Michael Morelli Profile picture
Jun 25, 2025 16 tweets 5 min read Read on X
The only FDA-approved peptide:

Tesamorelin.

It forces your body to produce growth hormone naturally, melts visceral fat & boosts brain function.

Here are its wild benefits (& the science behind them): 🧵
Image
First, what is Tesamorelin?

It’s a GHRH peptide that signals your pituitary to increase natural growth hormone by up to 2–3x.

Unlike synthetic GH (which shuts down your own supply) Tesamorelin enhances output without suppression:
Why this matters ?

When you inject growth hormone directly, your pituitary says "we have enough" and stops working.

Tesamorelin does the opposite - it makes your pituitary work HARDER to produce its own growth hormone: Image
Benefit No. 1: Destroys belly fat

Studies show 15-25% reduction in abdominal fat, including the dangerous visceral fat around your organs.

This isn't just surface fat - it's the deep metabolic fat that causes disease:
Benefit No. 2: Increases IGF-1

IGF-1 is the most anabolic substance your body produces.

Higher IGF-1 = faster muscle growth, better recovery, increased metabolism.

Your body becomes a fat-burning, muscle-building machine: Image
Benefit No. 3: Better sleep quality

Growth hormone is released during deep sleep cycles.

Tesamorelin enhances this natural process, leading to deeper, more restorative sleep.

You wake up actually refreshed: Image
Benefit No. 4: Mental clarity boost

Studies show GH can improve memory recall by up to 20% and enhance cognitive speed.

Tesamorelin increases IGF-1, which supports neuroplasticity and protects against age-related decline.
Benefit No. 5: Enhanced recovery

Whether it's from workouts or daily stress, Tesamorelin accelerates tissue repair.

Muscles rebuild faster, injuries heal quicker, you bounce back from everything: Image
Benefit No. 6: Improves cardiovascular markers

Tesamorelin has been shown to reduce triglycerides and C-reactive protein (CRP), lowering inflammation & supporting heart health

Especially in people with high visceral fat: Image
Benefit No. 7: Reduces liver fat

Clinical studies show Tesamorelin can significantly reduce liver fat (NAFLD), which is common in people with metabolic syndrome.

A healthier liver = better energy, digestion & hormone regulation: Image
A few more tips:

Cycling is crucial:
• 16-30 week cycles maximum.
• Take 2-3 months off between cycles.

Long-term use can affect insulin sensitivity and blood glucose levels.
When you'll feel it?

Week 6-10 is when most people notice significant changes.

Better sleep starts earlier, but fat loss and muscle gains take time.

Second cycle feels faster because your pituitary is already "awakened."
⚠️ WARNING: Monitor your blood sugar ⚠️

Tesamorelin can reduce insulin sensitivity in some users.

Watch for rising fasting glucose (if it climbs from 85–90 to over 100, stop immediately)

Get full bloodwork (glucose, insulin, HbA1c) every 12 weeks to stay safe and optimized.
Who shouldn’t use it:

• Pre-diabetics or diabetics without close medical supervision
• Anyone unwilling to track blood sugar and run labs regularly
• People expecting results without fixing sleep, diet, or training first
Want to learn everything about peptides & how to benefit from them?

Follow @realpeptides on X (endless educational content and exclusive giveaways are coming soon)

The most premium, science-backed account on the platform. Image
If you enjoyed this thread and want more like it, retweet the first post & follow me @morellifit for more.

See you on the next one!

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More from @morellifit

Feb 3
Standard labs miss what kills you.

Here are the 9 biomarkers that predict lifespan, disease risk & how your body ages:

1. ApoB (True Heart Disease Risk) Image
Standard cholesterol tests measure LDL.

But ApoB measures the actual number of atherogenic particles in your blood.

High ApoB = high cardiovascular risk, even if your LDL looks "normal."

This is the number that actually predicts heart attacks. Image
2. hs-CRP → Chronic Inflammation

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I saved my brother’s life.

He was obese, had chest pains & our mother thought we were losing him.

So I moved in with him & helped him drop 52 lbs in 90 days (steal the exact protocol): Image
The first and most important thing you need to focus on to lose weight?

Your diet.

The meal plan we used:
⤑ 3 meals a day, spaced 5 hours apart.

PS. We ate whole foods, stayed in a deficit & never mixed fats with carbs:
For lunch, we kept it simple:

• Lean protein (salmon, chicken +)
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• Healthy fats (avocado, eggs, etc.)

Dinner looked like this:
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The goal was fat loss without starving or burning out (something all of you need to copy):
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Jan 19
I’ve been testing peptides for over 5 years...

So here are the top 5 fat-loss peptides that helped me get more shredded than your favorite Hollywood star at 44:

1.Retatrutide Image
A next-generation peptide that targets three hormones (GLP-1, GIP & glucagon) at the same time.

It helps reduce hunger, improves blood sugar control & increases fat burning.

Phase 3 trials showed up to ~28% bodyweight loss (one of the highest results ever recorded in obesity treatment):
With Retatrutide (0.6mg every other day, guided by labs), I went from 178.7 lbs at 11.9% body fat to 172.8 lbs at 7.2% (dropping ~9 lbs of fat while gaining 1.5 lbs of muscle)

With no starving or suffering: Image
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Jan 7
If you’re overweight and want to lose belly fat in 2026…

Here’s the exact 11-step protocol to drop 20+ lbs in 90 days (without starving):

Step 1: The 3x5 Diet
3 meals per day. 5 hours apart. No snacking.

Breakfast + lunch: protein, veggies, fats (no carbs).
Dinner: protein, veggies, carbs (no fats).

Avoid fats and carbs in the same meal (this helps prevent insulin spikes that lead to fat storage).
Step 2: Protein First (Always)

Protein keeps you full longer.

When you eat protein first, then veggies, then fats or carbs last, you naturally eat less without forcing it.

PS: Aim for 1g of protein per pound of bodyweight per day.
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Dec 28, 2025
In 2025 you ate 40+ credit cards worth of plastic.

These microplastics sit inside your body (heart, brain, testicles) & are linked to 10+ deadly diseases.

In this thread, I'll show you the only proven ways to detox them & how to avoid the hidden sources you're exposed to daily:
Microplastics have been linked to 20+ diseases – including cancer, 4–5× higher heart attack risk, and gut–brain damage.

Around 80% of us are already contaminated, so let’s start with the best way to stay safe: lifestyle changes (then we’ll cover how to detox a portion of them):
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• Plastic cutting boards
• Plastic bottles
• Glass bottles (yes, they can contain microplastics too – read till the end to see how)
• Plastic coffee cups
• Plastic Tupperware
• Teflon pans

But the goal of this post is to expose the sneaky sources most people miss – so let’s get into it:
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Dec 14, 2025
Peptides are behind Hollywood’s most impossible transformations.

They use them to look decades younger, build lean muscle & recover faster (even Jennifer Aniston calls them "the future" & Stallone admitted using them)

Here are the top 7 peptides making stars ageless: Image
Peptide No. 1 + Peptide No. 2

Tesamorelin + Ipamorelin = the GH powerhouse combo

Tesamorelin stimulates growth hormone release.
Ipamorelin increases the frequency and strength of those pulses.

Together, they keep your body’s repair switch turned on 24/7:
Peptide No. 3 + Peptide No. 4

BPC-157 + TB-500 = the Wolverine stack

BPC-157 (Body Protection Compound) speeds up healing from gut to joints.
TB-500 boosts tissue repair and cuts down inflammation.

Together, they help the body recover faster – the kind of edge stars look for during long filming days:
Read 11 tweets

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