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Crémieux Profile picture
@cremieuxrecueil
Jul 17, 2025 • 9 tweets • 4 min read • Read on X
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It's so good to see more gene therapies getting worked on.

This one is particularly amazing because it's effectively a one-shot, permanent Exenatide—making humans produce a version of the compound in Gila monster venom like lifelong Ozempic!

But is it safe?

Probably! Short🧵 Image
In the picture I posted above, you can see the effects of having variants that increase the effect of the gene GLP1R.

This was relevant when I was discussing compositional effects of GLP-1RAs. As you can see, bodyfat *percentage* declines with higher natural GLP-1R agonism.
I went ahead and checked the effects of the same SNPs and an extended set of SNPs on the effects of GLP1R on colorectal cancer risk.

It seemed to reduce it (pic is an excerpt from one of my subscriber-only posts). Image
But the thing here is exendin-4, which has a synthetic analog in the early GLP-1RA exenatide. It shows 53% sequence identity with human GLP-1, but with a glycine substitution and 9 extra amino acid residues on its C-terminus, for stability.

So it's not exactly what I targeted.
But it is highly similar, and the differences should not make it have many different phenotypic effects.

That said, exendin-4 has been associated in preclinical data with reduced incidence of various types of cancers. Image
Image
Image
As far as I can tell, exenatide has the same cancer risk profile as the newer, stronger GLP-1RAs like semaglutide and tirzepatide, it's just weaker.

So, it should come with a reduced risk of several obesity-associated cancers like GLP-1RAs in general seem to be. Image
It might also come with increased odds of survival for certain types of cancer. Image
Since this stuff should have the same safety profile as the drug itself, it's likely just as safe.

And that means, it's likely safe. But not only is it likely safe, it's likely effective and protective.

I'm reasonably certain that this gene therapy will deliver major benefits.
Sources:

ec.bioscientifica.com/view/journals/…

link.springer.com/article/10.100…

diabetesjournals.org/diabetes/artic…

jamanetwork.com/journals/jaman…

gynecologiconcology-online.net/article/S0090-…

Also: liebertpub.com/doi/10.1089/di…

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More from @cremieuxrecueil

Crémieux Profile picture
Feb 3
Indeed!

This research directly militates against modern blood libel.

If people knew, for example, that Black and White men earned the same amounts on average at the same IQs, they would likely be a lot less convinced by basically-false discrimination narratives blaming Whites. Image
Add in that the intelligence differences cannot be explained by discrimination—because there *is* measurement invariance—and these sorts of findings are incredibly damning for discrimination-based narratives of racial inequality.

So, said findings must be condemned, proscribed. Image
The above chart is from the NLSY '79, but it replicates in plenty of other datasets, because it is broadly true.

For example, here are three independent replications:
Read 4 tweets
Crémieux Profile picture
Jan 29
How well-known is this?

A lot of the major pieces of civil rights legislation were passed by White elites who were upset at the violence generated by the Great Migration and the riots.

Because of his association with this violence, most people at the time came to dislike MLK. Image
It's only *after* his death, and with his public beatification that he's come to enjoy a good reputation.

This comic from 1967 is a much better summation of how the public viewed him than what people are generally taught today. Image
And yes, he was viewed better by Blacks than by Whites.

But remember, at the time, Whites were almost nine-tenths of the population.

Near his death, Whites were maybe one-quarter favorable to MLK, and most of that favorability was weak. Image
Read 5 tweets
Crémieux Profile picture
Jan 28
The Pope, like his recent predecessors, is good to take this position: anti-Semitism is manifestly idiotic!

On that note, did you know that the Catholic Church was actually one of the biggest forces in stopping the rise of the Nazis?

It's true!🧵 Image
You might say that the Catholics didn't vote for the Nazis because they had their own party: Zentrum.

This isn't the explanation.

Note: the Catholic Church opposed both forms of totalitarianism in Germany, but it had an asymmetric effect against the Nazis, not the Communists.Image
The real "Catholic effect" on far right vote shares was small.

In reality, Catholics only became poised against the far right when the church began to actively campaign against it.

But when the local clergymen were "Brown Priests" (Nazi-supporting priests) like Alois Hudal? Image
Read 22 tweets
Crémieux Profile picture
Jan 27
The researcher who put together these numbers was investigated and almost charged with a crime for bringing these numbers to light when she hadn't received permission.

Now we have an update that goes through 2020!

First: Where are Sweden's rapists from?

Mostly not Sweden. Image
What countries were those foreign rapists from?

We only got information on the top five origins, constituting roughly half of the foreign-born samples, and thus about a quarter of all the rapists. Image
What about welfare usage? 35.1%.
Alcoholism? 14.9%
Drug addiction? 23.7%
A diagnosed psychiatric disorder besides that? 13%

What about a criminal prior? 52%. That compares to 13.4% of non-rapist criminals. So rapes? Considerably more preventable.
Read 5 tweets
Crémieux Profile picture
Jan 17
Greater Male Variability rarely makes for an adequate explanation of sex differences in performance.

One exception may be the number of papers published by academics.

If you remove the top 7.5% of men, there's no longer a gap! Image
The disciplines covered here were ones with relatively equal sex ratios: Education, Nursing & Caring Science, Psychology, Public Health, Sociology, and Social Work.

Because these are stats on professors, this means that if there's greater male variability, it's mostly right-tail
Despite this, the very highest-performing women actually outperformed the very highest-performing men on average, albeit slightly.

The percentiles in this image are for the combined group, so these findings coexist for composition reasons. Image
Read 6 tweets
Crémieux Profile picture
Jan 17
One of the issues with understanding Greater Male Variability on IQ tests is that groups that perform better tend to show greater variance

Therefore, to estimate the 'correct' male-female gap, you need to estimate it when the difference is 0

In the CogAT, that looks like this: Image
In Project Talent, that looks like this: Image
And comparing siblings in the NLSY '79, that looks like this: Image
Read 5 tweets

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