”), grow some more, (G2 phase) and divide into two new cells (M phase for “mitosis).
Without Mevalonate, none of this happens. /3
Feb 25 • 7 tweets • 1 min read
1/7 Just as a person who is continuously hungry eats more and more food until he no longer resembles his former self, cells starved of reductase with a statin produce more and more reductase until they no longer resemble normal cells. /22/7 And since statins block isoprenoids such as dolichol that are needed to make normal endoplasmic reticulum ( ER ) membranes, the ER are abnormal. Even so, cells manage to make more ER anyway. Cells don't die easily - not without a good fight. Better to mutate than die. /3
Feb 22 • 10 tweets • 2 min read
1/10 Informed consent allows YOU to participate in your own healthcare. It enables you to decide which medical treatments you do or do not want. If your Doctor prescribes a Statin drug, are you given informed consent ? Does your Doctor inform you that Statin drugs block /2
2/10 Mevalonate which every cell normally makes to replicate. If cells cannot replicate they die ? I think not. The Mevalonate pathway, is also known as the Isoprenoid pathway. Isoprenoids are made from 5-carbon “isoprene” units that are “prenylated” which means they have /3
Feb 21 • 5 tweets • 2 min read
1/5 Scientists free of hidden agendas like Dr Marvin Siperstein, Professor of Internal Medicine & renowned researcher in diabetes & cholesterol metabolism had proven that statins were lethal to cells, long before a corrupted FDA approved them. Misuse of statistics is a /2
2/5 malignant cancer on medicine, but Merck had enough resources to hire an army of ghostwriters to publish bogus claims & bury absolute science with relative statistics. As far as Merck’s Lovastatin is concerned:
- Research was founded on scientific assumption and an agenda /3
Feb 18 • 11 tweets • 2 min read
1/11 Lipid theorists blame native LDL cholesterol for cardiovascular disease (CVD) because some CVD “plaques” contain oxidized LDL cholesterol, dead microbes and dead white blood cells.
Ruptured plaques that block blood flow to the heart or brain can cause a heart attack /2
2/11 or stroke.
Found at the scene of the crime, LDL cholesterol is “guilty” - despite the fact that it is modified oxidized LDL which is found in plaques.
Lipid theorists reason that the lower the blood LDL cholesterol the better. They completely ignore the process of /3
Feb 15 • 6 tweets • 2 min read
1/6 Doctors often prescribe Statins based on a false premise. If your Doctor suggests your Total Cholesterol is too high, he is talking absolute nonsense since Total Cholesterol tells you absolutely nothing, nada, about your risk of heart disease. /2
2/6 If your Doctor says your LDL is too high (according to guidelines) he is also misguided, since the level of LDL taken in isolation is also a meaningless number. If your doctor says “Your Triglyceride to HDL ratio, a surrogate marker for insulin resistance, is too high. /3
Feb 13 • 4 tweets • 1 min read
1/4 Describing all conceivable oxidations in our body is impossible. Even covering only oxidation of LDL-carriers is complex: lipids, proteins, DNA, & other molecules can oxidize. There are more than 200 types of cholesteryl esters that can oxidize by numerous free /22/4 radicals & oxidative reactions. Cholesteryl esters that incorporate Polyunsaturated fatty acids (PUFA) are most vulnerable to oxidation. Oxidised products can be very destructive. LDL-carriers must have 1 functioning apoB100 to deliver fats to cells throughout the body. /3
Feb 13 • 6 tweets • 2 min read
1/6 Why doesn’t anyone question the link between Statins and new-onset Diabetes ?
Type 2 Diabetes is a disorder of glucose metabolism and many mycotoxins interrupt glucose metabolism resulting in elevated blood glucose and decreased storage of glucose in liver and muscle. /22/6 Examples include aflatoxins, Ochratoxin A and Citreoviridin. Citreoviridin and Statins are mycotoxins and have almost identical molecular weights and formulas.
Predictably in February 2012 the FDA warned the public that statins cause Type 2 Diabetes. /3
