The TRUTH about Statins, formerly @holmanm
Info is provided for educational purposes only & should not be considered as medical advice. (NO DM's please)
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Jul 2 • 9 tweets • 2 min read
1/9 Have we been misled again ? Do statins need to cross the blood-brain barrier (BBB) to cause cognitive dysfunction, or does their blockade of the mevalonate pathway alone do the job ? I believe the latter, and it’s a serious concern. /22/9 Statins are prescribed to lower cholesterol by inhibiting HMG-CoA reductase, blocking the mevalonate pathway. This doesn’t just reduce cholesterol, it deprives brain cells of mevalonate and its critical products.
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Jul 1 • 4 tweets • 1 min read
1/4 Yes, Astrocytes, specialized brain cells, produce cholesterol locally via the HMG-CoA reductase pathway. The blood brain barrier,(BBB) a tightly regulated network of endothelial cells, effectively prevents lipoprotein-bound cholesterol (LDL or HDL from the liver and diet) /2
2/4 from entering the brain. This isolation ensures the brain maintains its own cholesterol pool, protecting it from fluctuations in blood cholesterol levels.
However, Statins are relatively small organic compounds (MW 390.5–558.6) of natural or synthetic origin, having /3
Jun 27 • 10 tweets • 2 min read
1/10 GLP-1 drugs (Mounjaro, Wegovy, Ozempic) activate GLP-1 and GIP receptors, boosting incretin hormones. This triggers more insulin release when needed, cuts liver glucose production, and slows digestion. Sounds great, but there’s a catch… /2
2/10 Pancreatitis Risk is Serious: These drugs can overstimulate pancreatic cells, causing inflammation (pancreatitis). MHRA confirms 10 UK deaths linked to pancreatitis from these drugs. This is a known class effect, yet the risks feel downplayed. Lives are at stake. /3
Jun 24 • 5 tweets • 1 min read
1/5 Statins are prescribed worldwide and a high percentage of Statin users suffer from adverse effects especially on skeletal muscle. More recently, new onset Diabetes has been reported in subjects on Statin ‘therapy’. The Pro-oxidant effects of statins are known & evidence /22/5 that Statins induce alterations in intracellular calcium homeostasis and mitochondrial dysfunction is clear. It’s not a giant step to conclude that Statin-induced inhibition of mitochondrial respiration leads to oxidative stress that opens a calcium-dependent permeability /3
Jun 23 • 9 tweets • 2 min read
1/9 Statins cause cellular stress (e.g., oxidative stress from statin-induced mitochondrial dysfunction) which can damage DNA, potentially leading to mutations if repair mechanisms fail. It is inevitable that everyone taking statins long term will develop one or more of the /22/9 direct effects of statin use. Despite all the hype of drug company engineered study results on the so called “benefits” of statins, the hard truth proves otherwise. Some people have immediate symptoms after one dose; others report symptoms only after /3
Jun 20 • 5 tweets • 1 min read
1/5 Magic trick - Take statins, choke off the liver cell life cycle so Reductase kicks into overdrive to trick liver cells into mass-producing cholesterol receptors that soak up supposedly "bad" blood cholesterol, most of which the liver normally makes via the mevalonate /22/5 pathway. Cells rely on the mevalonate pathway to produce essential molecules for growth, energy, and survival, making its disruption significant.
Get a blood test and -Eureka ! LDL "bad" cholesterol is lower, just like magic. However, statins block key mevalonate pathway /3
Jun 19 • 6 tweets • 1 min read
1/6 STATINS: THE GRAND ILLUSION: When statins are ingested, the liver absorbs most of the drug, blocking mevalonate synthesis. This deprives liver cells of cholesterol & isoprenoids. Cells respond by increasing reductase to restart mevalonate production as a survival mechanism./2
2/6 Elevated reductase tricks the nucleus into producing more LDL receptors, which pull cholesterol from the blood into liver cells. However, cells remain starved of isoprenoids due to the blocked mevalonate pathway. As cholesterol rises in liver cells via LDL receptors, they /3
Jun 18 • 6 tweets • 1 min read
1/6 No one can deny that Statins do exactly what they are designed to do: suppress cholesterol production and reduce measurable blood serum levels. The question is, rather, at what price do they accomplish this feat, and for what ultimate purpose ? /22/6 With the National Cholesterol Education Program Guidelines, having been designed by "experts" on the payroll of Statin drug manufacturers, requiring ultra-low levels to obtain a strictly theoretical and numerical definition of "health," Statin drugs are guaranteed /3
Jun 17 • 10 tweets • 2 min read
1/10 Statins, like Lipitor, are prescribed to lower cholesterol but can damage the pancreas and liver through well-defined mechanisms. These effects are more common than often acknowledged, impacting critical organ functions. /2
2/10 Pancreatic beta-cell dysfunction: Statins impair beta cells’ ability to produce and release insulin in response to glucose. This disruption in insulin secretion stresses the pancreas and can contribute to type 2 diabetes.
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Jun 16 • 8 tweets • 2 min read
1/8 The diagram below highlights a compelling case that insulin resistance, diabetes, and associated risk factors, such as obesity, hyperinsulinemia, and metabolic syndrome are the true drivers of heart disease, rather than elevated Lp(a) or ApoB levels. /22/8
Jun 16 • 6 tweets • 1 min read
1/6 If your doctor suggests your cholesterol is too high and you need a statin, you need to question the drug's mechanism, which inhibits the enzyme HMG-CoA reductase and blocks the mevalonate pathway critical for cholesterol synthesis.
