Share this page!

Enter URL or ID to Unroll

You can paste full URL like: https://x.com/threadreaderapp/status/1644127596119195649
or just the ID like: 1644127596119195649

How to get URL link on X (Twitter) App

  1. On the Twitter thread, click on or icon on the bottom
  2. Click again on or Share Via icon
  3. Click on Copy Link to Tweet
  4. Paste it above and click "Unroll Thread"!
  5. More info at Twitter Help
Brain Inflammation Collaborative Profile picture
@BrainInflCollab
Jun 1 • 5 tweets • 2 min read • Read on X
A new study on COVID-19’s cognitive impact shows:
- 3-point IQ drop for recovered mild cases
- 6-point IQ drop for Long COVID cases
- 9-point IQ drop for ICU patients

Reinfections may worsen the effect, adding a 2-point IQ hit...🧵 ID: Image of a hovering brain in the air as it spontaneously shatters into smaller pieces.
These cognitive deficits, linked to memory, reasoning, and executive function, persist for a year or more in some.

Although a 3-point drop is subtle, akin to mild fatigue, a 6-point loss could make complex tasks noticeably harder.

Read more here:
unmc.edu/healthsecurity…Image
Here is the good news.

These symptoms might not be permanent.

Adam Hampshire, the study’s lead author, explains that the IQ rebound for those with longer-term symptoms “gives us a little bit of hope that those who are struggling with long covid at the moment — when their symptoms eventually resolve — may experience some cognitive recovery.”
Did you notice an IQ drop following COVID?

Did you recover?

Check out TestMyBrain.org, a nonprofit platform offering engaging, science-backed cognitive tests to explore your memory, attention, and reasoning skills.

By participating, you contribute to brain research while receiving personalized results that compare your performance to others in your age group and education level.

It’s an accessible, fun way to establish a cognitive baseline and learn about your mind.
We will be launching our brain fog study soon.

Turn on notifications for details or subscribe to our newsletter using our pinned post.

• • •

Missing some Tweet in this thread? You can try to force a refresh
　

Keep Current with Brain Inflammation Collaborative

Brain Inflammation Collaborative Profile picture

Stay in touch and get notified when new unrolls are available from this author!

Read all threads

This Thread may be Removed Anytime!

PDF

Twitter may remove this content at anytime! Save it as PDF for later use!

Try unrolling a thread yourself!

how to unroll video
  1. Follow @ThreadReaderApp to mention us!

  2. From a Twitter thread mention us with a keyword "unroll"
@threadreaderapp unroll

Practice here first or read more on our help page!

More from @BrainInflCollab

Brain Inflammation Collaborative Profile picture
May 30
An Epstein-Barr Virus (EBV) infection increases your susceptibility to developing multiple sclerosis (MS), among other chronic conditions such as:
- Celiac disease
- Long COVID
- Sjogren's
- ME/CFS
- Lupus
- POTS

A new study might have discovered why (at least for MS)...🧵 ID: Decorative image of virus on a blue green backdrop
A group of Italian researchers discovered that a single copy of the HLA-E*01:01 gene, in addition to a documented history of mono, increases your odds of developing MS by 74%.

The HLA-E*01:01 gene alone did not increase the risk of MS.

This was determined from analyzing 487,114 individuals from the UK BioBank cohort.

Here's what this suggests, in simple terms.

Read more here:
buff.ly/ZEqHmdJ
\ EBV Background:
It's estimated that 90% of the world's adult population is currently infected with the mononucleosis-causing virus (EBV).

Once infected, you're infected for life.

Here is the kicker.

You don't have to have had mono to be infected with EBV.
Read 14 tweets
Brain Inflammation Collaborative Profile picture
May 24
Neuroinflammation can lead to repetitive movements similar to those observed in:
- Obsessive Compulsive Disorder (OCD)
- Autism Spectrum Disorder (ASD)

New evidence suggests it might be (partly) fixable with FDA-approved drugs...🧵 ID: An image of an MRI brain scan with a finger pointing to a specific region near the left rear side of the brain.
South Korean researchers found that two FDA-approved drugs can reverse these repetitive movements:
- Memantine - licensed for Alzherimers
- Interleukin-1RA (Anakinra) - licensed for rheumatoid arthritis

Here are the details... simplified.

.neurosciencenews.com/inflammation-a…
Researchers stimulated neuroinflammation in mice by activating the inflammasome in white blood cells called macrophages.

Thus, the macrophages in the brain (i.e., the microglia) had a hyperactive inflammasome, causing neuroinflammation.

⬆️ inflammasome = ⬆️ inflammation.

