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Richard Lewis Profile picture
@Z3R0Gravitas
Jun 4 • 34 tweets • 13 min read • Read on X
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1/ Overview of my #MEcfs improvements quantified! #PartialRemission #MEcfsEgress

Context: I've had moderate ME for a decade, gradual onset worsening CFS since teens.

tl;dr - major improvement contributors:
- BornFree minerals (half into stage 1).
- Environmental/mold avoidance. Over 2 years of data. Productivity (left vertical axis) and steps (right vertical axis) graphed together with basic annotations (year starts marked). Steps shoot up from a nadir of under 1k per day to around 3k at the start of this year, where they've plateaued. From Pedometer, an app on my phone (I take everywhere). My most accurate step count. This is close to my limit, avoiding mild (same-day) PEM. "Productivity" is (for me) synonymous with having viable cognitive/executive function (my biggest problem) and a lack of physical malaise; I start doing something (semi)useful soon...
2/ More discussion in ALT texts!

Above graph shows most tangible metrics:
• Productivity - almost 2x since pre-Covid1 baseline.
• Step count - up 3x, resuming daily walks (paused a decade).

Down-thread: Improvements in HR rise, FUNCAP, weight... Unroll & blog version at end. Table of contents: - Annotated graph timeline - Pacing not pushing note - Non-24-hour circadian fix - Weight regain - FUNCAP breakdown change - Other improved stats (crash hours, music enjoyment, physical tasks, BMs, gassiness) - Orthostatic intolerance HR & BP rises (POTS/OI). - BornFree protocol, supplements, diet - Mold/environmental avoidance - Personal comments, requests - Tracker sheet overview - Thread reader unroll & blog link
3/ A much more detailed version of the first graph (same 830 day period). I think of my recent history in terms of the landscape of this productivity plot!

More recent improvements dwarf those I made a fuss about in my post-covid analysis threads: I've annotated the starting times of most interventions that I've stuck with, or that had a big temporary effect. Light blue is "good" and orange "bad". The ones I'm sure were most significant are circled. Some uncircled are likely to have been quietly having a major effect over time (eg B9 - folinic acid). Major features are: - Two acute covid infections, with the second plunging me very low for a month or two. - The ozone generator disaster, that left me stuck into the spare loft conversion bedroom (with my original causing me flu symptoms and burning parosmia). - St...
4/ All above annotations are listed in this table. Maybe easier to parse & gives exact dates (splitting some of the labels).

[Sheet linked in image ALT text, for anyone wanting to re-order or search it.] Google docs sheet (shared for anyone with link). Please make a copy of it to re-order it by eg most significant event (highest number): https://docs.google.com/spreadsheets/d/1-iE4QkJljGEttRY2N9lM-tbxQOpWOluKgqHgysCDt9Y/edit?usp=sharing
5/ Quick point: my step count began increasing *before* I started daily walks. Not because of them.

I've never pushed activity/exercise & accommodating to more movement felt quite natural & quick.

I reached a plateau, around 3k steps, I had to back off from (mild PEM). Plotting daily pedometer step count (from phone app) vs step count from just walks outside the house. This shows that my step count had already nearly doubled before I even started going for walks. Just moving more freely. It is a pleasant use of an already extended physical envelope. With advantages for lymphatic stimulation, light exposure (UV, NIR, visible eg circadian effct), mental health wellbeing.
6/ A huge knock-on win has been fixing my #non24-hour circadian rhythm. Held steady for the longest time since university (2008), or before.

Something (minerals, avoidance, antihistamines..?) has let me tolerate melatonin. Not destroying next-day function. Dopamine suppression? Sleep tracking graph. Later times of day go upwards and later dates head rightwards. My norm has been a roughly 16 day cycle; 1-3 hours later each day. My breakfast, dinner and bed times followed steep upward slopes (colloquially a "staircase plot" in the non24 community). "Best effort" attempt to hold my rhythm in place was sleeping on the sofa in the run-up to Christmas (a lot of pressure). And still couldn't quite hold it. The progression abruptly levels off with restarting melatonin, to around the same time every day. Albeit delayed times. Much more manageable! Eg:...
7/ I use the trick of taking melatonin 6h before desired bed (that I suspect might work for DSPS too):

Oddly, the recommended 0.3mg dose still wrecks my next day function and mood. But 3-5mg *or more* is fine.
8/ Weight regained with nutrients and/or mold avoidance? Up from borderline 'underweight': 54kg at 173cm. Without notable dietary changes.

