1/7 What happens inside your body when you take a cholesterol lowering drug ? Does that ‘bad’ cholesterol evaporate ? Magically disappear without trace ?
Of course not.
/2 2/7 Once you fully understand the mechanism of action of cholesterol lowering drugs, you will realise that a) you have been played, and b) using cholesterol lowering drugs may cause heart disease but these drugs cannot possibly prevent heart disease.
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1/5 Happy New Year ! 😀 Ezetimibe (Ezetrol) was prescribed to my father 16 years ago. This drug prompted me to research cholesterol lowering drugs. While taking Ezetimibe my father experienced acute pancreatitis leading to hospital admission. Ezetimibe use also resulted in
/2

https://twitter.com/Kevin4Liberty/status/1641406039827312640

2/5 a ruptured tendon, brain fog and dizziness.
I vowed to find out what the hell was going on - and YES, my father’s triglycerides were through the roof after using the drug.
/3

1/9 Most mycotoxins come from 4 species of fungi. Aspergillus, Penicillium, Proteus & Monascus. These same fungal species are used to develop Statins. Statins are secondary fungal metabolites made to kill competing microbes. Statins 'look like' the precursor to Mevalonate /2 2/9 so that Reductase is "tricked" into bonding with the Statin. Reductase in turn is inhibited. The Scientist working on Statins, Akira Endo reasoned that fungi make secondary metabolites that block Reductase, overlooking the fact that cholesterol and Isoprenoids /3

1/11 How adversities become rare:
The drug companies have developed a smart way to minimise the adverse effects of statin treatment. The method is called selection. To be included in a trial the participants must satisfy a long list of criteria. /2 2/11 In most cases about half of those originally chosen for the trial have been excluded because they did not satisfy the selection criteria. All kinds of pre-existent maladies or frailties disqualify a potential participant. Cancer is one of them, but also kidney and /3

1/4 I’m curious. Can BP lowering medications cause more extensive coronary artery calcification ? This is a question (open for debate), not a statement of fact.
Calcium channel blockers are often the first-line medication for lowering blood pressure.
/2 2/4 These drugs prevent calcium ions from entering cell membranes, which allegedly reduces the contraction of smooth muscle cells. However, low endothelial calcium levels in the area of disturbed flow at an arterial
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1/3 A 2015 investigation found that people with particularly low blood pressure and those taking multiple BP medications faced more than double the risk of death compared with others with high blood pressure, highlighting the dangers of over treatment in frail populations. /2 2/3 BP medications are also prescribed to avoid kidney damage. However, some research has suggested that going on BP medication for the long term may do the reverse and actually cause kidney damage. Sound familiar ? /3

1/6 Not all statin "direct effects" are reversible !
Statin Forum : “As a 47 yr old healthy female, I was diagnosed with high cholesterol. My father had high cholesterol and the Doctor said with my healthy diet, exercise, but genetic background, he wanted me to use Lipitor. /2 2/6 In August 2023, I started taking it, in October I developed some body aches I’d never had before. I ignored until late November when the pain got so bad that I could not do daily activities. Doctor immediately stopped the statin. /3

1/4 This week I looked at the Lipid profile of a person using Repatha to lower his LDL cholesterol, while using Jardiance (a medication used to treat T2 Diabetes) in an attempt to counteract the diabetogenic effects of Repatha. /2 2/4 Repatha is a PCSK9 inhibitor. Inhibition of PCSK9 reduces insulin secretion and promotes glucose intolerance, but his doctor doesn’t appear to know this.

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1/4 Cells must modulate cholesterol content to prevent lipid intoxication. Cells can not modulate cholesterol content when Statins up-regulate LDL receptors forcing serum cholesterol into cells until those cells can take no more and undergo apoptosis. /2 2/4 Cells also require Mevalonate to survive. Statins block the Mevalonate Pathway.
The liver eliminates excess cholesterol into the bile. Adipose tissue can store excess cholesterol within lipid droplets. However, muscles need to more finely regulate cholesterol uptake. /3

1/6 Not only are men who are overconfident in their theories or ideas unlikely to discover anything, they are also very poor observers. Indeed, their observation will necessarily be influenced by their preconceived convictions and, when they are the instigator of a trial or /2 2/6 experiment, they are most likely to focus on those results that support their theory. Thus, because they do not point in the desired direction, certain essential facts are often neglected. In 2004 the Clinical Trial regulations were tightened up. Prior to 2004 Statins /3

1/11 Statins are promoted as anti-inflammatory drugs which ‘stabilize’ plaque. In my opinion nothing could be further from the truth. Geranylgeranyl diphosphate (GGPP) is an intermediate in isoprenoid biosynthesis. Isoprenoid compounds are a diverse group of natural products /2 2/11 which are essential components in all cells. Statins induce GGPP depletion via their Mevalonate blockade. GGPP is a vital biochemical necessary for cell survival. /3

