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Vipin M. Vashishtha Profile picture
@vipintukur
Jun 18 • 2 tweets • 2 min read • Read on X
A NEW study showed that pre-treatment with NMDA receptor blockers #memantine or #ifenprodil reduced brain inflammation in the pons and medulla and significantly improved survival after SARS‑CoV‑2 infection. 1/ Image
These findings support further exploration of NMDA antagonist drugs like memantin which is already used in elderly neurological patients, as a possible neuroprotective therapy against COVID-related neurological damage. 2/2

nature.com/articles/s4159…Image
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More from @vipintukur

Vipin M. Vashishtha Profile picture
Jun 19
I think, therefore I age!

As people get older, a growing population of cells starts to consume more energy — perhaps because the cells accumulate damage that leads them to rev up processes such as inflammation. 1/ Image
An emerging hypothesis suggests that the brain accommodates these energy-hogging ‘senescent cells’ by stripping resources from other biological processes, which ultimately results in outward signs of ageing, such as greying hair or a reduction in muscle mass. 2/
It’s one example of a growing understanding of how our brains control ageing and how psychological stress can accelerate the process at a molecular level. 3/ Image
Read 5 tweets
Vipin M. Vashishtha Profile picture
Jun 17
A NEW study found that the SARS-CoV-2 nonstructural protein 15 (nsp15) helps the virus hide from the immune system in human lung and nasal cells. The nsp15 endoribonuclease is important in promoting virus replication and influencing disease severity. 1/ Image
SARS2 variants lacking this activity exhibit impaired replication & cause milder disease, highlighting nsp15 as a key virulence factor. This underscores the importance of nsp15’s endoribonuclease activity in both promoting virus replication & influencing disease severity. 2/ Image
The viral variants lacking nsp15 endoribonuclease activity elicited higher innate immune responses and exhibited reduced replication in human stem cell–derived lung alveolar type II epithelial cells, as well as in the lungs of infected hamsters. 3/ Image
Read 5 tweets
Vipin M. Vashishtha Profile picture
Jun 16
Researchers developed a 23-amino acid peptide that mimics ACE2 and effectively binds the SARS-CoV-2 spike protein, preventing viral entry. 1/ Image
The peptide demonstrated potent antiviral activity against both the original and Omicron strains, with a therapeutic index greater than 20, indicating strong potential for therapeutic use. 2/ Image
Moreover, future viruses from this family of coronaviruses may likely use ACE2 as their host cell receptor, as recently demonstrated in the MERS Virus of bats and, therefore, the ACE2 decoy therapeutic may have future applications as well. 3/ Image
Read 4 tweets
Vipin M. Vashishtha Profile picture
Jun 5
A NEW preprint found that submaximal exercise in people with #LongCOVID caused large microclots to fragment into smaller microclots and this then triggered increases in inflammatory and vascular injury markers. 1/ Image
The breakdown of large microclots, rather than clearing them from circulation, was linked to reduced oxygen uptake and heightened inflammation. 2/ Image
The data suggest that while the immune system tries to control inflammation caused by microclot fragmentation after physical exertion, its compensatory mechanisms are inadequate or failing. 3/ Image
Read 6 tweets
Vipin M. Vashishtha Profile picture
Jun 2
Globally, NB.1.8.1 is now the dominant variant. The WHO has issued a warning about rising COVID-19 activity in the Western Pacific, Southeast Asia, and Eastern Mediterranean, driven by NB.1.8.1 this week.

H/T: @RajlabN Image
Classified as a "variant under monitoring" by the WHO & “ Nimbus” by @TRyanGregory, NB.1.8.1 has triggered a seventh consecutive week of surges in Southeast Asia. Taiwan has seen ER visits double again this week. 2/

focustaiwan.tw/society/202505…
@TRyanGregory China is reporting widespread infections with NB.1.8.1 causing severe throat pain described as “razor blade throat.”

However, the #Nimbus aka NB.1.8.1 wave in Hong Kong and Singapore may have peaked. 3/ Image
Read 7 tweets
Vipin M. Vashishtha Profile picture
May 31
The relationship between the gut and #LongCOVID:

Researchers found that people with LongCOVID fatigue have damaged gut barriers & signs of immune activation.

Preexisting gastrointestinal symptoms before COVID infection predisposed people to developing LongCOVID fatigue. 1/ Image
LongCOVID patients were found to have an increased LBP/sCD14 ratio & lower IL-33 levels, which indicates altered immune activation & a reduced intestinal barrier. In addition, there were increased IL-6 levels, which are considered a marker for systemic inflammation. 2/ Image
LBP/sCD14 is the ratio of lipopolysaccharide binding protein to soluble CD14.

This study emphasizes the impact of SARS-CoV-2 infection on the gut, which might be associated with the onset of Fatigue seen in LongCovid patients. 3/ Image
Read 4 tweets

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