I'd lost 2kg in each acute Covid infection. A further 2kg with worsened fructose intolerance after 1st. Then stuck lower after 2nd (worse). Graph of my body weight in kg measured on digital scales at the same point in my get-up routine, every day. Verses productivity (for context). I eat literally as much as I reasonably can. A high (meat) protein balanced diet with two large dinners per day + small breakfast. But intolerances limit food choices and snacks a lot. Low histamine, oxalate, goitrogen, FODMAP and no yeast, wheat or dairy (repeated reintroduction attempts failed). There's a small increase in weight after B9 + zinc. (Methylation -> cell creation?). That stalls back down with the tumult of sleep-bounce reactions (the...
9/ FUNCAP (function metric) increased from low-moderate to mild? Having been mostly pre-limited by fatigue, weakness & executive dysfunction, more than PEM.

I don't feel the (eg) "being upright" score captures how disabled I still am. And encumbered by my health regiment, etc. Visible app overview of monthly check-in scores for the whole time I've been using them. Executive dysfunction from fatigue, plus daily weakness 'crashes' (after food) had been my main limiters. Kicking in before I can worry about PEM. Which I seemingly only got from physical activities. Not the cognitive ones (that I was able to do). Note that despite moderate functional impairment, my symptom burden has been quite low. For which I'm thankful. When they have kicked in, I've been very motivated to find supplement fixes and accommodations.
Roughly worse to best check-ins, compared side-by side (my image combining). Note that even though I score very high for being upright, I still spend around 2/3rds of my days sat with feet up or laid down. Various other questions fail to get at my issues too.
10/ Also improved:

- 'Crash hours' (when too physically/mentally slumped to function).

Note: my graphing sheet runs a basic statistical correlation between the two sets of data selected. Also with offsets of up to ±5 days, to look for causation. Unsurprisingly strong link here. Correlation scores are 0 to 1, or -1 for negative correlation. ±0.3 is my heuristic for meaningful significance (not taking into account amount of data points compared). Crash hours were originally just the number of hours between breakfast and cooking dinner where I didn't have the executive function for any top-down activities. Or the physical strength. After dinner was assumed to be a write-off. (Could usually watch a show, 30min light reading, social media scroll.) But now I often can function after main meals. Also, I only have a couple hours between breakfast and dinner, due to cir...
11/ Scoring scales & details in [ALT] texts.
- Music enjoyment way up!
- Physical tasks up.
- BMs back to better GI consistency (food additions were also made, eg chia seeds).
- Gassiness trends upwards roughly in line with BM and general improvements (gut biome change?). 'Music joy' clearly trends up with function. Maybe indicating that both are related to improved neurotransmitter function (particularly dopamine and norepinephrine). Qualitatively, I've also been hearing new details of audio texture and lyrics I'd missed for decades. Details: I listen to my usual Spotify playlist of ~3k curated mostly liked songs. Rating scale (highest across day): 1 = can listen to music. 2 = "turn it up". 3 = "hell yeah!" feels, dancing. 4 = very intense emotions (rare), etc.
Physical task examples: 0.3 = putting grocery delivery away; watering all my plants; shaving (although I don't particularly count that now). 0.5 = unload dish washer; very short vacuum clean of kitchen. 1 = shower & hair dry; laundry load (tumble dried); vacuum full kitchen and hall; remove and replace bed sheets (when I had used a bed); weekly Sainsbury's shop (when I used to go). 2 = 2h shopping trip; hospital appointment (being driven). Note that physical tasks went up *as well as* steps (and walks). The big spike was a lot of (ultimately futile) effort to make space to go upstairs for ...
BM = bowel movements. Bristol ratings score recorded, with 4 being the ideal middle ground. Harder stools correlated with slower transit & bloating. Which I thought started after tweaking electrolytes in summer 2023 (with too much sodium salt, then potassium). And maybe TUDCA after that... But! I've only started recording it after consistent problems, which coincides with moving into the more mold affected loft bedroom. So possibly another indicator of that.
Gassiness - is a somewhat subjective rating from 0-2 (in 0.5 increments). More beans were eaten, but the correlation isn't overwhelming. BiomeSight follow-up not run so far this year. To be clear, more flatulence isn't intrinsically better, but seems to correlate with better GI movement. And I've not had a notable issue with gas related bloating.
12/ To assess orthostatic intolerance (borderline POTS), I've been doing a mini-NASA lean test every day I get up from bed.

