Comprehensive molecular characterization of post-COVID condition: Immunoglobulin suppression and persistent SARS-CoV-2 antigens as key pathophysiological drivers
🔥Very, very interesting and impressive Spanish study identifying a DOUBLE molecular pathophysiological LONGCOVID profile!
➡️‘This study provides a comprehensive molecular characterization of post-COVID condition (PCC), defining a consistent global profile marked by two major alterations:’
1. ‘Profound downregulation of immunoglobulins:’
➡️‘One of the most prominent findings from the SWATH analysis of plasma samples (v2024 library) was the significant reduction in immunoglobulin levels, particularly kappa and lambda light chains, in symptomatic PCC patients.’
➡️‘This marked humoral immune dysfunction strongly correlated with disease severity, as revealed by clustering and principal component analyses.’
➡️‘Potential as biomarkers for clinical classification and therapeutic targeting.’
➡️‘The downregulation of immunoglobulins suggests a critical vulnerability in resolving viral remnants and controlling inflammation, aligning with immunodeficiency-like profiles observed in chronic immune disorders.’
2. ‘The persistent presence of SARS-CoV-2 antigens, particularly the spike and nucleocapsid proteins.’
➡️‘MRM/SRM analyses provided definitive evidence of the persistent presence of spike and nucleocapsid proteins in symptomatic PCC patients.’
➡️‘The spike protein's pro-inflammatory and pro-thrombotic properties likely exacerbate systemic symptoms, including cardiovascular and respiratory manifestations.’
➡️‘Nucleocapsid protein, detectable through both SWATH and MRM/SRM, amplifies inflammation via complement activation and interferon suppression, potentially sustaining a chronic immune response.’
➡️‘These findings indicate that residual viral antigens evade immune clearance through mechanisms such as sequestration in cellular compartments or association with extracellular vesicles, thereby perpetuating pathological immune activation.’
‼️‘This molecular characterization of PCC underscores the intertwined roles of immunoglobulin suppression and viral antigen persistence in driving disease progression.’
‼️‘The observed immune dysregulation parallels profiles seen in primary immunodeficiencies, suggesting that symptomatic PCC patients are particularly vulnerable to chronic inflammation and impaired viral clearance.’
‼️‘The results define a global molecular signature of PCC that highlights the suppression of immunoglobulins and the persistence of SARS-CoV-2 antigens as central pathophysiological mechanisms.’
➡️The molecular #Leonardieffect evidence
CC: @fitterhappierAJ
sciencedirect.com/science/articl…
🔥Very, very interesting and impressive Spanish study identifying a DOUBLE molecular pathophysiological LONGCOVID profile!
➡️‘This study provides a comprehensive molecular characterization of post-COVID condition (PCC), defining a consistent global profile marked by two major alterations:’
1. ‘Profound downregulation of immunoglobulins:’
➡️‘One of the most prominent findings from the SWATH analysis of plasma samples (v2024 library) was the significant reduction in immunoglobulin levels, particularly kappa and lambda light chains, in symptomatic PCC patients.’
➡️‘This marked humoral immune dysfunction strongly correlated with disease severity, as revealed by clustering and principal component analyses.’
➡️‘Potential as biomarkers for clinical classification and therapeutic targeting.’
➡️‘The downregulation of immunoglobulins suggests a critical vulnerability in resolving viral remnants and controlling inflammation, aligning with immunodeficiency-like profiles observed in chronic immune disorders.’
2. ‘The persistent presence of SARS-CoV-2 antigens, particularly the spike and nucleocapsid proteins.’
➡️‘MRM/SRM analyses provided definitive evidence of the persistent presence of spike and nucleocapsid proteins in symptomatic PCC patients.’
➡️‘The spike protein's pro-inflammatory and pro-thrombotic properties likely exacerbate systemic symptoms, including cardiovascular and respiratory manifestations.’
➡️‘Nucleocapsid protein, detectable through both SWATH and MRM/SRM, amplifies inflammation via complement activation and interferon suppression, potentially sustaining a chronic immune response.’
➡️‘These findings indicate that residual viral antigens evade immune clearance through mechanisms such as sequestration in cellular compartments or association with extracellular vesicles, thereby perpetuating pathological immune activation.’
‼️‘This molecular characterization of PCC underscores the intertwined roles of immunoglobulin suppression and viral antigen persistence in driving disease progression.’
‼️‘The observed immune dysregulation parallels profiles seen in primary immunodeficiencies, suggesting that symptomatic PCC patients are particularly vulnerable to chronic inflammation and impaired viral clearance.’
‼️‘The results define a global molecular signature of PCC that highlights the suppression of immunoglobulins and the persistence of SARS-CoV-2 antigens as central pathophysiological mechanisms.’
➡️The molecular #Leonardieffect evidence
CC: @fitterhappierAJ
sciencedirect.com/science/articl…
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