While there are different inflammasome types, the NLRP3 inflammasome is highly relevant to humans...
Read 10 tweets
Brain Inflammation Collaborative Profile picture
May 16
Data suggest there is a broken ion channel on the surface of white blood cells in patients with (1):
- Long COVID
- ME/CFS

New evidence suggests it can be fixed.

Here is how...🧵 ID: Cartoon image of a plasma membrane with a cylindrical ion channel embedded among phospholipids.
Research from Dr. Sonya Marshall-Gradisnik in Brisbane, Australia, verified that Long COVID patients, like ME/CFS patients, have a dysfunctional calcium ion channel called TRPM3(1).

The function of this ion channel can be restored with low-dose naltrexone (LDN) in ME/CFS-isolated immune cells (1).

New evidence suggests the same for Long COVID patients (a provisional publication shown in the image).ID: Screenshot of the newly published paper suggesting that LDN can restore the function of an ion channel expressed by natural killer cells of patients with Long COVID.
This ion channel is located on the plasma membrane of cells, where it is highly permeable to Ca2+ (ions).

This means it lets Ca2+ ions into the cell.

These calcium ions play an important role in:
- calcium-dependent signaling pathways
- calcium homeostasis
- cell differentiation
- cell adhesion
- cell division

It also plays an important role in the function of immune cells (1).
Read 7 tweets
Brain Inflammation Collaborative Profile picture
May 10
Want to ensure that NIH grant funding prioritizes medical research for Long COVID?

Here is how you can help...🧵 ID: Decorative image of a different planes of an MRI brain scan on a teal background.
But first, here is the issue.

HHS budget cuts have been recently proposed.

This is important because the HHS budget funds the:
- NIH
- CDC

These cuts likely wouldn't be minor.

A proposed $40 billion HHS cut was made by the current administration, which could slash the NIH budget from $47 billion to $27 billion.

ajmc.com/view/prelimina…
Thus, a massive HHS budget reduction could result in a slashing of the NIH's budget and potentially their Long COVID RECOVER Initiative.

A cut to the RECOVER Initiative could:
- Halt Long COVID research
- Reduce much needed clinical trials
- Have harsh economic and public health impacts
Read 7 tweets
Brain Inflammation Collaborative Profile picture
May 6
Infection-associated chronic conditions and illnesses (IACCIs) affect tens of millions of U.S. citizens (1).

This includes (but is not limited to):
- Chronic Lyme
- Long COVID
- ME/CFS
- MCAS
- POTS
- PANS

Yet there are no cures.

This is why science moves slowly and how to supercharge it...🧵ID: Decorative image of a researcher pointing to a anomaly on a brain scan.
Obviously, many of these IACCIs have experienced decades of underfunding.

But let's set the lack of funding aside and look behind the "biomedical research curtain" so you, the patient, can understand how research works.

This will help you understand the research bottlenecks... and how to fix them.
Finding a cure for an IACCIs means understanding how the disease works at the molecular level.

For example, is there:
- a critical gene being turned off?
- is the protein product of a gene not working?
- is an autoantibody blocking (or activating) a receptor? etc.
Read 16 tweets
Brain Inflammation Collaborative Profile picture
Apr 29
🚨 BIG NEWS 🚨
We are supercharging clinical research on ME/CFS, Long COVID, and other infection-associated chronic conditions by teaming up with:
1. Solve M.E.
2. CareEvolution
3. Complex Disorders Alliance (formerly Metrodora Foundation)
4. ChronicleBio

Here is why this is a win-win for patients...🧵Image
2/ Faster Diagnoses

By pooling decades of patient-reported data, we’re helping doctors better understand ME/CFS, Long COVID, and infection-associated chronic conditions, so patients get answers sooner.
3/ Better Treatments

Our collaboration fuels clinical trials with rich patient data, paving the way for exploring new therapies to ease symptoms and improve lives.
Read 10 tweets

Did Thread Reader help you today?

Support us! We are indie developers!

This site is made by just two indie developers on a laptop doing marketing, support and development! Read more about the story.

Become a Premium Member ($3/month or $30/year) and get exclusive features!

Become Premium

Don't want to be a Premium member but still want to support us?

Make a small donation by buying us coffee ($5) or help with server cost ($10)

Donate via Paypal

Or Donate anonymously using crypto!

Ethereum

0xfe58350B80634f60Fa6Dc149a72b4DFbc17D341E copy

Bitcoin

3ATGMxNzCUFzxpMCHL5sWSt4DVtS8UqXpi copy

Thank you for your support!

Follow Us!

Send Email!

:(