Pulse rate rises have almost halved, from ~40 to ~20bpm (rebounding a little recently). Data from my Omron pressure cuff. See next graph's ALT text for more comprehensive list of features. But: - Drastic decrease in pulse rate rises imply blood volume increase and/or neurotransmitter (norepinephrine suspected) improvements. - Spike in pulse rate rises in July 2024 potentially from start of potassium. But various other explanations may fit.
13/ Less HR increase on standing. But also slightly higher HR in bed. (Catecholamines up? Bradycardia previously?)

Blood pressure (BP) readings all dipped down after Covid2. Then rose *preceding* insomnia reactions. (Electrolytes, minerals?)

Pulse pressure (PP) unsure meaning. Data exported from my Omron wireless pressure cuff and plotting in a separate spreadsheet. The pulse rate rises, in the previous tweet's graph, were calculated by subtracting the laid down pulse rate (orange) from the stand pulse rate (light blue). Features show: - Decrease in laid and stood systolic BPs after second covid (March 2024) which take most the year to recover upwards. - Small spike in HR rise with Covid 2. - Large 2 month increase in standing pulse rate, and dip in standing systolic pressure, starting in June 2024. Possibly following introduction of supplemental potassium (and ...
I think an immediate drop in pulse pressure is healthy-normal? But mine seemed to have improved from dropping further and being generally lower, both laid and standing.
14/ I started these get-up (from bed) measurements 2 years ago: x.com/Z3R0Gravitas/s… Per @angryhacademic @Naomi_D_Harvey.

Hoping to see if my HR rise would predict productivity that day, per @KatBoniface @hiimchiralkthx: x.com/KatBoniface/st…
@angryhacademic @Naomi_D_Harvey @KatBoniface @hiimchiralkthx 15/ I've held back a couple dozen more graphs for a part 2 thread. They are mostly less decisive, covering:

- More nuanced patterns: symptom burden, sleep, libido, etc.
- Light therapy, NIR.
- Heart rate & HRV trackers: Visible band, Fitbit, Garmin, Welltory.
- Temp, pH, etc..?
@angryhacademic @Naomi_D_Harvey @KatBoniface @hiimchiralkthx 16/ I think the BornFree protocol has a wide applicability to #MEcfs, #LongCovid, etc. As @Joshua_TM says...

... But unfortunately narrow accessibility for now: complex execution, indecipherable info, cost. My overview explainer thread:
@angryhacademic @Naomi_D_Harvey @KatBoniface @hiimchiralkthx 17/ My main inaccessibility: admin off ordering various supplements (internationally) while cost conscious.

So I've been slowly blundering in piecemeal. Not ideal, nor is my current regiment; I've pulled back from many good supp's that wreck my next day
energy & cog' function...
@angryhacademic @Naomi_D_Harvey @KatBoniface @hiimchiralkthx 18/ ... Prioritising electrolytes (always essential), key trace metals that tested low, & generally targeting supps that should optimise norepinephrine (NorE) synthesis. To bootstrap top-down thinking (my weakest link).

A different take to @tamararivc's: x.com/tamararivc/sta… Clip from Joshua Leisk's huge Figure 1 diagram of (mitochondrial) metabolism/dysfunction. Focus on the catecholamine synthesis section: - Substances needed to support Norepinephrine (NorE) production highlighted in green. - Problems caused by low/dysfunctional levels of NorE, etc, highlighted in red (on the right). Mostly autonomic. I'd like to make another thread focusing on this topic. (Maybe discuss the intersection with Tamara Carnac's hypothesis. Ambitious.) Also on all the minerals and testing them.
@angryhacademic @Naomi_D_Harvey @KatBoniface @hiimchiralkthx @tamararivc 19/ Almost everything that's helped me I've tried/failed before, or was still taking! In different forms and lesser amounts.