/22/6 This pathway is vital for producing essential cell components, and its disruption by statins can lead to cell cycle arrest if cells can't compensate.
Statins also up-regulate LDL receptors, potentially forcing cholesterol into organ and muscle cells, which may trigger /3
Jun 14 • 4 tweets • 1 min read
1/4 If credentials equalled wisdom, no cardiologist or doctor would prescribe statins. A drug that inhibits HMG-CoA reductase, depleting cells of vital isoprenoids and coenzyme Q10, essential for cellular energy and survival. /2
2/4 Yet, despite their expertise, many doctors push statins to lower LDL cholesterol, assuming it prevents heart disease. Reality check: people with ultra low LDL still suffer heart attacks. Credentials didn’t foresee that flaw. /3
Jun 13 • 5 tweets • 1 min read
1/5 THE BIG FAT LIE about Cholesterol may well kill millions of people without ever interfering with their rights, their beliefs, or their backgrounds. The cholesterol juggernaut has figuratively rolled over the world’s population and shows how government agencies /22/5 and heart associations, have forced a drastic change in dietary habits with mostly manufactured evidence, and how those dietary changes, along with dangerous drugs such as statins, can cause far more disease, disability, and death than the illness they are supposed /3
Jun 10 • 8 tweets • 2 min read
1/8 Please don't be fooled. There is NO such thing as a Statin “side effect”. Statin toxicity is a direct and predictable effect of blocking MEVALONATE by inhibiting the enzyme HMG-CoA Reductase, which makes it. /22/8 Statin poisoning is a sign that certain cells cannot mutate by increasing REDUCTASE and are unable to overcome the direct CELL TOXIC effect of the Mevalonate blockade of Statins. Pharmaceutical companies knew this back in 1980, but failed to mention this to the FDA. /3
Jun 7 • 10 tweets • 2 min read
1/10 For years people have been led to believe that cholesterol is some kind of evil fatty substance that somehow gets into the bloodstream, where it doesn’t belong, and clogs arteries. Since everyone is being taught to fear cholesterol we should know that cholesterol is /2
2/10 actually a crystal of solid alcohol known as a steroid - specifically a sterol. The word cholesterol comes from Ancient Greek chole- 'bile' stereos 'solid', followed by the chemical suffix -ol for an alcohol. Cholesterol is vital in the membranes of cells /3
Jun 6 • 16 tweets • 3 min read
1/16 I’m more than happy to work with @DoctorTro
on heart health. His dietary advice and focus on preventing heart disease are spot on. But I cannot accept the claim that statins are plaque busters. /2
2/16 It is based on flawed, industry-funded studies that don’t hold up to scientific scrutiny
Statins’ mechanism of action tells a different story. Statins increase blood glucose, cause apoptosis in smooth muscle cells lining the endothelium, damage miochondria, and induce /3
Jun 3 • 4 tweets • 1 min read
1/4 Claiming “no ideological conflicts” is a lazy way to dodge the real debate. The argument over statins isn’t ideology, it’s about their actual effects. Statins block the mevalonate pathway, which doesn’t just lower cholesterol but also starves cells of compounds needed
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2/4 for signaling and membrane health. This can lead to myositis, memory issues, and calcification in arteries that makes heart disease worse. Rosuvastatin, which you seem to like, can still mess with brain cholesterol enough to cause problems like brain fog. /3
Jun 3 • 6 tweets • 2 min read
1/6 @DoctorTro Your tourniquet analogy is a stretch, and honestly, it feels dismissive of the real risks statins pose. Tourniquets are a temporary, external fix to stop bleeding, while statins cause systemic, biochemical changes with long-term consequences like muscle damage, /2
2/6 neurological effects, heart failure, autoimmune issues, and even increased artery calcification. Tourniquets don’t alter cellular pathways or cause widespread cell death, but statins, by depriving cells of mevalonate, can kill cells and lead to serious effects like
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Jun 3 • 8 tweets • 2 min read
1/8 I certainly do have an opinion on this article, because this post highlights the oversimplified advice often given about statins like Rosuvastatin. (Crestor). Suggesting that supplementing with CoQ10 alone can mitigate statin-induced damage is reckless and overlooks the /2
2/8 broader biochemical disruptions these drugs cause. Statins inhibit HMG-CoA reductase, which not only reduces CoQ10 levels but also blocks other essential isoprenoids like dolichol and prenylated proteins. These compounds are vital for cell signaling, membrane integrity, /3
Jun 1 • 4 tweets • 1 min read
1/5 Years ago, my stepsister was prescribed 40mg Lipitor for “high cholesterol” b/c “it runs in the family”. Her dad died of CVD at 53. He smoked, drank heavily, & ate terribly. I warned her statins would harm her. She didn’t listen, fear-driven, and following a low-fat diet. /2
3/5 Fast forward 10 yrs. She’s seeing a neurologist for hand/foot tremors. He says it might be early Parkinson’s. I begged her to stop the statin before it does more harm. Statins can deplete CoQ10, mess with brain function, and may worsen tremors. She still wouldn’t listen. /4
May 31 • 5 tweets • 1 min read
1/5 Statins are widely used to lower cholesterol, but blocking the mevalonate pathway can cause Parkinson’s disease (PD). How does this happen ?
The mevalonate pathway produces more than just cholesterol. It makes CoQ10, FPP, and GGPP. /2
2/5 Statins block this pathway by inhibiting HMG-CoA reductase, reducing these key molecules critical for brain health. CoQ10 is vital for mitochondrial function. Blocking mevalonate lowers CoQ10, causing mitochondrial dysfunction in dopamine neurons./3
