Crémieux Profile picture
Jun 16 4 tweets 1 min read Read on X
Yet another grooming gang profile has been released.

The suspects were almost two-thirds Pakistani. Image
This lines up with the findings of several earlier operations:

This also lines up with a more comprehensive investigation:

Whenever you look systematically, the reality is clear: Britain's rape gangs are overwhelmingly Pakistani.

Source: politicsuk.com/wp-content/upl…

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More from @cremieuxrecueil

Jun 16
Novo Nordisk failed to pay a small patent maintenance fee in Canada a few years ago.

As a result, a generic version of Ozempic will be available there soon.

The HHS can exploit this oversight to decisively end the chronic disease crisis, if it has the courage🧵 Image
First, a bit of background.

Novo Nordisk is a pharmaceutical company that makes drugs for diabetes.

The blockbuster drug that turned them into a major pharma player is semaglutide, which they sell under the brand names Wegovy, Ozempic, and Rybelsus. Image
Semaglutide has been amazingly successful.

It greatly assists in the management of diabetes, and it causes major weight loss with minimal side effects for most.

Its utility for treating obesity is somewhere between an earlier daily version (liraglutide) and bariatric surgery. Image
Read 26 tweets
Jun 14
One of the reasons I'm bullish on Eli Lilly over Novo Nordisk is that I don't think Novo can hack it against a much more R&D-focused American company run by a shrewd corporate climber.

Novo seems like its leadership is much more naïve. Image
Eli Lilly's investments just seem to be superior to Novo's, which have mostly been falling through recently.

The best Novo seems capable of doing now is mimicking Eli Lilly's next drug, retatrutide.

If they were smart, they would do some collaborations.

But I am a believer in something like a Great Man theory of business success.

There's lots of evidence for it. For example, when high-earning business owners die, the profits of their businesses drop right away.

Turns out, they were compensated for real value to the business. Image
Read 5 tweets
Jun 13
Companies are rapidly improving on GLP-1 weight loss.

Regeneron just paired semaglutide (Ozempic/Wegovy) with a myostatin inhibitor and the result was...

- More fat loss
- Less muscle loss Image
The problem is that adding things to GLP-1RA treatment might lead to more side effects and worse adherence as a result.

But that seems to not be a concern with a low-dose myostatin inhibitor: added side effects only become concerning with more advanced treatment. Image
The weight loss that comes with using GLP-1RAs is already similar to normal weight loss compositionally.

These new drugs thus present with an interesting prospect: that pharmacotherapy-driven weight loss will soon be superior to normal weight loss!Image
Read 8 tweets
Jun 4
This 91 vs 103 thing is either ignorance or chicanery.

The issue has been explained to him multiple times, but TL;DR:

(1) The standardized difference is still the same 1 SD its always been, (2) IQ does not have a ratio scale, (3) the population hasn't gotten smarter. Image
If you want to understand this error, I have material aplenty for you.

First, on the issue of rescaling differences, here's a post:
Second, on the issue of the scale of the gap, as of 2023, it had not shrunken from where it stood in World War I: cremieux.xyz/p/the-state-of…
Read 8 tweets
Jun 4
The Wall Street Journal just published the FDA's Opinion piece-length rationale for banning talc.

I was happy to see they were citing studies, but after I read the studies, I was dismayed:

The FDA fell victim to bad science, and they might ban talcum powder because of it!

🧵 Image
The evidence cited in the article is

- A 2019 meta-analysis
- A review by the International Agency for Research on Cancer (IARC)
- A 2019 cohort study from Taiwan

Let's go through each of these and see if the FDA's evidence holds water. Image
The first piece of evidence they cite is a meta-analysis, and it's a doozy.

The study includes 27 estimates of the observational association between talc use and ovarian cancer rates.

Three estimates come from cohort studies. Those are fine. The problem is the 24 other studies.
Read 42 tweets
Jun 3
Let's make this even clearer.

The severity of COVID vaccine-related myocarditis was far lower than the severity of COVID-related myocarditis, which instead looked like regular viral myocarditis.

You can see this in many cohorts. For example, this was seen in France: Image
This result replicates everywhere it's tested.

We knew this from the initial small studies... Image
Image
And we knew this based on somewhat larger Scandinavian register-based work as well

Do note, however, that the Scandinavian work had a poor case definition for infection-driven myocarditis compared to other cohorts. As the long-term study linked in the QT shows, they missed most Image
Read 22 tweets

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