beowulf888 Profile picture
May 21 16 tweets 7 min read Read on X
20-1/ My pathogen update for epi weeks 17-20 of 2025.

X seems to be shadow-banning my posts ever since I suggested Musk's erratic behavior was due to his ketamine abuse. Oh well. I'll continue to post here. Let me know if you're seeing them. On to the update...
20-2/ US SARS2 wastewater concentrations have dropped to the lowest interwave levels since June 2021. They haven't dropped to June '21 levels yet, but they're continuing to fall everywhere except the West—but the West is at lower levels than the previous two interwave gaps. Image
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20-3/ As of the beginning of May COVID hospitalization rates were the lowest they've been since the start of the pandemic. But SARS-CoV-2 is still circulating. Patients are still testing positive for COVID, while the positivity rates for influenza and RSV have fallen. Image
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20-4/ COVID deaths are down to ~128/week. Of course, these are preliminary numbers, but as they stand, they are lower than those from the 2nd week of March 2020, when the pandemic was just revving up. Image
20-5/ After a big 2o surge in April, Influenza B is exiting the scene. Biofire's proprietary tracking system shows Rhinoviruses are on the rise. Notice that when the rates of COVID fall, RVs rise—and vice versa. No one has explained this pattern yet, but it's held since 2020. Image
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20-6/ LP.8.1x has pushed XEC aside without creating a secondary wave in the US. Image
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20-7/ If previous patterns hold, I suspect we'll see the beginning of a summer wave in the mid-June timeframe. Which variant is a possible candidate to drive a summer wave? Possibly NB.1.8.1. Its numbers are rising. And it's driving a big wave in Hong Kong, Singapore (and China). Image
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20-8/ Here are Hong Kong's wastewater numbers. Notice that HK went half a year without a COVID wave! The rest of the world does not necessarily follow the US pattern of summer and winter waves. There's no reason we have to have a summer wave—but I'm pretty sure we will. Image
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20-9/ Australia has displayed the same biannual wave pattern as the US, and there are indications a new COVID wave is revving up Down Under. New South Wales, its most populous state, shows COVID cases are rising w/ LP.8.1x as a likely driver. Image
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20-10/ It's interesting that while LP.8.1x is unlikely to drive a wave in the US, it's likely to drive a wave in Australia. But they had an XEC wave earlier than we did. Timing seems to play a role in the success of variants (?).
20-11/ In other pathogen news, the US measles outbreak may be slowing. Texas only reported one new case in the past week. The CDC reported 1,024 total cases across 30 states as of May 16.
Measles caused 3 deaths in the US. Image
20-12/ Canada has been hit harder than the US. It's had over 1,800 cases, but no deaths (so far). Image
20-13/ In Mexico, measles has spread beyond Chihuahua into Sonora and Durango, with outbreaks in Tamaulipis and as far south as Campeche. Officially, the case count stands at 421, but it's probably higher. 4 deaths in Mexico, with 3 of them children. Image
20-14/ The WHO has nice map of measles cases across North and South America. The last update was 18 April. They haven't updated it with May's current numbers, yet. Image
20-15/ That's it for this update. Again, let me know if you're seeing these. I see that I'm getting a few likes, but the engagement numbers for my posts are zilch. Serves me right for daring to criticize Elon "Free Speech" Musk.
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More from @beowulf888

Apr 22
16-1/ My pathogen update for epi weeks 15-16 of 2025.
Per Biobot, national SARS2 wastewater concentrations as of 12 April were almost down to the levels of post-Omicron interwave gaps. I suspect they're there now. Image
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16-2/ If patterns hold, SARS2 should maintain this low level of circulation for a few weeks before climbing again in an upward curve. Though previous summer peaks have been late Aug/early Sept, I wouldn't be surprised to see the next wave peak in July or early Aug. We'll see.
16-3/If the trends hold, COVID-19 weekly mortality rates and ED visits will drop below levels of previous interwave gaps in the next few weeks. COVID-19 is still holding on to 14th place as most common cause of death, but I wonder if it won't drop off the top 15 by the end of 25. Image
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Read 14 tweets
Apr 7
14-1/ My pathogen update for epi weeks 13-14 of 2025.

As of 28 March, we're not down to previous interwave SARS2 circulation levels yet—except for the Western region of the US. But the rest of the US should be there by the 3rd week of April. Image
14-2/ COVID hospitalizations, ED visits, and deaths all tracking downward as of two weeks ago. Image
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14-3/ Flu season is receding as well. As with most previous seasons, we've got a long tail of influenza B cases, but they're nowhere near the numbers of influenza A cases. Image
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Read 15 tweets
Mar 25
12-1/ My pathogen update for epi weeks 11-12 of 2025. The XEC COVID wave hasn't fully receded yet. Biobot shows that as of March 15, SARS2 wastewater levels haven't fallen to previous interwave gaps except for the Western region of the US. Image
12-2/ The CDC's ww numbers indicate a long tail for this wave, but it shows the West and NE back to interwave levels. These numbers are all normalized to the previous year's numbers, so I don't know if this long tail may be an artifact of the way they normalize. I trust Biobot. Image
12-3/ If there is a long tail, it's due to the LP.8.1x brood that continues to gain traction against XEC.x. I expected the LP.8.1x's to top out at about 30%, but CoV-Spectrum shows they've reached 50%. O/c, there were only 3 LP.8.1x descendants a month ago. Now there are 19. Image
Read 13 tweets
Mar 11
10-1/ My pathogen update for epi weeks 9-10 of 2025. I'm renaming this a "pathogen update" because SARS-CoV-2 is fading into endemicity. That doesn't mean that COVID-19 won't remain a public health problem, but we've got a bunch of other pathogens that we need to keep our eye on.
10-2/ But speaking of COVID-19, the current wave is receding. Both the CDC's wastewater activity levels and Biobot's wastewater concentration chart show a downward trend in all regions of the US, Image
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10-3/ This XEC wave had the lowest rates of hospitalizations, ED visits, and deaths of any variant wave so far (at least for the US). And rates of test positivity for RSV and Influenza outpaced COVID this respiratory season. Image
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Read 13 tweets
Feb 24
8-1/ My COVID update for epidemiological weeks 7-8 of 2025.

The current COVID wave continues to be the mildest in terms of hospitalizations and mortality since the pandemic began. And it doesn't look like LP.8.1 will break out to boost the current XEC wave. Image
8-2/ The CDC's wastewater survey shows SARS2 numbers are trending downward in all regions except the Midwest. Note: The CDC normalizes these against the previous year, so they don't give us absolute concentrations. Biobot does, but they haven't published an update in past 2 wks. Image
8-3/ While ED visits and deaths due to COVID remain low compared to previous waves, influenza is the respiratory virus causing the most ED visits — although we're probably past the peak for flu cases now. Image
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Read 13 tweets
Feb 11
6-1/ My COVID update for epidemiological weeks 5-6 of 2025.

Biobot's latest wastewater numbers indicate the current XEC wave has receded a bit—but we might see a secondary bump as the numbers level off in West and Midwest, and climb a bit in the South. Image
6-2/ As US COVID waves go, wastewater numbers indicate this has been on the low side, but we don't really know if the viral shedding of JN.1 and its descendants has remained consistent with previous variants. Image
6-3/ When it comes to ED visits, hospitalization, and mortality, this has been the mildest wave ever in the US. But... Image
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Read 11 tweets

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