Here's most of my ~40 supplement current regimen (copy sideways to read easier). BornFree would be 60+ in greater quantities.

Other protocol parts..: DKP - DiPotassium Phosphate LoSalt (2K:1Na) Cal Citrate (g, Ca) Mg Spray (16.5mg/spray) B1 - Bentothiamine B5 - Pantothenic P5P (B6, microspoon) Folinic Acid (mcg) Chromium (1mg) 5-HTP (100mg) Lysine (fingertip) B12 (sprays) Molybdenum (200mcgs) Manganese (mg) Mineral Mix (1g scoop) D-Ribose (5g scoop) BCAAs (1000mg) Mag Orotate (45mg) K2 MK7 (200mcg) D3 + K2 MK-7 (90mcg) Marine Calcium, NOW (250mg Ca) CoQ10 (100mg) PQQ (20mg) Alpha-GPC (300mg) Phos-Serine (100mg) Quercetin (1000mg) Vit-C (1000mg) Bicarb, Sodium (grams) DHM (500mg) Lecithin (grams) Vit A - Retinol Acetate (3mg) Vit-E (0.5...
[See previous image ALT.]
@angryhacademic @Naomi_D_Harvey @KatBoniface @hiimchiralkthx @tamararivc 20/ Lymphatic massage: 2 minute routine, from armpits, down neck, head/face. (Don't feel impact.)

Food: I was already on the low histamine & oxalate + high protein diet (recommended), from past struggles. Also low FODMAP & IgG exclusions:
@angryhacademic @Naomi_D_Harvey @KatBoniface @hiimchiralkthx @tamararivc 21/ I'm pretty sure that I wouldn't have seen such improvements without moving out of my loft conversion bedrooms.

Seems they had a mycotoxin (mold) issue from rotten roof gable ends. Now mostly replaced. Pressure to return, but cleanup is ??? & VOCs *now* elevated, ironically. Green mold/algae growing through the corner of an asbestos soffit (for decades). Replaced in January, with much difficulty dealing with a company not quite willing/able to do full roof work. I also ran out of wearable clothes, having to buy more to cover me (literally) while I figured out a viable washing regiment. At great expense of personal energy, time, resources and lost clothing durability. Intolerance was hard to pin down, with delayed reactions. So having to go by scent/discomfort, that has been hard enough to resolve, but still not covered the whole issue. I'm currently using uns...
Most of the gable end timber was rotten and worse on this side of the dormer roof, adjacent to the spare bedroom I moved into (after ruining the room on the other side with ozone).
@angryhacademic @Naomi_D_Harvey @KatBoniface @hiimchiralkthx @tamararivc 22/ From the timing of the reactions (and slight improvements before) I'm thinking the nutrients I added might have provoked sensitivity, or... Detox?

See big thread on my sleep-bounce insomnia reactions:
@angryhacademic @Naomi_D_Harvey @KatBoniface @hiimchiralkthx @tamararivc 23/ The improvement period mostly wasn't fun; reactions causing/leading to dark hopeless thoughts...

Winter a continuous scramble (without a PC); new capabilities eaten by extra challenges, swamped until April.

My current situation is as tenuous as ever, still stuck on sofa. Graph plotting depression, showing a bit spike in November 2024: - The environmental reactions involve a neurotransmitter roller-coaster, with being wired at night and then depressed during the day. Dark, existential thoughts. - Also, the difficulty of the situation and complications of trying to resolve each little subsequent task were overwhelming. Eating up all additional function out until April.
@angryhacademic @Naomi_D_Harvey @KatBoniface @hiimchiralkthx @tamararivc 24/ A big challenge now is a lack of discretionary time to get big research and things like this done.

I need contiguous chunks, but mostly have only slivers in the whirling merry-go-round of meals. To stay on a 24h rhythm. Extra distractions, with no quiet room of my own ,etc. A rough itinerary of my days, at the moment. With substantial variation in capability, depending mostly on issues with whatever supplement I'm trying to tolerate next. Moderately good day and best case days shown. Mostly, eating my first dinner still wrecks my energy for an hour or few. But breakfast not any more.
@angryhacademic @Naomi_D_Harvey @KatBoniface @hiimchiralkthx @tamararivc 25/ So this mega-post has taken a few weeks to pull together!