1/7 Don't blame Cholesterol for what Hyperinsulinemia/inflammation did.
Insulin has a profound effect on Cholesterol. It turns up the Cholesterol making machinery by turbocharging the activity of the enzyme that actually controls cholesterol manufacturing in your body. /2 2/7 This enzyme is called HMG-CoA Reductase. You can improve your lipid profile by simply lowering your insulin levels. By doing so you avoid all of the serious "direct effects" of taking Statin drugs, and will lower your risk of cardiovascular disease. /3

1/4 Animals will keep eating until they satisfy their protein requirements, so a diet low in protein naturally stimulates overeating. This is why the most effective strategy for reversing Metabolic Syndrome is increasing protein while reducing carbohydrates. /2 2/4 This way of eating tends to stabilize hunger and satiety hormones incredibly well. It also decouples your mitochondria so they become active and eager to burn off energy as heat, increases your lean muscle mass, your metabolism, and your bone density. /3

1/8 When seeking approval for Lovastatin, Merck failed to tell the FDA that in early studies Lovastatin caused cataracts in beagle dogs. Sacrificing safety for profit !
It is obvious how cholesterol lowering drugs adversely affect the eye.

https://twitter.com/markeatsmeat/status/1870187325235372437

2/8 Cholesterol plays an important physiological role in the eye lens, and the need for high cholesterol content is validated by the observation that defects in the cholesterol synthesis pathway and the use of cholesterol-lowering drugs contribute to cataract formation. /3

1/9 Insulin resistance represents a major underlying abnormality driving cardiovascular disease. Statins are not the answer. Statin drugs impair glucose homeostasis and lead to pre-diabetes by decreasing pancreatic β-cell insulin secretion or inducing insulin /2 2/9 resistance of skeletal muscle cells, adipocytes, or hepatocytes. Geranylgeranyl pyrophosphate depletion by statins compromises skeletal muscle insulin sensitivity. CoQ10 lowers blood glucose levels and increases insulin sensitivity by modulating the insulin signaling /3

1/13 People often ask me “If Statin drugs are so toxic and detrimental to health how on earth did they gain approval” ?.
On February 19th 1987, the FDA held an advisory committee meeting to review the NIH clinical guidelines for altering cholesterol with Merck’s new drug, /2 2/13 Lovastatin. The NIH hosted the event at their facility in Bethesda, Maryland. Remarkably, an FDA employee did NOT chair this meeting. Dr Frederick Singer, A Merck Consultant chaired it. If this was a boxing match, Merck was weighted to win. In one corner of the ring /3

1/5 For decades doctors have prescribed Statins in the belief that elevated LDL-Cholesterol is a major risk factor for cardiovascular disease. This is a tragic error. Doctors have failed their patients because LDL-cholesterol is not a “bad” molecule. /2 2/5 However, when LDL-cholesterol becomes oxidized, it becomes a “damaged” molecule that is capable of causing vascular endothelial injury which contributes to atherosclerosis and cardiovascular disease. CoQ10 is an antioxidant that is packaged /3

1/4 Interesting that a Cardiologist acknowledges statins can indeed cause interstitial lung disease which, sadly, has led to the death of this lady's mother.
The fact that statins can induce Interstitial Pneumopathy has been known since November 2009 !
/2

https://twitter.com/LadyDFreedom/status/1868646429604090066

2/4 where it is mentioned in the MHRA product safety information document on statins.
Statins block the production of CoQ10 which can lead to lung diseases such as asthma, COPD, and fibrosis. Low levels of CoQ10 can also lead to increased oxidative damage in the lungs.
/3

1/4 “His ‘miracle’ reprieve from ALS or 'miracle' reprieve from Statins" ?
This is a very lucky man ! He was diagnosed with ALS/ Motor Neurone Disease until doctors discovered that Statin drugs were causal in his condition, at which point they “undiagnosed” him. /2 2/4 What a strange turn of phrase.
“Undiagnosed” generally refers to patients who have undergone tests and neurological examinations, but doctors haven’t been able to find the cause of their symptoms. It is patently obvious that Statins were causal in his condition. /3

1/4 “Pleiotropic effects of Statins may be more hype than real - done by researchers more interested in pleasing pharmaceutical companies for personal gain”
That sounds familiar !
/2 2/4 We hear a lot about the "pleiotropic" effects of Statins, which are actions in addition to lowering cholesterol: These pleiotropic effects are touted as “beneficial”
Is it beneficial to reduce the ability of the body to deal with oxidative stress ? /3

1/8 Statins are derived from mycotoxins. Mycotoxins are neurotoxins. When you ingest a statin you are ingesting a nerve toxin. Cholesterol is an essential component of myelin. Myelin is an insulating layer, or sheath that forms around nerves, including those in the brain /2 2/8 and spinal cord. So when Statins interrupt cholesterol synthesis, essential functions of the nervous system, and by consequence, the body, begin to severely fail. Imagine if your dog chewed through the cord of your vacuum. What happens when you try to use it ? /3