Data suggest there is a broken ion channel on the surface of white blood cells in patients with (1):
- Long COVID
- ME/CFS

New evidence suggests it can be fixed.

Here is how...🧵 Research from Dr. Sonya Marshall-Gradisnik in Brisbane, Australia, verified that Long COVID patients, like ME/CFS patients, have a dysfunctional calcium ion channel called TRPM3(1).

The function of this ion channel can be restored with low-dose naltrexone (LDN) in ME/CFS-isolated immune cells (1).

New evidence suggests the same for Long COVID patients (a provisional publication shown in the image).

Want to ensure that NIH grant funding prioritizes medical research for Long COVID?

Here is how you can help...🧵 But first, here is the issue.

HHS budget cuts have been recently proposed.

This is important because the HHS budget funds the:
- NIH
- CDC

These cuts likely wouldn't be minor.

A proposed $40 billion HHS cut was made by the current administration, which could slash the NIH budget from $47 billion to $27 billion.

ajmc.com/view/prelimina…

Infection-associated chronic conditions and illnesses (IACCIs) affect tens of millions of U.S. citizens (1).

This includes (but is not limited to):
- Chronic Lyme
- Long COVID
- ME/CFS
- MCAS
- POTS
- PANS

Yet there are no cures.

This is why science moves slowly and how to supercharge it...🧵 Obviously, many of these IACCIs have experienced decades of underfunding.

But let's set the lack of funding aside and look behind the "biomedical research curtain" so you, the patient, can understand how research works.

This will help you understand the research bottlenecks... and how to fix them.

🚨 BIG NEWS 🚨
We are supercharging clinical research on ME/CFS, Long COVID, and other infection-associated chronic conditions by teaming up with:
1. Solve M.E.
2. CareEvolution
3. Complex Disorders Alliance (formerly Metrodora Foundation)
4. ChronicleBio

Here is why this is a win-win for patients...🧵 2/ Faster Diagnoses

By pooling decades of patient-reported data, we’re helping doctors better understand ME/CFS, Long COVID, and infection-associated chronic conditions, so patients get answers sooner.

Neuroinflammation is a hallmark of many conditions, including, but not limited to:
- Autoimmune Encephalitis
- Traumatic Brain Injury
- Long COVID
- ME/CFS
- MS
- etc.

This immune cell, at the base of the skull, was found to reduce neuroinflammation.

Here is how...🧵 Harvard scientists discovered that regulatory T cells (Tregs) sitting between the skull and brain (meninges) prevent inflammatory immune cells from entering the brain and making a proinflammatory molecule called interferon-gamma.

This protects against neuroinflammation and short-term memory loss.

Read the study here:
science.org/doi/10.1126/sc…

A recent study "estimated that 5.8 million young people have Long COVID." (1)

Let's put these numbers into perspective...🧵

cbsnews.com/video/millions… It would take about 71 average-sized professional football stadiums to seat 5.8 million children.

To get them there, you’d need 80,556 buses to transport them.

If you lined up each bus from end to end, it would stretch 610 miles, about the distance from Dallas to Denver (or from Munich to Paris for our European friends).

A new study just revealed how psychologically damaging it is to tell a patient that their symptoms are in their head.

Here is what they found...🧵 "More than 80% of [systemic autoimmune rheumatic disease] patients reported that having their symptoms dismissed as... psychological, along with comments like "it's in your head," harmed their self-worth. For 72%, the experience remained upsetting even decades later."

Read more here:
medscape.com/viewarticle/au…

In 2017 Alina Sternberg, a psychiatrist, was hit with crushing fatigue and brain fog.

Neurologists told her the symptoms were caused by depression.

"No, I can enjoy my life and I know what depression is... I’m a psychiatrist!”

It took another long 6 years to discover the culprit...🧵 Alina's symptoms became progressively worse.

By 2023 she spent most of her days in bed.

Not only was she hit with soul-crushing fatigue but her memory deteriorated.

One day she forgot her way home, a place she had lived for 20 years.

One of the biggest discoveries in diagnosing brain inflammation was recently made, and nobody is talking about it.

Here's how it works and why it could be a game changer...🧵 \ The Discovery:
Researchers from the National Institute of Health used positron emission tomography (PET) imaging to measure the activity of an enzyme, COX-2, involved in inflammation.

COX-2 levels are acutly elevated in response to inflammation.

And COX-2 activity contributes to inflammation.

It's the same enzyme that ibuprofen inhibits.

Here's how it works.

67% of 2,314 Long COVID patients surveyed reported symptoms of a dysregulated autonomic nervous system such as:
- A drop in blood pressure when standing
- Brain fog or cognitive disturbances
- Dizziness or light-headedness
- Heartbeat irregularities
- Gastrointestinal issues
- Tingling or numbness
- Bladder dysfunction
- Shortness of breath
- Sleep disturbances
- Chest pain
- Fatigue

This translates to 38 million Americans with Long COVID dysautonomia.

But there is a problem...🧵 "There are only 52 doctors in the US who are board certified in autonomic disorders and fewer than 50 dysautonomia specialty centers throughout the US equipped to diagnose, treat and study dysautonomia."

Read more here:
einpresswire.com/article/570476…

Inhaling this gas has been reported to:
- modulate the immune system
- mitigate oxidative stress
- reduce inflammation

It's been proposed as a COVID-19 treatment(1).

But could it also help those with Long COVID?

(hint: it's not oxygen). High carbon dioxide (CO2) in your blood can be lethal.

But, low levels of CO2 in your blood is also harmful, causing (1):
- increased free radical production
- reduced cerebral blood flow
- worsened inflammation

If this were a healthy brain would light up evenly.