Which calls into question posting any of a bunch of other important threads I've been wanting to, for months/years.

Writing this raised more topics - I hoped to dig more into various parts I've crammed in above. Previously planned threads: - Ozone generator disaster - Acute Covid data - BornFree core testing (vits, minerals) - Biomesight (over time) - NHS test history (visualisation, patterns) - BornFree/Josh insights, critique - Simplified protocol info (various) Ongoing/Asking for help: - Mold testing options (personal/environmental) - MCS & laundry sensitivity (progress) New/related: - Part 2 of overview (HR trackers, sleep, etc) - Commenter requests/inspiration..? - More thorough data correlation analysis - Rainfall vs parosmia (and other symptoms) for mold - Urine pH vs eggs/choline (kidney ...
@angryhacademic @Naomi_D_Harvey @KatBoniface @hiimchiralkthx @tamararivc 26/ Anyway, this post is to ask for input as well as report details of success!

Eg: I'm still lost in mold remediation & chemical sensitivities.

Questions welcomed, to decide what I post next. Requests for data too. Or for me to do a quick comparison of specific things.
@angryhacademic @Naomi_D_Harvey @KatBoniface @hiimchiralkthx @tamararivc 27/ My tracking spreadsheet has ~150 data columns, including:
- Separate symptoms
- Foods of interest
- Supplements (almost all)
- Imported data
- Key measures & times manually input
- Diary for context, etc.

I can quickly select any 2 fields to graph and correlate. Zoomed out screenshot of my main tracking sheet. Diary & issue columns hidden. List of columns (data sets): Date Day - [Times] Breakfast Dinner Bed - [Bio] BM time (first) BM Bristol # (ave) BMs (Count) [Diff] BMs (Count) BM Details BM Amount Gassiness (0-2) Pee pre-get-up Sleep (h, total) Main Sleep Nap Temp (ear, get-up) Weight (kg) Urine pH (sticks) Urine cloudy - [Function] Crash hours Productivity Physical Tasks Walkies (steps) Bike Ride (min) Music Joy (0-4) Gaming (h) Outside light (h) NIR use (min) NIR places Lymph drain Nasal Rinse Ear clean (outer) M (Libido) Shower Sainsbury...
Graph of total cells in each row (each day) with some data entered. Line ramps up from 50 to 150 over the 830 day period. A jump up occurs in December 2023 with the addition of all the supplement amounts (temporary dip during Covid2 is failure to record these). Continuation of ALT text for previous image; Main sheet column headers, starting with the remaining symptoms: Eye twitch (fasc 2) Wrist pain (thyroid) Eye defocus - [Foods] OATs (Poridge) Breakfast Fruit Chia Seeds (grams) Egg Peas Nuts (Macadamia, etc) Beans (Lima/Black) Spring Onions Brown Rice Seeds Water Chestnuts Thyme Salad ...
28/ All the above info is duplicated on my newly organised health blog (ALT text as image captions): zerogravitashealth.blogspot.com/2025/05/mecfs-…

Thread reader unroll (lacks ALT text): x.com/threadreaderap…
Tagging... Renegade Researchers & adjacent: @RenegadeRes @remissionbiome @tessfalor @IsabelRamirezRD @Really_Richelle @KatBoniface @NovaSupport @SplendidSpeseia @TaraFotiPhD @Fighting_LC @Canal1point5 @emmiskyten @TopazStudiosCOM @sunsopeningband @doc4care @RenzPolster
@arta_semita @LongHaulerBear @ThosVarley

Data nerds (quick analysis suggestions and data sharing welcome): @wecrunchme @RorPreston @JackHadfield14 @HarryLeeming @visible_health

Some twitter-active BornFree types: @joshual_tm @RachelO87357156 @noralove
Boffins (who've helped me 🙏): @exceedhergrasp1 @MarekSJF @lifeanalytics @JeffLubell_C19 @Vickyvdtogt @renesugar @AllyTransforms @SEPfieldPatient @KinSpin @8Eevert @arisonsned @arianek @PanickedFoodie @emily_rj @internetuserf12 @MeredithWTS @DiamonDie @CortJohnson @jenbrea
Mates & general interest (sorry I've been haphazard): @HoagieHoag @davro_t @Loster @mc_cheapo @PlanetEarth_HD @elle_carnitine @Nick_Wellings @cfs_jo @Annakwood @subversivepsych @KSchnickelfritz @IleanaNaish @PaulRKeeble @BottsieHicks @TomKindlon @Gmwetz @MatthewJDalby ...
@Dan_Wyke @laurenancona @ahandvanish @FatigueMe92484
Mold/environmental toxin experts/experienced, etc: @julierehmeyer @scott_scientist @dr_todd @x3r0gx4 @SamRNolen @chydorina @irishiker @Yrrepmot @crispychipp..? Sorry, I should know more.

