A massive Nature study of 27,885 GLP-1 users just dropped some major news about Ozempic and tirzepatide.

Your DNA determines how much weight you lose and how bad the side effects hit.

1 in 3 people see minimal results, and now we know why: (1/9) Researchers found a variant in the GLP1R gene (the specific receptor these drugs target) that affects weight loss.

Each copy of this variant adds about 0.76 kg to your total loss.

If you have two copies, you'll likely lose significantly more than someone without them.

I’ve personally used over 20 peptide and longevity compounds since 2017.

Retatrutide, BPC-157, Selank, MOTS-c, and plenty more.

In this thread, I'll share my exact protocols, the data behind them, and what I’ve actually achieved so far: (1/18) > GLPs are the most impactful compounds I have ever used.

I have done 6 cycles of Retatrutide and 1 of Tirzepatide. Retatrutide is a triple agonist: GIP, GLP-1, and glucagon.

It is the strongest weight loss tool available right now.

Nicotine is wildly misunderstood and demonized.

Separated from tobacco, its risk profile is close to caffeine.

Paired with two neuropeptides, it becomes a full cognitive enhancement stack that doesn't fry your brain like modafinil.

The breakdown + my protocol (1/19)
Most negative claims about nicotine come from tobacco smoke research, not the nicotine itself.

Papers often title their work "nicotine" while actually studying "maternal smoking."

Smoke has over 7,000 chemicals, nicotine is just one of them.

I am using sauna to cut my death risk in half at 44.

There are 50+ studies linking its use to a 40% lower cardiovascular death risk & 45+ benefits to the human body.

Here’s everything you need to know about sauna (+ how to use it properly to get all the benefits): 1. Temperature

Most people think hotter = better, but your body needs specific heat stress to trigger protective mechanisms.

The sweet spot: 70-90°C (158-194°F) for 20-30 minutes.

This raises your core temperature by 1-2 degrees, activating heat shock proteins that repair cellular damage and boost longevity.

I’ve spent $10s of thousands over the last 5 years trying dozens of different peptides.

So these are the 10 best peptides for performance, fat loss & muscle preservation (ranked by effectiveness):

#1: Retatrutide A triple agonist hitting GLP-1, GIP & glucagon receptors simultaneously.

It suppresses appetite, controls blood sugar, and promotes fat loss.

One of the most powerful tools for body recomposition and metabolic performance I've ever seen:

I’ve tested 10+ peptides over 5 years.

So here’s the truth about how they work & the 8 most viral ones people inject without knowing what they do:

1. Peptides are natural. Most peptides are already working inside your body right now.

Here’s exactly what they do in just 60 seconds:

Your doctor will never tell you this…

But these 9 biomarkers show why you can’t lose fat and keep gaining weight no matter what you try:

1. Fasting Insulin → Fat Storage Signal High fasting insulin means your body stays in fat-storage mode (even when you're eating less)

When insulin is chronically elevated, fat burning becomes biologically impossible.

Standard labs miss what kills you.

Here are the 9 biomarkers that predict lifespan, disease risk & how your body ages:

1. ApoB (True Heart Disease Risk) Standard cholesterol tests measure LDL.

But ApoB measures the actual number of atherogenic particles in your blood.

High ApoB = high cardiovascular risk, even if your LDL looks "normal."

This is the number that actually predicts heart attacks.

I saved my brother’s life.

He was obese, had chest pains & our mother thought we were losing him.

So I moved in with him & helped him drop 52 lbs in 90 days (steal the exact protocol): The first and most important thing you need to focus on to lose weight?

Your diet.

The meal plan we used:
⤑ 3 meals a day, spaced 5 hours apart.

PS. We ate whole foods, stayed in a deficit & never mixed fats with carbs:

I’ve been testing peptides for over 5 years...

So here are the top 5 fat-loss peptides that helped me get more shredded than your favorite Hollywood star at 44:

1.Retatrutide A next-generation peptide that targets three hormones (GLP-1, GIP & glucagon) at the same time.

It helps reduce hunger, improves blood sugar control & increases fat burning.

Phase 3 trials showed up to ~28% bodyweight loss (one of the highest results ever recorded in obesity treatment):

If you’re overweight and want to lose belly fat in 2026…

Here’s the exact 11-step protocol to drop 20+ lbs in 90 days (without starving):

Step 1: The 3x5 Diet 3 meals per day. 5 hours apart. No snacking.

Breakfast + lunch: protein, veggies, fats (no carbs).
Dinner: protein, veggies, carbs (no fats).

Avoid fats and carbs in the same meal (this helps prevent insulin spikes that lead to fat storage).

In 2025 you ate 40+ credit cards worth of plastic.

These microplastics sit inside your body (heart, brain, testicles) & are linked to 10+ deadly diseases.