But the brains of Long COVID patients light up in patches...🧵 \ The Discovery:
Researchers from the Department of Nuclear Medicine at Université de Lorraine, in Nancy, France intravenously injected a radioactive tracer in those with Long COVID and healthy controls.

Here is what they found.

Study:
link.springer.com/article/10.100…

Traumatic brain injuries (TBIs) result in an immune response that can become dysregulated leading to neuroinflammation.

Could the first ever licensed treatment for TBI be a nasal spray? 🧵 Harvard scientists evaluated the efficacy of Foralumab in a mouse model of TBI.

This monoclonal antibody, which can bind CD3 and block T cell activation, is currently being tested in human clinical trials for treating MS and Alzheimer's.

sciencedaily.com/releases/2025/…

Pro-inflammatory cytokines, like IL-1b, can cause the neurotoxic buildup of quinolinic acid (QUIN).

QUIN can cause cell death and neuroinflammation that triggers a never-ending loop of even more cell death and more neuroinflammation...🧵 But detecting QUIN in the brain is problematic due to inaccessibility and low concentrations.

That's why the QUIN precursor, kynurenic acid (KYNA), found in the blood is more routinely measured as a proxy for metabolic flux through this QUIN-producing biochemical pathway (the kynurenine pathway).

Study:
buff.ly/62ukC9h

A surprising discovery finds a new mechanism that might explain the way beta-amyloid proteins accumulate in the Alzheimer's brain.

It could be the next big drug target for treating not only Alzheimer's but:
- Parkinson's
- Psoriasis
- Cancer
- Lupus
- etc.

🧵 \ The Discovery:
Researchers from the German Center for Neurodegenerative Diseases (DZNE) found that blocking the NLRP3 inflammasome enhanced the ability of immune cells in the brain (microglia) to phagocytose (eat) amyloid beta proteins.

This suggests that NLRP3 activation might contribute to amyloid beta plaque formation in Alzheimer's disease.

Read the more here:
buff.ly/4i5Fiu7

There is a multi-protein complex that plays a role in a vast number of diseases.

This includes, but is not limited to:
Amyotrophic lateral sclerosis (ALS)
Rheumatoid Arthritis
Sjögren’s
Alzheimer’s
Parkinson’s
Crohn's
Psoriasis
Epilepsy
Lupus
MS

Here is what it is and why there is a race to block it with a drug...🧵 \ Inflammasome:
The inflammasome is a multi-protein complex that (indirectly) activates the proinflammatory cytokines IL-1b and IL-18.

Many human diseases are characterized by high IL-1beta (IL-1b).

Significantly more than previously mentioned.

And blocking IL-1b can improve many disease outcomes.

But IL-1b and IL-18) are different than other pro-inflammatory cytokines...

Over 18 years ago a 26-year-old woman was admitted to the ICU due to inappropriate laughing, paranoia, and combative behavior (psychosis).

The medication she was given did not work and she fell into a coma.

The true cause of her condition led to the discovery of 10 brain diseases...🧵 Her only physical abnormalities, "were mild brain inflammation and a teratoma—a rare kind of germ cell tumor—in her ovary."

Dr. Josep Dalmau and his team began treating the woman with steroids and she soon recovered.

"It dawned on Dalmau that three other young women with similar symptoms referred to him in previous months also had benign ovarian teratomas."

Neuroinflammation is a hallmark of many conditions including, but not limited to:
- Autoimmune encephalitis
- Traumatic Brain Injury
- Long COVID
- ME/CFS
- MS
- etc.

A new discovery finds a gatekeeper of neuroinflammation below the skull ...🧵 Scientists from Harvard discovered that regulatory T cells (Tregs) between the skull and brain (meninges) act as gatekeepers preventing inflammatory immune cells from making interferon-gamma and entering the brain,

These Tregs also protect against inflammation-induced short-term memory loss.

In other words, these Tregs are like nightclub bouncers blocking entry into the brain.

But first, let's back up and explain what Tregs are...

Read the study here:
buff.ly/3CFMTjS

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) can cause:
- post-exertional malaise
- soul-crushing fatigue
- cognitive difficulties
- sleep issues
- sensitivities
- pain
- etc.

A new NIH RECOVER study shows how surprisingly common it is for a SARS-CoV-2 infection to trigger ME/CFS...🧵 According to a new longitudinal study from the NIH RECOVER initiative, a SARS-CoV-2 infection increases your risk of developing ME/CFS by 393%.

Here are the study cliff notes...

Full study:
buff.ly/3CbQqWS

Long COVID in adults is characterized by (protein) markers of:
- inflammation
- blood vessel clotting (thrombosis)

However, similar studies in pediatric cohorts are non-existent... until now.

The following confirms that pediatric Long COVID isn't a mental health condition...🧵 \ The Study:
Scientists from the University of Rome and Fondazione Policlinico Universitario discovered that 34 children and adolescents between the ages of 2 and 18 have an abundance of pro-inflammatory cytokines in their blood.

A subset of the cytokines have angiogenic (blood vessel growth-promoting) properties.

Certain gut bacteria are associated with major depressive disorder in a subset of people.

A new study might have discovered why...🧵 \ The Discovery:
Researchers at Harvard University found that the gut bacteria Morganella morganii enzyme mistakenly incorporates diethanolamine (DEA) into a lipid molecule.

DEA is a molecule found in:
- industrial products
- consumer products
- agricultural products

The DEA-containing lipid molecules are proinflammatory making IL-6.

Read more here: buff.ly/3E8K9fh
Full research study: buff.ly/3E4QiJr