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More from @Z3R0Gravitas

Richard Lewis Profile picture
Jul 10
1/ My highlights from the very well run webinar of @PatientLed funded study results on #MEcfs & #LongCovid.

Interesting patient directed funding + colab design. But I've focused more on science titbits. See also @IsabelRamirezRD live-tweeted thread via:
@patientled @IsabelRamirezRD 2/ Braeden Charlton - Long COVID & MEcfs:
- Poor oxygen extraction, earlier lactate (& steeper HR slopes).
- Retain muscle mass vs deconditioning = severe atrophy.
- Poor mitochondrial function vs deconditioning = loss of mitochondria.
- Basement membrane thicker (biomarker?). Presentation slide showing differences between patients, controls and deconditioned subjects.
Presentation slide about upcoming projects. Hints about thicker basement membrane (or muscle tissue) and narrower lumen (of eg mciro-vasculature?) came up as a question afterwards.
@patientled @IsabelRamirezRD 3/ Dr. Caroline Dalton - Microclots:
- Recently infected have my clots than patients without problems.
- Counts normally take ~1 year to fade.
- Only half of LC show high counts (not sensitive marker).
- Meds reduce clots, but often not symptoms.
- Clots indicate inflammation. Image
Read 14 tweets
Richard Lewis Profile picture
Dec 10, 2024
Insights on my new symptoms please!?🙏

Mostly: environmentally triggered sleep transition glitch - something pushes me firmly away from the moment of unconsciousness, etc.

Low on room options, clothes, sanity! Unsure how much is mold/chemicals/dust (& supps). Overwhelmed…
1/n Image
… trying to figure/arrange many things. Awkwardly living, day-sleeping, on my parent's sofa for a month. Worried about losing this refuge.

Any thoughts/questions welcome, even if covered in my kitchen sink information approach, below. (Getting things straight for me too.)
2/n • Details of symptoms: - Reaction - Go to bed fine & sleepy, but instead of (usually quick) nodding off, I get pushed back from that transition. With varying co-symptoms. Or at minimum woken an hour or few later. Overly alert, then very fatigued and miserable later (sleep loss + neurotransmitter swing?). - Urine production and GI movements sped up 2-3 times right after sleep-glitch (without diarrhoea). Several toilet visits during expected sleep time. - Resting heart rate ramps up (55 -> 70bpm ish). Sustained for a day, declining over a few. But standing up HR is not much higher (than usua...
Full details in ALT texts. In short:
• Sleepy *then* wired after bounce.
• Kidneys & GI overdrive (weight OK).
• Reclined heart rate up ~20bpm.
• Internal vibrations (proportional).
• Lip numbness (brief, slight).
• Overactive then exhausted, miserable.
• Parosmia.
3/n - Internal vibrations. Mild afterwards (electrolyte gradients?). Or in the worse case, briefly intense acutely in chest/neck/head during build up to an unconsciousness rebound (repeatedly). - Sometimes: briefly numb lower lip and/or pre-mouth ulcer lumps pop up a bit in cheeks. (Hypoxia, viral activation?) - Energy and motivation initially up (wired, agitated & snappy at worse) but then fatigued and awful later if no sleep. Some dark/hopeless thoughts. - Weight - lost 1kg over first week (half regained). But often weigh in just as heavy in morning after increased urination. (So sometimes re...
Read 20 tweets
Richard Lewis Profile picture
Oct 14, 2024
My notes on @KatBoniface's @RenegadeRes lightning talk. YT vid linked below. Covers:
• #Glutamate (Glu) dysfunction types: excitotoxicity vs hypometabolism.
• Glu transporters (GLAST, GLT-1), aspartate.
• Causes: #TBI, #LC, etc.
• Relation to #ADHD, #autism, not epilepsy.
1/n
Glutamate (Glu) researched for 30 years in #MEcfs & related diseases.