In this thread, I'll show you the only proven ways to detox them & how to avoid the hidden sources you're exposed to daily: Microplastics have been linked to 20+ diseases – including cancer, 4–5× higher heart attack risk, and gut–brain damage.

Around 80% of us are already contaminated, so let’s start with the best way to stay safe: lifestyle changes (then we’ll cover how to detox a portion of them):

Peptides are behind Hollywood’s most impossible transformations.

They use them to look decades younger, build lean muscle & recover faster (even Jennifer Aniston calls them "the future" & Stallone admitted using them)

Here are the top 7 peptides making stars ageless: Peptide No. 1 + Peptide No. 2

Tesamorelin + Ipamorelin = the GH powerhouse combo

Tesamorelin stimulates growth hormone release.
Ipamorelin increases the frequency and strength of those pulses.

Together, they keep your body’s repair switch turned on 24/7:

Sugar is linked to 340,000 deaths/year.

It drives diabetes, heart disease, cancer & 10+ other deadly diseases.

In this thread, we explain why sugar is so addictive & how to eliminate cravings (with insights from a $1,000+/hour functional medicine expert): 1. Sugar cravings explained

When you eat sugar, your blood glucose spikes fast.

Your pancreas releases insulin to handle it, which crashes your blood sugar below where you started.

Now your brain screams for more sugar because you've got low blood glucose and it thinks you're starving:

In 2025 being fat is a choice.

But they made you believe fat loss required pills & powders just to drain your bank.

Here are 13 science-based hacks I used to get shredded at 44 (copy them):

1.Stopped eating like a child "Healthy eating is expensive" is a lie designed to keep you sick.

Cancer costs $150,000+.
Diabetes management: $800/month.
Heart surgery: $122,000.

You can pay $200 extra for quality food or $400 per doctor visit:

PEMF therapy is the ultimate anti-aging hack.

It can reduce inflammation by up to 50%, speed healing by 60% & delivers 20+ proven benefits (results start in 1–2 sessions).

In this thread I’ll explain how to use it safely & how to supercharge the results: PEMF = Pulsed Electromagnetic Field therapy.

It uses low-frequency magnetic pulses to “wake up” tired cells – restoring their charge, boosting circulation & increasing ATP (cellular energy).

Think of it as charging your body the way you charge your phone.

Heart attacks can be prevented.

Proper bloodwork reveals heart-disease risk 10–15 years before symptoms appear.

Here are 8 markers that saved ME from a heart attack & what no one told you about heart health (+comment “ME” & I’ll send you my full 4-week heart masterclass): First let’s see what’s destroying your heart DAILY:

• Chronic stress
• Poor sleep
• Ultra-processed food
• Alcohol
• Sedentary lifestyle

You have 60,000+ miles of blood vessels inside you (& every one of them gets damaged little by little, day after day):

Your cortisol decides the quality of your life.

Everything from burning fat to building muscle to silently destroying your hormones depends on it.

Here’s how cortisol works & how to manage it (+ comment “ME” & I’ll send you my Cortisol Reset Masterclass): Cortisol is like your internal alarm clock.

It spikes high in the morning to wake you up, then gradually decreases throughout the day so melatonin can take over at night.

This is your natural rhythm. When it's working, you feel energized in the morning and sleepy at night.

You can predict how long you’ll live.

Proper bloodwork reveals heart attack risk, cancer & 250+ diseases years before symptoms appear.

Here are 8 markers that can predict illness 10–15 years early (+comment “ME” & I’ll send you 116 more that doctors never test): 1. ApoB (Your Heart Attack Risk)

Measures the number of lipoproteins (LDL, VLDL, remnants) damaging your arteries.

The most accurate predictor of heart attacks – far more reliable than total cholesterol or LDL-C.

PS. High ApoB = plaque buildup and inflammation, even when LDL looks “normal.”

Red-light therapy is the ultimate anti-aging tool.

It speeds up healing by up to 50%, reduces wrinkles, boosts hair growth (& results start showing in 7-14 days).

Here's how to use RLT to get 100% of the benefits (+ 6 insane science-backed effects): I’ve been using RLT for over 5 years, so let me explain how it actually works:

Red and near-infrared light (600–1000nm) penetrate the skin, reach the mitochondria, and boost ATP production (your body’s cellular energy).

The results are more impressive than you might think:

Peptides are behind Hollywood’s most impossible transformations.

They use them to look decades younger, build lean muscle & recover faster (even Jennifer Aniston calls them "the future" & Stallone admitted using them)

Here are the top 7 peptides making stars ageless: Peptide No. 1 + Peptide No. 2

Tesamorelin + Ipamorelin = the GH powerhouse combo

Tesamorelin stimulates growth hormone release.
Ipamorelin increases the frequency and strength of those pulses.

Together, they keep your body’s repair switch turned on 24/7.