everything we’ve been told about aging may be wrong

scientists just discovered that the “biological clock” tracking your aging isn’t actually controlling it, it’s just reporting the damage.

the real driver of aging are permanent dna mutations
1/ for years, researchers have treated epigenetic clocks (DNA methylation patterns that correlate with age) as a fundamental driver of aging itself.
the assumption: reset the clock, reset aging.
but what if the clock is just a byproduct of dna damage?
2/

male-only reproduction just happened.

scientists in china created living mice from two fathers. no mother involved

1/ in a new paper published in @CellPressNews, chinese scientists were able to generate bi-paternal mice that developed to adulthood.
but there’s a catch: the mice had growth abnormalities, most didn’t survive, and the ones that did lived shorter lives.
2/

OpenAI new trademark filing
humanoid robots, wearables, VR and all of SaaS - operating system
- cursor
- autonomous agents
- AR and VR

frequent weed smokers have lower brain activation during working memory tasks. and no, the effects don’t go away after a break

1/

https://twitter.com/hubermanlab/status/1886875042098897183

this study analyzed 1003 young adults (22-36 y/o) using MRI scans while they performed cognitive tasks.
heavy cannabis users had significantly lower activation in key brain regions for working memory, including the prefrontal cortex and anterior insula

2/

while DeepSeek R1 is down, they just released a new model, Janus-Pro, for image generation and visual understanding oh boi

1) what

foundational generative models for materials design are here

https://twitter.com/MSFTResearch/status/1879833084356395359

"hey mattergen, generate a room-temperature superconductor"

chat can have hot takes ok, wow

“freedom” is the lie we tell ourselves to feel noble while outsourcing responsibility for our lives to institutions, ideologies, or algorithms

my european mind cannot comprehend americans complaining about healthcare.
don’t they realize the so-called “free healthcare” in europe is a massive scam you pay for with your own money?
sure, you don’t have insurance premiums, but you’re hit with a 60% tax rate to fund an overburdened, inefficient system that fails at even basic care. europe’s “free” healthcare is obviously not free
it’s wildly expensive, just hidden behind layers of bureaucracy.
doctors earn less but the system bleeds money because of waste and inefficiency.
for example, in italy, public healthcare workers rack up over 11,000 sick days annually during flu seasons, leaving patients stranded in understaffed hospitals.
many doctors double-dip with private practices just to survive.

holy shit

a team at EPFL in switzerland just published a paper where they restored walking in people with spinal cord injuries using deep brain stimulation (DBS).

this isn’t just nerves reconnecting. they targeted a new brain region for movement
the results are insane
1/
normally, DBS is used for things like parkinson’s by stimulating motor-related brain areas.

but in this study, researchers targeted the lateral hypothalamus (LH), a region better known for controlling hunger and arousal.

and it WORKED

holy shit, it’s happening.

a new paper in science just presented “evo”, an ai model that learns biology like a language, from single dna mutations to entire genomes. it doesn’t just predict biology; it can design it.

we’re so close to creating new life i can taste it. here’s the short version:
evo is a genomic foundation model with 7 billion parameters trained on 2.7 million genomes. it works like a universal decoder for dna, rna, and proteins—all the ingredients of life.

imagine giving an ai the genome of a bacterium and saying, “improve this.”

evo can.

this is incredible.

for the first time, japanese researchers have successfully treated blindness caused by limbal stem-cell deficiency (lscd) using reprogrammed stem cells.
in a world-first clinical trial, they transplanted sheets of corneal cells derived from human induced pluripotent stem cells (ipscs) onto patients suffering from lscd, a condition that destroys the cornea’s stem cells and leaves people unable to regenerate the corneal surface.

this is crazy, in a new paper they just found two massive medieval cities hidden in the mountains of uzbekistan using drone lidar scanning
one is like 120 hectares at 2000m elevation
historians used to think big cities couldn't exist up in the mountains bc it was too hard to grow food & survive the harsh conditions
i wonder how much history will have to be rewritten in the coming years

a new paper shows how women's brains change during and after pregnancy, and it's so over

they get smarter nature.com/articles/s4159…

what do people even do in a country where the average iq is 60?!
like, how does it function?

https://twitter.com/cremieuxrecueil/status/1831531274172760236

more importantly, how can you even integrate them?
in a country where the average is 100, what do you have them do?

e/acc fashion week wen?

🧵