Main focus on excess release = high inter-synaptic levels -> excitotoxicity.

Which causes cell death and hypersensitivity symptoms.
2/n
Glutamate is a key regulator of metabolic & immune functions.

Glu used as fuel by glial brain cells that recycle it for neurons.
3/n
Read 17 tweets
Richard Lewis Profile picture
Jul 4, 2024
High level BornFree overview: it's ultra-detailed functional medicine fundamentalism.

• Stage 0: cellular nutrient status assessment - unconventional tests for what's actually in tissue (Oligoscan, CMA, OAT, HTMA).

This modulates a dozen supplement levels, y/n on a few.
1/n
• Stage 1: "remineralisation" is patching up the serious deficiencies we all have, in order from most fundamental/dangerous, like electrolytes up the B-vits trace minerals you've not heard of.

Complex diagrams show where these break/fix key cellular energy, etc, pathways.
2/n
This groundwork supports bodily resilience to weather pathogen die-off, etc:

• Stage 2: beating back biofilms. Primarily in gut, but also importantly nasopharynx, skin, all orifices! Overall burden.

Mostly custom made 'antiseptics', but more probiotics in future.
3/n
Read 25 tweets
Richard Lewis Profile picture
Mar 15, 2024
I just made my first ever batch of DrT inspired, Myhill recipe flax/linseed 'buns'. 😀🍞
1/n

Image
Image
Not sure if I cooked them long enough or too long. Still a little moist in the middle, not sure how well they'll keep?

Bland, but not bad tasting. Could do with something on them. Not sure what (given my HIT, etc). Maybe just eat them with my quick stewed dinners.
2/n Image
I tried a mix of golden and brown linseeds (no bigger packs in Sainsbury's app). Don't think it matters much.

Food processor failed to have any effect on them. 😅 But the basic blender managed, thankfully. With some persuasion.
3/n
Image
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Read 12 tweets
Richard Lewis Profile picture
Mar 7, 2024
Alcohol intolerance in #MEcfs, #LongCovid:

The #ALDH enzymes, that preferentially detoxify ethanol via #acetaldehyde, also degrade histamine! After either DAO (gut) or HNMT then MAO (liver, kidneys).

A major focus of @joshual_tm's BornFree protocol is inadequate ALDH…
1/n 🧵
Crop with my yellow highlights from Joshua Leisk's big metabolism diagram, available here: https://bornfree.life/understanding-the-model/6/updated-disease-model-wip/45/ Shows the two histamine degradation pathways, both requiring ALDH enzymes. Also co-factors of magnesium, zinc, NADH (B3). Before that FAD (B2) and methyl donation from SAMe for HNMT.
… And excess acetaldehyde, from fungus (candida) and gut bacteria. From die-off or just downstream of eating.
2/n HERXHEIMER / DIE-OFF / ACETALDEHYDE SUPPORT Acetaldehyde is one of the primary toxins released during microbial die-off events and also in smaller amounts, multiple times per day, in response to normal dietary intake of nutrients. Our food intake also feeds our resident microorganisms -including the pathogenic species which allows them to produce (toxic) metabolites and poison us downstream of each meal.
ALDH enzymes are critical to many (!) important processes we #pwME tend to have problems with:

• Synthesis: collagen, carnitine.
• Metabolism: GABA, glycolysis, pyruvate, choline, methylation.
• Degredation: fatty acids.
• Detoxification: vit-A, B6, lysine ethanol...
3/n Acetaldehyde potentially places a difficult burden on our metabolism in key places - histamine degradation, neurotransmitter degradation, collagen synthesis, carnitine synthesis (needed to transport longer chain fatty acids), fatty acid degradation, glucose transport and glycolysis, GABA metabolism, choline metabolism, methylation, Vitamin B6 degradation, Vitamin A degradation, lysine degradation, pyruvate metabolism and other pathways. Aldehyde dehydrogenase enzymes (ALDH2, 1A1, 1A2, etc) detoxify acetaldehyde into acetate as a priority over their normal substrates. Having low...
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