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vittorio Profile picture
@IterIntellectus
May 19, 2025 • 4 tweets • 1 min read • Read on X
it’s happening!

a human was just edited

prime editing (the advanced CRISPR) was used to fix a broken immune system
a teenager with a rare immune disorder just had his DNA rewritten
1/ Image
they removed his stem cells, corrected two missing DNA letters and reimplanted the cells after chemotherapy.
now 66% of his neutrophils function normally.

no major side effects (for now).
this is a world first
2/
caution is still needed, but this is a very promising result Image
source:
nature.com/articles/d4158…

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More from @IterIntellectus

vittorio Profile picture
Dec 29, 2025
your brain doesn't evaluate people on merit
it runs two calculations in 7 seconds: can they help me (warmth) and can they hurt me (competence)
status is the shortcut for both
1/ Image
for more: open.substack.com/pub/iterintell…
dominance built through fear creates fragile hierarchies that collapse under pressure
prestige built through freely-given respect compounds indefinitely. only one survives succession.
3/
Read 18 tweets
vittorio Profile picture
Dec 6, 2025
elon is right that collapsing birth rates are THE existential risk

the problem is that the real cause is not "career" or women or "housing costs"
the uncomfortable truth is that a huge share of people are already biologically sub-fertile and don’t even know it
1/
since the 1970s, global sperm concentration has halved.
HALVED
50% less in 50 years!!!

total sperm count is down SIXTY TWO PERCENT

the decline has accelerated to about 2.6% per year since 2000
this is a species-level signal

2/
on the female side, infertility cases have increased 84% since 1990, doubled in 40 years
more than 110 million women meet clinical infertility criteria now, and the age-standardized rate keeps increasing even after adjusting for population growth.
3/
Read 33 tweets
vittorio Profile picture
Nov 28, 2025
Bret is 80% right, which is the most dangerous level of right. partial truth sticks harder than full error.

few thoughts
1/
yes, remove cost from sex and you uncouple it from bonding
remove bonding from reproduction, you get maternal circuitry firing without children
that energy doesn't vanish and it's redirected to ideologies which become surrogate children and parties surrogate husbands
but these are second-order, the first-order chain is biological:

testosterone decline → reduced male drive → collapse of provisioning → marriage becomes bad deal → women redirect instincts → ideology becomes child
Read 16 tweets
vittorio Profile picture
Nov 27, 2025
you're not having sex anymore. she says she's tired, you feel rejected, she feels pressured. you both think the spark is gone and you're both wrong. here's what's actually happening in your bodies and what you can do about it
1/ Image
for the full essay: open.substack.com/pub/iterintell…
she doesn't want sex, you don't feel appreciated, and you're basically roommates who occasionally argue. you think it's her fault, she thinks it's yours, and therapists keep saying you need better communication. you've tried talking and nothing changed.
2/
Read 22 tweets
vittorio Profile picture
Oct 23, 2025
this was thought impossible just 2 years ago

now, AI built a working calcium ion channel from scratch, a synthetic molecular gate that conducts charge through living cells

this is the first building block of an artificial synapse
1/ Image
for decades, we have only been able to design proteins that folded
but ion selectivity (distinguishing Ca²⁺ from Na⁺) was untouchable
it demands atomic control at ~0.2 Å precision. miss by one atom, and it doesn't work
2/
now the Baker’s lab at the university of Washington just solved it

they used RFdiffusion, a generative deep-learning model that builds protein backbones from geometry

you input a carboxylate ring and get a new membrane channel
3/
Read 10 tweets
vittorio Profile picture
Sep 29, 2025
first cousin marriages double the risk of birth defects, shave ~10 iq points off the offspring, and their ban by the church was one of the biggest drivers of europe’s rise.
but sure, let’s go back to being fucking troglodytes
i severely underestimated how bad things were in the UK
The next obvious step is saying that “marring an 8 years ago girl is encouraged to keep the woman from rebelling since she can be properly disciplined early and can bear enough kids”
Read 4 tweets

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